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Tea leaves......
He is certainly of an age where a CI might be needed to help the immune system if an immunotherapy is in his future. Would not put it past him to take the risk to try something "experimental" in order to further knowledge base and ultimately make things better for those who come after him (service).
Vator, Certainly seems plausible and could/would validate many posters positions on both sides. We'll see......
Hope you endured Irma with everything intact.
Opdivo is BMY (BMS).
Longfellow95, Thanks, we've got some shaky hands on this side of the pond (some in elected office). "Prevention" would like to think that is next, but they/we have some near term hurdles to clear first.
Dime is U.S. currency you are hedged. (Albeit I don't think it is a intentional hedge)
Doc, Depending on how this ultimately plays out. I will either need or enjoy a stiff one..... preferably the latter.
Woodford (assume) remains. Interesting confluence of leaves next week see posts 134269 and 134462. Read the leaves as you will.
I think ex came up with "reading the tea leaves" on this message board.
Keytruda is from MRK.
Perhaps a gofundme initiative is in order?
Good stuff, thanks.
Well, hello there too.
Yes I know. Was simply spitballing ideas since it was her third time for the surgery. And apparently CI's have been used in some instances. Also noted in those instances it was Merck's and upcoming combo is with BMY's.
Well hello there.
Yes, yes he did. Let's hope the plurality of technology being deployed is synergistic and efficacious. Would really like to see something move the needle much further than Optune. Dude is handling his predicament with a lot of grace (class) which is in short supply in Washington.
This is interesting based on his comments they are doing something new and innovative. Beyond Optune, CI's and virus infusion therapies not a lot of options in this space. You've correctly eliminated Optune (which also would have provided some more fodder for McCain's senate "colleagues" on his mental capacity to rationalize in their mind his votes with which they disagree). He one tough hombre I hope what their doing works. If it is L I'd suspect it is with a CI element as at his age the immune system possibly/probably could use a little help.
Wonder if the complete response is that of Kat?
Good stuff, thanks. Prins and Liau with others continue to forge ahead in a collaborative manner in this endeavor.
We'll see......
If there were it may turn out to be like soccer (football for the EU/Brexit/SA contingent) with supplemental time......
A clean safety profile or even relatively clean profile on the combo trial could (would) open up "leap frog" use of the combo in newly diagnosed GBM. I think that is at least part of the intent of the combo trial with more risk of ASE here. If ASE's were to occur my guess is they would be seen relatively quickly and it would be best to have phase III L across a finish line in some fashion IMO.
I think becoming Chair at UCLA can put to rest the earlier speculation (stepping in at NWBO) about Liau getting her MBA.
Upon approval DNDN also faced headwinds from lower cost competitive products showing similar efficacy.
NICE. The 220 peer reviewed publications worth noting.
(Disclosure: I have no peer reviewed publications)
It does add to the intrigue. Albeit intrigue I could do without from scientific/investment perspective. I agree with diver on the entertainment value/interest....... however my wife's entertainment preference for GOT (Game Of Thrones)
Thanks. Always nice to have a fresh set of eyes/perspective on PFS/OS potential.
Doc, It is at minimum intriguing. I think process automation has tremendous potential in this space to increase effacacy or "optimize" Direct and L.
Interesting on many fronts and possible senerios. One that I will briefly touch on is the class of clean room suites. The B (or class 10,000) could be used for a closed system manufacting. The suites going into Memphis (my assumption if for L production) are likely class A (or class 100). With L they have one shot and we don't know if they have developed closed system manufacturing. Either way the class A (class 100) room would be needed for manual production of L and prudent to mitigate risk for closed manufacting.
Ah the wheels of justice and we get details next week. Thanks.
Thanks for picking up the slack. I'm tied up on a couple of projects making my ihub contributions limited at present.
New 8k out.
Yes, I don't think both events have occurred.
I'll take the under....based on recent maneuvers.
He will be in senate this week to vote.....one tough hombre.
McCain was Navy and he flew off carriers which had their own risks (see USS Forrestal fire) he survived one of their more notable incidents of Vietnam war before becoming a POW (and getting disrespected by current commander and chief for being captured)
So far CI efficacy has been limited and it appears something that would help target the immune system could push efficacy to the next level.
Short or long?
We will see if there is to be more than SOC-TBD*. Fortunately Sen. McCain has good healthcare plan (not same coverage as he was to vote on). He is a good dude and tough cookie who has survived and overcame more than most face in their lifetimes add GBM to the list. Wish him the best.
* If there is more treatment it might not get any immediate publicity due sensitivity of the current political climate and pending issues related to healthcare.
If that is the case, a prudent move after more time has elapsed and more data becomes available on immunotherapudic tumor responses, would be to go back and reevaluate scans.