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Kiwi,
I know you think of yourself as the norm for trial participants as I can gather such from your posts. However, have you ever stopped to think why you were not accepted into the RI trial? Because your lifestyle and prescription portfolio are not the norm for this trial or any other. Just let that sink in.
For instance what if you took everyone of your arguments and put them against recent or ongoing trials they would have no merit there as well, because you have no idea what the selection criteria is you are just shotgunning ideas that resemble your lifestyle, but unfortunately your ways are not the norm as others have pointed out before me.
Are you serious? (Man I have been waiting to say that to you)
The only reason I can think of is AMRN dealing with the FDA is like walking on egg shells. I can only assume they want RI all wrapped up and in analysis before they convey more information just to be sure the FDA dosen't cry foul and try invalidate the RI study. I really feel the company is that cautious around the FDA. I mean look at all the BS they have had to deal with pointed out by BioBill and many others. Plus after giving the FDA a few black eyes in court and now possibly with the ITC I guess I would be looking over my shoulder for that bully as well.
ORBAPU can't thank you enough for sharing your history with the board. I learned alot from it and am really glad how your numbers are coming out that is fantastic.
I am 53 and exercise 0-4 times a week with either running or biking for 30 to 45 minutes.
My HDL-C is 39
My diet is very good a healthy shake for breakfast, salad with my healthy dressing and very little and protein for lunch, fruit, nuts and yogurt in between meals. Dinner is a little tougher to control as we have kids and my wife and I make a dinner that works for everyone usually more on the healthy side but I admit not always.
One interesting thing I did learn from your numbers is after you started taking Omega Via your LDL-C did increase from 105 to 117/119 so it went up a little but not as much as mine which went up almost 40. This is helpful to know that it contributed some to my LDL-C increase but I have going to have to take a closer look at what we eat for dinners and see if there is better choices we can make as this could be the culprit for the remaining LDL-C increase.
Again thank you for sharing and good luck to you, but with those kinda numbers you don't need luck.
Great to hear and thank you for the feedback just ordered mine. I for one would be interested in hearing your lab results and any background info you can share.
TY
Orbapu, Since I am only in the 5% risk category and not on statins my doctor won't order those.
Almost for got HDL-C stayed the same.
Thank you for your reply
Kiwi,
To make it more clear my diet and exercise did not change since I had the 106 reading. I am not a heavy drinker and my proteins are mostly supplied by my hunting a fishing affliction except for Chicken. When I eat read meat it is 80% venison and steak maybe once every few months. My fish is only ever wild caught by myself or bought as such no farm raised stuff. I am not a cheese person at all more into fruit and nuts for me. Pretzels instead of chips. I don't eat a lot of eggs but perhaps I could remove the yoke when I do eat them.
Thank you for the reply.
BioChia how are you making out taking PharmEpa? I am very interested to know.
Thanks in advance.
Quick update on my year taking Omega Via. I just got my numbers this morning after being on Omega Via a year. Not perfect but not terrible. Here goes:
Trigs down from 271 to 127
LDL-C up from 106 to 146. (This is by far my highest LDL-C ever)
A1C - remained the same.
What this tells me is that there is DHA in them thar Omega Via pills.
A little more background I am a healthy eater and exercise regularly and I was very careful to be off alcohol and my morning shakes for a week and fasting for over 12 hours before getting my blood draw. I do not take statin's and am enjoying the physical benefits of reduced inflammation. My LDL-C has never been this high only leaves me with one conclusion as I have had no change in diet and exercise.
What I was wondering is those that are taking Omega Via but are on statin's are your statin's hiding the fact that there is DHA in these pills or for that matter can your statin more than make up for the amount of DHA in them.
I am going to switch back to trying PharmEpa which I think BioChia is still taking and try it for longer than a few months before getting my blood draw. BicChia would love to hear how you are making out with PharmEpa.
This has been my experience and own personal research and wanted to share it with others in case it may help.
Oh pay no mind to old Jimmy Murphy for he has been in an out of here with more of the wildest claims than one can imagine. I remember the one where he states "because of this stock he lost his house and his wife." With that statement alone I don't know how he can afford to bet a grand to BioBill. He knows nothing of the science and even less about investing and his posts have not been making sense for a very long time. I best describe him as a bull with a bear up his a$$.
Maybe because the stock market is on the rise(nice call JL), trial starts to wrap up in 14 days, and no overhangs till final RI readout. God forbid if is because an amicus breif is being submitted in the ITC case we will never get the swelling in BioB head to come down ;)
Relief of joint pain, bursitis, dry eye, and more yet to be discovered. I my self have experienced the first two. Also good general health to lower inflammation that could cause other issues yet to be discovered.
Except of course for you hey Ralphie-boy!
Ah, ignorance...
Good Luck Pyrrr...
by the way thanks for showing up and giving me the conviction I needed to buy more shares.
Thanks for the wise words. I hear you us lowly investors are always the last to know.
Yes these announcements will help the PPS I agree, but it seems to me that everyone is ignoring or for that matter thinks the PPS rise has nothing with the coming announcement that the company is break even including reduce it. Which means they are starting to pocket money and more than anticipated as the year end numbers will be higher than the previous forecast. Money that could mean a lot of good things for investors and the company. I mean scripts have been on a steady increase and are starting to embark on numbers even BP can't ignore.
Or does everyone think that is a known and should have no effect on PPS?
Just me thinking out loud.
I take each product for about a year and then get a blood draw and go over results with the doc. Yes I fast for 12 hrs before and stop alcohol and breakfast shakes for like 5 days before the draw just in case.
Liquid intake is the same when on all three I just though it was my age at first, but then remember it was way less when taking Vascepa. Just a quirk I thought perhaps someone on the board may have had a similar experience.
Both PharmEPA and OmegaVia are rTG form.
Just go to the OmegaVia homepage and scroll down in the list and you will see rTG.
FYI
I have taken both for my own research as well as Vascepa.
When on PharmEPA and OmegaVia I urinate like a crazy amount more than 10 times a day. I did not have this experience when on Vascepa.
Blood test after PharmaEPA raised my Trigs and LDL-C numbers way high.
They were very low when on Vascepa.
Will soon get checked on OmegaVia.
Noticed on all three less joint pain and no issues due to exercising. No bursitis pain in my hip that I had before taking anything.
For what it's worth,
The only thing I can come up with is a handful or more of high prescribing doctors did not like what they saw happening to there patients biomarkers or worse yet events of some sort while on generic lovaza. So they switched there patients back to Lovaza being uneducated on Vascepa.
The board has discussed this before that generic lovaza is garbage.
zip
You also forgot to add to the list of lesser importance. The updates on Middle East and China of which I believe company said would be out later this year.
I believe the comment was Shaking in my boots. Oh please no the all knowing ralphey is going to go to the FDA. Go head and they will laugh your pet rock mentality right out of there. Much like what is happening here.
Kiwi,
Yes TY I am running my own assessment of Omega Via from yours and other recommendations. I have my wife taking my Vascepa.
When Ralphey quotes use OTC everything you get at Walmart, Amazon, and Online Retailors, I have tried has been crap and made me feel worse than Vascepa, and now Omega Via for four months. I really hated Krill Oil from Neptune when I gave it a trial.
So just to say use OTC without knowing what to possibly recommend is dangerous and reckless in my opinion. Omega Via is not the first thing that comes up in an online search so it took me a while to get to something over the counter that did not make me feel worse.
Thanks for your contributions to the board.
If your local cardiologists are telling people to just take over the counter then they are even less informed to the dangers they are exposing there patients to. You can easily research the poor quality of OTC stuff and it doing more harm than good.
Again best of luck to you and your patients really going to need it. Since Whaletine stated your practice is in upstate NY I hope I never come across it.
Raf,
You are correct the key is reducing CVE which only RI can confirm what Jelis already told us.
I think everyone that replied to him has done a good job pointing out the flaws in his logic.
Yes Marine and Anchor trials are part of what I was talking about in doing our own research as well as gathering your own RWE.
Don't be surprised now if we get a post all 300 or 8000 just died.
Keep up the good work enjoy reading your posts.
Kiwi I also enjoyed your last reply to him.
Sorry but you cannot answer that for sure. Did you spend the previous 12 hours with the patient to be sure he didn't have a week twinkie moment. I bet not.
Since we are on a public forum hiding many realities nothing is for sure or real here.
Many on this board have talked with cardiologists and the like and have there own RWE data. They have done there research on Jelis and the many medical research papers and watching the scripts grow and know that is speaks volumes more than your anonymous posts here.
Again I am not attacking you as you are entitled to your opinion I am just pointing out the fact that no one on this board should be or is making investment decisions on what they read here alone. Yet you come across as an expert expecting us to only use your posts as to how we should invest. That is what is rubbing people the wrong way. FYI.
Call us canary haters or to blind to see the wondrous truths you bring us just know this we are not swayed from our research by your posts on this anonymous message board.
Again best of luck to you in your practice and future investments.
Ok since I liked my pet rock so much I will bite.
The diagnosis of this patient is they did not fast before their last blood work was taken therefore skewing the Trig. results.
I do notice you have a lot of spare time on your hands to be posting on our little old AMRN investor page and I second the notion that your writing is terribly hard to read. I thought doctors were to busy to come and helps us poor chumps out in seeing the error of our ways.
Another RWE is my mother on Vascepa since 2014 Trigs are down from 353 to 160. It took close to a year of taking Vascepa before she was able to achieve these results and maintain them to this day.
Yeah Rx's going up the Jelis study and many medical papers all saying the opposite of you. I know not much to go on but I will have to get by with what I have.
By the way I loved my pet rock and you are not going to believe this his name was Ralphy.
Ralphy you are certainly entitled to your point of view and I am to assume you do not prescribe Vascepa to your patients any longer. So we are supposed to take your expert advice of one and sell this sinking ship but there is a problem with your logic. There are many of us here who are having great results on Vascepa as well as loved ones. Also I just can't get over the fact the prescriptions just keep growing and being prescribed by more doctors everyday, ahh but what do they all know compared to the great ralphy and his plentiful 300 patient experiences which now does not seem to be impressive enough and has grown to 8000.
Also the the coin has two sides and if you were confident in your conviction you wouldn't have to keep posting your already known point of view.
One more point thanks for sharing your inside information on how the trial is turning out it is always great to hear from people in the know.
Best of luck to you in your practice and future investments.
Yes and they also got a good gauge that things are tracking as expected with no changes. I agree with most just not enough SE numbers to stop such an important and expensive trial.
Citi note. FYI
We previously highlighted that the success of canakinumab in the ph3 CANTOS outcomes trial suggests that reducing inflammation can reduce CV events. Since Vascepa also has anti-inflammatory effects, we see this as an encouraging sign for AMRN's ongoing REDUCE-IT outcomes trial. If Vascepa's anti-inflammatory effects contributed to the positive results seen in the JELIS outcomes trial, then there's a few reasons we would expect a greater benefit from inflammation in REDUCE-IT. Recall that JELIS was an open-label outcomes trial conducted in Japan that showed a 19% Relative Risk Reduction for Vascepa compared to placebo. 1. Vascepa dosing is higher in REDUCE-IT than in JELIS – In REDUCE-IT, 4g of Vascepa is given daily, compared to 1.8g in JELIS. We expect this higher dose to contribute to a greater anti-inflammatory effect in REDUCE-IT than JELIS. This is because in both the ANCHOR and MARINE studies of Vascepa the 4g dose arm had more than a 3x lowering in the inflammatory patient population to REDUCE-IT], and -36% for 4g vs. -10% for 2g in MARINE). 2. Statin dosing is higher in REDUCE-IT than in JELIS – In both REDUCE-IT and JELIS, all patients in both arms are treated with statins. However, in JELIS patients received just 10mg of pravastatin or 5mg of simvastatin compared to the more typical dose ranges in the US of 10-80mg and 10-40mg respectively. This is an important difference that could lead to a greater decrease in inflammation in REDUCE-IT than JELIS, because in ANCHOR patients on 2g Vascepa and low dose statins (resembling JELIS) had a 10% increase in CRP (not statistically significant), compared to the 4g Vascepa and medium/high dose statin groups (resembling REDUCE-IT) which had a 23-29% decrease in CRP (p < 0.05). 3. Fish intake is likely lower in REDUCE-IT than in JELIS – We expect the worldwide REDUCE-IT trial will have lower dietary fish intake compared to JELIS which was solely conducted in Japan, a country that reportedly has above average fish consumption. Since the active ingredient of Vascepa is EPA, which is found in fish, this could lead to a greater benefit on CRP and other measures in REDUCE-IT than JELIS, in which participants likely had higher baseline levels of EPA. Finally, some remarks on readthrough from the REVEAL outcomes trial of the CETP inhibitor anacetrapib to several stocks in our coverage. We see the positive results announced last week as providing another example that supports drugs can show an outcomes benefit on top of statins, which is encouraging for REDUCE-IT, and FGEN's outcomes trials of Roxadustat.
Also for those of you that might say well there is only five years of data out there for Vascepa which is pretty minimal compared to Lovaza. Hey wait a minute there is a boat load of data out there on Lovaza basically telling the company how STRENGTH will turn out.
Also when you put together Jelis and Vascepa data the company should get a pretty good picture of how REDUCE-IT will turn out.
All this equals confidence.
"There should be a world wide move to test for and tell people their APOE genotype. It's at least as important as blood type. But maybe more so, as it could inform your susceptibility to risk at a very early age, and tell you which dietary habits would promote longevity or not. Especially if you are an E4/E4 carrier."
Pyrr again you have to be corrected on your ill conceived understanding of what really matters. There should be a world wide test to tell people if they carry the DOPE genotype, and they should be instructed to stay away from message boards, or any pubic venue.
You are partially correct the locomotive is coming with big letters on the side "EPA".
What you fail to see in your narrow vision is that you are tied to the tracks and your hero overdosed with DHA is having a heart attack and can't save you.
Good luck,
If that is your investment strategy. I can see why you lost your house and wife due to previous investments. Might be time to find a new hobby.
Kiwi is extremely quiet today must be trying to find some evidence to save face in the Repatha data. Which I believe he hung his hat on and said wait until this data is released and we will have our answer on LDL-C lowering.
jfmcrr and couldbebetter,
From the OmegaVia website FAQ:
Can I break open the capsule and consume the oil inside?
You should avoid doing this. Here is why:
The oil used in OmegaVia is extremely concentrated and is not formulated to be taken as a liquid. It will taste unpleasant compared to low-potency, flavored liquid fish oils.
The oil used in OmegaVia is very sensitive to air exposure. It will begin going rancid when exposed to oxygen. This is why it is delivered in capsules in an air-tight, opaque container.
The oil inside the capsule will almost certainly squirt out in the process and begin to smell bad over time, as the oil droplets go rancid.
Vascepa is icosapent ethyl so after ingestion, E-EPA is metabolized to EPA and EPA is absorbed in the small intestine and enters circulation; peak plasma concentration occurs about 5 hours after ingestion and the half-life is about 89 hours. EPA is metabolized mostly in the liver like other dietary fatty acids. E-EPA is an ethyl ester of eicosapentaenoic acid, which is an omega-3 fatty acid.
So the two would be very different in smell and taste when cut open.
Raf,
Thank you for reminding me to cut open one of my OmegaVia I just got them and was meaning to do it. So I did cut one open tonight, and it does smell like and taste like fish. However, it does not smell or taste like week old salmon you forgot to cook. I have found some buried in the frdge that was ripe before and tried to make the best of it but it was to far gone. Instead it smells and tastes like a fresh peice of fish. So no real rancid or heavy odor or taste to it.
How about I clarify this for you in much easier to understand terminology.
The study using Lovaza is a prelude to a kiss for the AZN study called STRENGTH. It is not going to work sorry AZN.
Why you say?
We have already discussed this on the board many times before you were around. DHA inhibits EPA from working, raises LDL-C, and does not reduce inflammation rather more likely increases it. Yes it does reduce TG better than EPA alone, but that is it.
Nuke I also have Aetna and get my scripts at Walmart and pay $9.
Hope this helps,
Sorry Phyrr but a lecture by your opinionated dominatrix does not count, and the FUD just keeps on rolling in.
I thought the DMC only reviewed the events quarterly?
You are saying it just happened now. So the company won't know until the end of March beginning of April about the 80% onset?
I have been following along here and post every so often and did not think I missed an update that the DMC is reviewing the events monthly, and if they were the company wouldn't find out until end of Feb. or beginning of March?
So how can you say they will let us know of the CC next week?
Here is what I find for Aetna formulary coverage for Vascepa in 2017 same as 2016. Tier 2. FYI.
https://client.formularynavigator.com/Search.aspx?siteCode=0407155982&targetScreen=3&drugBrandListBaseKey=vascepa%2Bcapsule%2B1%2Bgm%2Boral
I started at this web page:
https://www.aetna.com/individuals-families/find-a-medication.html
then I choose 2017 and a plan and clicked continue. Then click on search to see if drug is covered and got the first link.
Hope this helps,