Monday, December 26, 2016 11:18:00 AM
"...Capsules may be dissolved in vitro prior to use in order to release the cells or implanted directly as capsules into the patient, depending on the application. The cellulose sulphate encapsulation technology Cell-in-a-Box® developed by the company SG Austria Pte Ltd/Austrianova Singapore Pte Ltd in Singapore allows for cryopreservation of capsules containing cells [4]. Frozen capsules can be stored for many months without appreciable loss of cell viability; an attribute that makes cellulose sulphate desirable over other more commonly used encapsulation technologies such as alginate which cannot be frozen (Fig. 6). This attribute has a high commercial value since cells can be frozen at -80°C for storage in chest freezers or transport on dry ice or at lower temperatures between -150 and -178°C which allows storage and/or transport under the gas phase of liquid nitrogen. Both are equally viable using cellulose sulphate. This long-term storage and long-distance transport option makes product validation and distribution possible, which are both necessary for the development of a mass production of a medical product...."
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