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So maybe this is exactly what Missling is referring to when he states "you'll know why we did it the way we did it after we do it" or whatever that quote is that he has used multiple times in the past?
The FDA can approve an NDA (New Drug Application) with one successful P3 trial and the repurposing of an FDA-approved drug.
So, if the FDA approves A2-73 for Rett, that would qualify for the first half of our Alzheimer's application. The other half would be our P2b/3 AD trial.
IMO, this is the main reason why Anavex wants the FDA to approve Rett first. Once it is approved, they can expedite the entire process for our Alzheimer's application. (Qualifying for the $100M voucher is a bonus)
Our FDA guys know what they're doing...especially Dr. Jin.
I'm just sitting back and enjoying the ride. smile
Cheers.
"subset"
LMAO!
Is nonsense a subset of absolute nonsense? Or is it just a lesser form?
ABSOLUTELY NOT
Would you even take his luck with Mega Lotto?
For those of us here (including that dumbass Leo...hehe) who are clearly ignorant of finance and mathematics, please explain how (based upon your comment below) AVXL could possibly enjoy a profit margin as high as 100%? This should be extremely easy-peasy for you Georgey...
Profit is sales price received minus related cost of which production cost and distribution, etc. is a major factor.
Why have you recently stopped including GOOD LUCK at the end of your posts?
I wonder if BioChecker4 has any thoughts on this...
Well I did meet him for drinks so.. could have been any number of things..
Please direct that question to Georgejjl. He is the resident math and finance expert here...
Does the "profit" margin account for amortizing the investment costs?
Speaking of Pfizer, whatever happened to that TooTallJones whacko? LOL
Merck has more interest in NWBO....Pfizer is the one to watch here.
A complete lie? Really??? Take a look at your post below...
georgejjl
Re: Gator328 post# 420901
Friday, June 30, 2023 2:34:00 PM
Post# 420902 of 425472
Anavex's profit margin for blarcamesine is projected to be in the high 90% to 100%.
The production cost of blarcamesine, which is a simple small molecule, is very inexpensive.
Nothing as ridiculous as Georgejjl's prediction of AVXL enjoying a potential profit margin as high as 100% on their future sales!
"...fantasies about ever higher $AVXL shares prices like $1249 or even Mayo's most ridiculous $6,000."
Absent substantial volume, any after-hours price movement is completely meaningless...
8.45 +0.20 (+2.42%)
After hours: -...does this count?
Georgejjl is a __________, a __________ and __________.
Feel free to fill in the blanks!
Doc328 is a liar, a fraud and ignorant.
Dr. Grimmer said that he thinks this to MayoMobile...or MayoMobile himself thinks that Dr. Grimmer thinks that...or MayoMobile himself thinks that?
Maybe BioChecker4 can shed some light on this based upon his convo's with MayoMobile...hehe
From MayoMobile’s interview on July 18 at AAIC-“Dr. Grimmer thinks they're
being approached/in-convo with big pharma for
purchase/partnering which is why we have not
seen data yet.”
The positive event that is desperately needed is the unfumbled release of truly excellent EXCELLENCE results followed by the prompt submission of an NDA. Here's to hoping that we are provided with these gifts for Christmas 2023. If so, then maybe we finally receive our sparkly red bicycles for Christmas 2024!
Only a material positive event, that the market believes , can change the trajectory and overcome the macro market challenges and I believe this positive event will occur in Q4.
Your post below reads as a statement of fact. Let's hope it ages well...
Within 90 trading days, at least 2 pieces of news will drop (maybe more) that will dramatically increase share price.
You mean we have to wait another five to ten years from now?!? UGH...
As I've contended previously, in five to ten years, the Anavex sigma-1 drugs will revolutionize medicine even more than did antibiotics in the 1940s and 50s.
Fantasy world timelines and price guesstimates from BigBioBoom over on Stocktwits. Of course, I sure as heck wouldn't mind seeing them come to fruition!
BigBioBoom
7:04 AM
$AVXL When is this $250? Timeline..My guess
alz results .. $35 .. aug
Ok to file for approval $50 sept
Partnership! $150 oct
And rising filing for approval in oct.
$250 heading towards alz approval. In march 2024 .
It is quite possible that the volume of AVXL shares sold today could exceed one million due to the high likelihood of yet another week of no news next week.
SHORT SQUEEZE MORE THAN LIKELY NOT GONNA HAPPEN ANYTIME SOON!!!
It is quite possible that the volume of AVXL shares bought today could exceed one million due to anticipation of news next week.
SHORT SQUEEZE SOON!!!
Mental math has been a lost art for decades now. What a shame :(
If one did not know Multiplication Tables by heart, then it was like a dead man walking.
Heck, up the price to just $2/day and using your figures what do you know -- $7500!
For the sake of argument and mostly out of boredom, here is a fun parlor game with back of the napkin math:
Penetrate 2% of the global population and charge $1/day for Blarcamesine. That's around 150 million people x $1 x 365 days. $54 billion/year gross revenue.
Assuming 20% of that gross is profit, that's about $10 billion net earnings. At 100mm shares outstanding, EPS is around $100. Figure a conservative P/E of just under 12.5 and what do you know -- $1249.
Is there anything interesting in the approx. 3,500 messages posted over the last 10 days that I missed while I was away? Judging from the share price and the 10 day volume, I'm guessing no...
"...but as I've said many times..."
Yes, WAY too many times...and I'm guessing many, many more times to come.
I don’t believe Missling is a crook but as I’ve said many times I do think he’s in over his head, to the detriment of shareholders.
Yes, really...hehe
I'm on pins and needles waiting for his answer!
georgejjl: Do you believe that the following is in general true or false???
If AVXL's revenue is $100M, the only way possible for AVXL's gross profit margin to be 100% (which you previously stated on numerous occasions as likely being between 90% - 100%) is for its COGS to be $0.00.
The only two (2) acceptable answers are as follows:
1) True
2) False
Note: Neither NONSENSE!!! nor COMPLETE NONSENSE!!! are acceptable answers...
Your response below is not a valid answer...
NONSENSE!!!
georgejjl: Do you believe that the following is in general true or false???
If AVXL's revenue is $1M and it COGS is $10K, then AVXL's gross profit margin will be 99%.
If you answer true to the above statement, then state the exact amount (your answer must be in the following format - $x.xx) that AVXL's COGS would need to be in order for AVXL's gross profit margin to be 100%.
georgejjl: Do you believe that the following is in general true or false???
If AVXL's revenue is $1M and it COGS is $10K, then AVXL's gross profit margin will be 99%.
If you answer true to the above statement, then state the exact amount (your answer must be in the following format - $x.xx) that AVXL's COGS would need to be in order for AVXL's gross profit margin to be 100%.
C'mon Georgejjl! Answer the question - How can AVXL's gross profit margin be 100%?
Both gross and net profit margin will be over 90% for blarcamesine.
Georgejjl - By "profit margin", do you mean "gross profit margin" or "net profit margin"?
If you mean gross profit margin, there is only one (1) possible way for AVXL's gross profit margin to be 100%. Do you happen to know what this one (1) way is? Can't wait to see your answer...
Anavex's profit margin for blarcamesine is projected to be in the high 90% to 100%.
That's all??? Only a lousy 100%? Sorry to hear that Steady_T...hehe
Maybe not. So far I'm up a bit over 100% on AVXL.
I'm guessing Biochecker4 will be sending Peter a donation right after he sends one to MayoMobile...hehe
I encourage everyone here to consider sending Peter a donation of $100 (more is better!) in acknowledgement of his considerable efforts as I have done multiple times including again today. Thanks.
Fun With Numbers - This comes out to 54,691 shares per week added to the O/S over the past 104 weeks.
By the way, AVXL closing share prices on the dates listed below were as follows:
9/30/2020 - $4.55
6/30/2021 - $22.86
6/30/2022 - $10.01
6/28/2023 - $7.98
[FWIW - 30.29% increase in O/S since 9/30/2020; 75.38% increase in AVXL share price since 9/30/2020]
FWIW - Issued & Outstanding Share Count for AVXL since September 30, 2020 is as follows:
9/30/2020 - 62,045,198
6/30/2021 - 75,149,833
(increase of 13,104,635 in 9 months)*
6/30/2022 - 77,942,568
(increase of 2,792,735 in 12 months)
6/28/2023 - 80,837,723
(increase of 2,895,155 in 12 months)
*includes the 2,380,953 shares sold @ $21.00 to Deep Track Capital
Here is a post that Georgejjl put on Stocktwits yesterday afternoon:
georgejjl
Yesterday 4:57 PM
$AVXL There is and has been virtually no dilution of AVXL shares for at least the last two years.
Ricter59
Yesterday 4:44 PM
$AVXL- Schwab now shows outstanding shares to be 80.84 million. Where is all the dilution coming from? Employee salary incentives? Anything else?
Hey Leo! Where you at?
Maybe one day we'll wake up to see AVXL up over 700% in pre-market on a deal where Roche (or maybe even Apple or Elon Musk) buys us out at a huge premium and throws in a monster CVR that could potentially turn into an additional 3000% gain!
Eli Lilly to Acquire Sigilon Therapeutics in Deal Potentially Worth More Than $300 Million; Sigilon Shares Surge
MT NEWSWIRES 7:44 AM ET 6/29/2023
07:44 AM EDT, 06/29/2023 (MT Newswires) -- Eli Lilly(LLY) has agreed to acquire Sigilon Therapeutics(SGTX) in a deal potentially worth more than $300 million, the companies said Thursday.
Lilly said it will pay $14.92 per share in cash for Sigilon, plus one non-tradeable contingent value right that will entitle the holder to receive up to an additional $111.64 per share in cash.
The contingent value right puts the total potential consideration at up to $126.56 per share, valuing the deal at a potential $309.6 million, excluding shares held by Lilly, the companies said. Lilly and Sigilon said there could be "no assurance" that any payments would be made under the CVRs.
Sigilon's board recommended that shareholders accept the offer and the companies said the transaction is expected to close in Q3.
Sigilon shares climbed by more than 700% in premarket trading on Thursday.
FWIW - AVXL has traded a total of 966,000+ shares today without one (1) single block trade of 10,000+ shares printed...
Actually, I think it's closer to 97.4%. Please double check your figures prior to posting. Accuracy matters around here...
I would note that 97.6% of NDA filings are publicly announced by the sponsors.
Let's see how big the MOC print is today. Over 268K? We shall see in about 90 minutes...
Per today's filing, the current O/S appears to be 80,837,723.
As Gator328 previously stated, any models being worked on would be well served by just using the entire 100,000,000 as the O/S...
It doesn't affect the AVXL "fully diluted" figure of 91M+ shares, but it does increase the 78M float.
"...someone with cognitive issues..."
Hence the extraordinary need for A2-73 approval, commercialization and worldwide distribution NOW!!! hehe
Only someone with cognitive issues would exercise only 1/2 of the shares available when the cost per share is 1.60 and the value today is 8.
268,000 shares sold at an aggregate market value of $2,144,000.00 ($8 per share)
144: Securities Information
Title of the Class of Securities To Be Sold Name and Address of the Broker Number of Shares or Other Units To Be Sold Aggregate Market Value Number of Shares or Other Units Outstanding Approximate Date of Sale Name the Securities Exchange
Common
Charles Schwab Corp.
3000 Schwab Way
Westlake TX 76262
268000 2144000.00 80837723 06/28/2023
Nasdaq
Furnish the following information with respect to the acquisition of the securities to be sold and with respect to the payment of all or any part of the purchase price or other consideration therefor:
144: Securities To Be Sold
Title of the Class Date you Acquired Nature of Acquisition Transaction Name of Person from Whom Acquired Is this a Gift? Date Donor Acquired Amount of Securities Acquired Date of Payment Nature of Payment *
Common 06/28/2023 Stock Option Exercise Issuer Checkbox not checked 268000 06/28/2023 Broker's Check