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Going private appeared to be a major strategy before, but the shareholders could see it coming and refused to support it. I can't really see the new end game, unless we are being beaten down so that we will accept the private plan next time around.
I fought it from the very first day last time, and will do so again if they try it.
Magic
Teedlum, first, here's a prayer that your pet scan is completely clear of any mets. I used to follow Oncolytics years ago but quit, but have heard good things about their research in recent times. So here's another prayer that you find the treatment that you need to win your battle. A good attitude has helped me through my NSCLC so far, and I believe it can significantly help you as well. My prayers will be with you.
Scott
So very, very true Pete. Well said.
Magic
Thanks for the great summary Pete. Sounds like Sept 9 is the big day unless something new comes up before then. So I can relax and recover till then.
Thanks for asking about my results. So Far so good, the surgeon said he got everything, but the caveat is that the nodes at the edge of what he removed did test positive. Will meet with the oncologist in a few days and expect to set up a program of radiation and or chemo to deal with any stray fragments just for safety.'
Thanks again for the very informative and concise summary and your kind expression of concern.
Magic
Thanks gov, wow, didn't know the Duke only had one lung!!! Guess I'm in pretty good company with him, me and the Pope!
Magic
Hey Pete, how's things? I've been out of commission for about ten days. Had a lung removed and hopefully all or most of my cancer with it. Home now beginning recovery & checking up on the world.
So anything new here in the last ten days? Price looks like not much happened yet, so any fresh rumors worth sharing? I'll be here on the couch for a good bit, so waiting is pretty much a fact of life for me right now till I get some strength back.
Thanks to all for their prayers and good wishes. They were certainly answered.
MAGIC
Certainly the best news I've gotten this year for sure. Now if Kevitrin works out so that noone has to go thru this again, ever, that would be just wonderful!!
Magic
Really great news at my house. Met with top thoracic cancer surgeon in my area yesterday. He's doing my surgery next Wed and is very confident about the outcome. Prayers answered for sure. Thanks to everyone. Maybe Kevitrin will be readily available if I need a fallback down the road sometime.
Ecstatic Magic!!!
Thanks to all for the good wishes and prayers. I appreciate all the help I can get. I'm taking another run at the Docs on Tuesday to see if.....well, we'll see.
Great news on the patent appl. Should get things moving again.
GLTA, and thank you,
Magic
Last I remember, this company had gross revenues of around 100 million dollars. I would think some wanna-be class action lawyer would jump all over this if he knew the story.
Magic
You can bet if Ph 1 proves out, I will be trying to jump the line to get into Ph II if I come anywhere close to fitting the protocol. As you accurately recall, I do have an inside track. It is likely that my Dr's practice may participate in the trial anyway. They have one the largest trial sites in the country. Their Ph 1 program is larger than M D Anderson's.
Magic
Orion, as a cancer victim who found out yesterday that my cancer was not operable, I would be absolutely thrilled to forfeit my investments if Kevitrin were proved effective against lung cancer and were available to me within the next 6 months.
Magic
Sounds like time for a class action law suit by all of the non-insider stockholders. We have been royally screwed, defrauded, etc.
Magic
So what does that mean to us that hold shares?
Considering the importance of the prurisol trial, I think it would be incumbant upon one or the other of them to be present to be sure things got off on the right foot and deal with any issues that may come up such as logistics, etc. This could be a company making trial!!! Sure wouldn't want to have something go wrong that could have been prevented, and wind up kicking themselves in the butt for not being there taking care of business.
Magic
I would expect BK is making preparations for TS Flossie, as well he should be, along with anyone else living in Hawaii.
Good luck to them!
Magic
Hmmmmm!!
Time Price Volume Market
15:51:41 2.19 250 OBB
15:50:46 2.18 1268 OBB
15:48:32 2.18 750 OBB
15:48:30 2.19 2531 OBB
15:48:24 2.19 7000 OBB
15:48:20 2.18 1000 OBB
15:48:02 2.18 12600 OBB
15:48:00 2.19 100 OBB
15:47:44 2.18 3000 OBB
15:47:44 2.18 4000 OBB
15:47:44 2.18 9000 OBB
15:46:57 2.18 1000 OBB
15:46:52 2.19 800 OBB
15:46:09 2.19 100 OBB
15:45:35 2.19 130 OBB
15:44:55 2.20 500 OBB
15:44:43 2.20 1000 OBB
15:44:40 2.20 5100 OBB
15:44:33 2.20 100 OBB
15:44:31 2.20 100 OBB
15:44:26 2.20 2013 OBB
15:44:25 2.20 10500 OBB
15:44:22 2.20 5200 OBB
15:43:51 2.20 1000 OBB
15:43:20 2.21 100 OBB
15:43:04 2.21 1000 OBB
15:42:57 2.21 100 OBB
15:36:55 2.21 1000 OBB
15:36:03 2.21 2000 OBB
15:31:25 2.22 500 OBB
15:29:39 2.22 2000 OBB
15:28:19 2.21 700 OBB
15:27:46 2.22 1250 OBB
15:26:38 2.22 100 OBB
15:24:54 2.22 200 OBB
15:24:41 2.22 1000 OBB
15:24:36 2.22 300 OBB
15:24:35 2.23 500 OBB
15:23:20 2.23 1050 OBB
15:23:14 2.23 100 OBB
15:23:13 2.23 100 OBB
15:20:37 2.22 100 OBB
15:19:14 2.21 500 OBB
CTIX up $ .30 today to $2.22. Thanks for the heads up last fall westeffer. Gonna be huge.
Magic
Was I once married to you???
You sound remarkably like my first ex-wife.
Magic
nice paint job, thanks.
Magic
Pretty insistant anyway:
Time Price Volume Market
15:40:14 1.93 2500 OBB
15:40:04 1.93 10000 OBB
15:38:01 1.94 100 OBB
15:37:10 1.92 2000 OBB
15:35:34 1.93 500 OBB
15:32:58 1.94 100 OBB
15:28:52 1.94 110 OBB
15:28:22 1.939 100 OBB
15:27:52 1.939 100 OBB
15:17:07 1.94 911 OBB
15:11:10 1.937 100 OBB
15:10:11 1.94 1000 OBB
15:03:19 1.95 100 OBB
14:59:12 1.95 500 OBB
14:57:57 1.92 1980 OBB
14:57:49 1.91 2400 OBB
14:57:40 1.911 100 OBB
14:57:10 1.91 100 OBB
14:57:10 1.911 100 OBB
14:56:40 1.91 100 OBB
14:56:40 1.911 100 OBB
14:56:10 1.91 100 OBB
14:56:10 1.911 100 OBB
14:55:40 1.91 100 OBB
14:55:40 1.911 100 OBB
14:55:10 1.91 100 OBB
14:55:10 1.911 100 OBB
14:54:30 1.92 2500 OBB
Got a link for that info??
Thanks, Magic
"On the other hand, most stocks drop immediately after I buy, so get ready for a REAL bargain!!! "
Told ya so!!
Magic
Added another chunk to my stash today at 1.70 - figure it may be the last chance to buy at or near these prices, and it could go up big any time now. On the other hand, most stocks drop immediately after I buy, so get ready for a REAL bargain!!!
Magic
From one cancer patient to another, give em hell bud!!!
Magic
This looks like an attempted takedown running into strong support to me:
Time Price Volume Market
11:43:12 1.64 200 OBB
11:15:46 1.62 1000 OBB
11:06:53 1.61 9300 OBB
11:06:50 1.61 500 OBB
11:05:54 1.62 1000 OBB
11:02:18 1.63 4200 OBB
10:57:41 1.64 1000 OBB
10:52:56 1.59 15650 OBB
10:52:31 1.60 200 OBB
10:52:31 1.60 100 OBB
10:52:29 1.61 500 OBB
10:52:26 1.62 700 OBB
10:52:11 1.61 100 OBB
10:51:57 1.62 2500 OBB
10:51:57 1.62 250 OBB
10:51:56 1.64 1000 OBB
10:51:55 1.64 300 OBB
10:51:01 1.62 1824 OBB
10:50:58 1.63 5176 OBB
10:50:50 1.64 2500 OBB
10:50:45 1.64 500 OBB
10:49:18 1.64 400 OBB
10:49:11 1.638 100 OBB
10:45:15 1.64 595 OBB
10:43:55 1.64 2000 OBB
10:43:31 1.64 1000 OBB
10:43:31 1.64 2000 OBB
10:42:58 1.64 3500 OBB
10:42:01 1.62 500 OBB
10:41:59 1.62 100 OBB
10:41:08 1.61 8800 OBB
10:40:53 1.62 200 OBB
10:39:31 1.60 100 OBB
10:39:20 1.60 11200 OBB
10:38:55 1.60 300 OBB
10:38:53 1.60 1500 OBB
10:38:53 1.60 1000 OBB
10:38:53 1.60 1000 OBB
10:38:52 1.62 100 OBB
10:38:50 1.61 100 OBB
10:38:50 1.61 16000 OBB
10:38:42 1.60 1000 OBB
10:38:41 1.62 5000 OBB
10:38:32 1.63 500 OBB
10:38:26 1.63 200 OBB
10:38:25 1.63 2000 OBB
10:34:22 1.63 3000 OBB
10:31:55 1.65 2500 OBB
10:31:31 1.66 200 OBB
10:31:17 1.65 100 OBB
BTWTFDIK, Magic
409,144 quite unusual, must be something in the wind!!!
Magic
Some of you may recall that I had asked my hotshot oncologist to talk to Dr Shapiro at ASCO, since they are acquainted. I wasn't sure he'd have the time since he had an oral presentation himself. Anyway, I met with him before my chemo yesterday and although he didn't have any specific info to share, he was much more enthused about kevitrin after talking to Shapiro than he was when I was telling him about it.
Magic
gov, I must be missing something. As far as I know the chemical name is "thioureidobutyronitrile", which does not contain the word cyanide. What am I missing here??
Magic
Tremendous work Sir. Thank you for your effort and for sharing. And a hearty Thanks to Leo for his generous responses. WOW!
Magic
Pete, I assume this is the post you were referring to:
"Well - I would hope for a bump to $3-4.00 range after mtd and safety established. A little more with documentation of decreased specific biomarkers and p53 activation evidence.
So - over the past decade - the model for PhII has totally changed. It used to be all about the single arm phII - using small # patients and historical control data (which is useless to novel agent study - no applicable null hypothesis for truly novel agent). For novel molecules - there are 3 main ways the company can go.
A randomized selection design has no control, randomly enrolls patients into 1 or more arms, testing different dosages and dosing schedules. The arms aren't compared with each other - researchers just choose the one that looks best (remember - this is about structuring the best phIII trial) and the false positive rate is 10-20%. This design is my favorite because researchers can run multiple arms at the same time (even 10 years ago people ran them sequentially), hugely saving time on the path to a phIII.
Second novel agent design is randomized comparison design - this uses formal statistical design to compare experimental groups with a control(standard of care treatment) or placebo. This design looks a bit like a phIII - but with the small numbers of participants, the false positive rate is much higher at 10-20%, and the small patient pool means toxicity and intolerance signals are often missed and then picked up in phIII, which is a really expensive mistake...
Third design is randomized discontinuation design. All patients receive treatment in the beginning of the trial. Nonresponders and patients that didn't tolerate the drug well are removed from the study. Patients who experience stable disease (no better but no worse) are then randomized into placebo and active treatment groups. Patients who showed good response (tumor shrinkage) from trial initiation continue treatment uninterrupted.
So - all of these designs help the company select a target population for a phase III trial. That is biggest goal - to provide findings that will be confirmed in phIII with the populations most susceptible to the drugs activity. They establish efficacy data - but with a much larger margin of error that a phIII. Tumor growth inhibition can be acceptable response criteria for a novel agent - as they have been seen to prolong life with minimal to no tumor reduction....They continue providing safety/tolerance/PK/PD info - and liver stress profile much more meaningful here. They further define biomarker correlates. Dosages are refined.
Phase II studies can take anywhere from 6 months to 2 years.
If I were running ctix - I would do a muti-arm phII and have about 6 small arms running concurrently - with the cancers shown to be the most sensitive in this phase one..."
Magic
Gelati, you will be pleased to know that you are no longer restricted to one post per day. Please feel free to share with us whatever info you feel is appropriate.
Magic
Gelati, not sure why you are limited to one post, but I have sent a request to Admin to increase your privileges, for whatever that is worth. Maybe if a few others did the same we could get it increased.
Magicatlast
Hello Marc, glad to see another of my old buddies showing up here. Pete, Dane, Pepsi, etc have been here a while. I think we have a real winner here. Hope all is well with you and yours in Belgium.
Magic
Isn't that just for privately held companies??
Magic
Good luck and better skill to ya!!
Magic
wild4nano, after reading thru this several times, here's the part that helps me:
"p53 has many mechanisms of anticancer function, and plays a role in apoptosis, genomic stability, and inhibition of angiogenesis. In its anti-cancer role, p53 works through several mechanisms:
• It can activate DNA repair proteins when DNA has sustained damage.
• It can arrest growth by holding the cell cycle at the G1/S regulation point on DNA damage recognition (if it holds the cell here for long enough, the DNA repair proteins will have time to fix the damage and the cell will be allowed to continue the cell cycle).
• It can initiate apoptosis, the programmed cell death, if DNA damage proves to be irreparable.
p53 pathway: In a normal cell p53 is inactivated by its negative regulator, mdm2. Upon DNA damage or other stresses, various pathways will lead to the dissociation of the p53 and mdm2 complex. Once activated, p53 will induce a cell cycle arrest to allow either repair and survival of the cell or apoptosis to discard the damaged cell. How p53 makes this choice is currently unknown.
Activated p53 binds DNA and activates expression of several genes including microRNA miR-34a,[27] WAF1/CIP1 encoding for p21 and hundreds of other down-stream genes. p21 (WAF1) binds to the G1-S/CDK (CDK2) and S/CDK complexes (molecules important for the G1/S transition in the cell cycle) inhibiting their activity.
When p21(WAF1) is complexed with CDK2 the cell cannot continue to the next stage of cell division. A mutant p53 will no longer bind DNA in an effective way, and, as a consequence, the p21 protein will not be available to act as the "stop signal" for cell division."
So the activation of wild p53 or the repair of mutant p53 (by Kevitrin) would then trigger the expression of p21 and thereby stop the replication of tumor cells.
Very cool!!
Thanks wild, doc, JB, etc. I think I understand now.
Magic
Thank you Doc, and JB. Apparently this is more complicated than I might have imagined. Anything that either of you, or anyone else can add to get a clearer picture of the process would be very much appreciated.
Magic
I guess I'm not the only one who doesn't understand the nature of p21, since no one took the opportunity to respond to my prior post and explain it. I thought sure someone more educated and/or informed than me would have the answer and be willing to share it with the rest of us ignorant investors.
Magic
I think I understand what p53 is, what is does, etc. What I do not have a handle on is p21. What is it, where does it come from, when does it arise, what is its purpose if any, etc, and why do I care? Is it a byproduct of p53 activation? Are there "normal" levels of p21 and we're looking for "above normal"?
Doc, anyone?
TIA, Magic