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"Archer Pharmaceuticals, Inc. (Archer) was founded in 2008 and specializes in targeted drug discovery for Alzheimer’s disease. Led by Chief Executive Officer and Chief Scientific Officer Michael Mullan, M.B.B.S., Ph.D. and Chief Technical Officer and Associate Chief Scientific Officer Fiona Crawford, Ph.D., Archer was created based on the groundbreaking research conducted at the Roskamp Institute in Sarasota, Florida."
Read about Archer and what is happening there at:
http://www.archerpharma.com/about.html
"NF-kB pathway may be suitable targets for therapeutic approaches against Alzheimer’s disease"
Article at Roskamp website:
The Roskamp Institute, a not-for-profit research Institute, is dedicated to finding cure for neuropsychiatric disorder, with the emphasis on Alzheimer’s disease (AD). Current research at the Roskamp Institute is focused on dissecting the molecular biological pathways implicated in Alzheimer’s disease pathogenesis in order to develop therapeutic targets specific to Alzheimer’s disease etiology. Dr. Michael Mullan (Director of the Roskamp Institute) and Fiona Crawford (Associate director of the Roskamp Institute) were part of the original team that discovered a genetic error called “Swedish mutation” which results in overproduction of beta-amyloid (Abeta) by aberrant proteolytic processing of amyloid precursor protein (APP). This mutation now forms the bases of most mouse model of Alzheimer’s disease . Previously, the Roskamp Institute published an article in a prestigious scientific journal, Nature, showing that Abeta plays a normal role in vasoactive mechanisms but also plays a role in vascular abnormalities and neurodegeneration mediated by free radical. Subsequently, Dr. Daniel Paris, a senior scientist at the Roskamp Institute, discovered that the vasoactive effects of Abeta are partly mediated via a pro-inflammatory pathway and showed that this effect of Abeta on the vasculature can be blocked by inhibiting specific target molecules. In order to further understand the role of Abeta in the vasculature, Dr. Paris investigated the long term effect of Abeta on vascular homeostasis. He then discovered that at low doses, Abeta promotes angiogenesis, while at high doses, certain forms of Abeta peptides are anti-angiogenic. Collectively, these novel findings resulted in new therapeutic prospects for the treatment of Alzheimer’s disease as well as Cancer. Researchers at the Roskamp Institute also showed that the presence of functional CD40/CD40L signaling is essential for the full development of Alzheimer’s disease like pathology in transgenic mouse models of AD. In particular, it was demonstrated that accumulation of cerebral Abeta is reduced in transgenic mouse models of Alzheimer’s disease by genetically or pharmacologically reducing the availability of CD40 ligand to CD40. The Roskamp Institute investigators subsequently revealed that loss of functional CD40L diminishes both APP processing to Abeta and microglial activation in the brain (Original findings published in journals Science and Nature Neuroscience). CD40L activated pathways in the presence of Abeta appear to mediate both of these effects as well as the hyperphosphorylation of murine tau in vivo at epitopes analogous to those which precede tangle formation of human tau. More recently, Dr. Ghania Ait-Ghezala of the Roskamp Institute showed that CD40/CD40L interaction also affects APP via the NF-kB pathway. Using NF-kB inhibitors and SiRNAs to silence diverse elements of the NF-kB pathway, she demonstrated that reduction in levels of both pathological forms of Abeta. These results showed that CD40L stimulation may be a key component in Alzheimer’s disease pathology and that NF-kB pathway may be suitable targets for therapeutic approaches against Alzheimer’s disease . Another major focus of research at the Roskamp Institute includes Traumatic Brain Injury (TBI) Program headed by the Associate Director of the Roskamp Institute. Dr. Crawford and her Roskamp Institute team demonstrated an important relationship between apolipoprotein E (APOE) and memory following Traumatic Brain Injury . She demonstrated that in Veteran’s with Traumatic Brain Injury , memory performance was significantly worse in individuals who had at least one copy of APOE epsilon4 allele than those who did not. She had subsequently been funded through the Veteran’s Administration to further study the relationship between different forms of APOE in Traumatic Brain Injury with the emphasis on finding treatments for this devastating condition. Drs. Michael Mullan and Fiona Crawford also received funding by the Counterdrug Technology Assessment Center (CTAC) to evaluate the newly emerged genomics and proteomics technology and find biological markers of substance abuse. Recently, Dr. Crawford’s team showed that cocaine treatment of human progenitor neuronal cells results in increased oxidative stress (possibly mediated by inflammatory responses) which precedes cell death. Thus, these findings may have implications for the consequences of cocaine abuse in situations where antioxidant capacity is compromised, as in the aging brain.As evident here, the Roskamp Institute team has been a pioneer in many area of research in neuropsychiatric diseases and will continue to do so to find novel therapies for these disorders. Currently, a new clinical trial based on the discoveries made at the Roskamp Institute is underway to assess safety and efficacy of nilvadipine in treatment of Alzheimer’s disease. Through the generous support of Diane and Robert Roskamp, the Veteran’s Administration, the National Institutes of Health, CTAC and the Department of Defense, the Roskamp Institute will continue to provide potential avenues for novel therapeutic interventions for neuropsychiatric disorders. Roskamp Institute is actively involved in Gulf War Syndrome or Gulf War Illness Research. Specifically the scientists are studying the effect of gulf war agents like PB & Permethrin on biological pathways using model organisms. You can read more about the research and clinical trials at: Roskamp Institute News and Articles . To learn more about Dr. Michael Mullan Alzheimer Research please visit Michael Mullan Alzheimer Research Notes or Michael Mullan Alzheimers Information website"
Article at:
http://www.roskampinstitute.us/
Inflammation-Cancer link article in Cancer Research UK titled:
"Feeling the heat – the link between inflammation and cancer"
Excerpt:
So how does inflammation lead to cancer? Here’s the current thinking.
When a tiny tumour starts growing from a few rogue cells, it can scavenge enough oxygen and nutrients from its surroundings. But as it grows bigger, demand starts to outstrip supply, and things start getting desperate.
As they struggle to survive, and as they accumulate more and more genetic faults, the cancer cells release chemical signals that lure immune cells called macrophages and granulocytes to infiltrate the tumour.
Once inside the tumour’s inner sanctum, these cells secrete molecules (called cytokines) that kick-start the growth of blood vessels (angiogenesis), which ferry in much-needed oxygen and nutrients.
Other cytokines encourage growth of a sort of cellular ‘pillow’ called the stroma against which the tumour rests. Meanwhile, other inflammatory cells spritz the tumour with molecules (free radicals) that further damage their DNA. Inflammation might also fire the starting gun for metastasis by producing chemicals that help tumour cells nibble through the molecules tethering them to their surroundings.
Taken together, it’s clear that fledgling tumours hijack inflammation and use it to accelerate the progression towards full-blown cancer. As one of our own experts once commented:
“If genetic damage is the match that lights the fire, inflammation may provide the fuel that feeds the flames.”
Stay cool, boy
So how do we turn down the heat? Scientists, including our own are working on how to dampen inflammation, making it much harder for cancers to flourish. They’re hacking into the molecular circuitry controlling inflammation, looking for ways to hotwire the system with next-generation drugs.
But what if we could manipulate inflammation to prevent cancer developing in the first place? Recent results suggest that the answer might be anything but next-generation. In fact, it’s been around since Hippocrates.
Better known to most of us by its brand name aspirin, acetylsalicyclic acid has been used for over a century to quell inflammation, and there’s now a body of evidence highlighting its potential in cancer prevention. While there’s still a way to go to work out who should take aspirin, how much, and for how long, it’s becoming clear that blocking inflammation will play a big role in cancer prevention and treatment in the future.
Rudolf Virchow will never know that his work sparked an entire field of cancer research but thanks to him, the fight against cancer is hotting up."
So what is better than aspirin? You know the answer.
Article at:
http://scienceblog.cancerresearchuk.org/2013/02/01/feeling-the-heat-the-link-between-inflammation-and-cancer/
Roskamp taking over promising drug firm
Article from EIN Newsdesk: Sarasota Herald Tribune article.
Some quotes:
"
The Roskamp Institute, convinced of the value of an anti-inflammation drug that has shown promise, has taken over the beleaguered pharmaceutical company that developed it.
Roskamp managers plan to move Star Scientific to Southwest Florida.
Dr. Michael Mullan, the institute’s president and chief executive, will become CEO of the fledgling company.
Mullan is shutting Star Scientific’s offices in Washington, D.C.; Glen Allen, Va.; and Gloucester, Mass.; as part of the relocation of roughly two dozen company employees, who will be housed at Roskamp’s south Manatee County campus.
In time, Roskamp — recognized as a national leader in the battle against Alzheimer’s disease — and Mullan hope to secure Food and Drug Administration approval for an anti-inflammatory prescription drug that Star Scientific patented."
"Moving to Sarasota is one of the best things that could have ever happened to this company,” said Robert W. Scannell, whose San Francisco-based Tradewinds Investment Management LP owns just under 10 percent of Star Scientific’s 181 million shares.
“Dr. Mullan and his staff are truly world-class researchers,” Scannell said."
"But even Roskamp officials acknowledge that winning FDA approval for prescription status could cost millions and take three to five years to complete — if it can be completed at all.
Still, the payoff could be huge: Prescription arthritis drugs alone represent a $15 billion annual market."
"Star Scientific’s over-the-counter product, Anatabloc, is, for now, sold at GNC outlets and online. It has been sold for more than three years and has attracted a following for its ability to reduce swelling in joints.
“The key developmental question is, can it be developed for a number of inflammatory disorders?” Mullan said. “That is the strategy of the company, to see if we can develop them for a number of inflammatory disorders — arthritis, ulcerative colitis, maybe some immune disorders.”
Roskamp was drawn to Star Scientific primarily because of evidence that Alzheimer’s disease has a strong inflammatory component to it.
One Roskamp peer-reviewed study showed that anatabine can suppress brain inflammation, which affects Alzheimer’s disease sufferers.
“It does have this anti-inflammatory effect,” Mullan said. “It seems to signal to inflammatory cells to calm down.”
"Both Mullan and Roskamp officials have a personal stake in seeing Star Scientific succeed.
Senior housing developer Bob Roskamp, the institute’s founder, bought 1.5 million of Star Scientific’s shares beginning in 2010, said Ted Jenkins, the company’s head of corporate strategy and development.
Mullan owns warrants or stock options on some 6 million shares, Scannell said.
In all, Star Scientific has 181 million shares outstanding, equating to market capitalization of $143 million based on its recent price of 79 cents per share."
The first two of three phases in the agency’s “investigational new drug process” could take two years. But Star Scientific has a headstart, in that its anatabine compound has been in use for years.
Mullan said the company has kept extensive data on consumers’ experiences — including misuse by patients who have increased dosages beyond the recommended amount — that could expedite the FDA research.
“They may say: ‘Look, it is in the food chain, it has been in an awful lot of people. We haven’t had any serious adverse effects directly attributable to it,’ ” Mullan said.
Irv DeGraw, a professor of finance at St. Petersburg College, said that Roskamp’s involvement is encouraging.
“That’s probably their biggest endorsement,” DeGraw said.
The drug — with FDA approval — could become very attractive to a big pharmaceutical company, DeGraw said.
“I am sure they are looking to get somebody else to get involved, one of the big players,” he said. “Think about it. I am making progress with the FDA. Now I go to some of the big guys. If they like the idea, they will take it over. That happens a lot.”
That prospect has also occurred to Scannell, the investor.
“My guess,” Scannell said, “is that there will be conversations with a major pharmaceutical partner going on over the next two years, and that a deal of some sort will be struck.”
The stock, traded via over-the-counter exchange, has been extremely volatile during the past five years. At one point in July 2012, the shares rose to roughly $5 before sinking.
The price could rise dramatically if FDA approvals are obtained.
Mullan hopes to file an application with the agency by the end of June, though the institute has yet to state which medical condition it intends to target."
Entire article at:
http://tobacco.einnews.com/article/199245437/abbuh1QhyQXgoZrE?n=1&code=nijBwKk8HTxXIdEs
Metabolic Syndrome:
"Metabolic (met-ah-BOL-ik) syndrome is the name for a group of risk factors that raises your risk for heart disease and other health problems, such as diabetes and stroke.
The term "metabolic" refers to the biochemical processes involved in the body's normal functioning. Risk factors are traits, conditions, or habits that increase your chance of developing a disease." (Wikipedia)
Common symptom: Chronic Inflammation
Common possible causes: Smoking, alcohol, diet, Genetically Modified foods, and sugar
Watch the video: "Fat Chance: Fructose 2.0"
at:
Ooops, got me saying it to. Should be MAOI
Maybe you are confusing with the term MOAI? "Anatabloc is a safe monoamine oxidase inhibitor, or MAOI. MAOIs are antidepressants that aid in focusing and task accomplishment. The term “MAOI,” by the way, is often pronounced like the Hawaiian island of Maui." (P. Cox)
"The top prescription is for your Arthritis, but it may cause a heart attack. The second prescription is to prevent a heart attack, but it could cause liver damage. The third is to protect your liver, but it may destroy your spleen. The fourth protects the spleen but it has been known to eat away at the prostrate. The fifth is-----"
Cartoon caption from caglecartoons.com
Inflammatory Foods---9 Of The Worst Picks For Inflammation
The Huffington Post | By Sarah Klein
"The causes of chronic inflammation can vary person to person, but include being overweight, experiencing lots of stress and even breathing polluted air, Women's Health reported. Lifestyle choices, like smoking or lack of exercise, also play a role. "Sedentary lifestyle, lack of sleep -- we have these repetitive insults that increase longer-term inflammation," says Jessica Black, N.D., author of The Anti-Inflammatory Diet and Recipe Book.
The foods we choose to eat -- or not to eat -- can also affect inflammation. Getting your fair share of fruits, vegetables, whole grains, lean meat and omega-3 fatty acids -- similar, yes, to the Mediterranean diet -- has been suggested to have anti-inflammatory effects. "Diet can serve as a protective function," says Sandquist. "When our bodies are best nourished, we're able to heal quicker if we do cut our finger and maybe even prevent chronic inflammation." It's likely that no one food is to blame for causing inflammation, she says, but that your overall diet could contribute.
For now, anti-inflammatory diet guidelines are simply suggestions. More research is needed to truly understand the relationship between diet and inflammation and, in turn, disease, WebMD reported.
Still, there are some general ideas about what foods to avoid to keep inflammation and illness at bay. "There are foods that exaggerate inflammation because they themselves are irritants," says Daniluk. Here are some of the worst offenders you might want to avoid."
"Trans fats, sugar, white bread, cheeseburgers, alcohol, omega 6 fatty acids, milk, MSG, and Gluten"
Article at:
http://www.huffingtonpost.com/2013/03/21/inflammatory-foods-worst-inflammation_n_2838643.html
Mayo Clinic Inflammation Article:
"Buzzed on inflammation"
Brent Bauer, M.D.
General Internal Medicine, Editorial Board member of Mayo Clinic Health Letter
"Inflammation is the new medical buzzword. It seems as though everyone is talking about it, especially the fact that inflammation appears to play a role in many chronic diseases. The July issue of Mayo Clinic Health Letter highlights inflammation's role in cardiovascular disease."
"My best advice concerning chronic inflammation is to stay tuned. This is a huge area of interest in the medical world and there are bound to be discoveries down the road that can improve well-being and the quality of health."
Article at:
http://healthletter.mayoclinic.com/editorial/editorial.cfm/i/163/t/Buzzed%20on%20inflammation/
NIH New Initiative on Alzheimers:
"Since 1998 there have been more than 100 attempts to develop a treatment for Alzheimer’s and all have failed. More than 5 million Americans have Alzheimer’s disease, the most common form of dementia, a patient population that is expected to triple by 2050, according to the Alzheimer’s Association. As many as a half-million people in the U.S. may die from the disease each year, making it the country’s No. 3 killer, researchers reported last month in the journal Neurology."
"NIH also is teaming with pharmaceutical companies to study new approaches to treat Alzheimer’s, diabetes, lupus and arthritis. Collins said he worked with the companies’ research and development units for three years to make the “unprecedented” partnership happen. The research will be made public for any scientist to use"
...So, ask yourself, what does Alzheimers, diabetes, lupus and arthritis have in common? Answer: Chromic inflammation!
Article at:
http://www.bloomberg.com/news/2014-04-11/alzheimer-s-therapy-may-come-from-new-look-at-old-drugs.html
Acute and chronic inflammation by Sarah Beck,DVM of John Hopkins
Excellent series of pictorial charts illustrating both acute and chronic inflammation, their pathology and mechanisms.
Article at:
http://www.hopkinsmedicine.org/mcp/Education/300.713%20Lectures/300.713%202013/Beck_08.26.2013.pdf
"Chronic Inflammation--An American Epidemic" article in: International Wellness Directory.
More and more information points to the same answers---it's the chronic inflammation!!!
"Inflammation is a part of the body’s natural defense system against injury and disease.
Chronic inflammation, on the other hand, is a disease. The system has gotten hung up, and instead of protecting the organism (our bodies) it starts to kill the organism, slowly but surely.
Today modern medicine is starting to admit that chronic inflammation is the main contributing factor to all chronic degenerative diseases, and the root cause of the two greatest killers in America: Cancer and Heart Disease. Indeed, chronic inflammation might just be the root cause of all degenerative disease.
Chronic inflammation may be the root of all degenerative disease. [Andrew Weil — www.drweil.com]
Accepting this would certainly simplify preventive medical practices (even as non existent as they presently are), but I find it interesting that once in our early history medicine tried to create a theory that reduced all disease into one or two categories. History does, it seems, repeat itself.
The Damage
Pro-inflammatory cytokines are the part of our immune systems that attack and kill cells with oxidative chemicals. If they don’t stop their attacks, they will start killing cells our bodies need. The inflammation in a joint can eat away at our cartilage and you’ve got a serious case of arthritis. Unchecked inflammation in an organ, say the pancreas, can cause diabetes. Unchecked inflammation is now thought to be responsible for cardiovascular disease and cancers. The elderly are especially vulnerable to this sort of unchecked inflammation since the body looses the ability to “down-regulate” inflammation with age.
You do not have to be old to have chronic inflammation. You can have it and not know it, until it is too late. Thus we are going to spotlight those tests for having chronic inflammation or being at risk for chronic inflammation.
After that, we will outline the therapies to bring down chronic inflammation and how to avoid it in the first place, for you will soon find that inflammation begins on the end of your fork.
Does anyone recall the headlines in the New York Times about blood vessels bursting like popcorn? The article told us that the latest theory on the cause of heart disease is inflammation. One of the doctors who made this discovery was Dr Paul Ridker. The results of his studies in the early 1990s landed on the front pages of the New York Times right around the turn of the century. We’ve covered this in our book, Bypassing Bypass (and in our Cardiovascular Articles section), but we must tell you a little about it right now.
Microorganisms cause inflammation within our blood vessels, and the inflammation attacks the inside of the arteries. Besides immune cells being sent to the site to fight the inflammation, lipoprotein(a) is sent to form a sticky patch over the damaged area; a patch that that can grab onto cholesterol (supposedly bad cholesterol) and a cholesterol bandage is created over the site. However, the inflammation is inside now. The patch grows and bulges. The inflammation grows and bulges. Eventually, “blood vessels explode like popcorn.”
The reason I called the cholesterol “supposedly bad” is that it tried to save your life. If the inflammation continued without being patched by cholesterol, the artery would eventually open and you’d bleed out.
However, because the inflammation was not halted, the bandaged area has burst and the body must quickly respond because your artery is about to open wide. How is this patch formed? By a blood clot.
A clot is formed at the site to patch up the damage. Eventually, lipoprotein(a) will come along and form a sticky patch and attract cholesterol to form a better bandage, but there is a problem, and it has to do with our diet and lifestyle, our hypercoagulable lifestyles. Our blood tends to clot “too” much. The clot formed is usually bigger than it need be, and being such, the chances of it breaking loose increase. If it does break loose and it goes to your brain, you suffer a stroke. If it goes to your heart, you suffer a heart attack.
This sums up a good deal of what we have to say in Bypassing Bypass (which we are rewriting) but there is a lot more to learn (so if you want a copy, go get it here: Bypassing Bypass, and keep in mind that you are eligible to get the updated online version free when it is released).
One final cause of inflammation is insulin resistance and high blood sugar, along with the associated weight gain.
First off, high blood sugar raises your inflammation markers, IL-6 and CRP (C Reactive Protein). Then high insulin levels in your blood activate enzymes that raise the amount of arachidonic acid in your blood. Arachidonic acid is a polyunsaturated non essential omega-6 fatty acid. The problem with omega-6 fatty acids are when they exist in large quantities in the blood without a proper ratio of omega-9s to balance them out and inflammation results.
Diets high in omega-6 fatty acids are very inflammatory; and considering that many of our foods come from corn (including our beef), the average American eats over 4 pounds of corn each day, resulting in an over abundance of omega-6s in our blood stream and consequentially, inflammation.
And we still have one more route for inflammation to set in: when our bodies are insulin resistant, our brains are leptin resistant. The more body fat we have, the more leptin we have in our blood which triggers the immune cells in our body fat to release Tumor Necrosis Factor Alpha, which is usually a good thing in that it helps consume nascent tumors, but in this case it's highly inflammatory, and it can set off a cascade of events ending in chronic degenerative illness such as MS, arthritis, cancer, and heart disease.
And if you have food sensitivities, your immune system is already overworked creating more chemicals that raise your immune markers. The problem is, most people with food sensitivities don't even know it."
Article at:
http://www.mnwelldir.org/docs/terrain/chronic_inflammation.htm
Approved OTC substances. (Anatabine Citrate not on the list):
http://www.fda.gov/downloads/AboutFDA/CentersOffices/OfficeofMedicalProductsandTobacco/CDER/UCM135688.pdf
Interesting that Choloform, Hydrochloric Acid, Mercury, and Opium are on this list.
The FDA says:
"Prescription Drugs and Over-the-Counter (OTC) Drugs: Questions and Answers
What is the difference between prescription drugs and OTC drugs?
A drug is a substance intended for use in the diagnosis, cure, mitigation, treatment, or prevention of disease. Here are the main differences between OTC drugs and prescription drugs.
Prescription drugs are:
Prescribed by a doctor
Bought at a pharmacy
Prescribed for and intended to be used by one person
Regulated by FDA through the New Drug Application (NDA) process. This is the formal step a drug sponsor takes to ask that the FDA consider approving a new drug for marketing in the United States. An NDA includes all animal and human data and analyses of the data, as well as information about how the drug behaves in the body and how it is manufactured. For more information on the NDA process, please see "The FDA's Drug Review Process: Ensuring Drugs Are Safe and Effective."
OTC drugs are:
Drugs that do NOT require a doctor's prescription
Bought off-the-shelf in stores
Regulated by FDA through OTC Drug monographs. OTC drug monographs are a kind of "recipe book" covering acceptable ingredients, doses, formulations, and labeling. Monographs will continually be updated adding additional ingredients and labeling as needed. Products conforming to a monograph may be marketed without further FDA clearance, while those that do not, must undergo separate review and approval through the "New Drug Approval System."
Article at:
http://www.fda.gov/Drugs/ResourcesForYou/Consumers/QuestionsAnswers/ucm100101.htm
Article in Yahoo Health by By Lisa Collier Cool
Jan 16, 2013
"In a medical version of the “unified field” theory in physics, many scientists now believe that most—or perhaps all—chronic diseases may have the same trigger: inflammation. This fiery process has been linked to everything from heart attacks and strokes to type 2 diabetes, Alzheimer’s disease, and even cancer.
Chronic, low-grade systemic inflammation—fueled by such disorders as excessive belly fat, poor diet, lack of exercise, smoking, and gum disease—may explain why lifestyle-linked diseases have reached epidemic levels in Western countries, while remaining rare in the developing world.
“There are clear indications that inflammation explains why plaque builds up in the arteries in patients with atherosclerosis,” says Philip Schauer, MD, director of the Bariatric and Metabolic Institute at the Cleveland Clinic. “Chronic inflammation also plays a direct role in diabetes, high blood pressure, sleep apnea, asthma and many other conditions.”
The Missing Puzzle Piece
Two groundbreaking new studies published in Lancet suggest that fire inside the artery walls could be the missing puzzle piece to solve the mystery of why many people with normal or even optimal cholesterol levels suffer heart attacks or strokes, while others with very high cholesterol never develop heart disease.
The studies were the first to show a cause-and-effect relationship between a specific inflammatory marker (interleukin 6, also known as IL-6) and heart disease risk—a discovery that could lead to revolutionary new therapies to treat or prevent the leading killer of Americans.
The researchers pooled data from nearly 135,000 people and found that those with a gene variant linked to a lower-than-normal number of IL-6 receptors were much less likely to develop heart disease, even though they had the same rates of smoking, diabetes, high cholesterol, and other risk factors as people without this variant.
The findings suggest that medication to block IL-6 receptors—currently used to treat rheumatoid arthritis (also an inflammatory disease)—could be a new weapon against heart disease.
Is Your Body on Fire?
Most of the time, inflammation protects health. If you stepped on a nail, your body would mobilize immune system troops to battle the invading bacteria by releasing signaling molecules, such as IL-6, to launch the inflammatory cascade. The immune system reaction involves more than 20 proteins that blast the invaders with chemicals to kill them, along with an assortment of odd-looking white blood cell components that resemble characters from Creepshow2.
The result of this immune system response is the familiar feeling of redness and warmth around the wound as it starts to heal. Chronic inflammation, however, harms rather than heals, because the immune system attack never stops. It’s like being shot by “friendly fire” during a perpetual war raging inside the body, says Dr. Schauer.
The #1 Warning Sign of Chronic Inflammation
The easiest way to tell if your body—and arteries—might be on fire is to measure your waist. A circumference above 35 inches for a woman or 40 inches for a man means you could be at risk for a variety of dangerous diseases linked to chronic inflammation, even if your weight is normal.
“Excessive visceral fat is very different than fat in other parts of the body,” says Dr. Schauer. “Abdominal fat cells are much more biologically active than subcutaneous fat cells, releasing several hormones and cytokines [chemical messengers involved in immune system and inflammatory responses]. There is also a genetic component to both chronic inflammation and obesity—it’s not just an unhealthy lifestyle that leads to these problems.”
8 Foods That Reduce Inflammation
A Deadly Gang of Metabolic Thugs
A big belly is also the leading indicator of metabolic syndrome, a gang of five metabolic thugs that quintuple risk for type 2 diabetes and triple it for heart attack. Fifty million Americans, many of whom are undiagnosed, suffer from this dangerous disorder.
If you have three or more of the following disorders, you have metabolic syndrome:
A large waistline. This also is called "an apple shape."
High triglycerides: a level of this blood fat above 150 mg/dL
Low HDL (less than 50 mg/dL for women and less than 40 mg/dL for men). HDL is the good cholesterol that keeps the heart and brain healthy.
High blood pressure: 130/85 mmHg or higher (or you’re on blood pressure medicine).
High fasting blood sugar: 100 mg/dL or above (or you're on medicine to treat high blood sugar).
11 Ways to Reduce Healthcare Costs
Can Targeting Inflammation Improve Alzheimer’s Disease?
Many studies have linked Alzheimer’s disease—also called “type 3 diabetes”—to chronic inflammation. A new study published in Nature Medicine reports that in mice with the memory-robbing disorder, levels of pro-inflammatory cytokines called IL-12 and IL-23 soar.
When the animals’ brains were treated with antibodies that target IL-12 and Il-23, their memory deficits were actually “reversed,” the researchers report, suggesting that anti-inflammatory therapies may help combat the disease’s progression.
Another new study found that statins—which are known to have potent anti-inflammatory effects in people—boosted memory in mice in the early stages of Alzheimer’s. The statin used in the study was simvastin (Zocor).
However, medication isn’t the only fire-fighter; research also shows that regular exercise helps keep both the body and brain healthy. Interval training, in particular, is one of the best ways to slim your waist—and put out the fire in your belly."
Article at: http://health.yahoo.net/experts/dayinhealth/inflammation-root-cause-all-disease
Lead from the clown board:Tomorrow's Cancer-Blasting Wonder Drug Could Come From a Tobacco Plant
Excerpt from article in Engadget
"When tobacco and cancer are used in the same sentence, the word "cause" usually goes in between. That's why a new research from La Trobe University in Australia could confuse some folks -- after all, the researchers discovered that tobacco could potentially be used for cancer treatment. Before you pick up that box of Marlboros, know that it's actually a flowering tobacco plant named Nicotania alata, which isn't even the same species used to make cigarettes, that has magical, cancer-beating properties. After a series of tests, the scientists have determined that NaD1 (a protein found in its pink and white flowers) can not only fight off plant fungi, but also kill cancer cells."
Article at:
http://www.engadget.com/2014/04/05/tobacco-cancer-treatment/
Traditional Chinese Medicine (TCM) on the verge of being westernized. TCM annual sales in China are estimated about $56 Billion. U.S. annual drug sales estimated at $10 Billion. Maybe STSI should market Anatabloc in China as part of the TCM arena? TCM is headed towards western markets.
"The US Food and Drug Administration (FDA) opened up a new pathway for approving botanical drugs in the mid-2000s, and Hong Kong-headquartered Hutchison China MediTech intends to be one of the first companies to walk down it. The company has created drug HMPL-004 derived from andrographis to treat Crohn’s disease and other gastrointestinal inflammations. The drug is now in the final phase of clinical trials and could be ready for sale in three or four years."
"The domestic market for traditional Chinese medicine alone should be enough to make Western drug firms salivate. The industry is now worth roughly US$55.9 billion (RMB342.6 billion) as of 2012, up from US$10.9 billion, according to statistics compiled by Roland Berger Strategy Consultants.
"Traditional Chinese medicine accounts for less than 5% of the US$10 billion in sales within the broader category of over-the-counter herbal medicine (generally not subject to FDA approval) in the US, Yuan estimates."
Traditional Chinese medicine represents 38% of pharma sales as of 2012. “If [Western drug companies] are talking about China but not doing TCM, they’re losing about half the market,” said Bruce Liu, a partner with Roland Berger.
That’s largely because TCM makes up 46% of the drugs approved for reimbursement under Chinese medical insurance. The market will continue to boom, Hogg predicts, because Chinese medical insurance schemes are being broadened and more rural residents on rudimentary insurance are being brought into more comprehensive urban plans.
Liu said he expects the market to continue to grow at about 17% a year."
"The FDA gave “botanical” drugs an avenue for approval in 2004. Since then, only two drugs have been approved and only one based on TCM, called Veregen. That drug, based on green tea extract, is used to treat warts."
Article at:
http://www.chinaeconomicreview.com/traditional-Chinese-medicine-TCM-healthcare-pharmaceuticals-botanical-drugs-FDA
Connect the dots---Anatabloc?
Article details chronic inflammation in 'Life Extension':
"Inflammation (Chronic)
Of the ten leading causes of mortality in the United States, chronic, low-level inflammation contributes to the pathogenesis of at least seven. These include heart disease, cancer, chronic lower respiratory disease, stroke, Alzheimer’s disease, diabetes, and nephritis (Centers for Disease Control and Prevention 2011; Bastard et al. 2006; Cao 2011, Jha et al. 2009; Ferrucci et al. 2010; Glorieux et al. 2009; Kundu et al. 2008; Murphy 2012; Singh et al. 2011)."
Article at:
https://www.lef.org/protocols/health_concerns/chronic_inflammation_01.htm
Maybe not a double blind test but my wife had gum infection and bleeding for about 5 years before she took Anatabloc. She has been taking Anatabloc now for one year and 9 months and the dentist says she is infection free. Her bleeding and pain is gone!!!!
Future of Experimental Medicine ~ Inflammation in Disease and Ageing
Novotel Manly Pacific Hotel, Manly Beach, Sydney, Australia. March 16-19, 2014---just held conference.
"Broad themes and Topics include:
Immunology | Cancer | Pathogenesis of Autoimmune and Allergic Diseases | Cardiovascular diseases | Nutrition and Inflammatory Diseases
Inflammation and Skin diseases | Inflammation and Liver Disease
Novel Therapies | Innate Mechanisms of Tissue Inflammation
Regulation of Inflammation by Cell migration | Inflammation and Ageing
Regulation of Inflammation by Endothelial Cells"
Article at:
http://femc.mtci.com.au/
Too bad Dr Mullan is busy growing RCPI, I would think he would fit into this agenda extremely well. But it does show quantum jumps in the research and interest of inflammation and it's connection with autoimmune dosorders, aging, and cancers.
"Health Basics: Processed 'vegetable' oils fuel inflammation and cancer"---interesting article we should all be aware of. Is this the reason for the rise in autoimmune disorders in our generation?
"In just 80 years, consumption of soybean oil increased a thousand-fold in the United States. When Monsanto figured this out, in came pesticide food for the masses. Using industrial chemicals and highly toxic solvents, most vegetable oils are processed until useless and sold as food. The omega-6 overload messes up the fatty acid composition of the body. Currently, most Americans' ratios of omega-6 to omega-3 is around 16 to 1. This ratio basically cripples your immune system, and Big Food and Big Pharma both know it. This is the number one reason why eating out at restaurants is bad news. The excess of these fatty acids sits in cell membranes and increases harmful oxidative reactions. Typical body fat stores of linoleic acid have increased three-fold in just a few decades."
Article at: http://www.naturalnews.com/044388_processed_vegetable_oils_canola_oil_inflammation.html#ixzz2wjZoQ5N4
Learn more: http://www.naturalnews.com/044388_processed_vegetable_oils_canola_oil_inflammation.html#ixzz2wjZVrJ2A
"Cancer and systemic inflammation: treat the tumour and treat the host" article in the British Journal of Cancer (2014) 110, 1409–1412
"Abstract
Measurement of the systemic inflammatory response Relationship between systemic inflammatory response, symptom clusters and survival Treatment of cancer-associated symptoms in patients with anti-inflammatory agents Conclusion References Figures and Tables
Determinants of cancer progression and survival are multifactorial and host responses are increasingly appreciated to have a major role. Indeed, the development and maintenance of a systemic inflammatory response has been consistently observed to confer poorer outcome, in both early and advanced stage disease. For patients, cancer-associated symptoms are of particular importance resulting in a marked impact on day-to-day quality of life and are also associated with poorer outcome. These symptoms are now recognised to cluster with one another with anorexia, weight loss and physical function forming a recognised cluster whereas fatigue, pain and depression forming another. Importantly, it has become apparent that these symptom clusters are associated with presence of a systemic inflammatory response in the patient with cancer. Given the understanding of the above, there is now a need to intervene to moderate systemic inflammatory responses, where present. In this context the rationale for therapeutic intervention using nonselective anti-inflammatory agents is clear and compelling and likely to become a part of routine clinical practice in the near future. The published literature on therapeutic intervention using anti-inflammatory agents for cancer-associated symptoms was reviewed. There are important parallels with the development of useful treatments for the systemic inflammatory response in patients with rheumatological disease and cardiovascular disease."
Article at:
http://www.nature.com/bjc/journal/v110/n6/full/bjc201490a.html
"Inflammation, Infection and Cancer"
Keystone Symposia held March 9—14, 2014 held in British Columbia.
"Summary of Meeting:
For many years, the presence of leukocytes in tumors had been thought to be a consequence of a failed attempt at cancer cell destruction. However, in the past decade it has emerged that tumors are not only effective in escaping from immune-mediated rejection, they also modify certain inflammatory cell types to render them tumor promoting rather than tumor suppressive. Indeed, inflammatory cells are an important component of the tumor microenvironment, and numerous clinical studies have established a positive correlation between inflammation and cancer progression. This conference will cover the latest research on the roles of inflammation and inflammatory cell subtypes on cancer initiation and progression. A special focus will be placed on emerging findings regarding the contributions of the host microbiome and infectious agents in eliciting an initial inflammatory response, and how that predisposes to specific types of cancer. Throughout the meeting there will be an emphasis placed not only on the mechanisms underlying the critical functions of infection and inflammation in cancers, but also on how to therapeutically target these processes in cancer. A critical component of this conference on “Inflammation, Infection and Cancer” will be the joint sessions held with the companion meeting on “Immune Evolution in Cancer”, emphasizing the latest results in understanding and therapeutically targeting the functions of different immune cells in the tumor microenvironment."
Some of the major subject focus presentation areas:
"Inflammation and Immunity in the Tumor Microenvironment (Joint)"
"Chronic Inflammation and Cancer "
"Inflammation as a Target and Modulator of Cancer Therapeutics "
Looks like more and more interest in chronic inflammation links and RCPI is positioned to take a lead.
Agenda at:
http://www.keystonesymposia.org/14X1
After thinking a bit about what Dr Mullan and Dr Chapman said in their webcast, it seems to me they have an enviable problem to solve. Most pharmaceutical companies focus on a specific drug for a specific disease. STSI has the problem of, which disease among the many potential diseases Anatabine solves, gives the biggest bang for the bucks with the least medical and financial risks. He already knows the tolerability and 'side-effect' issue are a slam dunk so he can focus the R&D on efficacy. Since the issue of teaming and/or licensing was not really discussed, this is the billion dollar question whose answer we should anticipate in the near future. I don't think it is lost on Dr Mullan that teaming with a strong financial partner is in the best interest of STSI, especially wherein he can team with an 'expert' company or license in that disease. He knows an agreement is in short order for him to proceed and be successful next year. Right off the bat, it would seem he would entertain teaming or licensing for Alzheimers, Thyroiditis, Multiple Sclerosis, Arthritis, and one or more Cancers or other Autoimmune disorders. Maybe a combination of both worlds. What do you think?
I saw and listened to the webcast and my take on the meeting:
STSI will soon use the symbol RCPI. The company is restructuring to become a pharmaceutical company. He said the company is working with the FDA to continue sales of the neutraceutical version. When asked about expanding sales beyond GNC, he said yes, as soon as the FDA approval to sell Anatabine as a neutraceutical is approved. Dr Mullan emphasized the successful results of both animal and human studies to date on Anatabine use to suppress inflammation. He talked about Alzheimers in great length and how inflammation was intimately connected with the development of Alzheimers. He said a defect in a person's genes (DNA) made some people more prone to Alzheimers and that Alzheimers develops over many years, ie over 30 years. He will present preliminary results of the testing done so far shortly. (why would they present results unless postiive?) He talked about Anatabine as applied to Thyroiditis and MS. (both successful). He said the company will apply for NDI status and start the research phase in the second quarter of 2014. He expects to see a phase 1, II, and III plan submitted to the FDA for approval. He sees Anatabine being developed for time-release because of it's short active half life. He did not see it being used as a IV. He went along with the idea of using Anatabine in water when brought up by a participant. He said that there were actually three versions of Anatabine being explored. Clearly, investors were worried about cash-flow and future funding scenerios and possible teaming possibilities. Dr Mullan and Dr Chapman said it is difficult to quantize at this time but things would be better to scope after the phase II completion, ie, my take is that funding could be a problem in 2015 if a teaming, joint venture, or additional investment funding isn't seen by that time. He did not say there were any ongoing discussions about teaming with a large pharmaceutical, nor did anyone ask. (I think this is common with most small biotech firms.) When the disease targets are selected and the research phase is completed, RCPI and we investors will know whether or not we have a winner or not. (I'm betting this company will be a winner,) Dr Mullan just couldn't say that in his position. Ask yourself: why would he stake his career and reputation unless he felt this wasn't going to be a winner? The comments above are only my comments on the discussion presented. Others may have interpreted otherwise.
"Statins may be useful in treating advanced multiple sclerosis (MS), say UK researchers.
Early trial results in The Lancet show the cholesterol-lowering pills slow brain shrinkage in people with MS."
"The researchers believe statins may have anti-inflammatory and neuroprotective properties that can guard the nerves from damage."
Article at:
http://www.bbc.com/news/health-26630025
Hmmmmm---isn't that what anatabine citrate does? Reduces inflammation!
Anavax, cancer, neuropathic pain---NEW YORK, Feb. 26, 2014 (GLOBE NEWSWIRE) -- Anavex Life Sciences Corp. ("Anavex" or the "Company") (OTCQB:AVXL) today announced that a research article in the current issue of peer-reviewed scientific journal Molecular Pain reveals a new opportunity for the Company's anti-cancer and neuropathic pain compounds. The article describes that sigma-1 receptor (S1R) modulation prevents neuropathic pain and mitochondrial abnormalities induced by the chemotherapy drug paclitaxel.
Paclitaxel is a first-line anti-tumor agent that frequently produces neuropathic pain, for which no treatment is available. The lifestyle of patients receiving paclitaxel can be severely impacted and the problem is compounded by the lack of efficacy and frequent incidence of side effects associated with currently available treatments for pain. There is an important therapeutic opportunity for drug candidates that simultaneously fight cancer and prevent pain. Research firm GlobalData estimates the global neuropathic pain market alone will reach $6.5 billion in 2015. This growth will be supported by the increase in the aging population.
"These recent findings validate our pipeline beyond the area of Alzheimer's and neurological diseases and expand Anavex's opportunity to address diseases with significant markets," said Christopher U. Missling, PhD, President and Chief Executive Officer of Anavex. "The unique synergistic mechanism of action of the sigma-1 receptor modulators support further investigation of our existing drug candidates involved in both cancer and neuropathic pain activity."
Article at:
http://online.wsj.com/article/PR-CO-20140226-907754.html
Also,----
"NEW YORK, March 19, 2014 (GLOBE NEWSWIRE) -- Anavex Life Sciences Corp. ("Anavex" or the "Company") (OTCQB:AVXL), a clinical stage biopharmaceutical company developing novel drug candidates to treat Alzheimer's, diseases of the central nervous system (CNS) and various types of cancer, announced today that it has closed, as previously announced on March 13, 2014, the private placement of $10 million in principal amount of convertible debentures with several institutional and accredited investors, including U.S. and international healthcare funds. In addition, the investors received warrants to purchase up to approximately 66.7 million shares of common stock in the aggregate.
The funds will be used to initiate a Phase 1b/2a clinical trial of ANAVEX PLUS and advance its product portfolio. ANAVEX PLUS is a promising, potentially novel combination drug for Alzheimer's disease that combines ANAVEX 2-73 with donepezil (Aricept®), the world's best-selling Alzheimer's drug. "
Article at:
http://www.globenewswire.com/news-release/2014/03/19/619478/10073221/en/Anavex-Successfully-Closes-10-Million-Financing-to-Initiate-Phase-1b-2a-Alzheimer-s-Clinical-Trial.html
"Caffeine Fuels Drive for Parkinson's, Alzheimer's Treatments" article from Newsmax:
"For clues to treatments for Parkinson’s and Alzheimer’s, scientists are looking at their morning cup of joe.
What they’ve found is that caffeine, the world’s most widely used drug, does more than wake people up. It’s been linked to improvements in memory and appears to protect against the destruction of brain cells. One study found that people who drank two or more cups of coffee a day had a 40 percent lower risk of developing Parkinson’s.
Emboldened by these findings, some companies have been designing drugs to replicate those benefits. The most advanced research has been in Parkinson’s. At least one drugmaker, Kyowa Hakko Kirin Co., won Japanese approval last year for such a product and then began U.S. tests. The challenge is to go beyond the buzz of a vanilla latte to achieve a more powerful effect on the brain -- without side effects like headaches, irritability and jitters."
Article at:
http://www.newsmaxhealth.com/Health-News/caffeine-Parkinsons-Alzheimers-treatment/2014/03/17/id/559926/?ns_mail_uid=29992204&ns_mail_job=1560421_03172014&promo_code=16D0D-1
Is it the caffeine or???
New post on STSI Yahoo Message Board by rcpnfkb1 :
Significant Cognition Improvement Reported for Roskamp Institute Sci-Brain Clients (were is this going is anatabloc involved?)
Significant Cognition Improvement Reported for Roskamp Institute Sci-Brain Clients
Scibrain Health's insight:
Sarasota, FL - - Dr. Michael Mullan, President/CEO of the Roskamp Institute, today announced a major development in the progress of Sci-Brain, its brain health program. 85% of clients, who have been re-evaluated thus far, have improved their Brain Reserve Index™ (BRI) score by an average of 50%. The BRI is Sci-Brain’s proprietary algorithm that measures “brain reserve” -- the number of neurons and connections that facilitate communication between neurons.
These links and their access to an abundance of neurons, provide the fundamental ability to preserve and improve cognitive functioning. The greater the reserve of these vital connections that individuals have, the better able they are to protect the brain from attacks such as stroke, head injuries and the clinical signs and symptoms of Alzheimer’s disease.
Significantly, more than 70% of the evaluated Sci-Brain clients now have BRI™ scores above 100, which is an indicator for reduced risk associated with Alzheimer's disease and related dementias.
Promising results in memory evaluation also were noted. On average, there was a 15% improvement in the composite score for verbal and visual memory.
We have identified a formula of actions that is driving the ‘needle’ in the right direction,” stated Dr. Mullan. “When dealing with a disease like Alzheimer’s, coming up with an integrated program that produces actual positive cognitive results – that’s big.”
Sci-Brain is designed to reduce risk factors associated with Alzheimer’s disease and related dementias by promoting and supporting lifestyle choices associated with improved cognitive functioning by building “brain reserve.” Clients are able to objectively monitor their results using Sci-Brain’s unique BRI measure.
The Sci-Brain program was under development for more than two years prior to its pilot phase, which was completed in March of 2013 Less
Low phospholipids biomarkers could predict Alzheimers...and is there a link to chronic inflammation?
"The latest study, which is published today in Nature Medicine, was led by neurologist Howard Federoff of Georgetown University Medical Center in Washington DC. He and his colleagues tested the participants' cognitive and memory skills, and took blood samples from them, around once a year for five years. They used mass spectrometry to analyse the blood plasma of 53 participants with mild cognitive impairment or Alzheimer’s disease, including 18 who developed symptoms during the study, and 53 who remained cognitively healthy. They found ten phospholipids that were present at consistently lower levels in the blood of most people who had, or went on to develop, cognitive impairment. The team validated the results in a set of 41 further participants."
Article at:
http://www.nature.com/news/biomarkers-could-predict-alzheimer-s-before-it-starts-1.14834
So is there a link between chronic inflammation and phospholipid levels?
"During inflammatory processes biologically active lipid oxidation products accumulate that modulate the inflammatory process and may determine the fate and outcome of the body's reaction in acute inflammation during host defense. Oxidized phospholipids may induce and propagate chronic inflammatory processes; however, evidence is accumulating that cells and tissues respond towards these oxidatively formed stress signals also by activation of anti-inflammatory, cytoprotective reactions."
Article at:
http://www.ncbi.nlm.nih.gov/pubmed/14501580
Take a look at an older post, especially the first link mentioned:
http://investorshub.advfn.com/boards/read_msg.aspx?message_id=81874537
Good info Nuke!!!
Per Wikipedia: "A Warning Letter is considered by the agency to be informal and advisory. While it communicates the agency's position on a matter it does not commit the FDA to taking enforcement action. For these reasons the FDA does not consider Warning Letters to be final actions on which it can be sued"
Article at: http://en.wikipedia.org/wiki/FDA_Warning_Letter
Interesting Cancer Information in email I received:
Cancer treatment is about making money. - provoking thoughts
I posted this article, which may have some provoking thoughts:
The below is absolutely 100% true and as a doctor I have been telling people this for 15 years now. No one wants to listen. Folks need to wake up. Cancer treatment is about making money. It is a 120 billion dollar a year industry in the United States alone and estimated to be a 600 billion dollar a year industry worldwide.
A successful cancer case according to the American Cancer Society and the American College of Oncology and Hematology means that the person survives for 5 years. Both the American Cancer Society and the American College of Oncology and Hematology admit that a person is likely to survive cancer for 7 to 10 years even if they do absolutely NOTHING. Of course, only the doctors get those magazines - not you, the cancer patient.
Alternative medicine's track record of curing cancer is 10 times higher than that of conventional medicine. Note that I say CURE.
Remember another thing. A TUMOR is just a symptom. It is not the cause of cancer.
Science is cause and effect. Remove the cause and the effect disappears.
I am in my third battle with cancer right now. I have not done any chemotherapy or radiation or surgery for any of my bouts with cancer. I survived leukemia, I survived Non Hodgkins Lymphoma and now I have Glioblastoma which is supposedly an incurable form of brain cancer. I was given two months to live 5 months ago.
I have been using Chinese herbs, high doses of vitamin C, acupuncture, chiropractic, homeopathy and nutritional changes. Yes, at first it got worse. It had metastasized to my lymph nodes, my lungs and my bones. As of this week, I am happy to say that there is no evidence now of any cancer in my lymph system or my bones. I had 6 tumors in my lungs, now there are only two. The tumors in my brain have shrunken tremendously. I never did any of their chemo, radiation or surgery.
Here is a very interesting statistic that you can only have access to by being a doctor. Every year more than 1,000 doctors oncologists (cancer doctors) are diagnosed with cancer. Less than 10% of them choose to do the treatment that they have been giving to their patients. Sort of like the fact that less than 25% of all pediatricians vaccinate their own children because of the fact that the risk of sudden death or serious side effects from the vaccination is higher than the risk of catching the disease one is being vaccinated for. This is not bullshit, people - it is truth.
Medicine is about money, not about your health and the system that traps people, especially the elderly, disabled and poor into a deadly treatment regime that puts them in an early grave. Meanwhile, all the jet set billionaires are flying off to Europe and paying big bucks for alternative treatments and getting cured.
Does alternative medicine work all the time? No. Of course not. Nothing works all the time. But there is a reason for that. You don't die until it's your time to die. Nothing can make you live longer than that time.
However quality of life comes into play. Those cancer patients who use alternative therapies for their cancer, yet still die from the illness, suffer a much higher quality of life. They die able to spend time with their families and even recognize their family members. They don't become emaciated like those who do chemotherapy or radiation do and rarely is a person who goes under the treatment of chemotherapy able to recognize anyone for the last few days of their lives. Their bodies become ravaged to the point that you can't even recognize them either. They suffer at a much much higher rate and they have one let down after another as doctors tell them, ahhh - it's looking good, only to tell them on the next visit it's looking worse, you need more chemo and radiation.
What is criminal about this is that YOUR DOCTORS KNOW THIS SHIT.
I took an oath as a physician. I have always followed it. That has certainly not made me successful financially as a doctor because I have consistently refused to go along with conventional medicine's bullshit.
Read the below carefully. It may indeed make a difference in your life.
Rick Cantrell, PhD, MD, PsyD
ALLELUJIA DR. CANTRELL, I AM 101% WITH YOU.
AFTER YEARS OF TELLING PEOPLE CHEMOTHERAPY IS THE ONLY WAY TO TRY ('TRY', BEING THE KEY WORD) TO ELIMINATE CANCER, JOHNS HOPKINS IS FINALLY STARTING TO TELL YOU THERE IS AN ALTERNATIVE WAY .
Cancer Update from Johns Hopkins :
1. Every person has cancer cells in the body. These cancer
cells do not show up in the standard tests until they have
multiplied to a few billion. When doctors tell cancer patients
that there are no more cancer cells in their bodies after
treatment, it just means the tests are unable to detect the
cancer cells because they have not reached the detectable
size.
2. Cancer cells occur between 6 to more than 10 times in a
person's lifetime.
3. When the person's immune system is strong, the cancer
cells will be destroyed and prevented from multiplying and
forming tumors.
4. When a person has cancer it indicates the person has
nutritional deficiencies. These could be due to genetic,
but also to environmental, food and lifestyle factors.
5. To overcome the multiple nutritional deficiencies, changing
diet to eat more adequately and healthy, 4-5 times/day
and by including supplements will strengthen the immune
system.
6. Chemotherapy involves poisoning the rapidly-growing
cancer cells and also destroys rapidly-growing healthy cells
in the bone marrow, gastrointestinal tract, etc., and can
cause organ damage, like liver, kidneys, heart, lungs, etc.
7. Radiation while destroying cancer cells also burns, scars
and damages healthy cells, tissues and organs.
8. Initial treatment with chemotherapy and radiation will often
reduce tumor size. However prolonged use of
chemotherapy and radiation do not result in more tumor
destruction.
9. When the body has too much toxic burden from
chemotherapy and radiation, the immune system is either
compromised or destroyed; hence the person can succumb
to various kinds of infections and complications.
10. Chemotherapy and radiation can cause cancer cells to
mutate and become resistant and difficult to destroy.
Surgery can also cause cancer cells to spread to other
sites.
11. An effective way to battle cancer is to starve the cancer
cells by not feeding it with the foods it needs to multiply.
*CANCER CELLS FEED ON:-
a. Sugar substitutes like NutraSweet, Equal, Spoonful, etc. which are made with Aspartame and it is harmful. A better natural
substitute would be Manuka honey or molasses, but only in
very small amounts. Table salt has a chemical added to make
it white in color. Better alternative is Bragg's aminos or sea
salt.
B. Milk causes the body to produce mucus, especially in the
gastro-intestinal tract. Cancer feeds on mucus. By cutting
off milk and substituting with unsweetened soy milk, cancer
cells are being starved.
c. Cancer cells thrive in an acid environment. A meat-based
diet is acidic and it is best to eat fish, and a little other
meat, like chicken. Meat also contains livestock
antibiotics, growth hormones and parasites, which are all
harmful, especially to people with cancer.
d. A diet made of 80% fresh vegetables and juice, whole
grains, seeds, nuts and a little fruit helps put the body into
an alkaline environment. About 20% can be from cooked
food including beans. Fresh vegetable juices provide live
enzymes that are easily absorbed and reach down to
cellular levels within 15 minutes to nourish and enhance
growth of healthy cells. To obtain live enzymes for building
healthy cells, try and drink fresh vegetable juice (most
vegetables including bean sprouts) and eat some raw
vegetables 2 or 3 times a day. Enzymes are destroyed at
temperatures of 104 degrees F. (40 degrees C.).
e. Avoid coffee, tea, and chocolate, which have high
caffeine. Green tea is a better alternative and has cancer
fighting properties. Water - best to drink purified water, or
filtered, to avoid known toxins and heavy metals in tap
water. Distilled water is acidic, avoid it.
12. Meat protein is difficult to digest and requires a lot of
digestive enzymes. Undigested meat remaining in the
intestines becomes putrefied and leads to more toxic
buildup.
13. Cancer cell walls have a tough protein covering. By refraining from or eating less meat, it frees more
enzymes to attack the protein walls of cancer cells and
allows the body's killer cells to destroy the cancer cells.
14. Some supplements build up the immune system
(IP6, Flor-ssence, Essiac, anti-oxidants, vitamins, minerals,
EFAs etc.) to enable the bodies own killer cells to destroy
cancer cells. Other supplements like vitamin E are known
to cause apoptosis, or programmed cell death, the body's
normal method of disposing of damaged, unwanted, or
unneeded cells.
15. Cancer is a disease of the mind, body, and spirit.
A proactive and positive spirit will help the cancer warrior
be a survivor. Anger, un-forgiveness and bitterness put
the body into a stressful and acidic environment. Learn to
have a loving and forgiving spirit. Learn to relax and enjoy
life.
16. Cancer cells cannot thrive in an oxygenated environment.
Exercising daily, and deep breathing help to get more
oxygen down to the cellular level. Oxygen therapy is
another means employed to destroy cancer cells.
1. No plastic containers in microwave.
2. No water bottles in freezer.
3. No plastic wrap in microwave.
Johns Hopkins has recently sent this out in its newsletters. This information is being circulated at Walter Reed Army Medical Center as well. Dioxin chemicals cause cancer, especially breast cancer. Dioxins are highly poisonous to the cells of our bodies. Don't freeze your plastic bottles with water in them as this releases dioxins from the plastic. Recently, Dr Edward Fujimoto, Wellness Program Manager at Castle Hospital , was on a TV program to explain this health hazard. He talked about dioxins and how bad they are for us. He said that we should not be heating our food in the microwave using plastic containers. This especially applies to foods that contain fat. He said that the combination of fat, high heat, and plastics releases dioxin into the food and ultimately into the cells of the body. Instead, he recommends using glass, such as Corning Ware, Pyrex or ceramic c
Re STSI Warning Letter from FDA. 2013 listing of letters from FDA shows over 600 letters issued. STSI letter on first page (late December)
Link at: http://www.fda.gov/ICECI/EnforcementActions/WarningLetters/2013/ucm20035841.htm?Page=1
"NIH, drugmakers, foundations partner to find meds'in Yahoo AP release.
Excerpt: "The partnership will start with three- to five-year pilot projects on Alzheimer's disease, type 2 diabetes and the autoimmune disorders rheumatoid arthritis and lupus. It could later expand into other diseases.
"Currently, we are investing a great deal of money and time in avenues with high failure rates, while patients and their families wait," NIH Director Dr. Francis S. Collins said in a statement. "All sectors of the biomedical enterprise agree that new approaches are sorely needed."
Article at:
http://finance.yahoo.com/news/nih-drugmakers-foundations-partner-meds-171547549--finance.html
Vitamins and dietary supplements are a waste of money? Wait a minute, isn't Vitamin D a vitamin?
"Vitamin D could slow multiple sclerosis"
Article at:
http://news.xinhuanet.com/english/health/2014-01/21/c_133060667.htm
Excerpt:
"Patients in the early stages of multiple sclerosis (MS) could "stave off disease symptoms" by increasing their vitamin D intake, U.S. researchers said Monday."------"The World Health Organization estimated that roughly 2.5 million people in the world have the disease."------"The results suggest that vitamin D has a strong protective effect on the disease process underlying MS, and underscore the importance of correcting vitamin D insufficiency, which is widespread in Europe and the U.S., the researchers said."
"Injected microparticles shown to greatly reduce heart attack damage"
Article at:
http://www.gizmag.com/microparticles-heart-attack-inflammation/30506/?utm_source=Gizmag+Subscribers&utm_campaign=c1c63f836f-UA-2235360-4&utm_medium=email&utm_term=0_65b67362bd-c1c63f836f-76708937
Excerpt:
"When injected into the bloodstream within 24 hours of a heart attack, the negatively-charged microparticles attract the positively-charged monocytes, as they're on their way to the heart. When one of the monocytes bonds to a particle, a signal within the cell is triggered, telling it that it's dying. This causes it to change course and head for the spleen, the organ that disposes of dead cells.
As a result, inflammation of the heart is minimized. In animal models, this caused a 50 percent reduction in the size of heart lesions.
Lab tests have indicated that the microparticles could be also used to treat a number of other inflammatory diseases, such as West Nile virus, colitis, inflammatory bowel disease, multiple sclerosis, and peritonitis.
The particles are now being commercially developed by biotech start-up Cour Pharmaceutical Development Company, with clinical trials on heart attack victims hoped to begin with two years. A paper on the research was published this week in the journal Science Translational Medicine."
Possible business model? Email from Stock Gumshoe, excerpt:
"Ligand Pharmaceuticals (LGND) - Hold or buy little nibbles, hope for pullbacks to mid-$50s.
This is a stock I've had to continuously re-evaluate because it's growing so very fast, just about doubling in the six months since we covered it and I bought shares. I did sell covered calls against the stock when it was heating up very fast in November or December and reinvest the proceeds from those covered calls, and do a bit of nibbling along the way, but otherwise I've just been watching and wishing it would dip more substantially. It's tough to buy in the mid-$60s if you remember it being in the $20s and $30s, but the past doesn't help us on that front - is the price justifiable today?
The numbers are ridiculous - it's trading at well over 100X trailing earnings, with a forward PE of about 50 based on expected 2014 earnings. Revenues doubled in the last quarter,and they've blown out analyst earnings estimates by 70%, 40%, and 70% in the last three quarters, but they're also trading at almost 30X sales. Ligand is a royalty company in the pharmaceuticals space, with a combination of drugs they developed and drugs they've bought in and drugs that are being developed based on their Captisol delivery platform, which bring in royalties and material sales revenue. Their goal is to have a large number of compounds in development (they call them "shots on goal") and not to pay for the development themselves, so a partner like GlaxoSmithKline or Pfizer partners in with them, runs and pays for the clinical trials, and Ligand earns milestone payments as drugs pass various checkpoints, then a royalty based on the sales of the drug if and when it's approved.
This is a relatively new business model for them, they used to be a money-blowing biotech like so many others but are now very, very focused on costs and distributing risks. Margins are extraordinarily high for a pharmaceutical company, which is what you would expect for a firm with only 20 or so employees that outsources most of their development - so over the last two years, since 2011, the gross profit has climbed about 50% but the operating expenses (SG&A and R&D) have remained pretty flat, that gives some confidence that the leverage we expect from this kind of firm will really emerge with climbing revenues from their emerging drug royalties.
The key reason LGND's price has risen so dramatically in the last few months? Well, other than the fact that the biotech sector in general is on a tear and arguably in a bit of a bubble I think a lot of that movement can be attributed to this sentence from their investor day back in November: "Ligand projects a compound annual growth rate in adjusted net income of at least 85% for the next three years."