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No prob!
I will say that the possibility of stopping a PIII study at say interim analysis would be more likely because of the larger patient pool. However this is still speculating until it happens. We must remember too that in order for sales reps to market the drug efficiently data is needed to show the prescribing physician. Sales professionals need all the info they can get.... This is coming from a Biotech Sales rep ;)
Best of luck to you!
That is correct. However, I do not see this trial doing that on the basis that when trials are stopped early it is usually due to super aggressive disease states that lead to a higher mortality rate in a very quick timeframe. More in the cancer disease you may see that.
I do like surprises though! I guess we will have to see and I certainly do not want to rule it out. Here's a good read with a lot of info...
http://www.fda.gov/downloads/drugs/guidancecomplianceregulatoryinformation/guidances/ucm358301.pdf
You will do well here long term. If I were you I would look to add on dips on the other. I do not see it mimici g what TPIV did. The pending PIIa data will make it a mover through the end of the year at the very least. I'm sure there will be dips along the way
Good Luck!
It is possible. That at be one reason they are trying to extend the b portion of the trial. I will be waiting to see if that is something that is addressed in the future. For the moment I am assuming a PIII will be necessary and hopeful that may change.
The patient pool being so low gives me my doubts but we will see
AIMO
Hopefully you sold after this recent runup! I like both company's. AVXL has more to move the needle in the next 6 months. There is still some time to build a position here at TPIV.
AIMO
I still have shares here though small at the moment
Good deal! Will be looking for a starter here as well.... Post split
Thanks for the mention Seel!
I'd second that RK. Worth a look...
JB. Check ur inbox
AVXL...Kei see my last post on AVXL board. September data is speculation at the moment. The only thing that's for sure is the study should be completed by end of the year.
IR said the company has not specified a timeframe to report additional data...
Maybe some ppl counting on a PR in regards to this???? but it's speculation at the moment...
Emailed Christine Payne at IR....So I asked IR about data release. Basically, it was stated that at this time the company has not specified a timeframe to report additional PIIa results.
Everyone should set expectations for getting data once the study is over at the end of the year. If we get more information in a PR regarding anything sooner it will be a great surprise. Until we get that PR it is pure speculation that we get data before the study is over at the end of the year.
Just in my opinion!
This isn't going to be an exact answer but I will try and make since of it. So $67 billion is the market opportunity. However, never will 100% of this market be on therapy. Many things to keep them from it,(finances,problem with compliance etc). Point is not everyone who needs it will get it.
You could have the only drug on the market and never have 100% of the market. Just the way it is.
Additionally, there are several treatment options available which limited Aricepts sales as well. The market has continually increased as well. Also, you have to consider people that took Aricept and had side effects which led to discontinuation of therapy
There are many many more factors.
I really don't even like to speculate on where the market cap should be for Anavex. Bottom line if the clinic keeps getting positive results we will be much much higher!
GL and hopefully this makes since of why the gap in the numbers.
Actually 30 day MA is .53.... Haha is there any truth in your posts????
http://stockcharts.com/h-sc/ui?s=AVXL
Attorney client privilege says his lips are sealed and he can't release any info...
Being an open label study I AM "SPECULATING"they have to release information that is substantial that needs to be public. This keeps news from leaking before results are made public. I'm in your court though. There are no hard dates listed yet
Top line results are supposed to be ready in Septmeber but could be possibly released in October. I agree this is coming from...
https://clinicaltrials.gov/ct2/show/NCT02244541?term=Anavex&rank=1
This link also shows that Final data is expected at the end of December. It has been made clear by the company that this portion is on schedule.
Anything else is speculation on data release....it would be nice if the company would make this clear which I'm sure with patience they will.
GLE
SYN...
KEEPS study highlights therapeutic benefits of estrogen for cognition and mood
http://www.seekingalpha.com/news/2684745
I'm with you Canoe...I hope it stays in this range for a minute so I can get more shares! :)
It is shaping up here...time to diversify! good to see ya here. Grab a seat and hangout for a while.
First I need GPS coordinates to those reds! Lol
Thanks $heff!!! Between your board and Jbem and Bobs there is a lot of info and excellent DD on many great company's.
I took about a year off of trading and investing while fixing up a home purchase. Also used the time to fine tune strategy and reassess long term goals. Been getting back in the swing catching up on the Biotech world since April. Started back trading and investing in June. Been lucky enough to get a few good runners and LT stocks. Little over 80% gains since June!!! Feels very nice to step back in like that!
Again thanks for the transparency and hard work!
AVXL ...Jbem and Bob thanks for bringing this stock to everyone's attention. And for your DD! It's very much appreciated! Been in since the .50's.
I think that it will continue to appreciate toward data release. Trading some but keeping a very decent core!
Thanks again!
Thanks for keeping it real! Much respect!
AVXL...up 22% on really good volume. Big buys came in this morning. Price at $1.12 as I type....
Haha. Never mind I got rejected. It let me place it though. I may not have had enough share wise for the order in pre market.
I just placed an order to buy 50 shares
What broker do u use? I have etrade and can trade Pre market
Sent you a PM
I think you are spot on with this analogy!
Hydrochloride in medicine is to prevent medicine from breaking down quickly which improves absorption and allows it to be time released. As it is basically a salt I think it has no relevance in the patent application as it is not proprietary.
It is the one thing that until it is completely taken care of does add a risk factor. Until it's taken care of one would have to speculate on the outcome....
Bottom line PII is too small for a placebo arm IMO...
Ye you would think placebo would be needed. However because the disease varies based on each person individually based on the how advanced the disease is. I don't think you could get an apples to apples comparison because of that. Therefore I think this trial option was the best setup. I'm sure a PIII whether it be the next step or in lieu of a possible early approval may have a placebo because the number of participants will be much larger therefore eliminating and skewed placebo numbers based on what I mentioned.
Make since?
That's why they have a washout period. They can show that the drug is working and then the dip while in transition. Did you see the graph on the poster presentation?
Anyway that's AIMO
$533 a share....
Thanks for posting that info! I'm excited about the ongoing Alzheimer's trial but the pipeline is deep for other indications and disease states. With the focus on ALz recently everything else has lost center stage but their is true value in everything else that's coming as well. As long as they keep executing value will be built.
PS I selfishly want the price to stay in this range so I can build a larger position.
Either way moving up to full value I will still have lots of buying ops as things progress.
I expect in 6 months you'll have a lot more play money
AVXL just exploded on huge volume.
.93 right now....baaaammm ;)
I agree. Timing is right for this info.
That's new info for me too! Thanks for the insight
Final Data for outcome measure is set for September 2015. See link...
https://clinicaltrials.gov/ct2/show/NCT02244541?term=Anavex&rank=1
I thought Eli Lily and Biogens drugs did NOT show positive improvement in cognitive function? Wasn't that just talked about at the conference?