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My hope and prayer is that Dendritic cell technology will one day be approved as an option for treating many cancers.
My sincere condolences are given to the many people who have lost the joy of being with loved ones because they could not fight the burden of disease that cancer imposes on the body.
May words like "few", "soon", and "shortly", turn out to actually be sometime before the 3rd quarter of NWBio.
GLTA
CEO of DMPI touts their treatment for GMB and shares up 25%.
Hope for good news sometime and see NWBO go up.
Also, BioBrooklyn, are you buying us New Yorkers a beer if we are unblended and proven to be effective and safe?
Thanks to all who post, who "stay tuned" and who hope and pray for patients and families, known and unknown.
GLTA
Thank you Exwannabe (and anyone else) for explaining "data lock".
Please, if you may, help me with the proper timeline for "L".
1. announce events reached
2. ? announce data lock?
3. CRO gathers correct data?
4. scrub data?
5. analysis data?
6. PR "top-line" data?
7. submit data to peer review journal?
8. possibly submit NDA to FDA?
Could you please comment on my time-line and perhaps give estimates of how long all this takes beginning with 2 events happening say by Aug. 1?
Or do I have the sequence of actions all mixed up?
I always like your considered approach Ex.
I am a believer who is loyal and long NWBio.
I sooooooooooo appreciate everyone who takes the time and effort to post facts, opinions and guesses here.
I hope we hear good news by Aug 1. but understand that "a few" in Les's dictionary could mean forever, LOL. I am "staying tuned"............GLTA
Thank you Doc Logic for your always considered and even responses to the many opinions and questions that are surrounding NWBio for the last 5 years. I certainly appreciate them.
I do have a question that arises because I spoke with someone from a major drug company and he said we would need a "confirmatory phase IV trial" before we could get approval.
that is scary. Have you heard of this? Anyone?
Thank you all and GLTA
Thank you Chris. Questions? 1. In your opinion and understanding
the peer reviews be released before the mOS is reached, or is it after data lock?
2. you posted 7/17 2 patients have not yet evented. any ideas on the time-line going forward.
Thank you in advance and I follow you on twitter and have sent twits to Dr. G. about NWBO.
GLTA reg
ShmeeaGato, Until real results are exposed after the DCVAX L trial is un-blinded, everything is open for opinions and best guesses.
You have only your guts to go by, as also I do.
I know it is a legitimate trial that has been going on for years and is close to its end stage.
U may be correct, but I am of the opposite opinion.
I am not a pumper or a dumper. I just don't know, YET.
Thanks for your opinion. We will all stay tuned and await the un-blinding and then the posts will fly. Should be interesting. Cheers, longnwbo. GLTA
What a great reply, Sparky, I so appreciate your concerns and thoughts. I am in Nassau and come out East often because my Sister lives in Sayville. Been out to SB hospital many times for various reasons. Would love to take u up on your invite. I also am not a scientist or analyst, so we can talk lacrosse. Played for 8 years, HS & College. Now the grandkids play and I cheer.
I am definitely a cheerleader for NWBIO only because it seems to offer so much for the right way to treat cancers. Go Immune Response. Go NWBio, Go longs. GLTA
Regina and all families and patients in trials or who have past on during trials, my heart and prayers go out to you and yours.
I have participated in 5 trials for Prostrate Cancer over the years which did not seem to help at all. Then it progressed to the point where a more aggressive treatment was recommended.
48 radiation treatments later, I now await a PSA baseline and then follow-up to see which way it trends, stable to down I pray every day.
I am long NWBO on Long Island and would so enjoy meeting with any person for a cup of Joe or a pint of beer and talk all things Bio Tech and NWBio.
I am not a paying member here so I cannot reply privately, but promise to read all posts that come my way and hook up sometime if possible.
I have learned so much through all the discussions on this MB and worry only about Exwannabie's posts because he/she seems to have the most knowledge about all things concerning trials. I really don't. I am just a believer, a person of prayer and support to all sufferer's of various diseases and I share a tear and a laugh with anyone who wants me to.
Again, Blessed Holidays to all. GLTA
NWDR, you and all cancer suffers are in my thoughts and prayers.
I believe in the power of prayer and in skill and research of science. I also hope and pray that DCVAX L AND D will prove effective for many types of cancer. Thank you for sharing your journey with us here on IHUB. May the good Lord bless and keep you. Cheers
Good Morning Happy Librarian. My Mom was also a very happy Librarian. (MLS) for over 30 years.
I can't say I totally agree with you about the smarts of the SAB. Certainly you are correct that they are most interested in the science of the DCVAX technology. I just don't think they are asleep at the switch as to the nature of the business from a governance stand-point. I honestly don't know what information they receive in that regard.
This is certainly wait and hold and see time. I am praying for all cancer patients to have a successful DCVAX alternative.
I hope and pray it is not a scam. JMHO, less than 1% chance.
But, 1% is still a chance and Ex and yourself give the best opinions as to why it might not be a working treatment. I am glad that many posters here enter into dialogue with you and Ex to counter your points. I really don't know enough. But your comments do show there are other sides to the coin, so for that I thank you.
GLTA
Thank you Biosectinvestor and the many other fair posters who have defended the horrible attacks against well meaning corporate exectutives, scientists, BOD'S and SAB's.
What has not been mentioned in some time is the work of the other SAB members who signed on, viewed the results that led to Max's presentation and to Ms. Powers guiding the company going forward.
I first joined in when Germany seemed to validate the science and power of the treatment.
Then nothing. That bothered me.
Then the SAB was announced. WOW. Those are really respected people who would never put their name on something that is a scam or a lie.
I certainly don't know the end results, but thanks to all the posters here who have put in a tremendous amount of time, effort and analysis to help us not so smart people believe in the future of the DCVAX technology.
Blessings to all and I am "staying tuned and long and loyal". (because I want to, not as a recommendation to anyone).
GLTA
Great Post Doc Logic.
Those were unbelievable days and posts and discussions.
I would so love to hear from those you mentioned when our trial of DCVAX L is unblended and topline results are revealed.
I particularly would like to hear from P MAN because he convinced me to wait till the results are published, then discuss them. I hope he comes back in when we longs are finished "stay tuned" and have actual #ers to tare into.
Blessings to all patients and families and may a new day in the treatment of many cancers be before us. GLTA
Electsol28,
I LOVE your optimism. I sure hope for some good financial news sometime in the near future. Someone said by Monday. I am always "waiting" and "staying tuned" and hopeful.
Thank you everyone who take so much of your day to add your DD and opinions and speculations about how things will shake out in the coming months.
Happy Summer days beginning tomorrow and fireworks for the 4th of July. GLTA
A HUGE THANK YOU 2 ALL.
O K. Now it is "stay tuned". GLTA
IS THIS A HUGE WEEK OR WHAT???
As a long, loyal and submerged supporter of NWBO, I want to ask this board if I am correct in thinking this is the most important week in our history from the financial stand-point?
JMHO, but if Linda has to dilute again to survive it will be taken as a sign of capitulation and surrender.
If she can find some kind of white knight to demonstrate that DCVAX treatments have "horsepower" and be able to put money behind that, that will demonstrate her ability to survive and prosper up to the un=blinding later next month.
This opinion of mine is based on the belief that $5 million is due by the end of this week. How will she finance this?
Is this opinion on target or am I mixed up about the timelines for re-payment of the loans? T. U. GLTA
Thank you CheeryTree1 so much. I was sooooo blown away by the segment I thought it was leaked news or something.
Anyway, I do hope something like it will be released this July or Aug. Waiting has really been tough on me. Lost some friends who I convinced to buy in back before the enlarged trial was announced when I expecting a read-out.
I sure appreciate knowing now when that piece aired.
This board is fantastic. Thanks to all who take the time to answer questions, share opinions and search out real news.
On to the finish line. GLTA
MD (Chris L) posted a Fox News video on Twitter. I tried to send it here, no luck for this old man. It was all about DCVAX L and how effective it is. Cited a Dr. from Long Island.
If anyone can tell me if it true and not fake news and when it was televised and where I can go to download it, that would be fantastic.
I am long, loyal, hopeful, submerged, praying for cancer patients and their families, getting over radiation for Prostrate cancer. I have kept telling my children to "stay tuned", but they don't want to hear this anymore. Can't blame them. I have been invested 4 years and never sold one share, but have seen thousands of options expire worthless.
Finally, anyone want to take a guess about the date for some "new" news?
I had hoped for ASCO. Got plenty, but not the final results or something like that.
So, I'll throw the fireworks out on the 4th of July.
GLTA
Iclight, Question please. You are 100% correct stating the protacall. My confusion is about when a patient, no matter what they received, progresses. that counts as an "event". Yes or No?
So even if whoever "crosses over" they have already "evented" for PFS? Yes or no?
It is not until the trial is un-blinded will we know who received the placebo and who received DCVAX L.
Then we see who crossed over and when and what the giving of the sure treatment did for the patent from the time of actually getting what was originally prepared for them and then what happened to their disease load.
See, I am confused about how the crossover population changes the PFS #? I would think it would effect the OS # if the treatment is efficacious.
Obviously, this is above my pay grade and I just hope and dream that cancer sufferers can someday have hope of their own immune system fighting and destroying ones own cancer. GLTA
I totally agree and support your analysis ad opinion, Biospect.
NW is not a friend. Management and Board are well aware of the finances and the problems that face them.
No one likes the position we are in and are at at this time.
We just have to suck it up and wait it out and believe that Linda will not drop the ball this close to the end-zone.
I mm buying more at these ridiculously low prices
I am either a genius or a poorer investor at the end of the day, but that can be said of any investment.
Till late July or Aug. I hope we see some real results that will light up this MB like nothing before it has, and there have been plenty of those. GLTA
JMHO, our future of nwbo as a company depends on today's presentation. So many disappointments and silence. So much discussion and speculation. I brought more and am happy I got it at below $.20. Either a dead give-a-way or dead, period. JMHO.
SO, for patients, investigators, and investors like me, GLTA.
Thank you Flipper and Maverick_1.
Naturally I am hoping for a good report on DCVAX L, but I still feel lost how a company gets seemingly detailed information and the trial remains double-blinded and can go on for another 12 months?
Does your answer to my question mean Les can release information whenever he wants to?
I have emailed Les about what "several" means, but he has never replied to any of my emails except the one where I wished everyone a Blessed Easter and Passover.
So, I wait and watch like everyone else and I appreciate your fantastic timeline Flipper and can't wait for ASCO and what might or might not be released. PS: I emailed Les if the event would be either played live or later on the companies web-site, but no reply yet. GLTA
Thank you Maverick_1. So, what I thought I knew and understood, I didn't.
"Top line" (what ever that means) can be PR'd before the data is locked and sealed up for analysis.
I guess that is why I am confused about what exactly is "top-line data"? Is it hope? Is it facts? Is it inc0mplete?
It can't be released until OS is officially reached?
Is that correct? Thank you again and I hope I am not wasting your time as I just can't seem to get my big head around this "several months till OS is reached" and then and only then, will data be locked and then scrubbed and then analyized and then published and then submitted and then, hopefully, approved and then manufactured and then given to sick cancer patients and then help them fight their personal cancer. GLTA
A different question. TU Flipper for your timeline
and what we should be looking for and about when.
Could you, or someone, help me with a different time line for the time from reaching OS, with a short summary of explanation of meaning for:
1. Company announces OS reached and data is locked-I get that.
2. "Top line" data released- I don't get that: a. when and b. what is it?
3. CRO's (2) collect all data (how long?)
4. data is scrubbed- how long?
5. data is analised (by who?) (how long)
6. data published (by who). Is that next? Is this the "un-blinding date? Is this when we see the results of "L" trial?
7. If the company is satisfied with the results they then submit them to the FDA for approval. (when? 2018?)
Thank anyone for posting an explanation of the term, "top-line data" and how that differs from scrubbed and analised data etc. GLTA
Please Linda and Max, start sending out "teasers" like a good movie does before release. Since you are presenting and it is not blinded or embargoed or anything, start by telling us what areas you will be reporting on, without giving the results, but showing us that you are on the right track. What say members of the MB?
Certainly an interesting day with more to come. Thanks for everyone's efforts to sort things out. I, for one, am hoping for some "teasers" coming along soon. GLTA
Great news. Finally some new word on DCVAX D. I will stay tuned and hopeful. Thanks to those who replied to my earlier post on setting up some kind of charity. GLTA
A word of thanks and a dream.
First, a word of thanks to everyone who takes the time and effort to un-cover news, opinions and rebuttals to what is posted on thIS fantastic MB.
Next, my word of thanks to the scientists and investigators AND PATIENTS who are developing and trying to understand our own personal immune system and how cancer has confounded it all these years.
We seem to be gaining on cancer. Cancer beware, we are figuring out your secrets.
Next a word of thanks to Ms. Powers and the BOD for putting up the funds to hopefully see us through to the finish-line.
Now my dream. Because I believe Ms. Linda is brilliant and the science is brilliant, I have been buying more shares at these distressed prices. What$ that might leave me with by next year = a kind of reunion with everyone on this MB at someplace like Vagas at sometime.
But, my real dream is, if, A BIG IF, the price per share say goes to $40. I would then propose to NWBO management and to any interested shareholder, the idea of setting up a charity fund for those patients who have lost their lives being a part of our investigations into L & D. Their names are probably confidential, but maybe not. I certainly respect them and do hope that many are still living. Having volunteered for several trials myself that, obviously to me, went nowhere, these trials of DC technology might end up being revolutionary. I do hope all trial participants are given somekind of recognition of being in them, not just Dr. Liau and Ms. Powers. JMHO. GLTA
So IMUC called it quits today, we didn't. I like that. So, we go down tomorrow. Chance to buy more with the same amount of capital.
It sure is a suspenceful ride, that is for sure. I am not selling till I see the results of the phase III DCVAX L. Wish I could send Linda $10 million. Hope they find some money soon and not BK us. I still believe in management. "staying tuned". Thanks for all the comments. Should be a wild ride tomorrow. GLTA
Guess we need money soon. Don't seem to have much left in the tank. Hope to hear from them sometime soon. I am nervous, but hopeful. Sorry, but I could not find anything good in the filing. Did anyone else see something we can hang our hats on? GLTA
Good morning and have success your trading this coming week.
I am adding my 2 cents to this MB because CBMG has just jumped about 70% because all it did was announce a proposed start of a phase I trial of 15 patents to be enrolled in a CART. I examination.
I find it absurd that we languish at $.15 with a ready to read out phase III trial of DCVAX L and this other tiny company is rewarded for just announcing an intention to begin a Phse I trial.
Thank you to all who so faithfully and honestly (JMHO) add your comments and opinions about may and may not be happening on the many issues surrounding NWBO.
I, for only me, am adding to my small position and am actually grateful for the tiny pps which obviously allows me to add so many more shares at this obviously distressed price.
I am hopeful of a realistic evaluation of the worth of this science and manufacturing and leadership which I applaud when our trial is un-blinded. JMHO.
So, maybe by July or August we will know more? hoe, hope, hope.
So, anyone who knows anything about NWBOW which I unfortunately brought at $4 +. Time is running out on them. My bad, but things looked much brighter back in those good old days.
Again, have a great week and I really enjoy reading everyone's comments. I only wish I had something of value to add. I am just a believer and a man of prayer for all cancer sufferer's and hope that NWBO is on the right track to aid in the fight against cancer and it terrible repro-cussions on the patients and their families and on our communities.
GLTA, Reg
My ideas: switched my regular IRA nwbo shares and payed the tax at this low total value over into my Roth account and now hope for a huge=gain tax free.
Congate must know who got the initial vaccine and who got the placilbo because they made the real vaccine for everyone, then sent out the real or the placbo and then the real if asked to the right hospital and could must track when it was first made and later when it really sent a second time. There is a shelf life, so I don't know how that enters into things.
I applaud the BOD loaning money. Seems like a real decent thing to do and shows confidence and maybe, some good news soon.
I sold off my long time losers (old positions that never worked out, like GE) and brought more shares OF NWBO at this level, $.18 because my losers will give me a tax advantage and if nwbo goes higher, a good return on a stock that even if it loses, I haven't really lost anything much anyway.
I have finished my 48 radiation treatments for Prostrate cancer and feel fine, thank the Lord and now it is wait and see, just like nwbo.
My Son-In-Law said that filing BK does not end the company. They have the time to re-organize or come out sooner without killing off the small retail investors if the situation changes during the proceedings. He thought it took about one year to actually become a BK company. So, even if it filed, it does not automaticly end the company or its shareholders. THOUGHTS?
So, GLTA. I really enjoy most everyone's posts, except Mil's. But, that is his opinion and I expressed mine. Hope he is proved wrong. I told my Daughter that I would hear something positive by her birthday, June 25th. Fingers crossed. "staying tuned"
FYI...follow-up
Just called the Texas Children's Hospital and they said their Cancer Center is closed over the weekend and to call back on Monday.
Also their Media center is also closed and they could possibly give me more information about the event at the auction.
I will try posting more information on Monday. Have a fantastic weekend.
LOng loyal and waiting. reg. GLTA
FYI...reg here. something really interesting just shown from the Mecum auction shown live on NBCSH, from Texas. Richard Petty just auctioned off his hat for the Texas Children's Hospital. The rep. from the hospital introduced a DR. named Eric, and described a new treatment for cancer that empowered the patients own immune system with a 95% success rate and costs only $25,000. Petty's hat auctioned off for $25,000 and they announced that it saved a child's life.
Wish they said what the treatment was. Maybe someone can contact the hospital. Maybe I will.
This is for real. I did not make it up and I only post something I think is related to NWBO. Long and loyal. GLTA
Great post Tadasana. Way to simple and pure. Thanks to everyone who added great posts today. That was some find about Max's patient proposal or was it granted? We have the science. We have the trials. We have the management. We have the manufacturing.
We just need to get to data lock and top-line and etc. to approval.
All in due course. I remain long and strong and hoping and praying for patients and investors and investigators.
I am done posting for today and the near future, unless something BIG happens.
GLTA
Thank you pgsd. Have one more month of radiation left. Piece of cake so far. don't feel anything, amazing. continue life as normal, thank God. Of course, it will take some months to check on PSA levels and see how well it went. Then more check-ups to see if it holds down the PSA. I thank you and everyone for your well wishes and prayers.
My prayer is for all cancer suffers that NWBO and similar companies that are trying to figure out how to make the immune system do what God first created it to do will uncover the plan and then our bodies will recognize and fight our individual type of cancer. I hope top-line data comes out by July.
Waiting, long, loyal and buying more almost everyday. GLTA
Thank you Smokey21,
So now I get it. I can expect some kind of news within days or a week of data lock. I, JMHO, think that this board will light up with spectulation about what the top-line #'s might look like after data lock is announced. Should be really interesting. I hope the results are great. GLTA
this is ol' reg asking a question, please. (excuse me not being sure as I am not a scientist or analyst).
I am long, loyal and waiting. Thanks to you, Flipper, Doc Logic, RK, Senti, psga, md, and many other posters who try to get out real news and then discuss what it might mean. It has really helped me.
So, here is my question as I can best ask it. Top-line data is the topic of the question.
I understand that OS events have to reach 233.
I understand (maybe) that the lead investigator is compiling these events. She then reports to NWBO when 233 is reached and then the trial is considered finished.
Then the data is locked. Then the independent observers go to each trial site and scrub the data findings.
Then all is sent (again I think) to Linda L. (the trial's lead investigator).
After she does all her analysis and has it checked by independent sources, the trial IS THEN UN-BLINDED???
so where and what is "top-line data"??? It is talked many times here and I don't get what it is and when it will be published and by who after the trial is locked because the 233# of events has happened? thanks to anyone who would take the time and effort to help me understand "top-line data" and my understanding of what happens right after OS EVENTS ARE ANNOUNCED.
thanks and GLTA
FYI....JMHO.....ASCO BOOTHS NOT CANCELLED....GLTA
NWDR
I want to share with you that my prayers and blessings are being sent to you and on high for your wife's healing and lasting life. This revolutionary science does seem to offer this hope. May you and yours have strength and courage to meet the days ahead. Perhaps you may post some time in the future about how things worked out as I know cancer suffers and, right now, do not want to advance a treatment to them that I, as a small retail investor, really know nothing about. With continued hope, yours truly.
FYI. Prins/Liau presenting tomorrow morning, 9:05-9:25 at UCLA CTSI Manufacturing and Gene Workshop on Dendritic Cell Vaccine. They are the lead presenters. GLTA
Thank you RKM. My big hope is that if NWBio is successful and we do have somekind of get together, I am able to be there and meet some of the very knowledgeable and steady supporters of this company. I could not make the shareholder meeting as it was to close to Christmas and I had duties it my parish that kept me where I should be and wanted to be. I will say goodnight and not really log on again for some time to come as I really have nothing of importance to add here. Wish I did. I do lift up prayers constantly for the families and patients suffering from many various disease and I do believe we humans can find the answers that are hidden for the ages but are now being discovered by Drs. and scientists like LL and Prins. GLTA