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Received this info at work today at the hospital. Awesome stuff. When I re read this I see that it is an edited version and the original version talks of the use of embryonic cells to "bridge the difference" with pluripotent cells. Anyone have the full version from Reuters? If not, I can recreate on Monday.
Reuters) - Two studies published on Thursday show new ways to fix damaged hearts, one by turning structural heart cells into beating cells and another by restoring a primordial ability to regenerate lost tissue.
The two approaches need more work before they can be tried in humans, but they represent big steps forward in the new field of regenerative medicine.
And they show it may be possible to repair broken organs in the patient's body, instead of resorting to transplants or artificial devices.
In one study, a team at the Gladstone Institute of Cardiovascular Disease at the University of California, San Francisco made beating heart cells from more ordinary cells called fibroblasts.
Stem cell researchers know they can reprogram these ordinary cells by adding three or four genes to take them back to an embryonic-like state. Teams are working to fine-tune these so-called induced pluripotent stem cells or iPS cells.
Taking this approach a step further, Dr. Masaki Ieda and colleagues found the genes that, in a developing embryo, turn an immature cell into a beating heart cell or cardiomyocyte.
They used these three genes called Gata4, Mef2c, and Tbx5 to convert mouse heart fibroblasts -- which provide structure but which cannot beat -- into the beating cells.
"Scientists have tried for 20 years to convert nonmuscle cells into heart muscle, but it turns out we just needed the right combination of genes at the right dose," Ieda, now at the Keio University School of Medicine in Japan, said in a statement.
When they put these transformed cells into living mice, they converted into beating heart cells within a day, Ieda's team reported in the journal Cell.
CURING HEART FAILURE?
When patients suffer heart attacks, heart cells die as they become starved of oxygen. If enough dead tissue forms, patients suffer heart failure and eventually often die.
Scientists have been trying a variety of ways to regenerate this scar tissue, but patients with severe heart failure must use mechanical devices or hope for heart transplants.
Currently, 5 million Americans suffer from heart failure.
The approach will need a lot of refining, said Gladstone director Dr. Deepak Srivastava. "Direct reprogramming has not yet been done in human cells," he said. And it would be better to find a drug that can turn on the required genes; currently researchers usually use a virus to carry new genes into the cells.
For the second study, a team at California's Stanford University looked to amphibians called newts.
"Newts regenerate tissues very effectively," said Helen Blau of Stanford's Institute for Stem Cell Biology and Regenerative Medicine.
"In contrast, mammals are pathetic. We can regenerate our livers, and that's about it."
Also working in mice, Blau's looked for the reasons that amphibians can regenerate limbs and mammals cannot.
Other studies suggest that mammals have had to give up regeneration because the same process can also lead to cancer. A so-called tumor suppressor gene called retinoblastoma, or Rb, helps control this process in mammals.
"We hypothesized that maybe, during evolution, humans gained a tumor suppressor not present in lower animals at the expense of regeneration," Blau said.
They found a second gene called ARF is also involved.
When they blocked both Rb and ARF in mouse heart muscle cells, they started to grow and divide.
The key will be to control this process, so the cells do not overproliferate and form tumors, the researchers report in the journal Cell Stem Cell. They also want to see if this will work in other organs.
(Editing by Philip Barbara)
Once again, Lawrence, you nailed the bottom line. This is lawyer speak. Of course the examiner is going to put forward their best position knowing that others (plenty of them) are going to refute every word and they won't score every point. Goal is to get to a workable middle ground as well as uncover meaningful facts. Filing was reassuring IMHO
Thus the pps as you describe. No worries. Just helps us all understand what is going on here. Thanks once again.
It is not my area of expertise to comment on legal matters as my connection to law is being married to a lawyer for several years. Big deal. However, what I am beginning to be pumped up about is the return of many legal minds on the board who can debate this thing to death (just make us money) They seem to be debating the finer points of the case in legal terms....all good...where there is smoke there is fire. My point being, Mehedi, my friend, is that "comfortably numb" translates to me like "posturing". I like it. If there is anything I can do to help with your boy, please email me at dlblevns@aol.com. I do actually know something about the situation you are finding yourself in. Would like to help.
I never thought the examiner would be approved knowing what those bastards are hiding. that being said, I still do not know why they are still letting this ride with comfortably numb attitude
ilenes I want to add my thanks for all that you do for the board. I value your observations from the courtroom and your tireless commitment to attend, deliver docs, etc etc etc. You are a great contributor to all the team work on the board!
Nice post Dion. You really are a good writer.
I think you should apply to work for Susman when you graduate. You're a quick study!
Believe it or not the high deductible policy came in under the previous admin. It is the only way employees could keep the cost down. Whole other story. But hold on to the low deductible my friend!
You have an excellent point mofnc. Unfortunately, very few insurance policies left with co pay. It's all about high deductible insurance policies.
I think nursing CE buzz is over rated. Every medical company in America is producing these web flicks for nurses to watch at lunch. It is not really that difficult to get CEs to meet the minimum licensure requirement and it is over a 2 year period. Any moron could comply. Most nurses stick within their given area of practice and the OB nurses get it. So they would be the target audience. I would normally agree with you that nurses would collect the cord blood but at least in my hospital it is the Obstetrician. They take this "kickback" business very seriously. No problem. They have a rough gig with the high malpractice insurance they have to pay to survive. It's been a different medical world in the past few years. For right or for wrong.
I think you nailed it Hammer. Patience is a virtue but I hate that it has to happen that way.
so, in essence she really is doing her job. and her job is to wait, and see what is postulated in front of her, and then disseminate it all accordingly.
PKU screening is so '90ish. Most states have expanded screening including 30 tests for genetic abnormalities. Here's the panel from Illinois. I believe Texas is the lead state. Still checking.
http://www.idph.state.il.us/HealthWellness/newbornfaq.htm
When specific testing is mandated by the state it is funded by the state, which many have adopted. nsurance no matter.
Maybe you had another thought in mind?
I think he's like JW. When he starts praising JPM good things happen to this stock. He's not going to bash a bankrupt stock on CNBC like the other poster is able to do on this board. Could be JD sweating bullets or more $$$ need to be set aside for ongoing litigation. JPM reports tomorrow AM.
Duct tape perfect. Think it would be a nice touch to the recently posted edited pic of Rosen with the red hair.
Hey Uz...Thanks for ur message, Seems like there was a lot of "where's the ibox?" type banter at the time. I tend to walk into those situations like a dumb blonde. No worries. I think all of our heads are spinning from this stock at this point in time, right? Thanks for all you do for the board.
Writes and sounds a lot like nurse jeff, don't ya think?
Why do you think that buyers buy 2-3 weeks before news? That's interesting.
You are too kind. I think you were being sarcastic and I always an one to be gullible. No problem.
Wasn't that what the At&T lawsuit was all about? Obtaining docs not intended for EC and perhaps the debtors? I can't even tell you when that occurred. Maybe May? Too many filings.
I don’t know what the Equity Committee means when they say that we have obtained JP Morgan’s documents from 3rd parties – such and such, doesn’t make any sense to me.
I'll quit being OT here but both Einstein and Newton had Asperger's. Sorry UZ. eom
http://news.bbc.co.uk/2/hi/health/2988647.stm
Hey friend. The only difference between today and yesterday is that you love your son even more. The diagnoses is not a death sentence. Just take one step at a time. Your family will make it through.
Whoa....post of the day. Awesome video. Worth watching.
Sly you could clearly be correct about the need to hire attorney to cover Rosen's sorry azz. On the other hand, it is possible that this is a posturing event from the debtor's perspective saying "Sure we could have a BOD election. Of course we would need legal counsel, experienced in those matters. With greater expense to the estate." All IMHO of course.
I would imagine with so many cord blood programs available to expectant parents, a few would be ripe for M & A. Couldn't tell you who, what,when, where but I will tell you that reproductive endocrinology/IVF has pretty much dried up as folks don't have disposable income at this particular point in time. Perhaps there is a parallel in cord blood storage market. In general, the overall market for Obstetrics has decreased by 15% in our state, not at all hospital specific. "Afford a cord" excellent idea IMO because we all believe in brighter days ahead. If it costs less on the front end and more as time goes on, I don't think that will deter people at all. On the other hand, in my personal opinion, I think coming up with marketable collection device is more or less the perview of a Baxter, or Covidien or medical supply company wanting to capitalize on a hot new procedure. The clinicians could live a very long life without it and you wouldn't believe how many "devices" for a variety of procedures making it easy for people at the bedside end up in the garbage, especially when it is part of customized packaging. If you are telling me that CBAI is developing this product to enhance their position in the cord blood market, I think their money would be better spent buying a struggling cord blood company. On the bright side, the product could be a good spinoff to a drug company who could take the next step and create an infusion of cash if they can target the correct buyer. All OB services are not the same and they are pretty good at identifying who needs what. All totally JMO and don't care to debate. If you don't agree, please disregard or put me on iggy. GLTU
He was here Friday. Check out 217033. Don't want to cut and paste as not worth the energy due to content. Have a good day.
Has been a few days since your response but I wanted to mention that by putting the cord blood decisions into the hands of the Obstetricians, many technical obstacles are eliminated. They are surgeons, after all, so handy with things like cord clamps, umbilical cords, test tubes and the like. The majority of the time at our institution, the physician puts on a cord clamp, lets the blood go into the test tube and he is done...nurses pick up and go on to the rest of the freezing/processing procedure. Our hospital works with 6 cord blood processing companies, CBAI being one of them. I imagine there are institutions who would benefit from the device you describe or the umbilicap. For example, rotating Residents in training may not have the surgical expertise. Midwives another thought. I think it is good to have options for folks but if it becomes the type of thing where physicians and nurses have to jump through hoops, probably a detractor and unnecessary expense. JMHO.
I am hopeful that he paid his lone ace by filing for the debtors to expand the services of an additional law firm they have used (whose name escapes me without flipping around through docs. It is a holiday after all lol) so that there can be a BOD election etc. Whining and such I imagine would follow talking about the expense to the estate. I am always the optimist so JMO but GLTY
[quote)And then what trick do you think Rosen has up his sleeve if we get the examiner and the shareprice takes off? This guy is milking us..(quote]
steel you indeed nailed the bottom line
Not sure which will take longer -- For Rosen to come up with numbers, or judge to rule for examiner.
Ur posts are the best, locks. thank you.
hmmauto, I think ur info is really important. Could u get to the bottom line inf 50 words or less? don't want to miss it, seriously.
Maybe it's the new marketing strategy. JMO of course. Good question, however. Haven't received a postcard myself.
I recognize that a few things have changed since 1997 as I am in the clinical field working directly in obstetrics and neonatal medicine (as well as pediatrics) and actually see the products and OB patients targeted by CBAI. As requested here is the link for the umbilicup, under blood and blood products, not drug category. http://www.fda.gov/downloads/BiologicsBloodVaccines/BloodBloodProducts/ApprovedProducts/SubstantiallyEquivalent510kDeviceInformation/UCM088921.pdf
Let's just end this little friendly "discussion" as I don't wish to wade through a lengthy response. I believe we are all here for the same reason to support CBAI rise to success and I would like to let it go at that. GLTU
A bit of news today.
Global Unichip Selects TranSwitch for Next-Generation HDMI® Supporting Full-Rate 3-D High Definition TelevisionBY Business Wire
— 2:47 PM ET 06/28/2010
SHELTON, Conn. & HSINCHU, Taiwan--(BUSINESS WIRE)-- TranSwitch® Corporation (TXCC) , a leading provider of semiconductor solutions for the converging voice, data and video network, today announced that (GUC; TW:3443), the world’s-leading fabless ASIC service provider, adopted TranSwitch’s HD-PXL™-1.4 IP cores supporting the latest HDMI 1.4 specifications. will incorporate TranSwitch’s IP cores in its ASIC service offering for Consumer Electronics applications.
“We have selected TranSwitch’s IP for HDMI primarily because TranSwitch (TXCC) meets the full HDMI 1.4 rate requirement including support for full-rate 3D HDTV,” said Dr. Keh-Ching Huang, Director of Marketing and IP Sourcing of GUC. “TranSwitch’s field-proven track record in providing world-class intellectual property cores for high speed interfaces gives us high confidence that it will accelerate the silicon success for our customers, and we look forward to working closely with TranSwitch (TXCC) going forward on this and future technologies.”
“Our HD-PXL-1.4 cores have a major performance advantage over competitors as we are the only IP provider that meets the full requirement of HDMI 1.4 including full-rate 3-D television,” said Amir Bar-Niv, Vice President for Systems and Applications at TranSwitch Corporation (TXCC). “The transmitter and receiver HD-PXL-1.4 cores are available today in the TSMC 65nm process, and will be offered in 40nm version later this year. In addition, we plan to introduce an HDMI 1.4 Ethernet Channel (HEC) offering based on our widely deployed industry standard Ethernet PHY IP cores,” concluded Bar-Niv.
OK I have read all of your lengthy post with interest. Could you kindly tell me the exact difference between the newer product by Pall with NAD status compared to the product on the FDA website from Utah Medical Services called Umbilicap? As I'm sure everyone knows the problem with umbilical cord blood collection is the harvesting and processing of the specimens once collected. How specifically is the product produced by Pall superior to the one used since 1997 by Utah Medical? Not that the one by 1997 was particularly good. I would like to understand better how is it an improvement that will overcome the general problem associated with umbilical cord blood processing. I agree that if there is a concrete reason that the filter produced by Pall is superior, there is yet another postive reason to be optimistic about the future of umbilical cord blood services. I am assuming that CBAI already or will employ those processes but don't have that information as well.
I will study your info later and respond but not sure why you keep referring to a hospital as the only frame of reference. I have been in the medical field as a nurse for over 30 years. That gives one a broad frame of reference.
Sure. If you take the example of a hospital who has a partnership with a reproductive endocrinologist or high end cosmetic plastic surgeon or Urogyne physician who does surgery for adult female incontinence, there are many possibilites. Hospitals are bound by all kinds of laws like the Starke law or antikickback law. So in the case of the reproductive endocrinologist, the hospital gets a few spin down revenues like ultrasound, labwork, etc but the primary purpose of the venture is to get the woman to deliver her baby at the joint venture hospital site. What ends up happening is the two entities make a legal agreement about what each entity would provide and try to sell it to the world at large. If I knew Matt I would tell him to market the Afford a Cord program directly to a hospital for at least half off. Sounds drastic but hospitals only get at best 40% of what they charge. Then the hospital could market that all their patients get umbilical cord services for free (at least for the first year or something like that) You get the picture. Does that have anything to do with your question? lol
Question, can there ever be a working partnership or relationship between a private individual and a public entity for storage whereby both sides benefit from the stored stem and the cost is defrayed or split. Somewhat like the middle of the road for cost and availability for usage. Is it a possibility or feasible?
Ok after reading ur most recent post as well as re reading the original, I think all Dr. Ahmad is tryng to say is that he is the Medical Director and responsible for Quality Control, probably of a number of blood bank providing umbilical storage services. Period end of story.You may or may not know that few hospitals have their own blood bank. It is often a contracted service and subject to all the things you mentioned like a QC coordinator, Lab Director (medical technologist) and Medical Director who takes all the credit and stipend but does none of the work. LOL but true.
Another thing that puzzles me a bit is the mention of PALL filter. PALL is a name brand like JNJ or COV. It filters umbilical cells but so do other companies with different products. Can u elaborate a bit on that topic?
Since no one answered you I will open my big mouth and say that one role of a Medical Director is to ensure quality in a program. Medical Director roles in an ICU, for example, is to make sure safeguards are in place to avoid events that are detrimental to patients as well as publicly reported like Central Line Blood stream Infections(CLABSI)or Ventilator Associated pneumonia (VAP) Check it out at CMS.org. Guess the idea on the table is that the Gov gonna get involved in setting standards for stem cell or embryonic cell storage. Not really a problem and perhaps an opportunity. IMO of course.
This is OT so may be deleted but I know there are many veterans on the board. If anyone has elderly parents or need assisted living services themselves, I just learned about some incredible veteran benefits for my mom. My dad served in WWII and died 32 years ago. Unbelievable that this resource exists. Aid and Attendance.
http://www.veteranaid.org/
I like (D)
D) He knows something that we don't and he wants the examinor to be appointed so it will be used against us in the end
I would delete the second part of the statement.
I think he knows he is in a no win situation in terms of representing the debtor with BOD's view of how estate should be handled, handling the document requests appropriately, reaching a settlement with the various special interest groups etc and of course keeping his license.
IMO his mouth moves saying NO examiner but he is pushing the judges buttons so she will rule FOR examinor.