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Someone calling me?
The usual prognosis for rGBM is nobody makes 5 years I believe.
Point taken about unbridled optimism of which I am guilty of at times, however while approvals take time, there has been time with constructive efforts along multiple fronts.
For example I wouldn’t be surprised if UK approval comes first and not too far out. DCVax was earmarked for priority treatment, has certified manufacturing in Sawston (UK) and is already treating patients with vaccine in the Uk.
Add the strong and urgent backing of an extremely well regarded top neurosurgeon who has treated many GBM patients at the top hospital, plus the additional bonus of being first in the world, and call me a wide eyed optimist but approval could come sooner than you may think.
Ooops, I did it again!! (Apologies Britney)
Ah yes, thank you!
Welcome back Scotty!
OK if you’re disappointed the 5 year survival wasn’t over 20%, you’re entitled to that, however the first major breakthrough improvement is a great start.
I’d believe the follow on work such as various combos and what Dr Ashkan urges of making the DCVax from the recurred tumor instead of continuing to use the original tumor may yield incrementally better survival.
Should we expect you to post more positively now?
Stranger things have happened
Would it be too much of a miracle for AF to suddenly turn a new leaf and admit that nwbo has the goods and DCVax is an exciting platform for the battle with cancer?
It seems like the patient and classy attempts to enlighten him at ASCO were meeting obstinate resistance.
However small the likelihood, perhaps AF will internalize the information and multitude of informed professionals opening up to the positive breakthrough news, and wake up with a new openness!
While I’m at it I need to check my Powerball and Megamillion tickets
Yes, indeed! Looking like I may be popping the cork on the bubbly soon enough. It’s nice and chilled !
Senti , I’m sure Scotty was so overcome with happiness and joy regarding the now clarified trial results and production readiness that he’s regaining his composure
Once again, if it looks like a duck and quacks like a duck and walks like a duck, it’s a duck!
They called it top line results and it’s top line data, and then some, since TLD announcements are usually just statements that the primary endpoints were met with statistical significance.
I don’t need an official sign on a duck to clearly recognize its a duck!
Quack quack!!
Just watched the Dr Ashkan presentation on Al Zmusella’s site and it is marvelous!
Even though we knew almost all the results from May 10th, the prep, delivery, and expert presence and credibility is outstanding!
Look call them unofficial results because nwbo didn’t publish them, but make no mistake that we have TLD and then some, and they are breakthrough good and real beyond a shadow of a doubt.
Plus the follow on work and opportunities with DCVax such as combo and even just recurrent tumor vaccine production are, in Dr Ashkan’s words, immense!
Yes grasshopper, one must bend to apposing force in order not to break and use the opponent’s own force against such a determined adversary… but wtf homey, don’t be trying to pull no dilution game on me bro! I’ll get real ugly on your solar plexus in a heartbeat!
It was reported on this board yesterday by a couple of board attendees, I think. One of the posts made it a point to convey the theatre attendance was about 200 people, the other just referenced the theatre as being full.
Perhaps attendees like alpha puppy and iwasadiver and Dr K can validate?
PM, great news that your wife made the trip to study non-violence from the monks, and not Kung Foo (rim shot here please, ba dump dump)!
I’m biting my tongue figuratively at the crassness and ignorance of “What difference does a doubling of survival percentage make” comment.
Did you go through caring for a loved one through the literal life and death battle to even achieve life extension under the death sentence of an aggressive terminal cancer situation?
I watched my mom tough out 4 years of a 3 years or less of life remaining prognosis, trying several drugs before the side effects and fear that the remaining drug choices might subject her to miserable QoL and sudden death due to resulting severe side effects. I influenced her to not try the remaining treatments in favor of having several more months without debilitating side effects until the unchecked cancer ended her life.
The first treatment she was given was the immunotherapy Tecentriq, which is given as an infusion. It had something like a 15-20% response rate, and for a lucky 9% perhaps a complete response (for urethelial carcinoma). Within the 15-20% you had various durations of shrinking or not progressing the tumors.
For the 6-9 months she was on Tecentriq she had no notable side effects and actually felt better than without treatment.
This period of treatment without side effects, just having to get her to the hospital for the infusions and regular bloodwork and imaging was wonderful and we prayed it would continue to work, but alas the tumors returned to progression.
The next drugs, the first being an anti vgef treatment if I remember similarly helped for a while and then stopped, and the next drug targeting another genetic target of the tumor had the same outcome after stretches at different dosages.
The pills had successively worse and multiple debilitating side effects, but at least my mom’s bloodwork remained good for the most part. The remaining possible drugs all had worse safety and blood count/infection/sudden death type profiles, and although I still second guess my ultimate recommendation to stop treatments, my mom had suffered progressively worse with the pills, having to temporarily stop to recover enough to resume taking the pills.
I’ve taken the time to go through this detail to try to emphasize that a treatment with an excellent safety profile with no significant side effects that extends life by any amount, is already a winner of an option and a wonderful thing for the patients and their families. Add a significant OS benefit and a chance to effectively be one of the lucky ones that are cured asa practical matter, and that’s a far better option for GBM and other terrible cancers!
What was particularly troubling in your post is the notion that 11% 5 year survival vs 5% is no big deal. It is a tremendous deal. And if you make it past 5 years with DCVax your odds of surviving much longer increase significantly.
Finally, staying alive longer with good QoL also gives a chance for further breakthroughs to become available, like the more promising combo DCVax-PD1 treatments or other new treatments.
That’s it my rant is over, but think again before making such a statement please.
I don’t remember who tonight provided the link to a C-Span coverage of a congressional committee grilling of a Bush administration on GATT, when young Ms Powers was deputy assistant secretary of commerce and was one of the three reporting out and being asked questions, but thank you!
I watched this roughly hour and forty five minute video and recommend that those who question LP smarts and ability to handle herself, to watch young Ms Powers in action.
You may gain a sense of the intelligence, poise, and grit, that she possesses. She obviously has dealt with very complicated interrelated issues and situations, and had to stand up for herself and negotiate with multiple nations, and states within the USA. She was cool and collected and confident, and communicated clearly, effectively, and comfortably controlled with no mis-statements, gaps/pauses, not even an uh!
LP is a women of great substance and ability, and I continue to have an abundance of confidence that she will continue to drive nwbo and DCVax to full success and we’re lucky to have had her leadership.
I know there are those with different opinions, which they are entitled to, about management’s performance. Again I recommend watching this C-Span video for what it’s worth to you, and it don’t make it harder to watch that young LP is easy on the eyes.
I can get behind that lease vs buy plan!
At the risk of sounding like I know too much about Kid Rock, he says that having had the private jet for years, it would be the hardest perk to give up.
He also loves the high tech bathroom toilets he owns. You know, the kind that warm or cool the seat, wash and dry you, and who knowhat else.
If nwbo goes to $10 in the near future I’ll be able to afford the new retirement dream house and put one of them newfangled toilets in. Not a gulfstream yet, need that much higher stock price eventually!
It’s not for my benefit, I’m already maxed out long, but for the many oncologists and industry players attending ASCO.
The other cue is the confidence that apparently came across, and that the theatre was packed full this time.
True dat !
Park bench in private part of cabin sounds excellent. East to retrofit safety belts, and the sleeping comfort! Who needs those little cubby type first class configurations when you can have the comfort of good ole American oak?
I tend to go lease, especially if you want a new one every 5 years or less, or have you considered those air BnB like jet share programs?
I hear private jets are the ultimate perk!
At least that’s what Kid Rock says.
Hey Arnold (Benjamin not Palmer) whose side are you on anyway
And did you include to keep your eye on the ball through the swing and follow through?
The ability to scale up impacts the ability and credibility to price the treatments at a lower price than otherwise, and make up the revenue on the higher volumes!
I believe RAs factor credible quality manufacturing at scale and pricing when considering approvals, don’t they? (He said, tongue firmly in cheek)
PM, you have to get used to becoming a Rich Man, in that you will be able to buy the carbon credits
Disclaimer: just a joke, I’ve been pro alternate energy and ESG for a (too) long time. But I have seen different credits bought by those who aren’t from those who are.
I was wondering if that’s the impetus behind REGN’s buyout news, to position for combo treatment with DCVax or perhaps with another similar vaccine that may be trying to catch up with nwbo?
Fantastic news Reg!!!
If you are able to private message (I’m not) would you mind sharing the Doctor info at MSK?
No, but they smile shyly at each other, and quickly look away, I think.
This suspected courtship may be longer than many Hollywood marriages
Endpoints met with very significant statistical significance !
Trial is successful!
GLTA
I never went to sleep!
Newsflash!
Management isn’t changing unless it’s through a buyout or voluntary succession!
All the rest is noise, and lots of it.
You are wrong!
If as they say, make a better mousetrap and the world will beat a path to your door, imagine what the world will do to extend lives and save the lives of a significant percentage of those treated.
The evidence is clear:
People alive well beyond SOC
People virtually cured of worst GBM
Scientific evidence of successful ph3 trial results so you can “validate” what is so obvious to the naked eye and even the least enlightened!
Ask yourself, God forbid you were to be diagnosed with GBM, would you not want dcvaxL treatment? How about for rGBM?
I understand!
And I preach the same all time.
That’s how perverse this marketplace has become, that we have a successful phase 3 breakthrough treatment trial for among the most needy indications (nGBM, rGBM) and the negative forces and manipulation just mislead and contain the sp as long as possible.
Tomorrow hopefully starts the irrepressible positive news and move towards true value!
The game isn’t over, the 3 pointer was disqualified due to unsportsmanlike behavior. We’re in OT bro and Le Bron is now really fired up!
Hey, watch it Jo Bro, don’t put down the horse and cart, that’s a little too close to home
It would save a lot of worry and injury protection if the sp would hurry on up to $20-$30!
Might change my standing from stupid old goat to clever G O A T !!!
Until then, sleep with one eye open, keep looking over your shoulder, and stay well clear of the spouse and inlaw’s club swing radii Fourrrrr!
That’s par for the course
That helmet and face mask you’re getting can’t arrive too soon!
I don’t see how everyone can nor should act like the facts haven’t been disclosed to the world. Once seen they can’t be unseen, so it would be surreal and childish for all these super intelligent people to not acknowledge the NYAS presented results.
I’d also be concerned that the FUDsters would be all over the opportunity to bash saying something like “see, we told you they failed .”
I could understand if the details are not shared if the circumstances are such that an embargo would be constraining such disclosure.
We will know what actually happens in a couple days.
GLTA
Whether attendees are aware of the NYAS presented endpoint met results, there would be no reason not to have those results available for all to see and hear at ASCO, at a minimum.
I can’t imagine attendees not looking for and asking for answers to questions they would have given the breakthrough results.
There’s no point in and not possible to put the toothpaste back in the tube, so to speak.
So at a minimum I expect nwbo at ASCO to:
1. Increase awareness of endpoint results
2. Provide support & credibility of results
3. Increase awareness of manufacturing
4. Increase awareness of UK availability
5. Educate regarding pseudo progression
6. Educate regarding external placebos
7. Educate application to all solid tumors
8. Visibility of long term survivors
9. Visibility of Drs Ashkan and Liau, & others
10. How to explore access for patients
11. Hopefully distribute DCVax tote bags
There may be a lot more, like calling out published paper if ready, more trial results and takeaways, official TLD statement and trial details, etc.
It could be like musical chairs pdl1 version - when the music stops you have to make sure you have a chair (pdl1) and Merck and BMY and AstraZeneca aren’t selling theirs!