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here's what stands out to me in that article
yea but the commercialization of an antifungal from the humble beginnings of sending your friends your soil samples. Must look like absolute crazy town from an outside observer.
And I think systemic candida has a route of contamination of biofilms on surgical implant devices. Not necessarily suggesting we take it orally. I've said before I would rub it on my face tho.
Ok the yellow rain link is bad because it doesnt detail how the toxin was discovered in the soviet union trying to determine the cause of wide spread deaths of unknown origin discovered to be a fungi infecting cereal crops.
https://ec.europa.eu/food/sites/food/files/safety/docs/cs_contaminants_catalogue_out88_en.pdf
so heres a link assessing the risks of contamination of crops.
http://blogs.discovermagazine.com/bodyhorrors/2015/08/31/nystatin-discovery/
https://en.wikipedia.org/wiki/Yellow_rain
https://moldsafesolutions.com/wmd/
Ok, although what we're looking at here is firmly rooted in agricultural developments. I have provided a few links for light reading to help better understand the potential implications here that may be injected into the macrocosms.
Hey Boston remember that time the analysts didnt even know what infinity fabric means and I made a bunch of money because theyre absolute Hellen Kellers on analyzing a company?
I am so excited today. I demand you partake in my level of excitement here.
Yup. What you posted on downy mildew may look nonsensical or irrelevant to the uninitiated. To me it looks squarely set up to enter the history books and leave a legacy of technological achievements. Great success. The Hellen Kellers on wall street are quite oblivious to the bomb just dropped.
Hey boston did Sint biotech just turn into an agricultural product stock? I dont think so. But since theyre the ones responsible for the research on the antibacterial properties break through I think theyre entitled to credit on the break through on IP R&D licensing rights in regards to this aspect of those properties. Stop me if their patents dont protect that IP here. That disclosure looks to legally constitute as prior art to me.
I`ll just keep googling Plasmopara viticola + silicon nitride. This seems worthy on journalism like farmers almanac or something.
Here's the next piece. Unlike copper which is a micro nutrient for plants and can potentially poison the plant and the soil in large quantities. Silicates are found in abundance in nature and are also important to plant health.
https://www.planetnatural.com/product/silica-blast/
Here we're talking potassium silicate. But since potassium(and nitrates) are an applied macro nutrient there might be a possibility chemistry would take place in the soil that would unlock the silicates or nitrogen for plant absorption. This is just a side effect. Real benefit is not being toxic in high doses.
Money?! HAHAHA They just killed MOLD. You have no idea how excited I am right now.
https://en.wikipedia.org/wiki/Plasmopara_viticola
We're talking a time frame of like 2 months and they've started dropping research into this area. That's impressive progress of rapid innovation.
That's really cool they're engaging in science. This is a company that wants to engage in science. This is rapid progress left to their own devices. I dont know what the hold up is on the medical device front but it doesnt look to be rooted in the company SINT based on this rapid progress.
I'll be posting about the implications of this later. Looks like its safe to turn this card over and show the card in the hand.
Oh good point. If bio tech. Innovation where gov. subsidized a new corp. would arise to attempt to tool up to take over market share and deliver the innovative products after reading the market unless the IP R&D where owned by the corp. that monopolized the market and doesnt want their existing product to be market cannibalized. So there would have to be laws that address attempts at corporate take overs to stifle the innovations development.
Spine seems developed. Dental looks to be a priority. Hip looks to be put on a back burner here. I wonder if this is a force? Seriously wondering not implying.
Im talking the macrocosm that drives markets that exist in tech stocks, But doesn't occur in biotech. biotech is not driving the market like tech stocks. That's driving force is based on rapid innovations. The core of the reason we're here is excitement for advancements.
"we'd love to settle your legal case on damage claims out of court but we demand our settlement payments be made in stock and stock options."
(joke) on Hanson getting paid.
Even if the innovation aspect is gov. funded the idea of trashing all your existing equipment and tooling up to produce a different product causes internal cash burn. IF you`re a monopoly that's cash burn on your bottom line that only cannibalizes your own bottom lines demand for existing products.
Unless innovative products cannibalize demand for their existing products. That's not a fundamental bump beyond avoiding settlement costs and delivering a product that could take some of the market from competition for growth.
What if it's a monopoly? where's the motivation to cannibalize your existing products demand for new innovative products that require a cash burn? that's when we stagnate. When we all want the cure for cancer?
Zimmer stock looks like a stagnation to me. Trying to predict it currently looks like it might bounce off a bottom bollinger..again. and continue to trade sideways somewhere around $100 on bottom bollinger. How would I leg up there without something that sticks on the fundamentals? a smoke and mirrors trick won't stick it will just reverse the course of a swing trade in the band they trade in. You could engage all of their shares into the swing and take the profits to buy back stock and take it to the next level on supply and demand. But at the end of the day You're left with a private company. Zimmer owns all the shares says the shares are $100 million per share and nobodies buying. thats artificial. Unlike increasing the share price based on the fundamental analysis which sticks.
I mean metallosis is a technological innovation. But the problem unleashed on society is rooted in our biotech financing of financial risk reward in costs of development. Perhaps they could have used a little more money to test in vivo and take a harder look. OR when the 10 year results come back and it's 5% they just fudged the number to 90% because they just dumped all this investment into something that didnt pan out and it became unfeasible to take the L and became a matter of corporate survival to release it anyway.
I think this is why the big names use shell companies. Not because they dont want to be named as innovators but because it allows the shells to engage in RS and reofferings to finance a biotech innovation where a simple IPO cant cut it. It's just way to expensive and this is the screwy financial subsidizing that has to be engaged in for innovation the industry is desperate for, for their big stocks not to stagnate
Ok maybe its a bad Idea to sprinkle RS protection on your bio tech shares. Because then the company goes belly up from lack of funding. But that suggests the expenses of developing in biotech is financially unreasonable. We hit a capitalist road block in technological progression where the financial risk outweighs the reward and go into screwy finance to make it feasible. So we need subsidizing like corn like space tech like Nasa. But then this bounces back to what Ive been talking about DOE and Berkeley national lab and national labs in general here and in biotech in general.
lloyd doggett is suggesting he address something that looks like FDA has already addressed with device tracking and new fda clearance techniques. I think there's a journalistic story here that starts with metallosis goes into the problem of how novel biotech financially attempt to stay alive and the problem with that and national lab IP then ends with addressing the need to financially subsidize development like corn to create a healthy state of biotech development to encourage it and remove the road block and foster innovation. That's essentially what the new clearance paths in the FDA attempt to do. Foster innovation.
can I get a basis for this? I'm not seeing anything bullish on their chart besides that dividend. But Im sitting here buying sint talking about teh milkies so what do I know?
what if we like invented a magic potion to pour on our shares to make them immune to reverse splits. that would produce buying opportunities. Through SEC legislation. The whole act of Reverse split seems non consensual and forced upon the value investor. Currency is backed by interest rates. That seems like a multi level marketing scheme. Shares here are backed by the value of the IP R&D. Sounds good until shares outstanding is shrunk and new shares pop out on a RS and offering. That could be infinity. So Value of IP R&D divided by infinity = 0.
How many more RS are in the future here? How many new offerings to stay alive on a negative EPS? Seems like attempts are being made to lower cash burn and CTL is a step in the right direction for cash flow that's not an offering. That's not consistent with someone trying to run a stock not a company. Especially when it coincided with an offering that brought some milkies. Why take CTL milkies when you got some milkies right here? Maybe you need more milkies? You like lots of milkies? I dont think so. Sounds strategic.
"NurOwn"
looks up tech. Well that looks promising. Looks up ticker. Oh gawd. Who controls this sector? Gold, Oil I mean even facebook and twitter in dot com bubble 2.0 has their day in the sun. Biotech's seem to trade inversely to what we've been seeing in the S&P 500.
I am by no means a stock expert and babbies first biotech.
What indicators are you using for that? RSI looks neutral. Bollinger suggests it's about to hit the bottom. MACD looks bullish. Most interesting thing is the RSI smoothing effect only takes a 14 to achieve the same result as 30 from the last time I looked at it and just ran the smoothing until I achieved around 30 on RSI from what looks like a bottom out. Interesting that fits right into the technicals math without having to calculate anything. I guess you learn something new everyday. Good luck on .45 for next week friend.
..And we continue the slow melt down on a company that looks like it has a fundamental pessimistic value of about $12 a share from my analysis against current float. You think Sonny would have handed over the keys if offered around $435 Million around the time of CTl deal with CL101 hyping the value at 2 to 1 Zimmer? I question that idea.
If forcing my hands forces to admit a defeat here, I think I`m ready to take the L cordially here and just chalk it up to "how the real world works". I refuse to admit a flaw with my interpretations here as what seems to be a strong buy on the fundamentals. No hard feelings.
Just pointing out the pessimistic outlook of less than stellar track record of lack of commitment or lack of progress with these strategic partners and JDA's. Reality is no results are shown. So far track record shows these are entirely ethereal. Only real world example of tangible consequences into these matters is with CTL.
Side tracking a bit since I mentioned cartiva.
So the problem with synthetic cartilage to better simulate a human hip we'd have to factor Cartiva and breast implants. What I'm suggesting is removing the plastic liner and replacing it with nothing. An artificial bone on bone. In human hips you find cartilage here. So why not just replace that with a synthetic cartilage? That would buffer wear of any liner or femoral head material. Wear would only involve synthetic cartilage material.
But look at cartiva. Seems like there's an issue with full bioabsorption here. Making the implant disappear. So maybe silicone material is a candidate but we find the complications with silicone breast implants. All these things are going to be recognized as a foreign body and dealt with accordingly. Also complications due to the facts it is in fact foreign material to the organism. In my opinion in order to make a synthetic cartilage work here they'd have to look at what seems to be stumbled upon here with SiNi. Elements similar enough to the components of the organism to not be recognized as a foreign body and cause no complication. The materials combined naturally like HA+calcium coatings seem to make sense with bone integration.
AND THEN they have to figure out how to affix it to make sure it stays in place. The only other possibility here in my mind is to trick the body into restoring the missing cartilage. Either on the natural join or an implant.
Until then SiNi continues to hold the edge here IMO. If you want to defeat SiNi in any manner. Instead of attempting to find novel means to mimic various properties. I would be focusing right here. AND STILL you might be looking at incorporating the properties of SiNi based on other aspects into these novel designs.
1. The problems with MOM could be attributed to removing the plastic liner
2. The previous complications in COC's could (I feel falsely)be attributed to removing the plastic liner (squeaking/edge wear)
3. The plastic liner is consistent with the designs revealed in the days of OMNI.
So I see why to anyone removing the plastic liner might be a hard sell. But Hanson I believe revealed a suggestion he returned to the drawing board on unique products of something. Honestly, you`d have to find the reference. Really wasn't paying attention here.
I feel the industry in hips is heading toward a direction and that direction looks like it's targeted toward superior designs and COC's seem to be a direction that's unfolding. Evidenced at least in part with the H1.
To me removing the plastic liner then dealing with it, seems to me like a no brainer smart guy move in the development of a SiNi hip.
Yeah, I was mainly considering SiNi on Poly vs. SiNi on SiNi. Other materials seem to compare like hot trash when compared to SiNi in my mind. That's what it boils down to SiNi vs Poly when considering the wear component of the acetabular cup. SiNi vs. Poly. Comparing the two based on their characteristics SiNi wins. This is just another arena the material out performs. Of course we need the data to back up my baseless claims. But I believe my hypothesis is firmly rooted in my understanding of the characteristics of both materials and considering the in vivo.
In an attempt to remain unprejudiced and consider the other options I've thrown heavy caution to the idea of Zimmer involvement. Mainly due to it being an unknown. The idea I stumbled upon of AMDA using Omni liners in clinical studies involving the infinia hip then Omni exiting the picture. Then a new hip study involving a Zimmer liner produced in Indiana with the unknown strategic partner wears heavily in my analysis here. The only words of caution in the spirit of critical thinking I can throw out now, based on these given facts is:...well, look at what happened with Omni. nothing came to fruition.
I also question any clinical data revealed in South Africa. Based on the fact it occurred in the medical fields of South Africa. The lack of quality medical care adds a variable too great here to take any data seriously directly related to the facts of the quality of medical care found in South Africa.
Another point that should be taken is tribological wear in other industries, we're not seeing SiNi coated ball bearings. We see solid SiNi ball bearings. The wear test on that should be easier to deduce.
Notice the Bears never picked up on using the lack of Infinia data released to attack here.
As a species we may not have the brains or time to fully wrap our heads around developments like these. Only enough to get us hurt. Thus perhaps we should just return to carving hips out of ivory like Tower suggests. Perhaps this relates to SINT taking it so slow and focusing on the data and producing studies rather than products, deviating from the standard business model here.
Ok, good point on where you put plastic on that list based on it's ability to resist bio absorbability, thus localizing complications. I would have bumped Titanium a place over plastics, but you drive a good point here.
On the topic of other potential elemental alternatives to coatings we where discussing in reference to Titanium nitride/Niobium Nitride coatings. Titanium Nitride seems to be half a point harder than SiNi on the Mohs hardness scale. No clue about why you would include Niobium. I believe Ive previously uncovered something on phase changing of Titanium and embrittlement making it a poor candidate as far as a material for larger femoral heads, hence why we're not seeing that and why chrome cobalt exists. No clue if this has an effect on the idea of using TiNi as a coating. I suggest they figure it out. Based on the industry track record I assume they won't bother.
Ok I screen grabbed the point in the power point presentation. Page 27 in the .PDF
http://www.cost-newgen.org/wp-content/uploads/2016/06/2A-On-the-history-of-bioceramics-for-hip-joint-replacement-C-Piconi.pdf
Here's a direct image link if the image isnt working
http://tinypic.com/r/2gwfeid/9
"ZTA CoC does not exhibit superior wear so im not sure why you keep insisting CoC is superior."
Well I just kind of owned myself on what a partnership can bring to the table beyond a big bag of money and a sales force. The design engineer IP licensing and a bunch of design engineers.
Now if they where working with Omni liners when Omni was the strategic partner it's a no brainer why they are working with Zimmer liners. Let's see if the SEC comes banging on their doors about that tidbit. Meh, rather have a co. excited about COC`s. Looks like Zimmer at least got some, unlike Omni.
Well it's certainly relevant it appears nothing was ever published regarding that infinia implantation and for 7 years an update was never released regarding anything to do with infinia.
"protein precipitation"