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more confirmation of CB2 effect..by ntrx-07!
great job cbd!
Anavexnow is going to hammer all patient advocates starting Dec 11!
We shall see what's possible.
We shall see!
The good Dr hesitated when asked which IND would be prioritized for A2-73, and IMO the upcoming Parkinson's Phase 2/3 is why..
But as all of you laugh at my reasonable suggestions to accumulate AVXL to the $3 Billion range or eve $40 Billion range;
Enjoy this number from an article regarging Biogen Adzucam, removes plaque but has some rather awful side effects.
"Delaying the onset of the disease by just five years, research studies show, could decrease Medicare spending by 50 percent. That's an important point to consider, because economists forecast that unless something is done to cure or even slow the symptoms, the number of people with Alzheimer's will rise to 16 million by 2050 and cost the U.S. economy $1.1 trillion. The portion covered by Medicare will balloon to $589 billion."
How much do YOU think Big Pharma is spending not only to Suppress Anavex Market Value ,,,,, But Anavex News? Big Pharma is spending ALOT! Don't listen to these delusional dilutionals nor the soft knife sliders.. you own greatness!
We are going to have Phase 2/3 for Parkinson's in 2017..the effect of A2-73 will be almost immediate and undeniable and patients and caregivers will DEMAND IMMEDIATE Compassionate Care Availability.
A2-73 will be Available in 2017 for everyone.. maybe first half.. depends on how quickly they populate Parkinson's Trial.. again. MJFF should not have hard time finding appropriate patients..
A drug that has positive side effects..
UNBELIEVABLE!
we will call it "A Gagged Gap FIll DIp" Guarantee IT! $2.66.5
Mumbles told me through the gag..
we do not all agree..we will see topline data in 2017!
we will see it because of COMPASSIONATE USE after 6 months of data which we will have after 9 months..
The key to qualified applicants is volume of applicants.. Anavex will have a lot of applicants
You think Caulfielf Hospital is going to have a tough time finding applicants after painter and golfer and piano player?
Yeah. Not
Years away?
Phase 3 are not YEARS AWAY! Not for Alzheimers or Parkinsons..
by end of 2017 we will have results..One year MAYBE..
OUR DRUG actually works..So IMO
Parkinson's sufferers will IMMEDIATELY see benefit(Compassionate Care Approval)..
and an Alzheiemrs Study will have 6 Month Review which will prove A2-73 to be UNDENIABLE NEW SOC..
Rett Syndrome..that may take longer as younger Patient Population..
You are forgetting the Safety/BENEFIT/Risk Ration of A2-73..
Side Effects are almost ZERO EXCEPT for Feeling Better and Sleeping Better.
and it's a Pill taken once daily..
in 2017 this DRUG BETTER BE AVAILABLE..
from Phil Mampilly who did a little research into Phase 3 BiopHarm Stocks and how they performed:
Watch Your Portfolio Skyrocket from Phase 3 Drug Trials
If you’ve been in this industry as long as I have, you know that it’s possible to estimate when a drug’s Phase 3 test results will be published. Why is this important?
A Phase 3 clinical trial is the most expensive and critical part of a drug’s clinical testing cycle.
Why is that?
Well, I want you to think about the time, money and brainpower that go into a drug that makes it to Phase 3.
Think about all the stages it had to go through to get there…
.......................................
............
A positive Phase 3 trial means that a drug is more than likely to get FDA approval.y.
But if it’s successful, it goes to Phase 3, the most important phase of all. Stick with me here, because this is where it gets interesting… and incredibly rewarding if things work out.
You see, Phase 3 trials usually involve at least 300 or 400 patients. For diseases like diabetes that affect a lot of people, it can be 3,000 or 4,000 patients. Often times, these Phase 3 trials can cost half a billion to a billion dollars to complete. Seriously. These companies have to invest this much money before they know they can get approval from the FDA to sell their product.
Which is why the results of the Phase 3 trial are so important.
These results are going to show the company, the FDA, investors and all the doctors out there — and of course, the stock market — whether or not the drug really works.
Note that as an investor in a drug company, you would prefer that a drug fail in Phase 1 or Phase 2 testing. Why? Because those two phases don’t cost that much. But a failure in Phase 3 can be catastrophic. Make no mistake about it: The stakes are extremely high when a Phase 3 clinical test result is unveiled.
You have to understand that by the time a drug enters a Phase 3 trial, it represents 15 or 20 years of drug development. It represents the hopes and aspirations of the company and a lifetime of work by its scientists and researchers.
One last thing on Phase 3 clinical results. Doctors and patients are not allowed to talk about it to anyone. That’s right. You are supposed keep mum until the results are announced. So everything is a big secret.
Now you understand why there’s so much potential for a stock price to swing big in one direction or the other.
And that’s why we want to get into a stock before a Phase 3 clinical result is released.
If the drug works, it’s a great thing. It now means that the company now has something it can put in front of the FDA for approval. The stock is going to soar by 50% or more. I have seen stocks go up by over 500% on the release of clinical results.
Why the huge jump in the stock price?
A positive Phase 3 trial means that a drug is more than likely to get FDA approval. And after it gets approved, it can be sold to patients and marketed to doctors, and businesses can be built on it. And the company gets to earn millions of dollars in sales and profits.
So I told you that a Phase 3 clinical trial is when you get to see if the drug really works in people that actually have the specific disease that you’re trying to treat or cure.
So first, it helps to come up with a list of stocks that have Phase 3 trials outstanding.
And the place to go to come up with this list is a kind of mysterious website where companies list ALL the clinical trials that they are doing. Seriously. Every company that’s doing a clinical trial puts the details of the trial on this website. Like what? When the trial started, for example. And its estimated completion date. With a little bit more research, you can work out when the trials results may be announced.
What’s the name of this website? Now, look, this is a bit of a secret, and I am giving you valuable information when I tell you this.
The website where this treasure trove of valuable information is stored is ClinicalTrials.gov. And here’s how you go about searching for a trial. You get the name of the drug and enter it into the search box… Or you can search for a trial by a disease like lung cancer or diabetes. Here’s one little hint that can make your life easier: Look up the scientific name for the disease before you search, as the companies like to use these terms when put the details of the trials up on the website. You can also search by company name.
Let’s do a quick search for biotech giant Amgen. And if you enter Amgen into the search box, you’ll see a huge list of trials come up. In total, Amgen has 147 clinical trials that it’s actively recruiting for. Now, to be sure, not all of these are Phase 3 trials. For you to figure that out, you have to dig in and do the work. And look up each trial and figure things out. Which is what I do when I come up with a Phase 3 rocket idea for my readers.
If you want to check out how profitable these Phase 3 clinical results releases can be, just look up the biggest stock market winner on any given day. What you’ll see is that on any given day, there is a biotech or drug company whose stock has gone up 50% or 60%. That’s because they’ve issued Phase 3 results. Now go back to ClinicalTrials.gov and put the company’s name into the search box and you’ll find the clinical trial that is making the stock move.
Now all you have to do is to change the order of what you are doing. You need to find the stock first and invest in it before it goes up. It’s hard work, but for 50% or 100% gains in a single day, I would say it’s worth your time.
Just a reminder that all the clinical trials are listed on the website, but you want to pay the closest attention to the Phase 3 clinical trials.
In the future stay tuned as I share more of my strategies in future Tomorrow in Review issues.
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Couple of QUick Notes sports fans:
Up to $500,000,000 to do a phase 3! Wow, who'd a thunk a Company with $9,000.000 in the Bank has the Partners that may handle funding 3 of them? Yep: Rett Syndrome, Parkinsons AND ALzheimers!
THe Author never mentioned what ti sthe upside of a stock that has has 3 Phase 3 Trials going and all should be finished in the SAME YEAR?
wow..and YOU OWN A LITTLE COMPANY THAT IS GOING TO SOON BE IN THIS POSITION..and somehow the good Dr. has gagged a stock transfer agent to hide Outstanding SHare count? I mean really..you can not make this stuff up..oh wait..you can
I just called them..
It sounded like they' were all gagged..
Mumbles galore!
mike did you drop that? ohhh
i can see it now..like in the old days..the
Western Telegraph Tapper..in his chair,
hands tied behind his back..and an old sweat rag
wrapped around his mouth..
GAGGED! GAGGED I Tell YOU! They'll never know!
Playing Snydley Whiplash of course is the good Dr!
and some poster from I HUB or maybe Corey Retanauer! of Motley
Fool Fame or Adam Fuersteing Play Dudly Doright! To SAVE
the DAY for ALL Anavex longs as everyone sells and sells and sells!
But who is buying?
maybe the people that read this little article:
https://dailyreckoning.com/watch-your-portfolio-skyrocket-from-phase-3-drug-trials/
Looking for things that go Bump in the night?
How about a compnay that is about to have THREE OF THEM! AT THE SAME TIME!
Maybe FOUR! (BIOGEN!)
Oh my..yeah I would worry about delusion alot!
the good Dr mentioned they were good on cash at one of the two investment seminars in a Q&A after his presentation. It was 2nd half of this year anyway..
look..i don't understand how $9,000,000 may accomplish what it takes BP TRILLIONS to fail..but I think it's because OUR DRUG ACTUALLY WORKS..
People get better and stay better..and therefor OTHER PEOPLE FUND TRIALS.
So..normally a small Co. that has engaged with a 60 BILLION (well regarded) goliath has accomplished much. A company that has taken a new Pharma through Safety Phase 2 succesfully..has accomplished MUCH..That they have a drug which shows Pharmacokinetics and Efficacy to Dosage Changes in an incurable disease patient population, they have accomplished much..when their safety profile includes more ancedotal positives! than negative side effects..they are deemed to have accomplished much!
IT appears ONLY in the REALM of the Netherworld where the forces of darkness and doubt have aligned to DELAY and DESTROY TRUTH that these
accomplishments of MUCH are questioned and thrown to the garbage can, because the Co. won't give out an Outstanding Share Count to an individual investor.
oh my..Anavex won't say how many rolls of toilet paper thay go through in a month either! SELL!
I don't like Anavex and what they have accomplished with so little..
I LOVE Anavex and what they have created from almost nothing!
When I see the pageantry of attack over not giveing out OS Count it makes me sick! The weakness, the fear..What else may a small BIO DO? Fear like being fomented here is WHY BioTechs like Anavex SELL to a bigger co. because they read the timidity of THEIR HSareholders, not based on WHAT THEY HAVE ACCOMPLISHED..oh no..on not giving out SHARE COUNT??
honestly, i can go back over just today's quibbling fear posts and I guarantee more whines were served than at a squished grapes Festival in Southern France.
With friends and longs of no faith, that turn on you like a pit bull, I am sure management may find other more friendly confines.
I BELIEVE IN THIS MANAGEMENT TEAM!
oh my gosh..the pain the agony..it's hard to take..honestly..
i read this meandering worry after worry after worry and you would think
the good Dr. has betrayed us at every turn! made horrible hiring decisions, failed every test..sold his own shares into rallies, put his girlfriend and wife on payroll(different departments-of course) and given his mother options(AXON Style)...
ALL ONLY because they won't give up Outstanding Share count?
We know we have TWO Phase 2/3 Clinicals coming in 2017!
Confirmed by Rett Syndrome Assoc. and Caulfield Hospital..
and really we have 3(Parkinsons) if you read the last PR from Anavex regarding Ariana properly.
We have how many IND's and how many FDA Designations and are working with BIOGEN, MJFF, really on and on and on..
and the palpable trepidation..that they won't give out share count?
Look the good Dr. has said he doesn't need anymore money..right?
so an In-Licensing Deal could include..a number of shares in Anavex to the right Partner..Anavex would do this to incentive the partner for $$$ and a more lucrative deal for Anavex shareholders..as our Partner is now entwined with OUR interests..
Honestly it is so disappointing to read this Board of all the longs and all the good Dr. has acoomplished with so little capital and just see the fear..Reminds me of a story about people falling asleep, when their great friend had gone to meditate and asked to stay awake.
With Longs like this, it it no wonder the Motley Fools, The Fuesrteinns and the Market Makers find fertile ground to short tops..
WOW
thanks cbd..apparently the anti-anxiety/insomniac properties of A2-73 are more in need than first thought. AnavexNow!
it is decent to end a relationship before you start another.
Biogen's early data from Anavex must be how do you say..impressive?
perfect SOKOL, i had not read the published reasoning behind the ending of the Biogen relationship and I agree with you, those are incredibly encouraging words. Selling Anavex at any price now becomes a great risk...
can not wait for Dec.10..
already know the outcome!
the Data is SOOO Goood we will have a phase 3 for Alzheimers, a Phase 2/3 for Parkinsons and a phase 2/3 for Rett Syndrome..
Reading backwards..Data can't be that bad..no sir..no siree
the good Dr brought onboard Dr. Neal Sharpe in August..
wow..check out his LInked In profile..
nice..screams Anavex..Safety First..
so for those of you thinking Biogen could suit up for Anavex sooner rather than later..
You think ending this relationship a sign that opens the door for Anavex?
That Biogen feels comfortable with A2-73's effect for MS to move forward with an In-Licensing Deal now?
When I reviewed test time frame from Supply Agreement Date I calculated end of First Quarter for Data Feedback..Obviously some on this Board think that
Biogen already has the Data Feedback necessary to cancel a different agreemsnt so as to move forward with Anavex?
Interesting..that would be wonderful..but that would be fast..
so if you are the good Dr and you know the Short and Distort crowd is awaiting your conference with a massive Sell Volume computer/Betraying foolish Investment advisors/ Market Maker accompliced sell off of YOUR VALUE destroying YOUR shareholders what do you do?
You do not have just a little something, something for after the conference..
You have a LOT of SOMETHING< SOMETHING for after the conference..
I would not be surprised if we saw very little news prior to conference..
That may be why the good Dr. did the interview..
Biogen I didn't have anything until end of first quarter..
yeah,,fluffing a Phase 2/3 for Parkinsons or Alzheimers or Rett Syndrome or maybe a Phase 2a for A3-71 or Phase 2 for Depression/Anxiety/Insomnia or a Phase 1 for Non-Opioid Pain Medication or Phase 2/3 for unnamed Epileptic IND..
something really FLUFFY!
trying to buy calls..
should have $$ to buy more by end of year..
wait for me!
Not true..
Powerwalker..I hope you are right! I wanted Patients to switch! the more the healthier!
this isn't the market..Accumulate..this is what's called
MANUIPULATION that normal market forces may not yet overcome.
When we do..there will be no mercy for those who have tried to destroy
the good Dr.'s character and delay treatment for the sick.
none
Did Anavex already announce Human Trials for Parkinson's?
Not once..
“Ariana has the expertise to fully support Anavex’s precision medicine approach to develop more effective treatments for devastating diseases including Alzheimer’s, Parkinson’s and Rett syndrome."
But twice..
"
The ongoing Phase 2a Alzheimer’s clinical trial was specifically designed to learn as much as possible about ANAVEX 2-73 in order to optimize trial parameters for future pivotal trials and potentially reduce the risk of failure in a later, larger Phase 2/3 study and in a planned Parkinson’s Phase 2 study."
See..this is called bringing value to the Board..We don't have to wait for the final MJFF report to know whether or not we are moving forward in a HuParikinsons trial..It's already been announce..
You are welcome!
Accumulate to $750 PPS
powerwalker, you think they changed patients to mono-therapy at 6 months?
that would be great!, but i don't think so..how do you come to speculate such a thing? because the trial is Adaptive?
I hope you are right, but I think you have very little to back up your claim. Please delve deeper into the logic of what tea leaves you are reading to come to such a conclusion? And although this is what I advocated, I never read anything that led me to believe the Company actually took people OFF ARICEPT..
"we" are so clairvoyant! I didn't know the good Dr. and the Board of Anavex ever saidn "WHY" they released data when they did! so it is good to know we have an inside source on the Board! Praytel, if the data was delayed due to it's failure, why did the good Dr. get a raise?
So much knowledge so little reason. The path of a hundred failures will be the path of 101 as the trench has worn deep and the sides steep.
A lighter traveled path above winds more, has less footprints but there are no walls to it's side and you may see all around you!
The many different genera of dimentia include at least 3 substratum just for Alzheimer's! Not to mention all the other CNS IND which may closely resemble Alzheimer's.
Why not separate (diagnose) them the best you are able before a Phase 3 Trial to determine To which YOUR treatment offers the greatest response! Than if others wish to Cross Prescribe they certainly may.
To do a 5,000 patient phase 3 is less than a stellar decision. It just due to TIME, COST but also to INHERENT failure! How much better to hypothesize your Strata than prove your Efficacy Points than to try and go backwards into a large group and separate out the Strata that did well!
Which then the Learned Minds in the Deep Well Followed failure Trail than call Mined Data!
The good Dr is trying to move this process forward as responsibly and intelligently as possible. Big Pharma is watching in utter disgust.
I watch in simple appreciation.
It's not sample size that causes the short and distort crowd. It's not bad science. It's not doubt about efficacy.
It is about a small low market cap company busting multi billion dollar markets of multi billion dollar conglomerates. Period. Having Biogen in our corner gives us a big dog which now has a vested interest. Like a little guy having a big dog for protection. Come dec 10 we rock we roll. Do not worry about whether or not the price is going up or down.. just accumulate if you able, advocate either way...
Not qualified to answer. Risk of
Younger patient is the point..
I don't know enough about Rett Syndrome either.
With elderly PArkinsons and ADS population
The risk return on almost any treatment may be justified, but if you are dealing with a population whose life is not being immediately threatened, than you need to be more cautious from a patient and company perspective.
We all feel very confident that A2-73 poses limited if not zero risk as a small molecule, sigma 1 agonist.. and Pharmkokinetics may also add to this belief, but the best way at this point to actually demonstrate safety is through in human trials. I am willing to sign up right now! Bet you could find a few million more at the drop of a pin..Anavexnow!
Retts s a much younger population and therefor
More time and effort must be given to preplanning for safety
And MTD. And is A2-73 a lifelong medication
Or temporary treatment?
If you look at other Rett Syndrome trials
They took years from start to enrollment even though they are
A trendies organization.
Parkinson's May be enrolling in 2017 before Rett..
Yes. Since we've had this drug for a decade and millions and millions have already suffered a slow miserable death, lets not risk killing anyone by allowing them to try an effective drug in trials that comes from a relatively safe classs of drugs with almost know side effects.. yeah that would be stupid and make us miseries and killers!
this bigger population stigma is a joke..really just a joke.
say only 7 people go better out our 400..only 2%, why wouldn't you figure WHY those 2 % are getting better! The number of people in the TRIAL doesn't matter to a great degree..because we KNOW WHAT HAPPENS TO ALZHEIMER PATIENTS..they get WORSE AND DIE! Don't need 10,000 Patients in a study with 5,000 Blind Placebo to know that 5,000(really other than Anavex) 10,000 are going to get sicker and die! How about we bring Medicine INTO THE 21 st Century and QUIT letting people DIE because our scientific heads are buried too far up our pontifical netherlands.
We process 1 million times the information than we did 20 years ago..
Why will not medicine and dr.'s move along up the evolutionary scale
are redirect their efforts to saving people rather than letting people die?
Once upon a time this made sense..maybe even in some cases it still does..
but mostly BLIND PLACEBO GROUPS are for when you can not tell if something works..We know what that looks like for ALzheimers..
Honestly, I understand having multiple lines with other drugs..but a placebo group in an Alzheimer study for a drug that already shows EFFICACY and has an incredible safety profile..Anavexnow! and you take the placebo.
Agree! In a word YES! Two words
YesNow!
lakeshore, coming along. be wary all you 30 day end of year loss takers..averaging down probably a better play..eh?
add in a little TAUrx and voila!
maybe even some Neuren..
Very exiting interview with the good Dr. His positive words
Are very encouraging! I am still of the opinion that Anavex
Should be immediately made available at minimum to all those who
Have been diagnosed with CNS related issues who Wish to take it.
Especially those Who have been diagnosed as having a
Incurable disease that foretells the patient's death, like
Parkinson's or Alzheimer's.
What are we waiting for? If Taurx has simular Safety Profile
Than bring Taurx into the market place as well!
As far as relationships, I liken it to having a choice of an inclusive party or paying for f
Everything -ala cart- if you do inclusive somebody is
Going to lose. If the Bar doesn't charge enough they don't
Make enough money and a good party could drink them
Out of house and home. if they charge a lot than the client
has paid for product they didn't need or use.
Either way someone loses. Someone has to lose.
We don't know enough yet to fathom what is "fair fare".
Even a deal based on percentage through "in licensing"
based on Industry standards would bring someone
A loser. Really what is A2-73 'potential?
My guess is Biogen has entered into a very general type commitment with
Anavex of that nature at least regarding MS.
I think it would be more than first right of refusal..
But I think Biogen has set themselves. Up to get first bite.
It is heroic of both companies to put this trust in each other.