is Retired - a status to which everybody should aspire
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Ex, You may be correct with your "methinks that many "longs" just prefer that NWBO say nothing" but wrong with your conclusion that it is " so they can pump fairy tale stories".
Most long longs have grown so used to Management keeping us all in the dark on day-to-day matters that we can now accept the deafening silence with equanimity because now we can see that Management do not need tell us anything because the company's future is now 99.9999% assured following the success of the clinical studies.
I strongly suspect that whether we get notification by the Company on validation of the MAA or not is simply not a world-shattering event. If accepted as valid - carry on regardless; if invalid, just correct the invalidities to the MHRA's satisfaction - not a death knell, just another pesky delay. .
On the other hand for notification of the licencing, I would like to be told as soon as possible because if successful I want to be cheered up at this most depressing time of the year. However, if a licence is not granted it will be bad news for all of us who have a meaningful chunk of shares in NWBO since failure (as unlikely as it may be) would mess up many forward plans for which mitigation should be instituted as soon as possible. So notification of the licencing verdict asap, please. Despite this, it is of supreme indifference to me whether DCVax-L gets its licence in 2 weeks or 2 months - but not 2 years. I'm well beyond my sell by date and would like to know that at the very least my family will not be short of a bob or two when I do shuffle off this mortal coil - hopefully later rather than sooner..
I wish you all a prosperous 2024.
Flipper, I have always understood that DCVax-L was injected "intradermally", ie into the dermis - into the skin itself. "Subdermal" is synonymous with "Subcutaneous". In practice, an intradermal injection produces a small raised wheal (sometimes described as a "bleb") in the skin which is clearly visible to show that the id injection has been correctly placed.
[addendum]
Apologies that I did not see that you had corrected the description yourself in subsequent posts.
Judge Stein quoted an SEC report on "Algorithmic Trading" in his section on "Collusive Activity" noting that NWBO had some of the characteristics that make it a more likely target for spoofing,
Hi XMaster; I agree with your prediction about iclight simply moving to another Board and this is a weakness in how these Boards are moderated - the system allows lying.
Is the ability to publish lies on iHub important? I accept that problems may arise with Moderators disallowing entries on the grounds that they contain lies because one person's perceived lie can be another person's perceived unintentional inaccuracy, but is this a good reason for allowing the status quo to continue? I believe that it is not. Most people who contribute to this Board are experienced investors (among whom I do not count myself) but there must be a sizable number of newbies and slightly experienced investors who visit this and other Boards to see whether they might invest in a Company or stay as far away from it as possible because of what they have read on a Board. There is a case for some oversight on all Boards to ensure that what is published on i-Hub can be trusted as being as truthful as possible for the obvious benefit it provides both for readers and iHub itself. (Just see what has happened to Yahoo.)
What is the definition of lying? Here are two: “A lie is a statement made by one who does not believe it with the intention that someone else shall be led to believe it” (Isenberg 1973, 248, Stanford Encyclopedia of Philosophy) whilst another is "Lying is making a statement believed to be false, with the intention of getting another to accept it as true” (Primoratz 1984, 54n2 ibid). It follows from this that just because something is not a lie, it does not mean that it is the truth. I have followed this Board since 2011 and the one thing I can now do more accurately is to tell lies from the truth and that is because those lies are usually told by the same people time after time after time. This is always despite the serial liars having been being shown time and time again that what they are saying are lies, this conclusion being based on the established information. It is abundantly clear that the liars have no interest in the truth except to misrepresent it on every available occasion.
In the early days of any company one might accept that there are people who genuinely believe that a company is too high a risk or is fraudulent and wish to advise their fellow investors of their concerns and on what those concerns are based. However, that is not the case now when the evidence base for the integrity of the company and its product are based on demonstrable fact and not on hopeful wishes. The purpose of the current liars cannot be to persuade current investors who, having fully researched the company and its products, can see that the product works as hoped. It can only be to dissuade newbies from investing and, perhaps, to give a veneer of logic for Hedgefunds and their Market Maker allies to continue their dishonest practices.
It should not be beyond the whit for iHub to put in place a scheme whereby flagrant untruths identified to iHub (with supporting evidence) by anybody reading a Board would be retrospectively highlighted as incorrect. Anybody who repeatedly peddles those untruths despite them being highlighted would clearly have an agenda in peddling lies which are not to the good for any company nor for iHub. Serial transgressor should be banned for life from iHub for the good both of iHub and the companies which are featured on iHubs boards.
iclight, from everything you have ever said on this board, whatever it is that you see it is certainly not TRUTH but is lying, self-serving LIES (and that is being mild). I doubt that anybody takes your statements to be the truth or even logically likely. You obviously need the money so will continue to spout such faeculent material as this latest flatulation (and get paid blood money by your master) until DCVax-L is licenced. When that happens (not "maybe" or "perhaps") your lies will no longer serve any purpose and your services will be dispensed with because your master will have lost and even the most naive newbie will take no notice of your manifestly mendacious messages.
I hope that you had an enjoyable Christmas (or whatever your religious tendency calls it) but from your behaviour on this board it is hard to envisage just what that would entail. Enjoy watching DCVax's success in 2024 and just reflect on what you are doing with your life. Take the lesson from Ebenezer Scrooge and reform before it is too late.
Thanks, Lykiri.
What is he relevance of the "North American Free Trade Area"?
Never let the truth spoil a good (?bad?) story.
Sun Burn, I think the MHRA are sensible enough to look outside the box if they are offered evidence which is compelling but not yet backed up by a formal clinical trial.
UCLA's as yet unpublished results of its recurrent GBM study which shows strikingly improved efficacy of DCVax-L when not preceded by SOC but with the addition of poly-ICLC and/or pembrolizumab will undoubtedly be factored into the MHRA's decision-making process even though a formal clinical trial has not yet taken place. The MHRA can see that the results of combination treatment are so obviously more effective than DCVax-L alone that they can see that it is the way forward for the treatment of all solid tumours (and probably haematopoietic ones too).
I have no doubt that NWBO have pointed out that in the Phase 3 Trial patients in the placebo arm whose GBM recurred had a better result from their delayed DCVax-L than those randomised to have SOC (surgery followed by Temozolamide and radiotherapy) followed soon after by DCVax-L. This is an important observation as it might indicate that the SOC impairs DCVax-L's efficacy. This postulate is supported by temozolamide's known toxicity to T-Cells (as also radiotherapy's T-cell toxicity, albeit less than temozolamide's) and that the delay in treatment with DCVax-L would allow temozolamide's toxicity to wane significantly. I doubt that the MHRA are not aware of this negative association and eventually might sanction DCvax-L to be used without temozolamide's inclusion in SOC.
I personally think that in within the next 5 years SOC for GBM will not include temozolamide.
Sir Pumpernickel!!!! When did he resurface from whichever cesspit he disappeared into such a long time ago???
On the other hand blinkered people only see what they want to see which frequently isn't even there.
It is soon going to be 2024 but the Hedge Funds are living in the (fictional) past, behaving as if it were still 1984 as described by George Orwell in his dystopian novel of the same name. In "1984" truth is lies, good is bad etc. with government institutions to spread the "truth". Today the Hedge Funds are trying to legitimise their illegal behaviour by claiming that naked shorting and other dubious financial manoeuvres are and have been the norm for years and are necessary for the system to work. In this they are mirroring Orwell's "Ministry of Truth" exactly.
What irony!! The liar expounding on truth!!!
Hygro's persistence in advocating a placebo arm in a trial of a lifesaving drug treating a disease with 99.99999% mortality with the current S.O.C. demonstrates his total lack of humanity and he should be barred from this Board as he contributes nothing of relevance only negativity.
As you correctly told him,
"Greater love hath no man than this, than to lay down his friends for his life." [1962 - Jeremy Thorpe MP on Prime Minister, Harold Macmillan's wholesale butchery in a Cabinet reshuffle to save himself from having to resign for his own failure.]
I am reminded of this quip when reading of Griffen's interview in Userofintellect's Tweet:
Hey Gary, That's not "goodness" - that's buying influence...
Gary, they could also come to some sort of agreement based on the individual success of the treatment. NICE bases its pricing on how long the patient survives in a state of good quality health. With the NHS playing a quasi-monopoly role as a "Health Insurer" with respect to payment for all forms of medical treatment of UK citizens, it should have little difficulty keeping track of all those patients who receive DCVax. Notwithstanding the bureaucracy involved, it should be able to keep track of the few thousands of patients who (initially at least) receive the treatment and if and when they die and of what they die.
So, rather than paying a single lump sum to NWBO for each patient treated, the arrangement could be for an annual payment to NWBO for each patient until they die of the malignant disease for which they received the treatment. For example, agree the price of the treatment and then 20% (+ annual inflationary increase) is paid to NWBO for 5 years or until the patient dies of whatever malignancy he was being treated for.
How to set the price is, of course, another matter.
EX - I have no knowledge of how either the MHRA or FDA work, but is it not possible that the MHRA's decision on the Vertex treatment for Sickle Cell Disease preceding the FDA's positive decision by such a short time could be due to the 2 Regulatory Authorities having recently come to some some form of information sharing? This might mean that in its final stages the FDA piggy-backed on the MHRA's decision? If so, it would be a very welcome decision for all to know that the FDA and the MHRA have now developed some degree of sharing so as not to waste time and treasure on duplication of resources.
This, however, is all conjecture.
Never mind! by the time his nGBM becomes rGBM DCVax-L will have got its licence and he can have it together with poly-iclc and all the checkpoint inhibitors - both presurgery and afterwards - that he may want.
Whether this is DCVax or not has certainly not been made clear by what has so far been reported. What has been reported is that Australia-based Prof. Scolyer ("the patient") is an expert in the immunotherapy of Malignant Melanoma and is currently involved in the NADINA trial [NeoADdjuvant Ipilimumab Plus Nivolumab Versus Standard Adjuvant Nivolumab in Macroscopic Stage III Melanoma] with centres in Australia, the USA and Europe. It has nothing to do with brain tumours (except, I suppose, unless the melanoma has metastasized to the brain).
The treatment he elected to receive for his own brain tumour was based on immunotherapy which they had developed as an effective treatment against Malignant Melanoma. It basically consisted of pre-surgical immunotherapy (aka "neoadjuvant") with one unspecified agent followed by post-excision immunotherapy with an unspecified combination of agents.
Prof. Georgina Long, "the world’s top melanoma expert", and a long-time colleague of Prof. Scolyer, reported that with the expertise that they had developed in the study of the immunotherapy of Malignant Melanoma,
johnny5isalive - but he's brain dead and doesn't know it.
LC, your thought processes are totally up the chute - your logic (if there is any logic in your mental make-up) is as twisted as a corkscrew.
Amen to that.
All the problems of growing old - but I prefer it to the alternative. It does, however, remind of an old "New Orleans jazz great" who a decade or so reached his century. When asked during a radio interview, "If you had your time again, would you do anything different?", he replied "If I'd known I was going to live to be a hundred, I'd have taken better care of my body!!"
Wotta Heap of Old Malarkey!! - Feeling a tad desperate, are you, LC?
"A picture is worth a thousand words". [Henrik Ibsen]
You're right,Dude; I wasn't sufficiently clear in what I said. The lie must be pointed out, but (and this is what I was trying to say) the lie is now out there and like the Covid-19 virus, once it is out it cannot be put back into the bottle. Instead it will spread around infecting susceptible individuals irrespective of what we can do.
Hey Dude, I think it's a bit too late to try and rectify this farrago of lies; its almost certainly well-embedded in uncritical minds, especially those who would do NWBO down. Remember the old saying - "A Lie Can Travel Halfway Around the World While the Truth Is Putting On Its Shoes"
Eton might not produce as many liars as does Harvard, but I would hazard a guess that Eton's (usually after a stint at Oxford University and the Bullingdon Club)
are posher and achieve more influential positions (eg Prime Ministers and Cabinet Members) than does Harvard whose duplicitous alumni are usually grubby financial tradesmen such as KG intent on amassing obscene amounts of filthy lucre. (No prizes for recognizing the fair haired oik (front row-centre) whose main achievements are a congenital inability to tell the difference between truth and lies and persistently amassing offspring irrespective of which side of the blanket they are conceived.)
Perfectly understandable that somebody needs to be resuscitated by the Heimlich Manoeuvre after reading your rubbish because it will stick in any sensible person's craw and need ejecting forcefully.
In Your Dreams, Loser. A strong hint of desperation is now clearly evident in the negative narrative.