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The market is completely dominated by the lakes of Fidelity, State Street, Black rock, etc. In my opinion the pool of risk taking retail and small institutions and risk takers with in the ward your entities is very small after a ten-year ramp of the General indexes through ETF and institutional buying. Question what is the median price now for a small cap bio starting a phase 3?
QAhh to have our problems andBiogens money!
Siri doesn’t know the word ameloid but here’s my story…The crowd jockeys for position and fills the room about 20 minutes early. The video and camera guys are upfront in the crowd is full of corporate suite and Wall Street suits and peach fuzz reporters. Along the back stand the white coats with a smattering of Birkenstock hedge fund guys who don’t have to impress anybody. Anabex text to the stage as the crowd gossips among itself. The member continues the Safeharbor is red in the first few charts showing disease progression or lack of it our projected. The biomarkers or discussed in the white coats start to take them out interest A slide of the progress over time of all the different measurements of the super responders is posted in the white coats eyebrows. The same slide is again soon but this time it shows the results of the M avoid pet scan‘s along with tape the same time scale. It shows that the Amber wide reduction occurs long after the clinical improvement gas goes up from the white coats. Oh my God! The hedges get it right away with the Wall Street suits run over to the scientist to ask them what’s going on. The reporters are clueless and never ask what the stock is $15 and two hours. And they still didn’t report it and we have a nice slow sip of 28-year-old whiskey and enjoy the rest of the day I had Gentex to the stage I hardly anybody is watching as an FX has just shown thatameloid clearance follows clinical improvement after along the Delay apologies for Siri screwup I am blind and not very good at editing
Snooze on the rumor, by on the news?
Who isn’t he associated with?…
Maybe stormy Daniels?
I’m not too sure how long ago fire was discovered it has played a major role in human evolution over I guess the last few hundred thousand years and yes the smoke from fire is extremely toxic. Measurements of toxic and Haugh Asian of people still cook with wood in open air fires or without a proper stove and smokestack are off the charts. The point is toxic chemical exposure is nothing new and probably has been greatly reduced with TNT introduction of electric stoves gas stoves and even propane stoves
Please ignore Siri dictation screw upsEvolution works through reproduction and then continued reproduction and continued reproduction. It works on many levels on the individual level on the team level and on the tribe level. He tribe they words number of old people may be less likely to survive then a tribe with a balance of ages to have the maximum of wisdom and a vigor. There are species that survive largely as individuals such as sea turtles where there is a little aging and death or actually occurs by accident or produce. It appears that aging is not just an accidental phenomenon but may have been actively selected for in order to keep the tribe with used for vigor.Tribes that had too many old people may have been selected out due to starvation or war with thing with dangerous neighboring tribes that’s it may be that there was no selective pressure to keep the singer one receptor active in many humans past the age of 60. It also might mean that there was actually active select selection pressure to turn off the chain. As this was all in the distant past and these evolutionary theories are largely in the battleground of ideas it would be difficult to answer this question. Hey somewhere argument might be made for cancer. Wraps there was just not enough selective pressure to prevent cancer from eventually overwhelming the body with age or in might be that the mechanisms for cancer or actually beneficial in an evolutionary sense because they called out the old and strengthen the youthful vigor of the tribe turning on the sigma one receptor excuse me activating it artificially appears to be a magic bullet in one of the Achilles heels of aging. The same could be said for the process is now being used in cancer to activate the immune system to recognize cancer. Both are using the natch natural processes that have lost their vigor through aging do to either lack of evolutionary pressure on people beyond reproductive age or active evolutionary pressure to kill them off. As a 64-year-old who is not doing a particularly good job of letting go of the youthful self image I am looking forward to taking this drug for my kinetic problems
At the end of got leaves June weather he said and I might not have this exactly right but pretty close… We await public comment on the draft documents. Question how long will the process take?
But polio has reemerged in Venezuela because the health system has no money and can afford no vaccines for that plague
Yes coconut oil may have been a trial or may not of been. But the FDA has strict rules about nutrition claims. And it uses the drug enforcement agency to stomp on the throats of those two just a baby it’s rules. Only if an artificial engineered or proprietary separation technique was used to create a product of pharmaceutical grade that was patentable in some form with the FDA grant an IND or approval. The worst example of how this pollutes the normal course of commerce and investigation is a product called Creon CREO in. Which is a digestive enzyme of certain purification and which costs I believe $2000 a month. It replaces a simple hormone excuse me a simple protein extraction from Cowell gallbladders that was sold over the counter for decades and cost approximately $20 for a months supply. That product is now prohibited so if you have digestion problems due to your gallbladder being removed and you have insurance everybody is going to pay for your two grand a month Madison. Now that’s a racket. And if you don’t have insurance what are you used to be able to just pick up the right stuff at the pharmacy now you’re SOL if you have no gallbladder
Thank you for making excellent analogies to clarify what Nassim Telab said in a talk to NYU and exposed on in his books full by randomness and the black swan. He said in the end of one can be significant and it and have 10,000 mean nothing or words to that effect in N of one real alien from another galaxy would be significant. And end of 2000 people who look like aliens not so much
For some reason this very simple logic completely eludes Wall Street. Some of that may be directly attributable to Autre corruption for example the hedge fund support of a X0 and when is clear after trial failure and rejection of the drug by the previous owner Plus these Wall Street guys are in general not the brightest crayon in the box. The hedges work with statistics all day long but they are working with the behavior of thousands if not millions of agents looking for patterns of behavior and wait to fun run them. As you said Fleming observation was made initially on possibly one plate or a few plates. And yet that observation change the world
Could be that the bear hunters have been awoken to shoot down bio Jen and while they’re at it they are aiming for anything else in the space. Just possibilit on any given day anything can happen for any reason in the stock market.y
You are correct but I would add that the social class of both the old-school and new school people demand that they be part of the capital or resistance. As the new Paradyne is viewed as a Republican Innovacio and Dr. Gottlieb as an appointee of evil incarnate the resistance is strong perhaps the resistance will finally melt into resignation and the FDA can get along with its work.n
I just bought a put spread on bio Jen for January 2019 buying the 325 foot and selling the 300 put for a spread of $6.50-ish. The stock is still up$50 on sleazy news. The only way I can lose on this one I think is if bio goes ahead and does a deal with the good doctor
Question, LOL probably not legal and probably rarely enforced, is it possible or likely that a potential take over execution can be accomplished in a sterile manner by using multiple entities to keep follow the 5% threshold? Please excuse series stupidity I mean keep under the 5% threshold?
Are there ethical concerns with continuing a trial where people’s brain swells?
Creamer is an idiot and a scumbag. He has told the audience directly about how he participated in shortWhen he was a traitor spreading false news and cooperating with other traders and media. I remember he did a very lengthy piece onPioneer just before a multi year or major top. He used to have a TV show with Larry Kudlow known cocaine addict and now chief economic adviser to the president. Reality is getting much more entertaining than fiction.
If I recall correctly a while ago there were links posted on this board to recruitment in Australia that seem to be for the end of next trial. If that is the case perhaps we could see read out in Q3 2019.
I believe there is precedent for a double blind study with a pussy bow arm to be stopped if the entire study group shows a significant improvement in multiple measures of the disease because if that is the case there are difficult ethical issues with denying the drug to the placebo arm. Please excuse series dirty mind at the first mention of the word pussy bow now I am going to have to manually spell it out placebo.
I think I read on this board that on our big update recently there was a multi million share block that traded. I think the number was 9 million? Could it be that bio Jen already has a 25% position. Once they go over 5% how long before they have to report?
Thank you for the correction. However I’m not sure that it will take six months to start all the dosing. Didn’t somebody say quite a while ago that they were already advertising in Australia for patients? Is it possible that the pull of patience is all tested selected and ready to go right now? How long did it take to recruit all the patients for our phase 2 study? How long is it taken in the past to recruit when a drug looks as good as ours in phase 2?
Nassim Nicholas Talib the author of the black swan also wrote a book full by randomness. He made a lot of money betting against Wall Street’s fix Seshan with the normal curve and the The fix Seshan of Wall Street that every statistical nail can be hammered down by the normal curve. In one of his lectures on YouTube I believe it was to NYU he said that and end of one can be significant and end of 10,000 can be insignificant. Our little 32–25 person study did have statistical significance in comparison to the well understood normal course of the disease in multiple measurements. If I were a regulator I would just approve it right now with follow-up studies but alas I’m not a regulator and I am blind because the regulators are too conservative. Barring market crash or or endless shorting of counterfeit shares or some other totally on for seen event I believe in 48 months or sooner we will have an answer at the regulators will except I mean 48 weeks
Correction he is a shrinkiatrist, not a shrinkologist????.
$10 million split among seven applicants. That’s not much. Plusone would have to then be captured by a bureaucracy that might have priorities other than getting the right answer. Imagine how difficult it will be to make line statistical decisions when you also have to meet diversity quotas. And a vex should run not walk away from this so-called opportunity. In my humble opinion as someone who has lost love ones and lost my eyesight and watch of my health due to in comprehensible delays and approval of drugs for my condition. Apologies for series bed dictation skills
To this excellent excellent thread I just might add that the FDA is located in Washington DC. In order to be socially excepted bowl in Washington DC one must be a member of the resistance with a R. Certainly within a bureaucracy such as the FDA membership in the resistance well also largely be necessary for social acceptability. The resistance is naturally allergic to any Innovacion that is perceived to come from republican or trump in direction. Therefore the snails pace in Dr. Gottlieb introducing the precision medicine paradigm as Dr. Gottlieb is a trump appointee and the precision medicine paradigm comes from a Republican Congress seeking to overcome the decades old sludge in the FDA’s process of approval even though I believe this post to be explanatory I Half life of about half an hour. Please excuse series poor dictation skills. I am blind and have difficult editing so I just let Siri do the job
One word… Shyster lawyer well that’s two words but oh well
Is it possible that they are just running it up and running it down with their own wash trading and really not affecting the ownership structure very much. Is it possible that they actually lost money pushing this up and down?
We are all Charlie Brown now. Lucy took the ball away again!
Just asking? But is it possible that under the new rules the FTA could approve 273 for a LZ just based on all the data collected over the last three years sorry that Siri can’t tell a tea from D
Because I am blind and a little bit wheezy I dictated this message so please excuse if it’s a few words are not appropriate.I have a friend who “teachers“ kids with severe autism. He is very honest and says that the work is deeply frustrating. After a conversation with him I googled out of X273 autism and up came and announcement from June 2016 of Amell study done by or sponsored by a nonprofit that concentrates on fragile X and related autism. And like all our studies are pre-clinical studies the ghost mice thrived and the poor control mice progressed in the disease. I have been investing in bio tech for over 30 years and believe me I know how to get busted I have never seen a molecule that had such extensive pre-clinical home runs in Vitro in mice and rats plus clinical results and Alzheimer’s this was just a reminder for me and a pleasant one of how solid are sciences and our management in the face of a totally corrupt market and final and basic financial system I hope the shorts drag the stock down to the basement and then get stuck in the big short squeeze overnight and that the shorts that were using counterfeit shares get caught and convicted. I believe the biggest short squeeze ever was when Porsche announce it it was behind Volkswagen and all the shorts got completely trapped and had to keep buying and drove Volkswagen up to I believe the number one position in the S&P. And finally I end with a question for the market experts… What happens when a short can’t cover an overnight pop. Does the broker have to go ahead and cover and then sue the short for the cost?
QSome of us longs are just loving this low price. It’s a lotto ticket at this point. It’s like walking into the 7-Eleven and instead of bye in a pack of Salem‘s and a bag of tortillas and a few of them cupcakes we can buy a lotto ticket that Scott probably more than a 50% chance of hitting if we hit that bag of tortillas pack the lemons and a couple Hostess cupcakes turns into a shiny new Escalade pimped out with white walls and rims. I now have four times more shares than I ever dreamed I would have and hope the price stays well so I can keep adding. And hey if it goes to zero it was just a lotto ticket but it this point it would take some very expert screwing up the blowup this company given all the fantastic results he’s gotten with B and P. Now we wait for further confirmation that bring here earlier success for PE into laser focus. Apologies for series poor dictation skills oh and not to mention the refinement of management skills with the combination of Dr. B’s class and Ehrlich‘s business StreetSmarts refined on the streets of Boca Raton
There were another two things at play the last time that I don’t think are at play this time. First of all Agoura financial featured and effects in all it’s publications and websites. This attracted the short coat cabal. Team short was not only evil but crafty and ran with the Agoura momentum using washed trades to help run the price up. After a period of complacency they dropped the hammer on massive volume I think it got up to 30 million shares in a day. This had to be massive wash trading and counterfeiting of short sales taking advantage of the wax enforcement Wednesday failed to deliver. Plus they piled on the bogus lawsuits. I do not believe that the same factors are in play now. Agoura is silent. The short cabal has seen one of its own take a trip to the big house, Martin should rally. And the SEC sheriff is the new boy in town. Question for the board is there evidence that there are less frequent and less affective short attacks over the last six months out there and small tech and bio land? Apologies for series dictation stupidities. If she was a secretary she would be in the unemployment line
Also didn’t and a vex have a win in the courts against a short couple? And were any warnings made by the judge in the case?
Why is there not some discussion hear that there is a new sheriff in town at the securities and exchange commission and that RVS wash trading and fraudulent fail to deliver short trading is getting punished. That means no more 10 million shared days up and 30 million shared days down on a stock with only a 40+ million dollar float. The prosecution of Martin Chevrolet was the shot over the bow to the short cabal from the sheriff. That is a big change in market dynamics.
Hey X oh and here’s a text book case of all that is wrong with our legalize counterfeiting and completely on punished fraud financial system divorced from reality since August 15, 1971
Question? Did the companies of any other participants in tomorrow’s panel discussion have a stock price up on Monday? I know I should do that DD myself but I am pulling the ways he blind card here.
Just putting this out there. Seeking Alpha articles may be dog whistles to collaborators, usually on the short side.
Link please?
Churning down in the 30s and well 40s for weeks finally exhausted the supply of fear and loathing share dumping. Then I guess there were more than a few Wong’s watching watching watching and hoping for a lower level finally as we approached a resistance level all the weight in the Longs just hadn’t gotten around to it picked up the phone or the mouse and bought. As for me I had $1700 sitting in my Brokeridge cash and so was good for 3400 shares of the total just my little self. Bottom line I think this is a classic psychological move off the bottom that may or may not last. And I don’t care because I am sitting on my accumulation as long as the science remain solid and the prospects for eventual approval or partnership remain and of course I’m still looking for that $.20 price to really love the boat but I don’t think it’s gonna happen
I think I saw a monkey playing in the cement.??
The usual caveats as I am blind and Siri does not dictate well with my Baltimore accent but I think the essence of my post gets through.Nasim tell web author of the black swan has very entertaining YouTube’s of lectures given at Stanford and other institutions including NYU pussy is the author of … Boy Siri has a dirty mind… He is the author of the black swan and his newest book skin in the game. One of his books for by randomness pounds home the idea that both the scientific and the business community are obsessed with a normal distribution and those are taken by surprise when five and six sigma events occur because in nature there are emphatically fat tails. Diana vex study in Australia draw strength from both ideas of probability. First of all it has achieved statistical significance in the classic sense in multiple measures of Alzheimer’s disease in comparison to well documented normal course of the disease. In addition it is a fat tail event because it is done this with an N of only 27. Thus the business community and many semi scientific investors or fold by the delusion that only a large and can be significant has Nasim tell him says in nature and and of one can be significant and and and and of 10,000 can be just noise. My only concern with this company is the possibility of continuous nefarious action and resistance with a R within the FDA and the ever present possibility of deeply illegal financials and shenanigans including massive fraudulent short selling. I believe we have a CEO who is perhaps best qualified to fight the forces of theft and fraud and darkness to bring us through the process to approval and improved health for millions including myself