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A little mineral oil might help unjam ya
Champagne is nice and chilled, awaiting some celebratory news!
Thank you for the complete set!
Nwbo has broadcasted their Industry Expert Theatre event live in the past and hopefully this special time.
No worries!
Trials have defined endpoints and a statistical analysis plan (SAP) that lays out how the data collected during the trial will be analyzed and presented.
The DCVax L phase 3 trial has multiple endpoints, however the two primary endpoints are mOS ( mean overall survival) for nGBM (newly diagnosed GBM) and mOS for rGBM (recurrent GBM.)
There were some secondary endpoints that were not presented at the NYAS event, and I don’t remember what they were, however meeting the primary endpoints is success and overall survival is the gold standard endpoint for GBM since 5 year survival for nGBM has been less than 5%.
The results that were “previewed/presented” at the NYAS for the mOS are the results of the trial and both endpoints were met with high statistical significance, meaning the probability of the successful results being a fluke are extremely small.
Now the trial collected a treasure trove of data and it ran so long that there was at least 5 actual years of data even for the last participants and much longer for some, so the long and fat survival tail is actual, not extrapolated!
Hope that helped a bit.
As much as I’m in the gutter, that loyalty to return is important!
However I love the look and sound of a basketball in nothing but net
And no matter how tough the situation me and my b-ball just come bouncing right back.
Except for the time I was having a fling with a golf ball. Those dimples were just irresistible
Hey don’t judge me harshly, when you’re a castaway you can get awfully lonely.
Just a couple more days now!!!!!
Better get some melatonin to help sleep with all the anticipation.
We got the TLD, whether called unofficial or not from the trial sponsor, at NYAS. There may be more but the bottom line meeting of the endpoints of mOS shouldn’t be different.
A paper and presentation giving more of the details would add immensely if available, establishing unassailable facts and the backing of being peer reviewed.
I never met a basketball I didn’t like
Nice dreams but could your next dream include Heidi Klum and Sophia Vergara?
Yes I’m currently watching Americas Got Talent!
Ohhhhh, now I get it, thank you, thank you very much!
jAMA kinmecrazy!
Me too with banana, thank you, thank you very much. You’ve been a lovely audience.
Elvis has left the building!
You betcha! FlaskWorks is another great acquisition!
Nwbo hasn’t bought much, but the two it has have been excellent:
1) Sawston land, and still owns valuable subsection after the sale to wawei
2) FlaskWorks with the founders and the IP
Very prescient indeed!
Yes, and we all shouldn’t have to be dealing with all the FUD and manipulation and distortions, untruths, and threatening of the fine doctors who dedicate their energies towards extending and saving lives!
For the almighty coin of the realm over the lot of our fellow humans, and for some the ego trip of the narcissistic…. Sad
My neighbor passed at Cantor at the WTC just weeks before he was going to be changing to a new local just minutes from home in NJ.
Our town lost many in 911
My uncle in Italy survived in a prisoner of war camp by sneaking some of the scraps they fed the dogs and potato peels, while starving the prisoners.
So I think genetically I’m predisposed to do well on ramen, pasta, and I can’t pass up perfectly good potato peels, scarfing them up before my spouse throws them out! With a little Chianti! Slurp slurp slurp
Could it be that all the FUD about changing endpoints that we’re dealing with now would have started earlier when the results were not able to be disclosed yet?
We have breakthrough results and we have to extinguish all the phoney BS. Imagine days/weeks/months of taking punches with both hands tied behind your back!
Distortions and untruths imo, no excuse for the behavior especially given the importance of getting the treatment to everyone who needs it!
Rest up for the coming two weeks!
Call me an optimist but I’m expecting some good things!
Scotty you can give up the 600 days counting schtick now.
It’s passé !
It has nothing to do with belief when you distort or misrepresent the truth, and I suppose you’re ok with threatening dedicated life saving neurosurgeons?
Contacting organizations under pretenses and alternate identities doesn’t ring wrong either?
Here’s to achieving a 5-10 bagger soon I hope!
The data derisked the efficacy, however I can’t assume some BS injustice doesn’t take place somehow or even some other black swan event.
I guess I just don’t have the guts or the mental makeup to go all in, nor do I have to bet the farm, but make no mistake it would hurt more than a little.
On the other hand if the stock goes to $10-$20 it would change our near term situation and remaining retirement years significantly, and I wouldn’t have to hear I told you so for the rest of my life
I truly don’t know what would be worse, the financial impact or the hellish I told you sos !
Happy (isn’t it ironic,)
I know Top Line Data
Top Line Data is my friend
We have Top Line Data!
Don’t mistake what we have, whether it has or hasn’t been “officially “ released by the sponsor yet, top line data was presented at NYAS.
You must know that TLD releases from the company that sponsors the trial is a brief standalone statement that the primary endpoints have been met with statistical significance.
The rest is provided/presented as separate presentation and publication of the trial results analyzed and presented according to the SAP.
NWBO will release the same TLD in terms of nGBM and rGBM mOS values along with the statement of statistical significance and/or the p values, etc
So, don’t worry, be Happy!
Well it shows quite successfully!
Analogous to the great line in the movie “When Harry met Sally,” if I were now asked which school I wanted to go to, I’d say “I’ll go to the school he (PM) is going to!”
Dr B et al,
I have just finished adding to and topping off my nwbo position.
I wound up investing substantially more than I had previously invested and raised my average cost per share from about $0.72 to about $0.84 in the process.
Although I believe the stock has largely been derisked, I’ve reached a bit beyond the limit of what I could painfully lose if somehow the stock/company busts down.
Of course I’m betting the stock/company ultimately climbs to new levels and looking forward to the next couple of weeks!
GLTA
Now that’s an SAT word exemplar!
The good doctor has been out to ASCO previously to participate in nwbo’s industry expert theatre activity.
The occasion I remember was when there was a panel of dcvax treated survivors and/or family members taking turns describing their horrible prognoses and how dcvax has kept them alive and well!
The good doctor gave his impassioned view as a clinician with lots of experience with GBM and he became emotional in his plea to get DCVax to everyone who could benefit!
As dream team lawyers they must look cool and under control, and be prepared with a snappy statement like:
If the trial stats improved
DCVax must be approved!
You’re so right about the OTC!
And there’s no way to get away from a determined angry spouse and the in-laws
And a time when values of decency are overshadowed by bad behaviors of those who should be positive role models !
A very timely point indeed!!!
I’m being serious. For some of us who are a little older time steadily increases as a factor.
Pound for pound, luck outweighs good analysis when it happens, therein lyes the rub!
Luck isn’t systemic, especially good luck
PM, have you considered building a boma around your park bench, like they do on those wildlife survival shows?
Seems to work in keeping lions and hyena away, but maybe not elephants, which wouldn’t be a problem in your park.
Of course some hostile humans might be harder to keep away. You can camouflage the boma and post photos of AF around to deter unwanted visitors.
Hopefully over the next couple of weeks nwbo sp will launch and you’ll be able to upgrade your living arrangement or at least put a security perimeter around your bench!
I’m surprised the sp hasn’t started a steady climb by now. The manipulative forces have been effective in suppressing the sp. That has to change very soon!
Mutiny is an outcome the enemies of nwbo seek. They know how much strength LP brings. Later investors may not know that LP stepped up to takeover leadership of nwbo rather than let nwbo fold along with this now successful outcome!
Guessing 80% chance this week, additional 15% by next week, 5% of beyond next week. (95% of sometime before/during ASCO)
They would probably arrange for the few employees they have to be taken care of, however if LP had to suddenly step away from leadership I guess Les would have to step up while the board determines a new CEO. Hopefully we are not going to need short term succession.
I’m ready to shift my attentions as well and would want solid management and organization to run my remain8ng investment.
If a Merck were to buy us out using their stock, that would provide nice opportunity to sell some for needs and keep the rest invested with a nice dividend stream!
Yes the crickets do have a nutty flavor, and some of the ants are lemony! Worms are just worms, like a wriggling lo mein
If I were LP, I think I’d be ready to hand the reins over if I could ensure that DCVax is properly developed and commercialized. I would either have to be trusting the new management, having their goals in alignment, or somehow retaining influence or control, all with a really nice financial outcome.
Having brought a major cancer treatment breakthrough to fruition in a 15 year or so commitment, shifting more energies towards other aspects would seem attractive, but that’s only an opinion.
So is that one of the new coordinated talking points?
You folks realize the dragnet is closing in around all the racketeering activities aimed at market manipulation?
Hopefully they are being Annal retentive
Partnering is a possibility, as are other arrangements, and there are multiple shots on goal for approvals, not only fda, although fda approval would be excellent.
Dr Keymours is respected and listened to in the UK, and approval of such a breakthrough, especially after high profile GBM casualties and the early distinction of dcvaxL being deemed high human value and in their special program, sure strikes me as very promising for expedited approval.
They already have certified manufacturing and an active specials program providing treatment!
I can’t bet the farm on any one investment because I have to insure my family is protected financially, however I am betting the north forty, so to speak!
Disclaimers:
Not investment advice and each individual must do their own due diligence and act prudently in their regard.
Experienced survival training is a must, as is ability to sleep on park benches, make campfires, and frequently eating ramen, occasionally protein boosted with worms, crickets, and ants.