$ME->Wakeup('2021-02-15 00:00:00');
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Bottom line is that the world is in desperate need for a therapeutic to clear out overcrowded hospitals. The over capacity reduces the ability to provide high quality care to "everyone". The primary endpoint of Resolution of respiratory failure seems to be reached if the length of stay is statistically significantly less than standard of care as has been shown in the preliminary data release. Further Secondary outcomes will also most likely be met. The FDA (and world) is in desperate need of a therapeutic that meets these outcomes and it looks like we have the answer.
Nephron being approved for sterile IV injections 2 days ago is extremely significant. Their recent plant expansion is too. Further data releases will also be coming as well as news. As quick as the recent decrease occurred, an increase can happen as well. Every share sold was bought by someone who saw potential increase -- I am with them
Best,
JB
Zyesami shows promise in critical COVID-19 patients with respiratory failure
https://www.europeanpharmaceuticalreview.com/news/142513/zyesami-shows-promise-in-critical-covid-19-patients-with-respiratory-failure/
Here's more info about our relationship with Nephron
https://www.fdanews.com/articles/199322-relief-therapeutics-and-neurorx-sign-manufacturing-agreements-for-covid-19-drug
On 02/10/21 Nephron was granted FDA approval for their sterile water to be used in injections. They are our fill finish partner.
https://www.accessdata.fda.gov/scripts/cder/daf/index.cfm?event=overview.process&ApplNo=211222
Pretty sure they don't let you out of the hospital with respiratory failure. Seems that happens faster with Zyesami than just current Standard Of Care. 2+2= ¯\_(?)_/¯
OO,
-JB
Highly volatile on low volume and many cashed out ~4.50 since they got <4 entries
Remember, for every share sold at a price, someone bought at that same price. Many have >4 entries and will wait for more news before even considering selling. They wouldn't have bought if they didn't see it as going up
9am EST Dr Yo link:
Every share that was sold was bought by someone who sees it increasing. I know more news will be coming about 15/16 indicators. I assume some are the type to rely upon the pictures (radiographic study) and they too will come.
I have just as much faith if not more in RLFTF than before. I now have confirmation that the metric other therapeutics have recieved an EUA upon was achieved and that it was not chance. Reduction in length of stay/hospitalization for critical COVID patients is a BFD! I have not released any shares and added more. It will take a lot more than panicked weak hands not understanding the significance of the preliminary data that was shared to shake my shares. It was confirmation of efficacy. Big Fkn Brass Bulls have lead me throughout life.
Best,
JB
Not seeing much movement here today
I saw that the length of stay was statistically significantly less with Zyesami. This is the metric for which therapeutics have been granted EUAs thus far. I saw that the standard of care has improved which took away the 28 day mortality difference. I saw more analysis is being done, more reporting on that analysis will be forthcoming and they will continue to work with US regulatory agencies. I added yesterday and have not released a single share. I don't have a crystal ball but the brass ones have served me well.
Best,
JB
I thought the report was good. more positive news and seeing that length of stay was reduced was very significant. This was the primary metric in which all other EUAs for therapeutics have been granted thus far.
I disagree and think the possibility of an EUA is even more likely given recent events. The significance of the reduction of hospital stay with such a high degree of confidence will not be overlooked. I remain holding...
-JB
Volume increasing, interest/dot-connecting happening. Massive pop incoming
NRX Tweet 2:03PM EST 02/08/21
"CEO Dr. Jonathan Javitt spoke with @NBCLA about our recent partnership with @UCIrvineHealth for the initiation of our Phase 2/3 #ClinicalTrial with the inhaled formulation of ZYESAMI™ (#RLF100, aviptadil) for Severe #COVID19."
CEO Dr. Jonathan Javitt spoke with @NBCLA about our recent partnership with @UCIrvineHealth for the initiation of our Phase 2/3 #ClinicalTrial with the inhaled formulation of ZYESAMI™ (#RLF100, aviptadil) for Severe #COVID19.
— NRx Pharmaceuticals (@NRxPharma) February 8, 2021
Watch now: https://t.co/Bga5KanJCL
I am pretty happy with the increase today (currently 17%), I assume most "real" investors would be too...
Best,
JB
NRX might have even had a "shareholder" CC for all we know... they are not a public company just a company we partnered with. RLF on the other hand issued a yet another positive PR indicating the inhaled trial has started and that IV results should be this month.
Best,
JB
"Furthermore, top-line data from the previously completed phase 2b/3 trial of the intravenous (“IV”) formulation of RLF-100™ are slated to be released this month."
https://relieftherapeutics.com/newsblog/relief-affirms-initiation-of-phase-2-3-trial-of-inhaled-rlf-100-aviptadil-zyesami-in-severe-covid-19-patients
It IS coming....
Best,
JB
NRX is a private company, they are our US partner whom we entered into a profit sharing agreement with in exchange for them shepherding our drug through trials and beyond. I assume not many reading this actually own NRX shares.
RLF is green, more positive news is coming, all is well imo.
Best,
JB
All signs point to a 1am PR, with a brief recap and Q&A on the call. The runaway train has left the station...
"Our favorite holding period is forever."
- Warren Buffett
Best,
JB
You better call the Swiss police and show them your evidence! Any US entity would let you know that RLF is not a company they provide oversight on...
Clear as mud... but how many pancakes does it take to cover the doggie?
Bottom line is It doesn't fkn matter even if your conspiracy theory was true. Are you saying that the company that kept RLF afloat and invested in them waaaay before any of us now has 135m more shares to tack onto their 1.4B. Good for them, they deserve it IMO! Have shareholders been "hurt" not unless they sold already and didnt get as much you hoped if this conspiracy was true. Bottom line, it doesn't fkn matter, it has been GEM's company, is GEM's company as they were smart enough to invest before any of us. My group has hitched our wagon to theirs and are going along for the loooong ride.
Best,
JB
It is not about me, this forum & company isn't about me, do not make decisions based on me... Rely on the facts!
Here are the facts about Relief Therapeutics:
- The company has publicly released results for patients that were too sick for the trial and were able to receive the drug under EA (Expanded Access), these results were amazing. diagnostic Imaging (Xrays) showing lung clearing and blood draws showing Oxygenation improvement were included. There is NO OTHER therapuetic that has demonstrated this undeniable evidence of efficacy.
- The company applied for a EUA under these preliminary results, they were NOT denied but were told by the FDA that they would like additional data, particularly the completed FDA sanctioned phase 3 trial results.
- The company has taken steps such as formalizing profit sharing arrangements and firming up manufacturing processes with their partners
- The company has acquired an additional BIO company (Advita) for ONLY SHARES of RLF. The Advita company, who themselves are scientists, are now our fellow investors
- The company has "partners" who have had some interesting information come out. NRX & BRPA merger documents have a ton of information about events that have transpired such as OWS cooperation/funding etc. This merger wouldn't be taking place if nothing was coming soon.
- The company has taken an interesting move 'partnering" with ACER who is a NASDAQ listed company. While it was announced to expand their pipeline, some think this is the fast track to be publicly listed on the top tier US exchange
- The company has recently completed its phase 3 trial and has announced that results could be released late January/early February. Based on preliminary results under EAP, one could expect these results to show a improvement over current standard of care.
There are links(backup) etc for all of the above. Here are 2 comprehensive documents that have more information than I can type out:
https://www.valuationlab.com/app/download/6648376062/vL+Relief+Therapeutics+Valuation+Report+25JAN21.pdf?t=1611618219
https://sec.report/Document/0001193125-21-019278/
Best,
JB
Well, you are wrong. The stock has increased almost 10x from its August price. The company has released a steady stream of PRs which has included acquisitions, partnerships and even outcomes for patients outside of the FDA trial.
It really seems your frustration stems from the results of the FDA trial not being publicly released yet (or fast enough for you). Well, I can assure you that many eyes are upon it and have been. Each and every patients medical history and outcome is being scrutinized. These things take time BUT you can rest assured that the RCT data will be coming.
Best,
JB
I agree completely, there will most like be some news this week but it most likely will not be the megalithic PR such as "RLF GETS FULL FDA APPROVAL AND IS NOW A TRILLION DOLLAR COMPANY" that many sometimes think. While it could, most likely will be yet another extremely positive PR as we continue along this path. All good things come to those who wait.
Best,
JB
Green today, nice to see!
There will be more news coming that will significantly spur interest into this ticker. It will cause significant movement. Long Hold IMO.
Best,
JB
While I am usually not one to attempt to predict the specific timing of RLFTF news, I actually do think this could be possible given recent events and timelines. I also can tell from recent interactions, something is definitely in the works...
Best,
JB
Great articles TCM55, Interest is building!
https://moneymidnight.com/2021/02/rlftf-stock-relief-therapeutics-partner-neurorx-brpa-to-begin-phase-2-3-inhaled-zyesami-covid-19-study/
This one is VERY intriguing too!
"GEM invested in NRX before RLF"
https://www.marketscreener.com/news/latest/NeuroRx-Secures-HK-750-Million-Capital-Commitment-From-The-Gem-Group-for-Development-of-NRX-101--29440975/
THANK YOU FOR SHARING THESE!
Best,
JB
Great info CarpeOmnia, seeing a 5% gain today on the SIX exchange is a promising sign!
https://www.six-group.com/en/products-services/the-swiss-stock-exchange/market-data/shares/share-explorer/share-details.html.html?valorId=CH0100191136CHF4#/
Best,
JB
I remain extremely optimistic about RLFTF, I wouldn't hold as many shares as I do nor would I keep adding on dips. It is not about me though, do not make decisions on me, this forum or company isn't about me.... Rely on the facts.
Here are the facts about Relief Therapeutics:
- The company has publicly released results for patients that were too sick for the trial and were able to receive the drug under EA (Expanded Access), these results were amazing. diagnostic Imaging (Xrays) showing lung clearing and blood draws showing Oxygenation improvement were included. There is NO OTHER therapuetic that has demonstrated this undeniable evidence of efficacy.
- The company applied for a EUA under these preliminary results, they were NOT denied but were told by the FDA that they would like additional data, particularly the completed FDA sanctioned phase 3 trial results.
- The company has taken steps such as formalizing profit sharing arrangements and firming up manufacturing processes with their partners
- The company has acquired an additional BIO company (Advita) for ONLY SHARES of RLF. The Advita company, who themselves are scientists, are now our fellow investors
- The company has "partners" who have had some interesting information come out. NRX & BRPA merger documents have a ton of information about events that have transpired such as OWS cooperation/funding etc. This merger wouldn't be taking place if nothing was coming soon.
- The company has taken an interesting move 'partnering" with ACER who is a NASDAQ listed company. While it was announced to expand their pipeline, some think this is the fast track to be publicly listed on the top tier US exchange
- The company has recently completed its phase 3 trial and has announced that results could be released late January/early February. Based on preliminary results under EAP, one could expect these results to show a improvement over current standard of care.
There are links(backup) etc for all of the above. Here are 2 comprehensive documents that have more information than I can type out:
https://www.valuationlab.com/app/download/6648376062/vL+Relief+Therapeutics+Valuation+Report+25JAN21.pdf?t=1611618219
https://sec.report/Document/0001193125-21-019278/
Best,
JB
Patience is crucial aspect of investing, especially when it comes to RLFTF. There is a lot going on and the company needs to proofread and have many look over any PR since they are official company statements. In addition, RLF attorneys now need to review EVERYTHING because some RLFTF "shareholders" in the past have written emails and letters that were worded like a formal complaint. The company now needs to scrutinize anything they release multiple times with a fine tooth comb.
The bottom line is that it IS coming... when exactly would be anyone's guess but based on prior communications I would think "soon" would be an accurate assessment.
Best,
JB
All is well, a RLFTF PR will be coming (They have been pretty steady actually). I expect the next PR to raise share price to a new level of support never before seen.
Think of the "tenacity" some shareholders have, that is very telling. Much like a man, its HARD to keep a good stock down.. .
Soon,
JB
This is spot on with regards to RLFTF. Projecting a false sky only to claim it has fallen with such tenacity. Ignore is one of the most useful features on this site when viewing information about RLFTF.
This news about RLFTF is not new nor is it any major catalyst. It is positive though(actually that's accurate in regards all of the news I have read imo).
Just be patient,
JB
Id say both: There will be others who figure out whats going on here, its just a matter of time. The outstanding shares are low, so there are not that many for sale honestly. I am not letting go and bought more on the dip since I originally got in above $4 but have now averaged myself much lower. I think the limited amount of shares makes this a really interesting one, it will remain volatile due to that
Best,
JB
Thanks for sharing your fears pegs, we all have a "something" to fear... I will share mine even.
I have always been a little fearful of clowns. With their fake happy face facade they try to guise their evil intent.
Don't forget all the Nephron job openings in addition to the Bachem job openings... Our manufacturing and fill finish partners are both looking for additional 24/7 staffing
https://careers.bachem.com/search
https://www.readysc.org/nephron/
Bachem pushing their manufacturing capacity to the limit was done for a reason. They didnt just decide to make this large batch of whatever peptide they made to run the risk of something going wrong for the fun of it. No, they did it to demonstrate to someone their ability to do so. Manufacturing capacity and process control validation is something the FDA is very adamant about. So I am not aware of any other peptides they make that they would risk money on making such a large batch but did so because needed to demonstrate their manufacturing to someone?
"No matter how great the talent or efforts, some things just take time. You can't produce a baby in one month by getting nine women pregnant."
-Warren Buffet
"Most people get interested in stocks when everyone else is. The time to get interested is when no one else is. You can't buy what is popular and do well."
-Warren Buffet
"Our favorite holding period is forever."
-Warren Buffet
Best,
JB
Bachem celebrates the largest peptide batch (>10kg) ever produced using Molecular Hiving™ technology.
#Bachem celebrates the largest #peptide batch (>10kg) ever produced using Molecular Hiving™ technology. 💪🥂
— BachemGroup (@BachemGroup) February 1, 2021
By reducing solvent consumption by 74% in this project we demonstrated that Molecular Hiving™ can be a true alternative compared to classical SPPS. pic.twitter.com/G9KpFbYbMe
Soon others figure out what ACER is going to be used for.
Best,
JB