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Perspective: $.28 would be the low if NWBO were JAZZ. JAZZ had a low market cap of approximately $31M in 2009 and $7.8B now. That would correlate now to a low NWBO stock price of $.28 with 110M shares outstanding.
JAZZ had 60M shares outstanding and went from a low stock price of $.52 in April, 2009 to now over $130 per share.
For NWBO to have the same market cap as JAZZ now would mean a stock price of $70 for NWBO.
DOWN WITH DISEASE!
$BNYC
On what date did the screening halt begin? The PR about the halt came out on 8/21/15: it also mentions that in regard to the label of "temporary halt" on the Europe database "...there is no category that corresponds to a temporary suspension of new screening only, while a trial is ongoing."
But it doesn't say when the halt began. Aug 8th was it?
Perhaps a one-year anniversary of that event is meaningful.
$BNYC
The NY Times wants to know, "Have you received Immunotherapy treatment?"
http://www.nytimes.com/interactive/2016/07/30/health/100000004557904.app.html?nytapp=ipad
http://www.nytimes.com/2016/07/31/health/harnessing-the-immune-system-to-fight-cancer.html?smprod=nytcore-iphone&smid=nytcore-iphone-share
No mention of NWBO, but there are 3 articles today in the Times on immunotherapy including an FAQ. Mostly about Checkpoint Inhibitors. The FAQ mentions vaccines but is wary of them, only says they're in trials and briefly mentions combo trials.
I keep buying NWBO. Hoping that August or September finally brings this long wait to an end - for my financial well being, but most importantly for patients.
Down the disease!
$BNYC
1) Ive heard, "Bulls make money, bears make money, pigs get slaughtered." In our current situation, I would certainly be considered a bull as I continue to buy at these low prices. Anyone who is selling now would be considered a bear. So the pig would appear to be those that are short above $2 but refuse to cover at $.48. History will tell us if they get slaughtered.
2) People here have been talking about a similarity here with JAZZ that went from a low stock price of $.52 in April, 2009 to now over $130 per share. Id like to point out that JAZZ has 60 million outstanding shares giving it a low market cap of approximately $31m in 2009 and $7.8B now. That would correlate now to a low NWBO stock price of $.28 with 110m shares outstanding. Ill be buying more if it goes there. For NWBO to have the same market cap as JAZZ now would mean a stock price of $70 for NWBO. That would be super sweet.
Just sharing recent thoughts as I remain devastated by the current stock price but incredibly hopeful that NWBO will be enormously successful...in due time. And that we will perhaps see the end of "cancer-as-a-death-sentence" in my lifetime.
DOWN WITH DISEASE!
$BNYC
I keep seeing it in my head:
"Northwest Bio Announces Worldwide Approval of DCVax-L"
The universe keeps feeding it to me. Its been weeks now. Its 2016 and the pps is in the toilet so I had to share with the board.
I keep seeing those words and it sustains me. Desperate long here. But you cant trust anyone on a message board can you?
Remember: Sometimes longs want a lower share price to buy lower and shorts wants a higher share price to short higher. So its all a crap shoot!
But I digest.
Im also very excited for DCVax-Direct being injected in multiple tumors much more frequently in Phase II, hopefully announced any day now?
I too cant believe the price, but the shorts are in control until the longs have validation or simply more information that makes sense to everyone. And if all works out, I win because Ive been buying more warrants (NWBOW) down here at $1.50. Thank you shorts!
Are shorts hoping longs just give up? When will the shorts cover? What pps are they waiting for to cover??? Zero/Bankrupcy? Really? Or $.50? Who's selling at $.50 without actual info?
Like I said Ive been buying the warrants (NWBOW) down here. Done for now. I own lots o' stock and underwater like every other long. But i keep seeing the words: "worldwide approval". I keep seeing it. And what a day that would be. Cmon universe! Lets have a win for science.
Thank you to all the patients, doctors, researchers, scientists, and educated empathetic posters on this board, both active and inactive.
DOWN WITH DISEASE!!
$BNYC
Market cap is around $360M ($12 ps)
Only 30M shares outstanding.
Outstanding indeed.
Nov 7 or bust.
Long AVXL, NWBO, CTIX
$BNYC
http://www.einnews.com/pr_news/276095639/northwest-biotherapeutics-joins-speaker-line-up-at-cancer-vaccines-summit-2015
Linda Powers, Chair and Chief Executive Officer, will join the stellar line-up at the Cancer Vaccines conference taking place on 16th & 17th September 2015 in London, UK
Through a case study driven address, the presentation will discuss personalized, dendritic cell based active immunotherapy for solid tumours, and unlike other conventional cancer drugs and immune therapies which use one active agent to hit one target, the capability to mobilize many active agents of the immune system to hit numerous targets on the cancer.
http://www.einnews.com/pr_news/276095639/northwest-biotherapeutics-joins-speaker-line-up-at-cancer-vaccines-summit-2015
Long NWBO since Summer 2013!
THANK YOU TO ALL NWBO EMPLOYEES, DOCTORS, AND ESPECIALLY THE PATIENTS!
Down with disease!
$BNYC
Can anyone give one reason to buy this stock now?
Keep in mind that really anything could be in play....yesterday morning i thought they were closing on properties in CA/CO. Now they are not. So what reason can you give, with assurance.
And raising AS to 10B is just silly.
Unless all the insiders are buying yesterday and today, and then Monday we suddenly become a company with a surprise PR. Stock goes to pennyland.
Hope is not dead, but is in intensive care.
But they may have 9 billion more shares to dump. Yikes!
$BNYC
OK, so....SCAM it is! Or at the least, we have a CEO that hates its shareholders, like with an evil passion. (The AS raise to 10B is just an insult, no AZ/CA is a cruel joke - and now michigan? - and no update from the company.)
Im assuming all the buys today are the smart shorts covering who have hopefully made a fortune. Why would anyone buy this today after that 8K?
I gotta get SHORT next time. I was able to sell some yesterday at .0013. Yay! Meanwhile Ill hold the rest because I may need extra toilet paper one day....u never know. YAY!
Oh well, Ive been scammed before. It happens. Really, I scammed myself, RIGHT?
So, how do we report scams to the SEC? Anyone know?
KEN, HOW DO YOU SLEEP AT NIGHT? ON A BED OF MONEY AND A CONSCIOUS OF EVIL. HOW ABOUT DOING SOME GOOD IN THE WORLD?
All IMO blah blah blah - ill consider this a sweet write off for years to come....YAY!
$BNYC
$20 pps with 800M OS is a market cap of $16B.....really?
$BNYC
Good news from Canada Supreme Court this am:
http://www.cbc.ca/news/politics/medical-marijuana-legal-in-all-forms-supreme-court-rules-1.3109148
I am correct: We can either say $.54 with 47M OS (which is what i said) OR we can say $.054 with 470M OS (which is what youre saying).
Either way, the MC is the same (approx $25M). And my point was ITS ALL ABOUT THE MARKET CAP!
News tomorrow finally?
$BNYC
When you say it hit .54, thats when there were 47M outstanding shares (OS) - all post split - which equals a market cap (MC) of approx $25M.
How many shares are outstanding now? At least 250M. (Anyone have an update from John?)
So at 250M OS for the same MC of 25M, we would have a price per share (pps) of .10. But i fear the OS is much higher. Who knows.
Heres the pps depending on OS:
OS - pps for $25M MC
250M - $.10
500M - $.05
750M - .033
So think about the MC for $1 a share right now. YIKES!
But A PENNY? i would say thats definitely doable!
GLTA
$BNYC
You said:
"MDCN to trade above $1.00/share once news starts rolling in. If we hit the equivalent of .54 on hype and expectation alone then signed revenue generating acquisitions should push the pps up multiple times higher this time around. Seems the entire OS is preparing for an epic run. I still think we do it 100% (or so) per day for many consecutive days. "
Before the 1-10 reverse split i owned 1M shares. After the split the company increased the number of outstanding shares four-fold (approx 50M to approx 200M). Since the split I have increased the number of my shares SIX-fold from 100K to 600K. So IF the company is legit (that's an unsubstantiated, unknown, and unwavering IF), i should fare well. Heres hoping i wasn't just scammed out of $20K (avg price: $.033). Yay!
Lets see if there is any humanity (and smarts) in the management team here.
Down with disease!
Marijuana is good.
TWOYBS!!!
$BNYC
I'm actually having six people over tomorrow to watch the webcast. I amazingly sold 10% of my shares in the last 10 minutes of Friday's trading ......just in case. But i am obviously hoping for fantastic news tomorrow and a huge gap up on Monday, which triggers a short squeeze of epic proportions. Comes at the right time for ol' $BNYC! Good luck to all NWBO longs, but this is really for all the patients and their families and all of humanity. Fuck cancer. Down with disease! TWOYBS!!!
$BNYC
The D is off! On both Fidelity and the Ihub app. Hopefully will be a good weekend for MDCN longs. Ive been buying since $1.50 and i aint stopped. Avg: $.08. Ugh for now.
GLTA
$BNYC
4/20 perhaps? "Northwest Biotherapeutics: Clinical Development of Dendritic Cell-Based Therapies for Both Resectable and Unresectable Tumors
Session Type: Exhibitor Spotlight Presentation
Session Start/End Time: Monday, Apr 20, 2015, 3:00 PM - 4:00 PM
Location: Exhibitor Spotlight Theater B, Halls B-E
Session Description:
Dr. Bosch will discuss NW Bio’s DCVax® platform technology, a personalized, dendritic cell based active immunotherapy for solid tumors. Unlike conventional cancer drugs and other immune therapies, which use one active agent to hit one target on the cancer, DCVax mobilizes many active agents of the immune system to hit many targets on the cancer.
NW Bio’s lead product, DCVax-L, is designed to treat all types of operable solid tumors. DCVax-L is currently in a 348-patient international Phase III clinical trial for patients with newly-diagnosed Glioblastoma multiforme brain cancer. DCVax-L has also been applied in a Phase I trial with metastatic ovarian cancer, and in various other types of cancers in compassionate use cases.
Dr. Bosch will provide updates on the clinical programs and related special access programs.
NW Bio’s second product, DCVax-Direct, is designed to treat all types of inoperable solid tumors, through intra-tumoral injection anywhere in the body. DCVax-Direct is being evaluated in an ongoing 60-patient Phase I/II trial, in which more than 7 different cancers have been treated to date.
Dr. Bosch will provide updates about this program and the technology involved."
Source: Google "AACR Annual Meeting" and search abstracts for "Northwest" under institutions.
When will we hear the full results of the Direct phase I unblinded trial? Why isn't anyone else asking this question? Thanks.
$BNYC
Bottom line: when will we finally hear the results of the phase I Direct trial? When oh when oh when? It's unblinded, they know how patients are doing, I'll bet WOODFORD knows EXACTLY how patients are doing. How about they let us simple, lowly shareholders/owners of the company in on the secret. I mean WTF? Or tell us the strategy at least.
Long and strong NWBO for years, but becoming very impatient on Direct phase I results, which are already known. It's an unblinded trial for Pete's sake. Out with it already!
So again, bottom line:
When will we finally hear how everyone in the phase I trial is doing? Oh, and GFY AF!!!
DOWN WITH DISEASE!!!!!!
$BNYC
Could the reason for the drop be the VICE special on HBO this Sunday, which just started advertising this week? I only saw the ad for it, but it's called "Killing Cancer" or something and they use the word, "cure". Apparently they document how someone is using viruses to kill cancer. That's the gist I got from it. BUT isn't our DNA vaccine technology safer and better than using virus delivery? Isn't that the point of INO?
Or am I WAY off base about VICE?
Whatever, I'm still long INO, but I'm only a lowly individual investor who wants to see some diseases get cured, and make some money in the process
I'm long INO for a long time now.
$BNYC
From Les Goldman: Let me put your mind at ease.
Linda’s reference to “expansion” of the Phase III GBM trial relates to an increase in the number of trial sites, not the number of patients in the trial. A key reason that we are continuing to add more trial sites, even in the late stages of the trial, is that this can only help shorten the time to completion of patient recruitment and the trial. In addition, continuing to add more sites during the trial means that more sites will be prepared in advance for commercialization.
Thanks for checking to clarify this important point, and thanks for your continuing support and inquiries,
Sincerely,
Les Goldman
From 8K - released today
Here is entire article - Source: Bloomberg.com
International Stem Cell Corp. (ISCO) won a ruling at the European Union’s top court that lawyers described as a victory for stem-cell research in the 28-nation bloc.
The use of organisms in stem-cell research that are incapable of developing into a human being can be patented, the EU Court of Justice in Luxembourg ruled today.
The decision “walks a clear line to exclude the sci-fi horrors of the abuse of human embryos whilst allowing the use of techniques to generate stem cells which may alleviate much human misery,” said Jason Rutt, head of patents at the industry consulting firm Rouse in London. “It seems a very sensible position.”
A non-fertilized egg in research must be considered a human embryo and cannot be patented if it has “the inherent capacity of developing into a human being,” the EU court said. Still, in cases where an “ovum commences a process of development” that is “not sufficient for it to be regarded as a human embryo” a patent may be granted for industrial or commercial purposes.
This ruling “is a real triumph for stem-cell research,” said Adam Cooke, a partner at DLA Piper U.K. LLP in London, which represents International Stem Cell. “The reasoning is clear and crisp.”
Under an EU law from 1998, research methods that involve human embryos for industrial or commercial purposes can’t be patented. A U.K. court referred the case to the EU tribunal to further define the scope of what consists a human embryo.
Today’s ruling helps determine whether International Stem Cell will get a U.K. patent on a process to extract stem cells based on unfertilized human eggs, which the Carlsbad, California-based company argued shouldn’t be considered a human embryo. A 2011 EU court ruling clarified that European law bans patents in stem-cell research that involve human embryos.
The case is: C-364/13, International Stem Cell Corporation v. Comptroller General of Patents.
To contact the reporter on this story: Stephanie Bodoni in Luxembourg at sbodoni@bloomberg.net
To contact the editors responsible for this story: Anthony Aarons at aaarons@bloomberg.net Peter Chapman, Andrew Clapham
Today, ISCO won a ruling at the European Union’s top court that lawyers described as a victory for stem-cell research in the 28-nation bloc.
The use of organisms in stem-cell research that are incapable of developing into a human being can be patented, the EU Court of Justice in Luxembourg ruled today.
The decision “walks a clear line to exclude the sci-fi horrors of the abuse of human embryos whilst allowing the use of techniques to generate stem cells which may alleviate much human misery,” said Jason Rutt, head of patents at the industry consulting firm Rouse in London. “It seems a very sensible position.”
NWBO is mentioned in this new article (link below) about ACTCs new patent for dendritic cell manufacturing.
$BNYC
Advanced Cell Technology wins US patent for dendritic cell manufacturing process
By Zachary Brennan+, 10-Sep-2014
Regenerative medicine company Advanced Cell Technology (ACT) has been issued a US patent from the US Patent and Trademark Office covering methods of manufacturing dendritic cells using a scalable process involving a renewable stem cell source as the starting materials.
http://www.biopharma-reporter.com/Bio-Developments/Advanced-Cell-Technology-wins-US-patent-for-manufacturing-process
Advanced Cell Technology Announces Issuance of Patent Covering Dendritic Cells Manufacturing from Renewable Stem Cell Sources
This headline was released this morning. Im long NWBO and ACTC. Saw "dendritic cells" and thought I'd share here.
$BNYC
In an email this morning MD Anderson wrote, "Dr. Buzdar has no associations or financial interest with this company or any other pharmaceutical company."
But then theres this disclaimer:
"Aman Buzdar is on the Speakers bureau and receives grant/research support from AstraZeneca and Genentech. He also receives grant/research support from Taiho, Lilly, Roche and Pfizer and is on the Speakers bureau for Amgen"
Wouldnt "grant/research support from AstraZeneca and Genentech" be considered a "financial interest with a pharmaceutical company"?
WHAT GIVES?
$BNYC
Had a long talk today with my broker today. We concluded that we just dont trust MD Anderson. NWBO has been saying for months that they're gonna release data as the unblinded trial progressed. This is either a heads up for LP and the gang or Dr Buzzkill f'ed up and they're covering his a$$.
Either way I dont like or trust MDA. Lets hope the patients fare well in spite of their callousness and/or carelessness.
Down with disease.
$BNYC
"The patients also report feeling significantly better." (From PR 6/11)
That moment yesterday morning when the doctors came back to the hospital after spending Fathers Day with their families and asking the patients in the Direct trial how they're feeling. Lets hope it continues....
Last Direct update was a week ago tomorrow morning (6/11)
GO NWBO!
DOWN WITH DISEASE!
$BNYC
Entire paragraph:
"We are also quite encouraged to see the patients' reactions growing as the treatments progress," noted Ms. Powers. "As of the 3rd injection in week 2 of the treatments, we now have 65% of the patients (13 of 20) showing some positive effects, and as of the 4th injection in week 8 of the treatments, we now have 100% of the patients (9 of 9) showing some positive effects. The patients also report feeling significantly better."
If we are at 20 patients and they had to treat them "just one patient at a time" every 2-3 weeks, and todays PR was up "to date" then at the very least, one patient should be very close to receiving the fifth treatment (@ 16 weeks) if 9 patients have received the 4th treatment (@ 8 weeks)
So the first patient was treated about 15-16 weeks ago? Does that sound right/possible to everyone?
Unless maybe some patients have gone further in the trial but they didnt mention that. All they said was "to date 9 have had the 4th treatment". They didnt mention if anyone has had the 5th treatment, right? But maybe its happened, or maybe more....
If one patient every 2-3 weeks with two centers recruiting and 20 patients to date then its POSSIBLE the first patients were treated 5 months ago, which means some have definitely had the fifth treatment (4 months) and one patient could finish they entire treatment (8months) just 3 months from now. Es posible?
Just parsing through PRs, thinking out loud and trying to make sense of it all. Could anyone provide some clarity?
FROM ASCO PR:
"As is often the case with first-in-man studies, the Company’s DCVax-Direct trial was required, as a regulatory matter, to proceed slowly until safety considerations could be assessed. The Company was required to treat just one patient with at least 2 of the 6 treatments in the overall regimen, then wait 2-3 weeks before treating the next single patient in the same way, and so on, treating just one patient at a time."
$BNYC
"It was with hesitation that we have responded to inane conjecture. However, we have received a substantial amount of communication from stakeholders and wished to reiterate the facts around our technology, products, and clinical study."
Fantastic!
$BNYC
AF bashed INO today. Stock went from $12 to $9 in minutes. Here's a piece I wrote on the INO board today. Thought y'all might appreciate it:
AF vs DR KIM
AF wrote today, "I suspect Kim knows his vaccine is in trouble, hence his need to prime retail investors with the "T-cell response" bamboozle."
Dr. J. Joseph Kim, Inovio's President and CEO, said in the PR this morning, "We look forward to our upcoming unblinded cervical dysplasia phase II study data on efficacy and T cell responses this summer."
Why would you look forward to something you know is a failure? So either Dr Kim is lying or AF is being disingenuous at best.
And Dr Kim should perhaps address the science and previous studies that AF discussed in his article, with relation to those increased T cell responses. A scientific debate if you will. Or can anyone here respond to AF's scientific claims?
And since we can just make up any opinions we want about anyone, can I give the opinion that "I suspect" AF is being compensated by Big Pharma or some Hedge Fund? Can I also give the opinion that "I suspect" he is being compensated by large amounts of cash waiting for him somewhere in the world? Can I also give the opinion that "I suspect" that somewhere in the world is the Cayman Islands? Can i also give the opinion that "I suspect" he sends a guy named Glenn to pick up some of the cash for him and smuggle it back into the U.S. every 6 months? Can I also give the opinion that "I suspect" AF likes to spend that money on nice dinners? Am i really allowed to voice those opinions? I suspect!
Long INO
[Long NWBO]
Down with disease!
-$BNYC
AF vs DR KIM
AF wrote today, "I suspect Kim knows his vaccine is in trouble, hence his need to prime retail investors with the "T-cell response" bamboozle."
Dr. J. Joseph Kim, Inovio's President and CEO, said in the PR this morning, "We look forward to our upcoming unblinded cervical dysplasia phase II study data on efficacy and T cell responses this summer."
Why would you look forward to something you know is a failure? So either Dr Kim is lying or AF is being disingenuous at best.
And Dr Kim should perhaps address the science and previous studies that AF discussed in his article, with relation to those increased T cell responses. A scientific debate if you will. Or can anyone here respond to AF's scientific claims?
And since we can just make up any opinions we want about anyone, can I give the opinion that "I suspect" AF is being compensated by Big Pharma or some Hedge Fund? Can I also give the opinion that "I suspect" he is being compensated by large amounts of cash waiting for him somewhere in the world? Can I also give the opinion that "I suspect" that somewhere in the world is the Cayman Islands? Can i also give the opinion that "I suspect" he sends a guy named Glenn to pick up some of the cash for him and smuggle it back into the U.S. every 6 months? Can I also give the opinion that "I suspect" AF likes to spend that money on nice dinners? Am i really allowed to voice those opinions? I suspect!
Long INO
Down with disease!
-$BNYC
D-Day? July 17, 2014
From todays PR:
Dr. Simon Craw, EVP at ISCO was recently interviewed by the BBC, giving an update on ISCO’s stem cell technology, Parkinson’s disease program and the upcoming decision by the Court of Justice for the European Union (CJEU) on the UK patent applications.
“The interview with the BBC highlighted the progress we’ve made in Parkinson’s disease and the importance of being able to protect our intellectual property in Europe,” said Dr. Simon Craw, the Company’s Executive Vice President. “The definitive ruling on our patents by the CJEU is important not just for ISCO but also for the whole stem cell industry in Europe. Demonstrating beyond doubt that ISCO’s technology is distinct from our competitors and patentable will not only enhance our ability to find partners to help develop stem cell therapies in the EU, but also stimulate investment by large pharmaceutical companies who up to this point have been somewhat on the sidelines”
The patent case involves two key patents filed with the UK Intellectual Property Office in 2012 covering ISCO’s core technology of creating pluripotent human stem cells from unfertilized eggs. Initially these patents were thought to contravene European patent law, the so called “European Biotech Directive” which excludes the use of human embryos from patentability. ISCO successfully argued with the UK IPO that its technology does not infringe on this directive, and the UK court has now requested a final ruling from the highest court in Europe with jurisdiction over patents, the Court of Justice for the European Union. The court’s final judgments will be delivered on July 17th 2014.
The full interview with the BBC can be found http://www.bbc.co.uk/programmes/p01zhkln
More information on the patent case can be found in a previous blog entry http://companyblog.intlstemcell.com/2014/06/an-update-on-iscos-important-patent.html
NWBO looks amazing at ASCO. What a layout! A friend just sent me a pic. Theres no way to post pix here, right? Any suggestions? Meanwhile, if anyone wants to email me at clstuuff@gmail.com ill send you the pic.
$BNYC
"The Phase I/II DCVax-Direct clinical trial includes a total of 60 patients: 36 in the Phase I portion and 24 in the Phase II portion. The DCVax-Direct trial began treating its first patients in Q3 of last year. " (todays PR)
"In the Phase I portion, it will test both safety and a variety of dosing regimes, and will do so in multiple different cancers – avoiding the need to conduct separate Phase I studies in each such cancer, as is usually the case. Then, the trial will go directly into the Phase II portion, testing for efficacy, without the need for another FDA review." (From 2013 PR)
Today they said 36 are in phase I and 24 in phase II (from todays PR). Does that mean that 24 already went through phase I and are now further along in the treatment AND we have yet to hear about THESE results?
Since todays PR was only about the 36 phase I patients, are we to assume that another PR will address the results of the 24 phase II patients?
$BNYC