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shouldn't you be out making sales calls instead of SO on your computer?
The best evidence that what I'm trying to educate you on are the following:
1) The analysts and investors response was a yawn. Look it up.
2) The PI highlighted 'walking distance / delay to amputations' - Do you really think these are the endpoints that PSTI hopes to crush?!?! Looks to me like grasping for straws.
Just sound out the big words and then google them
Ariad Alum
Abu the problem is for so long the market came to same reading
What bothers me is the lack of transparency throughout.
Tell tale sign this is a POS
Actually, these endpoints are weak from a reimbursement standpoint.
The type of results that it will take to get from fast track to expedited review need to look like 1) Reductions in amputations - patients requiring no longer requiring 2) Patients coming off of disability and returning to work 3) Revascularization via angiogenesis, verifiable through imaging, etc.
And think about it... Truth be told,
This indication, at the time of trial design was PSTI's highest opportunity of success. Higher than any other possible indications based on the MOA (mechanism of action) - mesenchymal stem cell activity, healing and regenerating - the 'promise' of stem cell treatment. CLI has the Highest chance of success for this MOA to demonstrate its most statistically significant effects. Literally, angiogenesis and vasculogenesis … growing new tissue, vessels, capillaries, in essence, re-birthing tissues, vasculature and limbs.
Hi Mikems, think big! Let's say Pluristem will have a market for the combination of CLI and ARS of about 2-3 billion dollars (I believe the statin market is about 10 billion, given the prevalence of PAD, I think I'm in the right ballpark), with that sort of income the MC of Pluristem should be in the 12 billion range. Even if we sell early, we should be thinking in the multi-billion range.
My fellow Ariad alumni can tell you that Ariad was bought for about 4 billion dollars, for one small molecule drug with a patient population that is a small fraction of CLI. Also note that PLX cell technology is a platform, many indications besides CLI and ARS and muscle regen. after hip surgery coming online. If Pluristem gets just a reasonable part of the regen. medicine market, we have an unimaginable growth potential.
Best Regards,
zzaatt.
Hi Saud, thanks for the very interesting link! The article nicely reiterates what we know and hope for Pluristem.
I like Dr.Weiss's comment below, I hope he was choosing his words carefully! The number of patients is quite staggering. If the study results are just statistically significant (I'm hoping for better, given that patients were able to walk 83% farther, and no revasc surgeries at all, looks like a real major therapy), the company will take off like a rocket.
Pluristem’s recent study results are highly encouraging and suggest that PLX-PAD cells may be the answer for both PAD patients and physicians seeking effective medical solutions,” says Professor Norbert Weiss, M.D., Director of the Vascular Center at the Technical University of Dresden, and the lead principal investigator for the European part of the study.
How do you know? How are they better than Neoantigen, Affirmed, Gritstone, and whatever may be cooking up in BP labs?
No evidence at all that ADXS is just as good. Wall Street doesnt think so.
BP partners dont think so.
Why do we NOT have a contract for R-18, for as you say, a perfectly good delivery device, 'vial & syringe' right now?
The speed at which technology and science are moving, new innovative approaches to battle cancer and other diseases are being developed.
There is a very good chance that we missed our chance.
I had tea and biscuits with the whole gang at ADXS
Good times ahead?
I will say a day trade opportunity could soon arise.
Look at the share price.
All you have left is a lot of "hope".
It's dead.
'SKTrader1' wants to sell you some wonderful Florida real-estate! Anyone buying?
I plan to re-enter I just don’t see real indicators to tell me now would be the time. Haven’t been convinced otherwise. Sorry if that doesn’t make you happy.
Fantastic find! Thank you!
Only plans and then badly executed. Stock is dead and money goes for salaries.
A lot of "guessing" and bad logic, then, the inevitable BAD NEWS!
logistical 'in-theatre' issue for over a year now... and was likely the reason there is NO contract with the DOD.
Pass the waffles.
Stick to your theory and post again to prove it.
What you don't know is that he needs to post it twice to make his point.
I would not put any penny in this equity until I see a sea of change in the management style.
Some have been saying it's idiocy to sell at a 90% loss. REALLY?? I sold at an 80% loss at 1.05, so I can buy back in today and increase my position by 20%. So someone please explain to me how that's idiocy.
I also believe a rs at this point is inevitable
I think it’s too dismissive to say the stock price is not an accurate reflection of the current state of affairs.
Even if you are bullish I don’t understand why stay in.
The market has decided adxs value. Buying more without news is asking for a loss.
This is the classic retail/amateur investor mistake. Sell your winners before they reach their potential and miss out on big gains, while holding your losers while they stagnate or until they go bankrupt.
I'm wondering, is today continued reaction to the new offering, or is it more of a negative reaction to the earnings release?
Our Money is Slipping Away- Can't Stop it! OMG!
There's nothing anyone can do about it.
With all the indicators so far, it's obvious that ADXS is now at the beginning of Death Spiral Financing process which will eventually wipe out all your investment within a year or twos.
Nobody knows ADXS better than long time investors
It is proportional to the quality of pps, governed by the constant...
When Ken knows that the company still had 40 million dollars, would he go ahead with the latest offering unless he knew that there is no money coming in the next few months that would take care of 'going concern' issues?
They have kicked the can down the calendar for another 6 months
What do we see first; A cash deal, or a new share authorization request?
Reverse split is the death stroke to all legacy holders.
After all everyone here agrees that curing cancer is noble and bigger than losing money.
Zzzalt/blue/etal......my advice is per what the market saying and what logic says
They need patients, not patents. Running out of patience. What are the portents?
Feel fortunate you can get near 1$ a share and relieve yourself of this burden.
The science isn’t good enough or not repeatable.
wow...
you are truly delusional at this point. Enterprise value lost for an unrelated death? Oh, my.