Rock Creek Pharmaceuticals Inc. (fka RCPIQ)

[Buddhahead]

Low phospholipids biomarkers could predict Alzheimers...and is there a link to chronic inflammation?

"The latest study, which is published today in Nature Medicine, was led by neurologist Howard Federoff of Georgetown University Medical Center in Washington DC. He and his colleagues tested the participants' cognitive and memory skills, and took blood samples from them, around once a year for five years. They used mass spectrometry to analyse the blood plasma of 53 participants with mild cognitive impairment or Alzheimer’s disease, including 18 who developed symptoms during the study, and 53 who remained cognitively healthy. They found ten phospholipids that were present at consistently lower levels in the blood of most people who had, or went on to develop, cognitive impairment. The team validated the results in a set of 41 further participants."

Article at:
http://www.nature.com/news/biomarkers-could-predict-alzheimer-s-before-it-starts-1.14834

So is there a link between chronic inflammation and phospholipid levels?

"During inflammatory processes biologically active lipid oxidation products accumulate that modulate the inflammatory process and may determine the fate and outcome of the body's reaction in acute inflammation during host defense. Oxidized phospholipids may induce and propagate chronic inflammatory processes; however, evidence is accumulating that cells and tissues respond towards these oxidatively formed stress signals also by activation of anti-inflammatory, cytoprotective reactions."

Article at:
http://www.ncbi.nlm.nih.gov/pubmed/14501580