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good questions I would like to know that too
look DD and Hof and this is the last post Im dedicting to this.
Both of you assert strongly there is no delay (nothing to see here people lol) in the journal publication timeline and this is all a normal process (300 days after results narrative). But its not normal and there is a huge delay in the publication. If you had paid attention you would have noticed that reasons for the delay in the publication are being laid out by different posters and I fully agree with them
Senti
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=167714399
Vubru
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=167713346
and has nothing to do with a normal process as the 300 days median you refer to would suggest.
That's all there is to it
ha well there is always some better technology in the future thats how humans have progressed so far haven't we :).
There are now two GMB phase 2 trials without radiation and chemo that are very promising and Im sure these trials will not just stop after DCVAX L has become SOC. If in 5? years or so these now phase 2 will have phase 3 data ready then whoever is the owner of the DCVAX platform (Merck?) will want to have a fair comparison and not be dragged even by a small percentage of IDH mutant.
ok clear sorry misunderstood then.
I have a question outstanding with you appreciate it if you could answer it which is
I believe NWBO will exclude IDH mutant from its data for future GBM trial comparison. There is no law that would withhold NWBO to showcase the data ex IDH-mutant without comparing it to any external trial data but very helpful for future GBM trials now in phase 1 or 2 to compare it with.
Would you not agree?
thanks for answering
Thanks Vubru very helpful.
I just told you to do exactly that. You are both struggling with the difference. Again especially for you after the statisticians had readied the results in October based on ready software and already inserted data would that mean that your 300 days would start counting when NWBO took the time to be informed about it?
Im not arguing that NWBO management was already unblinded in Oct 2020 they were most probably not Im saying that results were ready in Oct 2020 just management choose not to be unblinded until X months later but certainly not May 2021 as you suggest (today minus 300 days).
The publication is late by Vubru and the 300 days after results are ready timeline
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=167706232
Im just referring to what you have as a source which is saying when the results are available + 300 which is not far after data lock.
Please tell me how could the results NOT be available in Oct 2020? The SAP was already in place and data inserted. It's not as if they had to program the software to process the data. You dont have to process the data many months after data lock to make results available. That is something actually we do know as an average / median from other trials.
You really have to make a choice here either the average/median of external results can be measured against the process NWBO is going through after data lock and in that case, the results were available fairly soon after data lock for that is normal with hundreds of other trials and then the 300 days can be mentioned in the discussion as well. OR not. But you cant say "we don't know" when the average of other trials doesn't suit the narrative anymore. You cant have both.
Aah yes the 300 days as has been iterated here many times now. Ok lets take a look at what it actually is saying
Can you please explain to me why it would be so out of grasp for NWBO to have come to the conclusion that pulling data from external trials ex IDH mutant was not feasible? And then to have concluded ok to be able to compare oranges with oranges for efficiency sake let's have our data include IDH mutant? For if you say this
absolutely no surprise in what you are saying
I'm going to ask and say it again.
I believe NWBO will exclude IDH mutant from its data for future GBM trial comparison. There is no law that would withhold NWBO to showcase the data ex IDH-mutant without comparing it to anything but very helpful for future GBM trials now in phase 1 or 2 to compare it with.
Would you not agree?
Flipper I think you should take Senti very seriously when she says she knows this from NWBO itself.
Would it be so completely out of grips that NWBO came to the conclusion that the external IDH-mutated could not be excluded from the external data so they had to let that comprising fly?
I'm pretty sure NWBO will make it known what the trial data would look like without the IDH-mutated so future GBM trials with true GBM patients can be compared to true DCVAX data.
hey Vubru
its good to see you back here!
Im happy to hear you did not sell.
what should follow from that post?
No one denies that a lot has happened over the last 13 months but nothing that could have delayed the publication by many months. If anything could have held up the publication its the change of GBM definition by the WHO. But Senti makes a good argument that the IDH-mutated will not even make it to the journal publication so that can not be it.
Last post for today CU tomorrow
No it doesnt matter what some guy hoffman6383 posted recently.
Again Vubru is on top of his field when it comes to medical publications. You? What he said 13 months ago about the DCVAX L publication timeline has not changed today.
I did not forget anything I did say this
that is a lame argument Hoffmann and you know it
The green book of good and bad arguments does not dictate that a first argument is always bad because its a first argument.
Vubru was not disregarding anything back then he had a good grasp about the trial following it for many years and being on top of his field of expertise.
Funny how back then 20 respected posters agreed with him and now not anymore?
PS
btw I personally agree with Poorman and think something else is going on (BO talks) which is the reason for the delay....
The ONLY reason why I have NOT sold my NWBO shares given the present situation is described precisely by SOS in his last blog
then I agree with you fully
But it still does not explain the point made you responded to which is
senti,
You are right that they will not remove IDH mutated from the data when comparing it to external trials for the reason you stated.
But I'm sure they will remove it to show how well the trial did without IDH mutated so that future medical trials now in phase 2, will be able to compare it with DCVAX L.
Lol
How about this one
ST stay tuned
I would put the overvalue of my holiday home in NWBO shares and double my already substantial holding in NWBO but I won't. The reason is not that I think that data is bad, I believe its overwhelmingly great. The reason is because of NWBO's silence and its refusal to update shareholders. This is the only biotech in the history of biotechs where the market is fairly certain that data is great but it is not certain management is capable to produce TLD and a journal publication ever, for whatever reason. If the market was convinced we would see topline and journal publication very soon we sit above $2.5 and stay there.
Perhaps after journal publication, the market similar not certain NWBO is capable of submitting a BLA?
thanks
aah if senti meant pseudoprogression in the treatment arm, which is the healing process, and is exactly what happened, then in there lies the confusion. But with eventing usually is meant dying and not pseudoprogression, so its good to clear up the confusion.
ha, thanks for the entertainment advice I will add this advice to my new novel "Waiting for Northwest".
My publisher Toucan Publishers told me my novel will appear in the coming months. So really excited about that.
men, you make me want to go to youtube and relive my childhood with BB
yes its absurd
you are both immensely appreciated here
judge predicted the downtrend just before it began end Nov with a huge reversal hammer
If I knew that all I had to say is what I said to make him leave I would have said that much sooner lol
$20? sold now lol me too!