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May be something as simple as giving a nice hefty Vascepa discount for anyone currently prescribed statins. R-IT is not about Vascepa. It is about Vascepa AND statin therapy.
Can anyone help me to understand how a company with a P/E of -28 can have a Market Cap close to $4 Billion?
As per the 13F filings for the last quarter, Fidelity added 2 million Amarin shares to their preexisting 2 million. Their fund value is just shy of a Trillion dollars.
How much is your fund worth Ralphy, and how many shares do you currently hold? Are you still hoping to get back in around $1?
And Kiwi, still hoping to get in under $3 are you?
Yes, same thing. Bodes well for R-IT that Vascepa reduced it in the ANCHOR trial, but doing it in a 12 week study is one thing, and another thing entirely to do it over the course of a 4-6 year time period.
I expect that if R-IT demonstrates efficacy >25% you are going to see a decent reduction in apoB levels, and >40%, a very significant reduction. I don't personally expect RRR to be less than 20% but if it is I expect there to be a correspondingly poor reduction.
Interesting times.
From the linked article:
"Across the United States, patients who have the highest apoB readings will suffer nearly 3 million more heart attacks, strokes, and other cardiovascular events in the next 15 years than will people with the lowest levels..."
In the ANCHOR trial, Vascepa lowered apoB levels by 9.3% at the 4g dose.
The FDA ain't gonna do jack until the results of R-IT have proven efficacy (unless forced to do so by a higher authority in the interim). Until then Vascepa is an FDA approved drug for the MARINE patient population, and essentially a mere DS caught in limbo for the ANCHOR / R-IT patient population.
Do feel free to post your analysis of the Amarin chart on the MONTHLY time frame. I would enjoy reading your analysis of the November and October price bars in particular.
HDG, thanks for the detail. Much appreciated!
HDG,
"As of September 30, 2017, Amarin had approximately 270.9 million American Depository Shares (ADSs) and ordinary shares outstanding, 32.8 million common share equivalents of Series A Convertible Preferred Shares outstanding and approximately 23.6 million equivalent shares underlying stock options at a weighted-average exercise price of $3.26, as well as 11.9 million equivalent shares underlying restricted or deferred stock units."
Who exactly has the option to purchase these shares, and on what date do these options expire?
I'm assuming that the other 11.9 million and 32.8 million are options to buy shares at whatever the market price is at the time they are exercised, if and when they are exercised, correct? If you have the expiry date of these options handy could you share it please? :)
I'm just trying to figure out how many of these options are likely to be exercised before end of September 2018.
Thanks
"Amarin complains to the ITC on the basis of unfair trading practices..ie, selling drugs which were never approved by the FDA..the unfairness the result of these companies not having to go through the costly FDA "marketing process". "
If the R-IT study is successful, it would be scandalous to have these DS products on the market competing with Vascepa and taking Vascepa market share piggybacking on positive trial results, without any of these DS manufacturers having contributed a red cent to the R-IT trial, and without them having a single ee-EPA patent or FDA approved drug.
It amounts to theft and the time is nigh for Amarin to nip this thing in the bud pre R-IT results before this drug potentially becomes a very big deal. The free ride these DS companies have been getting is over.
February 8th / June 20th / 35%
"we've been over this before" .......
Indeed we have, and you didn't get it then and you're still not getting it now. So let me try one more time.....
You seem to have a bee in your bonnet about the whole arithmetic vs semi-log vs log scaling systems. I don't. The scale that I use serves its purpose which is to tell me whether or not prices are trending UP or DOWN. As is evidenced on the first picture you posted, it doesn't matter whether or not the arithmetic or semi-log scale is used because they both clearly show that prices are trending UP, and that dear boy is all I need to know.
Amarin monthly semi-log as posted before, clearly showing the UP trend in prices:
And the Amarin monthly using the arithmetic scale:
Lo and behold it also shows prices trending UP. Case closed. Im not going to debate this further. Have at whatever scale you want. I couldnt care less.
In the next picture you state some nonsense about "Expanding volume!"
Now as anyone familiar with the concepts of UP and DOWN can see (I know you're struggling with this, so bear with me here), the volume has been steadily DECREASING (or going DOWN if you please) as is evidenced by the black line that I have drawn. Expanding volume? Not by a long way.
Next you post this....
.........and state that the currently monthly volume is "already" double last months. Lets take a closer look at the facts:
With 8 trading days left in the month of May we currently sit at a volume of 25 million vs an average monthly volume of 50 million. Last months volume was a mere 18 million. Tiny. So with 8 trading days left lets look at the average daily volume as it currently stands:
The average volume is just over a million. So multiply that by 8 and add it to the current monthly volume and you get 25M + 8M = 33M which is still way below the 50 million average monthly volume. Nothing to see here.
The whole point of this is to highlight the FACT that the professionals still hold their shares - over 100 million shares in total currently as of end of March, and we know by looking at the total volume of shares traded for April and the fact that it was only 18M, that the vast majority of the pros holding the stock STILL hold their stock today. Point being that until you see spikes in volume >100M on the monthly charts the trend will continue UP. The pros sell at market highs, NOT at market lows. Could prices dip down to $2.50 temporarily? Yes they could, but prices as they currently stand are in zero danger of collapsing below that.
"Do you still stand by your statement?"
I do, yes.
"You might think this is garbage but I think it is the proper way to interpret TA tools without changing the goal posts just so you can continue to sleep at night."
I do think its garbage, yes. Changing the goal posts just so I can sleep at night? What a bizzare statement. The monthly charts contain the most volume (activity ie buying and selling) and therefore hold the most weight in terms of analysis for predicting future price moves. That's why I use them. If you want to persist in trying to call minor price fluctuations in a $3 biotech stock with an average daily volume of just of 1 million shares traded using daily and minute charts be my guest. I aint interested. Any analysis that fails to include a comprehensive overview of the monthly time frame is flawed big time.
"broken the uptrend"???
Complete garbage.
Here's the monthly chart again....
Can you please explain to me how the uptrend has been broken please?
The support zone is between 2.56 and 2.97. Unless it closes BELOW 2.56, the UPTREND will CONTINUE. There is NOTHING currently on the weekly/daily charts indicating that prices are going to collapse (and by collapse I mean close below 2.56) so I will be taking advantage of any dips in price to pick up more shares while the going is good.
Can we have less of the "the sky is falling!!! duck for cover!!!!" crap and more of a grounding in reality please? Thanks.
There's a mountain of evidence clearly showing the negative health effects of consuming red meat. Hell, even the WHO (a ridiculous enterprise if ever there was one, but how and ever...) are partially on board the ship these days:
http://www.bbc.com/news/health-34615621
The same way that it took thousands of studies showing the negative effects of smoking tobacco before it was finally accepted mainstream, the same will be the case with the meat industry who wont be going down without a fight.
The average punter just doesnt care about their dietary/lifestyle health consequences, and is happy to continue rolling the dice gambling with their health until their day of reckoning finally arrives. Life is hard enough without taking away your favourite food addictions. That idea is simply out of the question.
Bon appetit.
In Ireland I can assure you that its Kerrygold butter rather than clotted cream which is more of a Devon, Cornwall, British type thing. I've had it many's the time though and agree that it trumps the butter, no contest. But the lemon curd? Never heard of that one before. Home-made mixed berry jams all the way any time ive had it with the clotted cream. Good eatin for sure. That was a regular desert after a meat and potatoes dinner for me back in the day. That and fresh hot-cross buns. Lovely stuff. Took its toll though along with all that milky sugary tea, so those days are over for me.
A few hot scones, Kerrygold butter, home-made jam, a nice pot of Barry's tea, a bit of sunshine, and Irish eyes are smiling again. Doesn't take much :)
100% its in the "eye of the creator". Its an art. The method that I use will see you succeed >90% of the time if you interpret the data correctly. The method that the other guy uses will see success around 70% of the time.
Its all just pattern interpretation combined with probability at the end of the day. NO TA offers a 100% success rate. The method I use (Wyckoff VSA) is the closest you're gonna get to the holy grail but it certainly isn't flawless, and nor is my analysis.
Dear oh dear. Use whatever scale you want - THE TREND IS STILL UP ON EVERY SINGLE ONE YOU USE FOR THE MONTHLY AND WEEKLY TIME FRAMES IE BULLISH!
Shall I explain the difference between "up" and "down" or have you managed to figure that much out?
The fact that it breaks down through the trend line that you have drawn is irrelevant when you factor in the volume. There was no major spike in volume on the weekly charts or monthly chart (so far this month) preceding the recent minor downturn in price, therefore the downside will be correspondingly limited. End of story.
Well played. The sky is far from falling in, despite what that other guy claims. As long as she closes above $2.81 at the end of May the bull train will ride on. If you study the volume for the month of May as it currently stands, that has a >99% chance of occurring in my opinion. If it dips back down to the low $2.80's over the next couple of weeks i'm buying more.
Looks for all the world to me like its last call for cheap shares before this thing gets marked up big time up and over $3.50 towards $10 June -> August pre the 80% announcement around September.
I personally see a trial continuation announcement in September, and market disappointment following plenty of hype in the run-up, so I plan on taking some profit off the table in August while the going is good before that sell-off, and then re-buying around $5 or whatever the charts indicate to be the best re-entry price.
Watch for Pyrronhian to disappear now shortly as the share price gets marked up and then watch him reappear from September -> December firing full throttle doom and gloom down everyone's throat again. Wait an see.
It's all good though, just a mind game like all the rest.
"Don't bother replying, I'm signing off."
I will bother replying because you're full of it.
You are making false claims that can easily be debunked by anyone who is even half way savvy with TA.
First things first lets draw the trend lines to determine if the price pattern is bullish (rising prices) or bearish (falling prices).
The weekly chart....
Now, as all the beautiful people reading this can see, the trend is BULLISH, not bearish. Prices have been trending up, not down. Clear as crystal.
"Ahh but the weekly charts don't hold as much weight as the monthly charts!", I hear you all screaming. "You're full of it yourself you fruit eating freak! Stick your TA up your !#@!". Settle down now folks.
Lets have a look at the monthly.......
Same deal. She's trending up as well. BULLISH.
Just for the record, as per end of the last quarter when they picked up those Amarin shares, Blackrock's marketvalue was $1.822 TRILLION (not billion).
How much is Pyrr's bathroom grouting operation worth do you know?
Nissen may be a moron with zero personal integrity but that doesn't mean Esselstyn is.
http://www.cardiobrief.org/2015/06/12/steven-nissen-conflicts-of-interest-and-the-new-cholesterol-drugs/
"Cleveland Clinic....whatever"
The point remains that its the best Heart disease hospital in the U.S and has been for the past 22 years running. Does it still fall way short of the mark? Of course it does, but you can say that about every single hospital in the U.S. Conflicts of interest? The whole medical system is a racket and im well aware of it.
Got my blood-work done after completing my "wacky" 6 months on nothing but fruit and herbs.
Glucose: 75
Odd that my glucose level is perfectly normal after all that sugar, isn't it JL?
The Cleveland Clinic has been the #1 Heart Disease hospital for the past 22 years in a row in the U.S. so I will use their recommended ranges for my lipids:
https://my.clevelandclinic.org/health/articles/cholesterol-guidelines-heart-health/measure-your-ldl
TG's: 135
They recommend lower than 150. Check.
HDL-C: 64
They recommend >45 ("the higher the better"). Check. This is the highest my HDL has ever been.
LDL-C: 75
They recommend <130. Check. This is lowest my LDL has ever been.
Total Cholesterol: 166
They recommend 100-199. Check.
My blood pressure on the right arm is 115/70; 110/75 on the left; Perfectly normal.
The above results were achieved without the use of any pharmaceutical products whatsoever (no statins, no Vascepa etc etc) and with very mild exercise daily.
As mentioned before, I get that eating nothing but fruit and herbs for 6 months isn't practical or remotely desirable for pretty much anyone reading this. But based on my research it is by far the fastest and most efficient method in terms of CURING disease (something alopathic medicine knows nothing about because its not the game they are playing).
What does the MD Director of the Cardiovascular Disease Prevention/Reversal Program at the Cleveland Clinic Wellness Institute recommend eating? (Caldwell Esselstyn, Jr; the guy that treated Bill Clinton for his heart disease and got him to go vegan: http://www.dresselstyn.com/site/about/about-dr-esselstyn/)
Fruit, lots of green veggies, beans and lentils, corn and potatoes; NO SALT; NO OIL; NO PROCESSED FOOD; NO REFINED SUGAR; NO DAIRY; NO MEAT.
Which is coincidently exactly what I recommended eating in a recent message on here, and is what ive started eating again - fruit still for breakfast and lunch and some cooked food in the evenings.
I'd personally allow folk to be slightly more lenient when starting out if moving from a standard american/western diet to the above diet and would allow small amounts of chicken, turkey and fish initially with the ultimate goal of removing them altogether from your diet. Id also allow a small amount of Himalayan salt or a natural good quality sea-salt. In terms of cooking with oil, if heating to high temperatures id recommend small amounts of coconut oil, and extra virgin olive oil for room temperature salads and dressings. Vascepa would also do more good than harm initially so that can be taken until your lipid panel is in the recommended ranges. In terms of alcohol, a decent red wine with no sulfites in moderation, but you'd be far better off just eating the red grapes instead.
Dr. Esselstyn keeps patients on their statins and titrates them off once they have achieved the desired goals. Id set up a small fire in my yard and burn mine if I had them.
The above is all my own opinion based on extensive research and personal experience. Take it or leave it.
I've noticed the very same thing. I'm tempted to study the timing of his fear based posts and heightened activity and see if there is a correlation between them and negative share price activity. I bet that there is.
For those of you concerned that the sky is falling....
Yesterdays action and volume spike on the daily time scale:
Doesn't look too pretty on the face of it if you are long, but before we start ranting and raving and getting our knickers in a twist lets pan back to the monthly time frame for some much needed perspective:
The sky aint falling according to the monthly chart, not by a long way. Yesterdays volume spike indicates that the pros are active. The average daily volume is currently 2 million shares and yesterdays volume spiked to 5 million. To determine whether the activity was pro buying or selling, we need to look at the closing price of today's bar. If it closes above $3 today, the volume spike yesterday can be attributed to pro buying. If it was caused by the pros dumping their holdings, down it will go again today to close under $3.
A closer look at the monthly chart....
1. January's price par. Prices are marked down but the volume is only 29 million vs an average volume of 49 million. From this price action and volume we can conclude that there is no selling pressure. The support price can now be set in the 2.97 - 2.81 zone.
2. Prices rebound back up but the price bar closes well off the high on lower than average volume, suggesting prices are not ready to overcome the overhead resistance.
3. Back down it goes on lower than average volume.
4. Aprils price bar closes down on a mere 18 million vs an average volume of 50 million. This tells you that there is no pro selling pressure.
5. This month three days in, hence the tiny volume; 7 million so far vs an average of 49 million. The closing price at the end of this month will tell a tale. As there was no selling pressure on Aprils price bar, I expect prices to probably dip down briefly into the marked support zone to no lower than around 2.80 before rebounding back up. Looks like the pros are having a final bear raid snapping up the last remaining "cheap" floating shares before we have another crack at overcoming the overhead resistance. Prices will be marked up when they have removed the float, no sooner and no later.
Just my interpretation of the what I see in the charts, take it or leave it. I'm long Amarin and slept like a baby last night.
"....if you are on an all watermelon diet and consuming 1500 Kcals of watermelon...You are on a pro inflammatory diet"
You think I ate 1500 kcals worth in one sitting three times a day? Are you nuts?
1500 kcals of watermelon = 5kgs worth of watermelon (almost 33 cups!!). This contains 378g of Carbs. No doc, I did not consume this amount of watermelon in one sitting nor did I even consume that amount in a whole day.
I consumed around 6 cups per sitting three times a day. 6 cups contains 69 grams of carbohydrate (including fiber). Too much? Lets have a look at the carb content of other foods (devoid of fiber for the most part).....
2 cups of cooked spaghetti: 93 grams
Little Caesars medium pepperoni pizza: 264 grams
20oz (591mls) bottle of Coca Cola: 65 grams
2 medium sized (346g) baked potatoes: 73 grams
McDonalds french fries (154g): 66 grams
Subway 12" club sandwich: 84 grams
Chocolate cake per slice (138g): 73 grams
I could go on and on but you get the idea.
If you are consuming any of the above crap you are on a pro-inflammation diet as they contain far more ingredients than just carbs.
I'll stick with the fruit and herbs thanks and feed my cells precisely what they require. Y'all do as you please.
*Im done discussing this. You're wasting your breath replying. I got your number and im far from impressed, although not in the least bit surprised.
"Fad diet?"
Can you explain to me what exactly is fad about consuming the diet that our species was designed to consume? Name me a single food group superior to fruit in terms of overall electromagnetism, vitamin and mineral content, and monosaccharide content. Shall I save you some time? There aint any.
If you want to consume animal products be my guest. I appreciate that what im doing and what I recommend is neither practical, possible or desirable for the vast majority of folk living on the planet. I also appreciate that a biotech investor forum is about the most hostile environment in which to discuss this kind of material which is why I will cease doing it.
My posts are aimed at the one or two folk out there reading that have the gumption to go research this stuff on their own like I did. I, like many others, have experienced first hand the health benefits that result from following the diet and lifestyle I recommend so the opinions of PhDs, MDs, and anonymous forum members are completely meaningless to me. Opinions are a dime a dozen. From personal experience comes knowledge.
Go wear the robe like I did before you start hurling cheap shots and posting 10 minute google search cut and paste jobs. If you cant wear the robe then dont. Leave it and jog on and eat whatever the hell you want. I won't lose any sleep over it.
*This is my last post on this subject matter for anyone in the peanut gallery thinking of aiming another cheap shot. You needn't bother because i wot respond to it. I'll post my lab results in 3 weeks when I get them then that will be that.*
Youre still not gettin it doc.
The reason you eat is to provide fuel for your body so that its cells can generate energy (ATP).
The chemical formula for this is:
C6H12O6 + 6O2 -> 6CO2 + 6H20 + energy (ATP)
In simple english the above formula reads.....
Glucose + Oxygen gets converted into Carbon Dioxide + Water + energy.
Glucose is a simple carbohydrate (monosaccharide) and along with fructose (also a monosaccharide) they represent the ideal source of carbohydrates for our species as they are the most easily digested and absorbed - particularly fructose (*NOT HFCS*) as it DOES NOT require insulin.
As fruit contains mainly glucose and fructose along with all the vitamins, minerals etc it is the perfect fuel for our bodies (and provided to us by nature for free no less). Sucrose and starch are also carbohydrates and can be consumed as fuel but they are more complex and therefore not ideal. If you are going to consume complex carbs potatoes (baked ideally/boiled is ok/not fried) and whole grain rice are the way to go. White flour products simply contain far too much glucose for your body to handle especially when you are also consuming soft drinks and a desert at the same sitting (hence the obesity/diabetes epidemic etc etc).
If you want to think of it in terms of calories you can consider this...
1lb of fruit/veg = around 300 calories
1lb of potatoes/rice = around 500 calories
1lb of pasta/bread = around 1700 calories
1lb of oil = around 4000 calories
The take home is that fruit and veg contain far less calories and "sugar" by weight than potatoes, rice, pasta, bread, oil etc etc.
Ever wonder why Asians in Asia are so slim? They eat rice 3 meals a day - not hamburgers, sandwiches, pasta, cake etc etc.
So if youre telling me watermelon is sugar and water im on board with that - it is. Our bodies are >70% water and as explained above we require sugar to fuel our cells. You dont seem to get that not all sugars are created equally.
If you are ignorant enough to think that drinking Coke (HFCS/processed sugar) is equivalent to eating fruit you have a hell of a lot to learn about how the human body works and I suggest you spend a few weeks googling the differences between processed sugar/high fructose corn syrup, and all the other forms of carbs. I could explain it to you in great detail but it would go in one ear and straight out the other with you - as it did the time you failed to understand that inflammation has a root cause and doesnt just spontaneously manifest on a whim the way you think it does.
Accept that you DO NOT know it all doc and that you never will. Your narcissism and inflated ego serves no purpose in the grand scheme of things. You are never too old to learn.
Watermelon not good? Absolute garbage. How am I still alive then?
Are you aware that cells require glucose and oxygen to synthesise energy (ATP)?
C6H12O6 + 6O2 -> 6CO2 + 6H2O + energy (ATP)
Basic stuff. Carbs are where the party is at. If you want to run your system on fats and protein be my guest but doing that is far from efficient.
Sugared soft drinks? You mean that processed crap that contains isolated sucrose/high fructose corn syrup devoid of any life not to mention vitamins,minerals etc. You're telling me watermelon is "pretty much the same" as Coca Cola and Sprite? Are you taking the piss?
How much nutritional training did they provide you with in med school? A week wasn't it? I'd advise you to stick to what you know - the medical field.
Re the plant protein thing ill let this article do the talking: http://nutritionstudies.org/animal-vs-plant-protein/
If you want to source your protein from chopped up rotting cooked dead animals be my guest. I did it myself for over 3 decades so no judgement here.
As a Biologist im fully aware of what protein is but thanks for the patronizing condescending remark anyway. Suitably narcissistic. I didnt expect anything less.
Nah im not so much into strenuous physical activity and certainly wouldn't recommend mountain biking for anyone who's obese and spent decades on the SAD diet. Those poor folk would be much better served by daily stretching (some form of yoga or tai chi - falun gong is ideal), fasting (ideally fruit fasting for extended periods; a 40 day black grape fast(feast) works wonders but you do what you can be it 1/5/10 days on a mono/mixed fruit diet- i personally did 40 days mixed fruit followed by 40 days watermelon followed by 10 days lemon water), and breathing exercises (think pranayama preferably in nature).
Do all that for a year or two while overhauling your diet and then you can up the ante on the whole physical activity side of things.
All just my own opinion as an open minded scientist (biologist) who has spent 8 years researching all this stuff and personally trying out various different diets and alternative health medicines in an attempt to get to the truth of it all. From experience comes knowledge. Take it or leave it and do your own research and be aware that there is a war on for your mind because its worth a lot of $$$ to a lot of people.
Where does Vascepa fit into all this? You do all of the above and alter your diet and you won't need it. Continue on with the diet and lifestyle that got you into the mess your in (genetics do play a role insofar as your genetically weakest tissue will be the first to further degenerate ie if your father had heart disease you are also at risk and your death from it will be hastened if your diet and lifestyle mirrors his) and Vascepa will at least buy you a little more time because it is an effective "treatment" (not a cure) to some degree for reducing the inflammation that is damaging your vascular system. But that's all it is and all it ever will be. And that's cool when your gig is treatment and symptoms rather than cause and cure as is the game the medical system (FDA, AMA, PHRMA etc) is playing.
Let the buyer beware.
Half decent. He has the jist of it down.
To his NO NO's list he should have added red meat (beef,pork), dairy (milk,cream,cheese,butter,yoghurt etc), table salt, and carbonated soft drinks among other things.
This isn't just about heart disease. You are what you eat.
My own take from my own experience is that the ideal diet is around 90% carbs, 5% fat, 5% protein. 80-10-10 is adequate for most folk but why half ass it?
Important to note that not all carbs are created equally. He doesn't mention this in his video. Of the 90% carbs I suggest aiming for 60% (2 meals/day; breakfast and lunch ideally) pure fruit (simple carbs; monosaccharides; glucose and frucose; easily digested and absorbed), with the remaining 30% of those carbs being vegetables (steamed or lightly stir fried; raw in the form of salads is preferred; lots of fresh herbs) and starchy carbs - think potatoes and whole grains (brown rice, quinoa etc). Avoid white flour (white bread, white pasta) and processed carbs like table sugar like the plague.
In terms of fat avoid all refined vegetable oils. Think avocados, coconut oil for light cooking, and olive oil unheated for salads and dressings and what have you. Avoid nuts or eat very sparingly.
In terms of protein think plant protein as its far more easily digestible than animal protein (mainly sourced from rotting chopped up dead animals).
I'd also supplement all of the above with herbal medicine (powerful natural anti-inflammatory effects).
Take it or leave it.
Finishing up my second 6 month pure fruit diet now, 3 weeks to go. This time no fats whatsoever (the first time i did it i ate durian, avocado and coconut but have omitted them all this time - all relatively high fat fruits). Will post the lab results when i get them.
How much does an annual supply of Vascepa currently cost?
Home-run RRR R-IT data would surely justify a price hike for Vascepa considering its proven benefit, placeboesque side-effects, and the fact it will be best in class.
This then obviously leads to higher future revenues making a mockery of all the current low ball "expert" analyst future price projections and valuations.
This stock is an absolute steal at the current price levels.
Thanks for posting that AHA paper:
http://circ.ahajournals.org/content/early/2017/03/13/CIR.0000000000000482
Had a read through there. They are setting the stage for Vascepa and R-IT.
"As noted previously, except for JELIS, all of the RCTs used low doses of omega-3 PUFA supplements. Higher doses of omega-3 PUFA supplements are being studied in ongoing RCTs (REDUCE-IT [Reduction of Cardiovascular Events With EPA–Intervention Trial] and STRENGTH [Statin Residual Risk Reduction With Epanova in High CV Risk Patients With Hypertriglyceridemia]). Additionally, most of the RCTs were of relatively short-term duration of omega-3 PUFA intake. We acknowledge that a lack of evidence of a benefit differs from evidence of a lack of effect. We look forward to future reports that address the gaps in evidence that we documented. As findings from ongoing RCTs are reported, we will assess the need to further update this advisory."
"CONCLUSIONS
Although recent RCT evidence has raised questions
about the benefits of omega-3 supplementation to prevent
clinical CVD events, the recommendation for patients
with prevalent CHD such as a recent MI remains
essentially unchanged: Treatment with omega-3 PUFA
supplements is reasonable for these patients. Even a
potential modest reduction in CHD mortality (10%) in
this clinical population would justify treatment with a
relatively safe therapy.
Although we do not recommend treatment for patients
with diabetes mellitus and prediabetes to prevent CHD,
there was a lack of consensus on the recommendation
for patients at high CVD risk. On the other hand, we
do not recommend treatment to prevent incident stroke
among patients at high CVD risk and recurrent AF. Because
there are no reported RCTs related to the primary
prevention of CHD, heart failure, and AF, we were not
able to make recommendations for these indications.
RCTs in progress with clinical CVD end points may inform
recommendations related to these potential indications
for omega-3 PUFA supplementation."
So basically they are stating that they are open for business pending a decent set of robust data.
Enter Vascepa and R-IT to knock this out of the ball park.
Thanks for the message.
Not sure I understand what you mean....
The total average monthly volume for Nov '09 was 320k.
In Nov '10 it was 14.9 million.
So it was obviously increasing.
Do you mean Nov '08 to Nov '09?
There was no volume back then because the smart money weren't interested. The company didn't have much in the way of revenue or much going on in the development pipeline so no reason to own the stock.
You can see from the chart that the accumulation of the floating supply (buying at wholesale prices) began 9 months before the MARINE trial results. The same thing has been going on now in the run-up to R-IT.
Can you post the 10 minute chart on here and ill have a look. I don't day trade the stock and am not interested in selling my holdings any time soon, so I dont have access to accurate volume data on time frames smaller than 1 day with the trading platform I use (you have to pay for that valuable info). I'll buy it soon enough though once the action starts heating up.
I wouldnt get bogged down trying to interpret the smaller time frames if you're new to this. The monthly chart holds the most weight because that is where you see the most volume. Then obviously the weekly and daily charts, so you're far better off understanding them 3 first. The smaller time frames are used to determine future price moves on precisely that - smaller time frames ie 5, 15, 30, 60 minutes etc. Useful obviously when pinpointing exactly when to buy or sell if you have identified a buying or selling opportunity on the larger time-frames, and also if you dont mind sitting in front of charts all day in an attempt to scalp the markets.
Is this clear enough for you?
Do feel free to ask me any questions you might have. To help you out a bit - the black down arrow means DOWN as in lower, and the black up arrow means UP as in higher. Ive put them to the right of the existing price bars as that space represents the "future" which has not happened yet - hence the fact that there are no price bars there yet.
Lets revisit the chart in the future once the price bars have appeared shall we?
Here's the monthly chart leading up to the MARINE trial and my brief interpretation of it....
1.The first thing to note is that before bar 1, the monthly trading volume is almost non existent (average volume 405k for the whole month!). This is the first bar that we see a volume spike ie smart money activity. The volume spikes to 3.1M on this bar. Was the spike due to selling? Lets see how the next two bars react and we will know.
2. Closes higher than bar 1 on a volume of 5M. This tells you loud and clear that the excess volume on bar 1 was buying rather than selling. But the high volume on this bar is concerning UNLESS the next bar closes higher as this would mean the excess volume was buying rather than selling.
3. 8.6M and another higher close confirming that there was buying on bar 2.
4. Closes higher again confirming that the excess buying on bar 3 was buying again.
5. Cooling off bar indicating some selling on bar 4. Nothing major though as this bar closes at 2.49, well off the low of 2.10, and on average volume (4.1M). This tells you that there is little selling pressure.
6. This bar is a test as it probes lower again calling all bears out. It barely closes lower than bar 5 on lower volume again (3.5M). No selling pressure. Expect higher prices immediately because we know the smart money has been accumulating and there is no selling pressure. The only place left to go is up.
7. And up it goes to 3.23 but the volume is too high (13M) and the close is 2.94 indicating that there is selling present. We need to see how the next bar responds to this selling pressure.
8. Closes down confirming the selling on bar 7, but the closing price stays above that of bars 5 and 6 indicating strength. The volume is also high again at 10.4 M suggesting that the extra volume is buying - if it was selling this bar should have closed below bars 5 and 6. But we need confirmation of this so we look at the next bar.
9. This is the last bar before the trial results are released and we badly need it to close up if we are long because of the excess volume seen on bar 8. If it does it means that any selling seen on bar 8 was absorbed and that would have only happened if the smart money was bullish. It closes up. You are now laughing.
That is how you do this. Its simple stuff. Every price bar tells its own story but you never read a price bar in isolation, always in the context of what you have seen before. If you can correctly interpret what you see you will have a >90% chance of correctly predicting the direction of future price moves.
Take it or leave it.
Thanks for that. Now back to the peanut gallery with you. Ignorance is bliss eh?