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Re: McMagyar post# 74032

Monday, 08/22/2016 8:48:48 AM

Monday, August 22, 2016 8:48:48 AM

Post# of 463742
The 1 Point reduction in SEM probably refers to an average of 1 Point improvement on the HAM D score. 3 Points is considered clinically significant. BUT..That is for a Depressed Population..I believe Anavex would have been purposefully avoiding a high HAM D score population to begin with..so an SEM of 1 Point is probably great. I could use some help here DOCS..
Still working on understanding importance of HAM D test results..
So the 8 Point reduction for Insomnia is shown as a 29% effect..
I think this means that the Overall Score for Insomnia for ALL Patients was
29..What we don't know is ..how many Patients were effected by insomnia to score 29! Was it 1 point per person. 9 Patients scoring 3 points each..

The reason this is important is..how many people experiencing Insomnia did A2-73 effect?
If, of the 30 Patients(rounded) assume 15(half) had a sleep issue of 2..
then you are looking at a reduction for those 15 patieints by an average of
1/2 point or 25% Improvement. Pooled Data is hard.
We need to shake some more HAM D data loose from IR.

Improved Sleep may be one of the keys to slowing the progression of Dementia and AD..BLOCKBUSTER
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