Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
we are in quiet period I would think with Registration being effective..
i think longs are basing and evaluating the company's progress and future on share price..
The company's value based on milestones is a over $500,000,000 or over $10/pps..(HUman Trials in Phase 2 for Multi-Billion Inidcation)
The company's future will be announcing success in Parkinsons Animal Model through Michael j Fox foundation..FACT!
What the heck else do you want..The FDA is designing Pahse 2/3 afor Alazhiemers.
we are close on Rett's
and we got an annual Annual Multi-Billion Brass Ring in Insomnia.
Short Cabal has more money..we are over sold..
we can get more over sold or gutless longs to can get greedy based on the above..
Thanks BA
-P2 for Insomnia
-P2 for some form of Epilepsy
-P2 for some form of Autism
-P2 for some form of Schlerosis
-P2 for some form of Mental Axiety
- Licensing $$ for Area of World(Japan-China)
-P2 for some form of Depression
I feel pretty old..
i think the old timers are tired of marshalling the great science only to
have the Shrot Cabal lie and distort the truth.
Us Old Timers who believe Anavex is already worth BBBBIllions..are
just waiting for the depressive thieves to get ransacked by the
truth of Anavex and it's efficacy and Great management.
What else really is there to say? We know we have PK, we know we have Safety..we Know we have multiple IND's that all have Anual Markets in the BILLIONS..
Until the Big Boys shoo away the leaches of hate..you just gotta wait.
nice story..
yes..you should sell and move on to another stock that will go straight up!
The possible announcement by the Michael J Fox Foundation of success at the World Parkinsons Conference in less than a month away, will probably be seen as a negative as well(tongue in cheek) ..especially when they announce a fully funded PHase 2/3 for Parkinsons..while Anavex has all the Funds they need to Fully Fund an FDA designed and approved Phase 2/3 for Alzheimers..
And Rett Syndrome announces their Fully Funded Phase 2/3..
and..since we have such a tremendous safety profile..
Some "Insomnia Institute" of the Universe may announces, or maybe Depression or maybe Epilepsy or maybe Anxiety or MS or maybe Autism/Fragile X.. a Phase 2/3 for better sleep et all the other possibel positive results of A2-73....Any Volunteers?
Man this stock..is really gonna..... when it has 30 Million in cash and 3-4 Phase 2/3 Clinicals going on for Annual Multi-Billion Dollar Markets that Hundreds of Millions of People Suffer from all over the World everyday..
JUST GOING TO --------
To keep it simple ,,in less than a month..
at the World Parkinson's Conference, a
TEAM of great and good Doctors that work with
the MIchael J. Fox Foundation,
will expand on these statements:
"
). Ongoing experiments on mice sustaining 6-
OHDA lesions show trends towards an amelioration of parkinsonian
motor symptoms in tests assessing spontaneous rotational activity
and forelimb use asymmetry.
Significance:
If successful, this study will accelerate the clinical
development of ANAVEX 2-73 as a potential disease-modifying
therapy for PD. We are in the fortunate situation that safety,
bioavailability, tolerability of this compound have already been
proven in human subjects, and that preliminary indications of a
cognitive benefit have been obtained in a Phase 2a clinical trial for
Alzheimer’s disease (ANAVEX)"
Page 85 of Abstract at World Parkinson Conference should give rise to a Phase 2 Announcement. Sept 20..
Anavex is not worried about funding the Phase 2/3 for Alzheimers..
We should not be worried about this either..
I am looking for a 1,2 3 Combo
with Rett SYndrome Phase 2/3 Announcement,
Alzheimers Phase 2/3 Announcement
The Go Ahead for Phase 2 for Parkinsons with Michael Ju FOx FOundation..
as the final piece..so when the Short Cabal attacks..
the last news from the Compnay will be from the Michael J Fox foundation.
lets see Shrkeili talk smack against curing Parkinsons by MJF ..
exactly Sokol.
Longs have lost sight of just how well our Company has performed in
every phase except..except stopping the Short Cabal..
There i sNO STOPPING the Short Cabal because it is Diametrically opposed to
Anavex's goal..The Short Cabal is not betting against Anavex..
The SHort Cabal is Investing FOR ANAVEX TO FAIL..
They are trying to delay Anavex until THEY come up witha SIMILAR COMPOUND..
Duh
there is a Big Difference..
great post sokol..
the Short Cabal is wicked..
Let's see them trash the Michael J Fox Foundation over "Mouse" Studies..
the pooled data for ADCS-ADL is tough to read..not that it was bad..
it's that you can't tell anything from it..you have to believe what they say when they say no decline..they see data from ALL Patients..
there could have been 1 or 2 Patients that had a more viral AD and destroyed the Dataset..
You just can not tell on the Efficacy side with pooled data..
Unless of Course it is like the line for pooled data from the
MONOTHERAPY GROUP of MMSE from 17 Weeks to 31 Weeks that goes
up 20% 4 MONTHS into the Studyt..That might give you a clue..
But honestly..the Short Cabal is Well Funded to DELAY and DESTROY Anavex..
The Short Cabal can Spend HUNDREDS OF MILLIONS OF DOLLOARS pooled from Market Makers, Big Pharma, Hedge Funds , Attorneys, Investment Guru Groups,
and the sons of _________ and making people die. They will pay before the Creator with their balckened hearts..I pray for them..
July 22 was approx end of 38 week based on 5 week release and notification.
all data is collected in real time at site..Data could be released anytime..
if it's not the greatest they could release it before the michael j fox positive WPC abstract data is released..and then do 53 week in Dec..
i think the chart reflects the typical 99% FAIL rate for Alzheimers..
ONLY we have ALREADY succeeded with SAFETY and IMO EFFICACY.
I DO NOT GET THIS PRICE other than SHORT CABAL MANIPULATION..
Are Longs really worried that 38 Weeks won't be MIRACULOUS?
Why? Insomnia is at least TWICE the Market of AD, Parkinsons..Depression,
Just Crazy..
its the michael j fox foundation! of course there will pbe phasd 2 and teh MJF will probably pay for it..it's only 5 weeks..the daTA AND STUDY WILL BASICALLY BE DONE BY THE time WPC happens..
I am at a loss for words..
CREDIBILITY..wow longs..i know we have been beat down..but WOW
is the favroabel Parkinsons News REALLY priced into this stock?
I don't think so..not even close..
The Michael J Fox Foundation..man some weak kneed longs..
buckle in..
until ..bam..3-71 in Human Safety Trials..
then..you know..Shrkeili can call in his friends ..
FAIL and that is too bad..
even if jerky people are running the show..it's always nice to find hope..
they offer nothing..we need a better way..
Phase 2/3 Trial Design/Enrollment Announcements
coming soon for:
ALzheimers
Parkinson
OPEN Trial for Insomnia (wouldn't that be fun!)
Phase 2 Design Announcements coming soon for
Rett Syndrome
Epilepsy?
MS?
Fragile X/Autism
Infantile Spasm?
So many IND's ..so little time!
very Exciting!
basparks..
based on two previous Rett Syndrome Orphan Drug developments, it looks like the process will take longer.
Orpahn Drug waas granted to Neuren in May of 2015..
Neuren began enrollmwnt of Phase 2(safety)about 1 year later..
I think they are currently enrolling for Phase 3 ..11 Week Trial..
Topline results next year..
So 2 Years from ODD..
2 Trials run and completed..
May of 2016..
We would be looking at 2018 for Topline results..
The time between Desgnation and Trial Design for Rett Syndrom
appears to be 3 Montrhs for NEWRON and 6 months for NERUEN..
SO..the GOOD NEWS is..
Sometime between now and Novemeber..We should hear some
POSITIVE RETT Syndrome Announcement!..
N
eworn Received Orphand Drug Designation in July of 2015,
Approval to Test in April of 2016
and Trial Enrollment . July of 2016..
Newron received Orpahn Drug Status in July of 2015 and
3 Months later Announced Pivotal Trial..
MAY, JUNE , JULY/August
So, the good News, probably within 2 months we will get TRIAL DESIGN..
Let the excitement begin!
Phase 2/3 for ALzheimers is in the works and that fact has already been mentioned wit the goal of beginning taking Trial Participants in 1Q of 2017.
People are not brain dead, and understand that a lower risk profile for a durg , A2-73(Sigma 1 agonist and Muscarinic) is going to come to market sooner than a Brain Hormone Injection!
It is going to be happen becasue the risk reward is so high..
Low Risk..as established by two human trials..and decades, millions of very similar drugs consumed..
High Return based on Paintings and Recitals and testimony and tests..
Again..I demand Anavex be allowed into Public Availability NOW!
I am nobody..but a bunch of Nobodies..are going to be heard ..
Loud and Clear!
Amateur do you KNOW that? Have you researched it?
How long have past Trials taken for Rett Syndrome to be filled?
I will go look at their past trials and report..
My hypothesis(guess)is that you are 100% wrong.
For Sarizotan..
Oct.28 2015..Announce/
May of 2016 IND/Orphan Fall Trial
July 2016 Begin Recruiting for 24 Week Study-Expect Topline 2017(don't say when in 2017)
I assume(danger) Trial still recruiting.
For NEU 2566 Neuren/
Trial Still Recruiting(Rett Syndrome)
6-16 Start study
Done Recruiting by end of 2016
Study Timeline and Current Progress
? 11 week study with 8 study visits
? Target Enrollment: 64
? Target Completion: Q4 2016
? Planned Study Sites: 12
? Enrolling Study Sites:
? University of Alabama, Birmingham
BRAIN GROWTH HORMONE
SO after reviewing Data..on length of time Rett Syndrome takes..
Anavex Feb-2016 Rett Syndrome Mouse Models Positive
June -2016 Orphan Drug Desgination for Rett
aNNOUNCE tRIAL: __/__
Fill Trial/tRIAL bEGINS __/__
TopLine Results __/__
Even with Anavex
s safety PRofile, Rett Syndrome is dealting with Children and longer term use..Safety for everyone sake and MTD need to redetermined to some extent..indeed..and after reviewng previous Rett Syndrom projects..
End of 2017 would be much more likely than beginning..It looks like I am wrong on rett Syndrome pushing the A2-73 Envelope in 4th Quarter 2016 or 1st Quarter of 2017 .
Maybe it will be Parkinsons Phase 2/3?
Or even an Insomnai Phase 2?
I still believe A2-73 will be available sooner rather than later..
and later is Fall of 2017..
wrong:
the ONLY data that really MATTERS is SAFETY: PERIOD!
The Efficacy Data is Pooled and you can tell very little..
ACCEPT..You can tell that the POOLED Data is BETTER than
BASELINE Alzheimers..Regardless of your stance on Data..
A2-73 is 100% better than Nothing!
The adaptive Phase 2s is designed to find MTD: Check 50 Mg, PK , check seen at 3Mg but 14 mg, more noticeable.
Look there are lots of Sigma 1 Agonists..but nothing like this.nothin!
All the positives are BILLION DOLLAR GRAVIES, not YEARS AWAY, but MONTHS,
because with A2-73 SAFETY profile and ALL the ANECDOTAL BENNIES,
the SECOND A2-73 becomes available for ANYTHING..
and I meand ANYTHING..CONSUMERS are going to BLOCKBUSTER
this Drug into the STRATOSPHERE..
Parkinson's, Depression, Insomnia, Alzheimrs delay..anti-convulsive,
Sigma 1 bennies not yet accounted for ..but..I believe Eyesight and heart issues will definitely come into play..
Any single ONE of these IND's makes AVXL a Multi-Billion Dollar Cash WOnderDrug..
But Anavex will just keep adding Multi-Billion Dollar IND's like
Country Sausage White Gray over Butter Milk Biscuits..The Good News will just keep coming IND after IND.
No one is waiting years..FDA will have A2-73 approval sooner than you think! Powerful People need drugs to brother..Powerful people don't want to die of Parkinsons or Alzheimers..You think THEY won't make FDA get them A2-73?
We will have A2-73 available by end of 1st Quarter of 2017!
Maybe even by end of THIS YEAR.
IF and that is a big IF, A2-73 keeps it's safety profile clean, squeaky,
and no additional side effects of any note are found..
A2-73 may be available because of and BY PUBLIC DEMAND even sooner in some countries..say in
Australia...A Painting or a Song speaks to people in a very basic language. LIFE is GOOD!
you are thinking of Computer models..
previous study referred to: https://www.researchgate.net/publication/261800638_Pharmacological_stimulation_of_sigma-1_receptors_has_neurorestorative_effects_in_experimental_parkinsonism
some additional Billion dollar Gravy:
Sigma-1 receptor ligand PRE-084 reduced infarct volume, neurological deficits, pro-inflammatory cytokines and enhanced anti-inflammatory cytokines after embolic stroke in rats
about pre-084, if anyone has updated info(I am slow) please share..
5 weeks..very, very exciting!
Seeing this valuation..
I keep thinking the bad guys know something I don't..
Maybe they know the PK preliminary trial failed..
from this report, there is no way A2-73 does not go into Human Trials
as the Safety profile will kindly allow for A2-73 in ANY TRIAL!
Maybe they know the 9 month Data shows a downturn in Patients with
ALzheimers? Maybe there is a downturn, it's Alzheiemrs, it's degenerative,
We need to get to Alzheimer's EARLY and use a combination Drug Therapy LATE. Apparently Aricept is not helping with new drug trials..
It looks like People are going to have to make some tough , tough decisions regarding Mono-Therapy with A2-73.
Ladies and Gentleman, if the Safety Profile continues to show the same risk level as taking a sugar pill, then the NeuroProtective Positives of activating the Sigma 1 Ligand co-committant with a muscarinic(Anavex's Muscarinic) is an absolute Blockbuster.
Why we are priced here, is not because the bad people know something we don't ..We are here because the bad people have more money than us and Stock Markets were NEVER DESIGNED to allow BAD PEOPLE to WIN..
Stock Markets were designed to ALLOW GOOD PEOPLE TO WIN..
Let us have faith. Let us pray. Let us demand of the Stock Market
that for which it is designed, for good ideas to flourish.
Anavex is a good idea whose time has come..AnavexNOW!
wow. promising is beautiful word
wow ..I am sorry ..and I didn't spend a lot of time researching the company's involved..but at first glance..not what one would call very promising, anytime soon..
It was gracious of miss Australia to ever share her and her family's struggles. God Bless. She could get back on and talk about the sun shining in Singapore..or wherever she travels..At this point she is one of us..
Loving all the ancedotal bennies..
Wonder if Vision has been a Sigma 1 Ligand that A2-73 has
caused to come out and play?
anytime you start blocking things..instead of AIDING NATURAL FUNCTION..you are going to cause problems..
You should do both..Larger Trial with Efficacy focus.. but
I don't disagree as HAM D was initially taken as just a Base and then added to the Regular Testing after so many Positive Effects were related by Patients and Caregivers.
Do you see separate testing altogether for Insomnia?
Insomnia is a Major Cause/SIGN of Multiple diseases and deserves it's own
Data altogether. You would fill an Insomniac Patient Phase 2 in about 3 days wherever you had it. Who doesn't have trouble sleeping!
It would not hurt the Market Place to know the depth of
Sleeping Comfort that A2-73 brings to patients.
What percentage of Insomniac Population showed relief would be my big question? That 8 Point reduction..was that 4 patients at 2 pts off of 20 patients that had insomnia issues.. or was it 1 point from 8 Patients that showed 4 points of insomnia issues..
And in the overall scheme, do any of the ACDS-DL questions refer to sleep and were those scores generally improved?
With Anavex's Safety Profile..and Alzheimers having a 99% FAIL Rate..
An expansion of the IND into a Daily and More Common health Isuue, could reduce the cost of Future Capital dramatically as it could reduce the risk factor of success.
A Non-Addictive, Non-Narcotic, Non-Drowsy SLEEP AID you take once a day.
BLOCKBUSTER
The 1 Point reduction in SEM probably refers to an average of 1 Point improvement on the HAM D score. 3 Points is considered clinically significant. BUT..That is for a Depressed Population..I believe Anavex would have been purposefully avoiding a high HAM D score population to begin with..so an SEM of 1 Point is probably great. I could use some help here DOCS..
Still working on understanding importance of HAM D test results..
So the 8 Point reduction for Insomnia is shown as a 29% effect..
I think this means that the Overall Score for Insomnia for ALL Patients was
29..What we don't know is ..how many Patients were effected by insomnia to score 29! Was it 1 point per person. 9 Patients scoring 3 points each..
The reason this is important is..how many people experiencing Insomnia did A2-73 effect?
If, of the 30 Patients(rounded) assume 15(half) had a sleep issue of 2..
then you are looking at a reduction for those 15 patieints by an average of
1/2 point or 25% Improvement. Pooled Data is hard.
We need to shake some more HAM D data loose from IR.
Improved Sleep may be one of the keys to slowing the progression of Dementia and AD..BLOCKBUSTER
HAM D Test for Depression was probably given at beginning of test
to excludedepressed patients, but also as a safety guage if patients
began acting or feeling psychotic. It was a fallback for safety.
Somewhere the additional observances from Staff and Patients made Anavex
review the HAM D in a different more Effical(is that a word?) Light!
And oh what a light that is..unfortunately..I am not able to share with you
how bright this HAM D light shines as..
We have no starting points other than what you see from AAIC which shows a tremendous % Gap Down in score(33% or MORE) indicating some real healthy positives.
Howver, the data is pooled and I simply don't know how the scoring starts, so when Anavex says an 8 POINT improvement to Insomnia..8 Points from WHERE? Was the Original Insomnia score 30 Points or 50 Points or 20 Points? 29% of Patient Population improved..was that 29% of Patient Population that Marked having an Insomnia Isuue? Or 29% of Patients in Total? If int' 29% of those patients that HAD INSOMNIA Isuues that is great!..BUT if it's 100% of ALL INSOMNIATIC Patients noticed a Point or more improvemnt in their sypmptons that THAT IS A HOMERUN!
I Just Don't know..It would be nice if Anavex released more Raw Date on everything. The "Billion Dollar Gravy" just keeps getting richer and thicker!
If you have insights into the HAM D scoring ..please share..
Thought everyone might like this..
RESULTS
Demographic characteristic are summarized in Table 2. The two groups did not differ in age, sex, Mini-Mental State Examination (MMSE) score at baseline, and apolipoprotein E e4 (ApoE4) status but were different in education. Presence or absence of insomnia was significantly associated with AD (odds ratio (OR) = 2.39, 95% confidence interval (CI) = 1.03–5.55). Depression did not confound the association, as excluding patients with depression increased the relationship (OR = 3.32, 95% CI = 1.33–8.28). Normal-AD patients with insomnia showed a faster progression to dementia (chi-square = 3.94, P = .047).
BLOCKBUSTER
so..I know it is hard to believe,,but
the Short Cabal which includes Hedge Funds, Market Makers, Well place media sources(Shrkeili) , Attorneys at the beck and call, Investment Advisory services..When you add them all together with Big Pharma that has NO INTERSET in Anavex and EVERY INTEREST in their DELAY or Failure..
it adds up to a very powerful destructive force..and one thing people of wealth and power understand, is standing between Goliath's armed to destroy and a newbie..your pebbles are best left to the sideline to see if the
newbie may give flight. Prana was close to same place as Anavex with their drug, and somehow a Dog getting sick shut down their test? A dog..I can not make this up..
Successful people understand the power of money and power and it's sometimes ultra wicked influence. They want a successful treatment for AD but are only willing to risk so much..apparently less than $250 Million in Market Cap..Above that and the Short Cabal steps in.Scaring , destroying, without cause but with a banroll and profiting from the Market Cap fall.
Do anyone on this board think Big Pharma wants Anavex to succeed in treating ANY of the IND's for which it shows promise?
It is like the people selling Mosquito Netting fighting the cure for Malaria..It is disgusting..but it is reality.
well,
for you longs i don't have to regurgitate the
insane accomplishments of Anavex or the good Dr with
the pittance of Capital Anavex has been allotted.
Psst..the good Dr. attracted much of this Capital himself, if
rumor is to be believed.
So for a pittance of Investment we have
- 2 Orphan Drug Designations..
- P2 getting ready to fire up for Rett Syndrome
(which in all likelihood will be funded by Rett Syndrome Association)
- p2/3 for Alzheimers in the works with announced FDA Guidance on design.
- Multiple extensions for sick patients to continue to receive A2-73 for three years vs scheduled 6 months! Thank YOu good Dr!
- A younger candidate A3-71 which may be even more proficient at everything A2-73 can do..(or Model II already made and waiting in the wings.
-the multiple IND's for A2-73 and teh Sigma 1 Agonist..
Honestly, Like stars in the sky..if you don't like what has been accomplished and trust Management to continue on Insane Value Return for Invested Dollar..
Please, Please, PLEASE SELL and MOVE ON!
It will be impossible to make you happy and the joy that eludes you
may be found elsewhere! Just keep looking..Elsewhere.Anywhere..bute
here. Thank You
thanks ba..
What I understand is that this data i snot readily available after being
collected..HAMD, ADCS-ADL, MMSE.EEG are available and accessible after collected as this is an OPEN Trial..
Anavex has 9 months data for PART B..
So retail long's expectations for data needed for victory(I am guilty) are too high. We don't need to immediately cure AD..
If we continue with safety profile and show SOC Efficacy...
And get A2-73 available for Cross Scripts we have a blockbuster..
so..
That is a reasonable thing to say.
I don't KNOW if the patients responding Miraculously with actions displaying a curative nature for A2-73, whether or not A2-73 was taken as a mOnoTherapy or in conjuction with DZP..
Normally I would say something here like..what does it matter?
But ..I agree ,,I do not know if the miraculous responders were
Mono 0r Dual..
What I do know is..Anavex's drug A2-73 is positively affecting a very weak, elderly and sick population in the throws of a degenerative disease. A2-73's variety and breadth of CNS positives in such a Population, would lead one to believe that it is highly probable, that the Positive Effects of A2-73 on a Stronger Patient Population, maybe those battling Insomnia or the anxiety of Alzheimer fears, would be at least equal to but probably even greater than the positive effects being experienced by the current Patient Population..
As I have believed all along..People are getting better in a myriad of ways..not just CNS, but I go even further! Their Hearts, Eyes, Digestion--everywhere the Sigma Ligand lives!
the two things that should already bring Anavex a Billion Dollar Valuation. WE KNOW!
Safety & PK..
Everything else that Anavex confirms or hints at ..is just
Billion Dollar Gravy
30% of Patients with Alzheimers showed an 8 Point response to improved sleep/insomnia..One would think that this is a more difficlut crowd than your usual insomniac..right?
But just saying Anavex EFFECTS 29% of General Insomnia Population..
HELLOOO..
30% ANNUALLY of over $30 BILLION Market is..
$9 BILLION ANNUALLY 10 TIMES FORWARD SALES..= Valuation $90 BILLION
$90 Billion Divided amongst future issued and outstanding shares of
60,000,000 = $1,500 PPS
No valuation for AD, or PK or Depression or Anti-Convusive or
General Population taking A2-73 for GENERAL HEALTH PREVENTION
BLOCKBUSTER! and you want to see news..haha..
Corey Renauer wants Anavex to buy a Lab..
I just want to start taking A2-73!
Anti-Insomnia & Reduce chance of Alzheimer or possible Delay = BLOCKBUSTER
Why is the HAMD Data being discarded with the trash?
these markers represent a Consumer Market that dwarfs Alzheimers.
Dwarfs it.
Many of these HAMD Markers are pre-cursors to Alzheimers thus encouraging
a longer period of use on A2-73.
I simply can not believe with all the intellingent wealthy people of
the World..that ALL of them are scared of Adam Shrkeili and Motley Fool..
When are we gonna see some champions announce their 5% stakes?
Unbelievable