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lol Nice!!! ...thanks
Encapsulation of Insulin Producing Cells for Diabetes Treatment Using Alginate and Cellulose Sulphate as Bioencapsulation Polymers
https://www.researchgate.net/publication/265850198_Encapsulation_of_Insulin_Producing_Cells_for_Diabetes_Treatment_Using_Alginate_and_Cellulose_Sulphate_as_Bioencapsulation_Polymers
Abstract
It has long been the holy grail of cell encapsulation to treat diabetes with insulin producing cells that are shielded from rejection or clearance by the host immune system. Indeed, the idea has been around for more than 50 years with the first demonstration in an animal model being published in 1980 and the first patient treated being reported in 1994. In the meantime, more clinical experience has been accrued with the use of encapsulated cells for the treatment of human diabetes. Most of these studies have focused on the use of alginate as the encapsulation material and although some promising data has been obtained and is reviewed in this article, it is still far from being a product that can be routinely applied. Cellulose sulphate has excellent properties making it ideal for cell encapsulation and has been shown to be safe in 27 patients. Moreover, data has been obtained showing safety and efficacy in a rat model of diabetes supporting that cellulose sulphate might be the material of choice for this application.
awesome...sorry if this has already been posted
"...Capsules may be dissolved in vitro prior to use in order to release the cells or implanted directly as capsules into the patient, depending on the application. The cellulose sulphate encapsulation technology Cell-in-a-Box® developed by the company SG Austria Pte Ltd/Austrianova Singapore Pte Ltd in Singapore allows for cryopreservation of capsules containing cells [4]. Frozen capsules can be stored for many months without appreciable loss of cell viability; an attribute that makes cellulose sulphate desirable over other more commonly used encapsulation technologies such as alginate which cannot be frozen (Fig. 6). This attribute has a high commercial value since cells can be frozen at -80°C for storage in chest freezers or transport on dry ice or at lower temperatures between -150 and -178°C which allows storage and/or transport under the gas phase of liquid nitrogen. Both are equally viable using cellulose sulphate. This long-term storage and long-distance transport option makes product validation and distribution possible, which are both necessary for the development of a mass production of a medical product...."
wow Rudy, so I believe this was the case for the CiaB/Melligen Cells patent...cool
Besides in vivo use, encapsulation of antibody or antibody like producing cells can be of great interest for the industrial production of antibodies by the biotech industry. The capsules can act as a pre-filtration device and eliminate cost-intensive steps during downstream processing of antibody products. Such encapsulated products should be seen favourably by industry since they may allow for new IP surrounding old technologies in combination with capsules. This may allow generation of new patents or extension of old patents, something it can be assumed is much needed when looking at the current portfolios of many of the large pharmaceutical companies.
With regards to JDRF having already funded the two other programs....is it possible they may very well regret not participating/funding the Ciab/MC combo for lack of involvement/support/belief if indeed PMCB gets FDA blessing?
Goldman said:
"As a result, PharmaCyte Biotech's Cell-in-a-Box®-based treatment system approach could not only emerge as the superior encapsulation technique used to treat T1D, but it could attract the attention of the JDRF and other major diabetes research sponsors"
Isn't it too late for JDRF now that we are where we're at in this point and time?
thanks in advance...Go PMCB!!! Go KW!!!
Would appreciate a rebuttal on these points from Bionewton, Rudy, or anyone else....thanks in advance
Thanks Rudy...hey can you, or anyone else here, post the link to the scientific review article that discussed the advantages of the Cell-in-a-Box® encapsulation technology over alginate? I tried to find it but I keep getting a "bad gateway"...thanks in advance
Let's hope, right?!!! Go PMCB!!!
Can't wait to review the statistics in three years from now of global export :)
I personally like the idea of the prolonged reasoning whether or not to legalize MJ in the US because it allows Canada to keeps its lion share of global export revenue.
For the U.S. ...Fate of MJ video??? ... http://video.foxnews.com/v/5259546245001/?#sp=s...
Go Canada!!!!!
That's right, and also...The bid price requirement establishes a minimum bid price for issues listed on Nasdaq. The Nasdaq Rules provide that, for an issue to be eligible for continued listing on Nasdaq, the minimum bid price per share shall be $1. An issue is subject to delisting from Nasdaq, as described in the Rule 5800 Series if its bid price falls below $1.
http://nasdaq.cchwallstreet.com/NASDAQTools/PlatformViewer.asp?selectednode=chp_1_1_4_2&manual=%2Fnasdaq%2Fmain%2Fnasdaq-equityrules%2F
Another good thing about our cell encapsulation acting as an artificial pancreas is that it works for all ages unlike the latest FDA approval of Medtronics MiniMed (artificial pancreas system) that must continue their research with post-market studies.
Risks associated with the use of the system may include hypoglycemia, hyperglycemia, as well as skin irritation or redness around the device’s infusion patch. This version of this device is unsafe for use in children 6 years of age or younger and in patients who require less than eight units of insulin per day.
As part of this approval, the FDA is requiring a post-market study to better understand how the device performs in real-world settings. While the device is being approved today for use in people 14 years of age and older with type 1 diabetes, Medtronic is currently performing clinical studies to evaluate the safety and effectiveness of the device in diabetic children 7-13 years old.[/ij]
http://www.rxeconsult.com/healthcare-articles/FDA-Approves-First-Artificial-Pancreas-Automatic-Insulin-Delivery-System-For-Type-1-Diabetes-1200/?utm_source=TrendMD&utm_medium=TrendMD&utm_campaign=trendmd_1
enjoyed that....keeping it in my favorites...thank you
already figured news out ..$SPRWF$..
lol but we do have a product dillweed!!!
been too quiet long enough imo ...looking for a dual news release ...predicting word of "change of exchange" and sales license just weeks, if not days, after task force announcement
I know it may sound crazy or even extreme, but since owning and holding PMCB, I have always been cautious of big pharma and their "might".
...their corruptive power to be precise.
Just hoping they welcome our therapies if indeed we prove positive to the FDA, rather than try to bury it.
I remain patient and positive, but I'm in the camp that thinks big pharma controls the FDA.
Go PMCB!!!
damn Brian, those are some good expectations ...I actually wouldn't have expected a couple of those
That might alarm a daytrader, but not me, I'm holding and LONG :)
Good morning everyone!....glad to be at .13 ...awesome week! ...I never made so much money that fast...luvinit! luvinit! luvinit!
It took everything I had in me to keep from going out this morning to buy a brand new Supercab F-150 ...but I kept it together and holding tight because I'm in it to win it "big time".
Glad to be moving upward...news coming soon!!!
Go PMCB!!!
CHRISTMAS HAS COMETH EARLY!!!
easy enough now??? :)
recapping the day, I think mind1's call earlier was nothing less than remarkable!!! ... respectfully, it shouldn't be overlooked as a shared opinion...in fact, I personally feel that some much deserved kudos from the board are in order :)
excellent close ...congrats to all!!! .... and as for therealist, concordia and frosr6 you guys can kiss my azz! lol
good call mind1
take no f****** prisoners !!!
push dammit push !!!!
my apologies .... I wasn't suggesting that you said that .... it was just my personal overall consensus .... I agree with what you just stated ....and btw I was one of those who bought in the 3's ..however, I have not sold and will not sell as I am a faithful long
so Bio, is it fair to assume that for the time being we can't push past .09 because there just aren't enough buyers?
if that's how it even works ...I'm not quite sure ...just asking
Blue skies indeed!!! ...thanks Rudy
lol ??? ... are you serious? ...I think the bio didn't post correctly, it's missing..... come on Pete, I was actually hoping to see an informative, yet respectful validation of his valuable participation.
Thanks Pete
Also waiting to see von Hoff info on the promo page ...thanks
Rudy and Bio, do you guys agree with that?
Go KW!!!!!
Perhaps between you and Rudy, one of you can come up with the correct amount ;)
ok, makes sense ...thanks Bio
ok so we hit .0824 ...how or when should/could we see an announcement on the contract/$50M ?
...???...