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Excellent seat prices!
Regarding Clapton in Copenhagen, I got to renew my passport and will be making trips back and forth to Georgia USA, but I would have loved to see Clapton again and Copenhagen for the first time!
With severe Covid hopefully behind us and the real start of our retirement travel ahead of us, Copenhagen in 2024 is a real possibility!
Springstreet, geeze! I hope this was autocorrect and not just my error. My retired dentist office was on Spring Street, but flubbing Springsteen! Then again it’s 5am where I’m at and I’m still up posting, so it’s probably my errors.
Probably should start practicing my golf swing and putting from now since I haven’t played golf in close to 40 years, and everyone’s a golfer that I’ve met on my trips to Georgia!
The house design plans are finalized now, but I wouldn’t rule out a minor tweak or two, and I’m hoping to complete construction by Thanksgiving - Christmas 2023.
Looking forward to the next phase of our retirement and all our new friends in the Alpharetta area!
Yes Copenhagen!
I sympathize re hard choices concerning the denaro!
Was seriously looking at ticket availability and prices for Clapton’s Madison Square Garden concerts this September.
The least expensive were $99 (which gets fees and I believe taxes added, so the actual cost is a bit more.)
The seats I would like to watch from started around $250-$300, and the closer seats in front of the stage were about $1200 and up per ticket.
About 15+ years ago I saw Clapton in Philadelphia in the best seats ( middle seats in about the 4th row) for $100 each!
Guess frugal tendencies are habitual, since it’s ok to splurge once in a while, but I haven’t bought the tickets and they’ll probably sell out.
I live just several miles from Springstreet and a few minutes from Bon Jovi, however I never saw Springstreet live, except maybe before he became famous, at a Jersey Shore club. I did see Bon Jovi concert at Asbury Park with Sambora.
I don’t like stadium concerts, so I haven’t tried to see Bruce when he plays East Rutherford NJ.
He’s truly the hardest working guy, doing 3-4 hour concerts, unbelievable.
So enjoy Springstreet, although if I remember weren’t you with him in his Holmdel farmhouse in the early days?
Kab, you are correct sir!
The difference between two medians is just the difference, a single value.
What I should have said and intended is that one or more individual cases of OS in the set of recorded OS may be significantly larger than the mOS, which in effect one would have with a fat, long survival tail.
Thanks for keeping me on my toes.
Haven’t seen a dilution in quite awhile except for expected warrants/options redemptions!
The treatment works now and will get better in combos and organic refinements.
The remaining risk is if somehow the RAs don’t approve, however UK looks ripe for approval to me.
Did you catch Clapton in Amsterdam June 7th?
It’s been a while for me however isn’t the median the value of a set such that there are as many individual members of the set below the median as there are above the median?
For example in the following set:
{1 3 5 7 9 15 25}
7 is the median
Did I get it right?
Kab, of course it is median, which is what I really meant but somehow used mean (average) which is opposite of what I was trying to convey. Thanks for catching it and the feedback!
I’ve been continuing to add as well for the same reasons, even liquidating some other marginal positions and diverting the proceeds to nwbo instead of the defensive dividend paying stocks I would have added to.
At the risk of Go big or Don’t come home (if nwbo doesn’t work out) however this is as derisked a high risk high reward play as I can imagine that is legal!
Nothing is a sure thing until after it’s happened but IMO the odds are exceedingly better than at a casino of winning
Also the 3 months more is mean overall survival and that means half the individual OS cases are more than 3 months longer including numbers of cases much longer.
I’m getting distracted more these recent days by the rest of the non investment responsibilities like replenishing dwindling food supply, lending support and expertise to my adult children who are dealing with milestones we previously experienced, and following up on new house design and components/finishes costs that I am still hoping nwbo stock will help me afford.
Heck, I had dreamed that by now the nwbo sp increase might have paid for a majority of the new house, but the optimist in me is still hanging onto hope we get some significant upside move to $3-5
before too long like when the journal article’s published and good press and professional support kicks up.
I’m feeling the effects of the continuing I told you so’s and you should have listened to me The psychological torture is testing my internal G. Gordon Liddy-ness!
For sentimental reasons, reminds me of the first apartment above the dress factory that my mom worked in and with the elevated nyc subway tracks directly outside the front windows.
We lived there until I was about 6-7 years old and my parents saved enough to buy their house, and it seemed like every time we came home or were home and turned on the lights, the “water bugs” would scamper for cover.
I guess you just accept and adapt because I wasn’t particularly grossed out by them, and my brain filtered out the very load trains passing just outside our windows all the time.
Can’t say I wouldn’t be bothered anymore, I’ve gone soft. Should toughen up a bit, maybe Poor Man should pitch a survival show like Bear Grillis.
Park benching with Poor Man!
No shortage of fat rats to cook over a trash can fire! Oops I meant ramen made with boiled park water!
Gary I trust you read the subsequent email with the Direct phase 1 results showing best outcome against the participant(s) with pancreatic cancer. Best wishes for your friend.
One must be laser focused on the GBM effort towards approvals and then having assured survival and finances in good shape, attend to achieving the full potential of the DCVax platform, but you knew that I’m sure!
Thanks Cherry Tree, I’ve forgotten how very promising the Direct Phase 1 results were, which was some time ago.
Potential pipeline looking really promising!
When the lights are turned on the roaches must scamper back into hiding or risk being stomped on!
Dr Freud I presume? It’ll all trace back to his mother
Wow!
Reading between the lines, which urgently needed brain tumor treatment in the UK has finally been shown by phase 3 trial results to extend OS, and is ready/being manufactured in the UK, and has been declared a priority treatment and must still complete the NICE recommendation process!!!!!
And has the prominent neuro oncologist community pleading for wide availability!
Looking good in the UK neighborhood
The regulator made the changes in the UK and EU, not allowed for company to make the changes.
Yes I believe the company either mentioned that or implied it in a PR or news piece on Sawston a while back.
That manual is in effect the default until the automated process is demonstrated ready.
Next thing you know we’ll be seeing one of those late, late night commercials on TV for him.
You know the type where they keep showing the neglected and abused dogs, with those sorrowful innocent eyes staring back towards the camera.
Although I don’t know that it’s in him to allow himself to look sorrowful with that I can’t be wrong ego.
I can sympathize about physical appearance because unfortunately over Covid my physique has become very similar, and I’ve just recently re-started regular exercise. We could form a support group if he’d turn a new leaf and commit to integrity and caring for fellow humans and especially patients in critical need given his media vocation.
See, I’m an optimist
Someone calling me?
The usual prognosis for rGBM is nobody makes 5 years I believe.
Point taken about unbridled optimism of which I am guilty of at times, however while approvals take time, there has been time with constructive efforts along multiple fronts.
For example I wouldn’t be surprised if UK approval comes first and not too far out. DCVax was earmarked for priority treatment, has certified manufacturing in Sawston (UK) and is already treating patients with vaccine in the Uk.
Add the strong and urgent backing of an extremely well regarded top neurosurgeon who has treated many GBM patients at the top hospital, plus the additional bonus of being first in the world, and call me a wide eyed optimist but approval could come sooner than you may think.
Ooops, I did it again!! (Apologies Britney)
Ah yes, thank you!
Welcome back Scotty!
OK if you’re disappointed the 5 year survival wasn’t over 20%, you’re entitled to that, however the first major breakthrough improvement is a great start.
I’d believe the follow on work such as various combos and what Dr Ashkan urges of making the DCVax from the recurred tumor instead of continuing to use the original tumor may yield incrementally better survival.
Should we expect you to post more positively now?
Stranger things have happened
Would it be too much of a miracle for AF to suddenly turn a new leaf and admit that nwbo has the goods and DCVax is an exciting platform for the battle with cancer?
It seems like the patient and classy attempts to enlighten him at ASCO were meeting obstinate resistance.
However small the likelihood, perhaps AF will internalize the information and multitude of informed professionals opening up to the positive breakthrough news, and wake up with a new openness!
While I’m at it I need to check my Powerball and Megamillion tickets
Yes, indeed! Looking like I may be popping the cork on the bubbly soon enough. It’s nice and chilled !
Senti , I’m sure Scotty was so overcome with happiness and joy regarding the now clarified trial results and production readiness that he’s regaining his composure
Once again, if it looks like a duck and quacks like a duck and walks like a duck, it’s a duck!
They called it top line results and it’s top line data, and then some, since TLD announcements are usually just statements that the primary endpoints were met with statistical significance.
I don’t need an official sign on a duck to clearly recognize its a duck!
Quack quack!!
Just watched the Dr Ashkan presentation on Al Zmusella’s site and it is marvelous!
Even though we knew almost all the results from May 10th, the prep, delivery, and expert presence and credibility is outstanding!
Look call them unofficial results because nwbo didn’t publish them, but make no mistake that we have TLD and then some, and they are breakthrough good and real beyond a shadow of a doubt.
Plus the follow on work and opportunities with DCVax such as combo and even just recurrent tumor vaccine production are, in Dr Ashkan’s words, immense!
Yes grasshopper, one must bend to apposing force in order not to break and use the opponent’s own force against such a determined adversary… but wtf homey, don’t be trying to pull no dilution game on me bro! I’ll get real ugly on your solar plexus in a heartbeat!
It was reported on this board yesterday by a couple of board attendees, I think. One of the posts made it a point to convey the theatre attendance was about 200 people, the other just referenced the theatre as being full.
Perhaps attendees like alpha puppy and iwasadiver and Dr K can validate?
PM, great news that your wife made the trip to study non-violence from the monks, and not Kung Foo (rim shot here please, ba dump dump)!
I’m biting my tongue figuratively at the crassness and ignorance of “What difference does a doubling of survival percentage make” comment.
Did you go through caring for a loved one through the literal life and death battle to even achieve life extension under the death sentence of an aggressive terminal cancer situation?
I watched my mom tough out 4 years of a 3 years or less of life remaining prognosis, trying several drugs before the side effects and fear that the remaining drug choices might subject her to miserable QoL and sudden death due to resulting severe side effects. I influenced her to not try the remaining treatments in favor of having several more months without debilitating side effects until the unchecked cancer ended her life.
The first treatment she was given was the immunotherapy Tecentriq, which is given as an infusion. It had something like a 15-20% response rate, and for a lucky 9% perhaps a complete response (for urethelial carcinoma). Within the 15-20% you had various durations of shrinking or not progressing the tumors.
For the 6-9 months she was on Tecentriq she had no notable side effects and actually felt better than without treatment.
This period of treatment without side effects, just having to get her to the hospital for the infusions and regular bloodwork and imaging was wonderful and we prayed it would continue to work, but alas the tumors returned to progression.
The next drugs, the first being an anti vgef treatment if I remember similarly helped for a while and then stopped, and the next drug targeting another genetic target of the tumor had the same outcome after stretches at different dosages.
The pills had successively worse and multiple debilitating side effects, but at least my mom’s bloodwork remained good for the most part. The remaining possible drugs all had worse safety and blood count/infection/sudden death type profiles, and although I still second guess my ultimate recommendation to stop treatments, my mom had suffered progressively worse with the pills, having to temporarily stop to recover enough to resume taking the pills.
I’ve taken the time to go through this detail to try to emphasize that a treatment with an excellent safety profile with no significant side effects that extends life by any amount, is already a winner of an option and a wonderful thing for the patients and their families. Add a significant OS benefit and a chance to effectively be one of the lucky ones that are cured asa practical matter, and that’s a far better option for GBM and other terrible cancers!
What was particularly troubling in your post is the notion that 11% 5 year survival vs 5% is no big deal. It is a tremendous deal. And if you make it past 5 years with DCVax your odds of surviving much longer increase significantly.
Finally, staying alive longer with good QoL also gives a chance for further breakthroughs to become available, like the more promising combo DCVax-PD1 treatments or other new treatments.
That’s it my rant is over, but think again before making such a statement please.
I don’t remember who tonight provided the link to a C-Span coverage of a congressional committee grilling of a Bush administration on GATT, when young Ms Powers was deputy assistant secretary of commerce and was one of the three reporting out and being asked questions, but thank you!
I watched this roughly hour and forty five minute video and recommend that those who question LP smarts and ability to handle herself, to watch young Ms Powers in action.
You may gain a sense of the intelligence, poise, and grit, that she possesses. She obviously has dealt with very complicated interrelated issues and situations, and had to stand up for herself and negotiate with multiple nations, and states within the USA. She was cool and collected and confident, and communicated clearly, effectively, and comfortably controlled with no mis-statements, gaps/pauses, not even an uh!
LP is a women of great substance and ability, and I continue to have an abundance of confidence that she will continue to drive nwbo and DCVax to full success and we’re lucky to have had her leadership.
I know there are those with different opinions, which they are entitled to, about management’s performance. Again I recommend watching this C-Span video for what it’s worth to you, and it don’t make it harder to watch that young LP is easy on the eyes.
I can get behind that lease vs buy plan!
At the risk of sounding like I know too much about Kid Rock, he says that having had the private jet for years, it would be the hardest perk to give up.
He also loves the high tech bathroom toilets he owns. You know, the kind that warm or cool the seat, wash and dry you, and who knowhat else.
If nwbo goes to $10 in the near future I’ll be able to afford the new retirement dream house and put one of them newfangled toilets in. Not a gulfstream yet, need that much higher stock price eventually!