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Just to confirm, ucla is in progress of a phase 1 DCVax-Keytruda combo trial in rGBM to determine whether combo is better than DCVax alone, and any side effects and safety!
It’s still enrolling but in progress.
Is the SPORE related work one and the same or does that work include nGBM and other aspects?
I should know this but I’m foggy about it.
Thanks in advance!
Wake me up for the revolution - Woody Allen, in Bananas, I think?
Thanks, I appreciate the backstory and relevance to you and glad to have had a small chance part in the nostalgia !
Vaja con Dios, amigo
Oh my, PM,
I haven’t been posting much lately but I’m afraid your extended stay in the proximity of the Beltway and the strange composition of the gases rising from the DC swamp are altering the interpretation of the progressively improving vital signs of dcvax and nwbo.
It’s quite understandable in today’s environment where you are correct that everyone is lying! I mean are we to believe it’s perfectly ok to have TS documents in a bathroom, I guess in case you run out of the Scott tissue? But I digress.
Every one is lying!
Except maybe not Dr Marnyx Bosch!
Except maybe not the good doctors at UCLA and Kings in the UK.
Except maybe not the 70-ish authors of the phase3 results published in JAMA-Onc!
Except maybe not the beating hearts long term survivors and their families!
Dr Bosch’s presentation cut through all the fog of the negative narratives with absolutely solid data and facts, leaving no informational gaps and crevices (crevasses?) for the negative narratives climbers to secure even a finger hold.
While funds are always a concern for pre-revenue biotechs, we’ve seen that concern managed, and recently without resorting to vulture financing.
I fear the swamp gas and accumulation of club swings to the head are taking their toll on balancing optimism and pessimism!
Then again I just finished off a bottle of Tuscan red (which tends to increase my optimism)
Consider taking a break from DC and spend a week or two in the clean rural air away from the money polluted park benches and clean out your physical and mental being, although I wouldn’t recommend sleeping overnight on a bench outdoors without a boma. Not even in NJ!
In parting and going back into mostly read only mode, DCVAX is efficacious in mono and remarkably in combo, and approvals will happen imho, the rest is noise and intentional interference!!!
Vaja con Dios, hombre.
No, it’s just Canadian wildfires smoke (if they dropped some Mary Jane in there it might make it more tolerable but also more dangerous) - it’s pretty bad in NY/NJ, oh, the smoke is bad too
I hear certain hedgies are moving to sanctuary towns like Menda City, where lying and stealing are minimum requirements for citizenship
Basically debunked all the bs narratives in one felt swoop in exceptionally clear and solid form!!!
And most importantly clarifies the efficacy shown in the trial and by long living humans in attendance, and the vast potential ahead!
A masterclass presentation indeed
As described in Casino, you dig the hole in advance
I suggest you augment knaster with some travel for a while, like until approval
Keep murcidencel nice and clean and shiny until it is approved, and there’ll be only one company providing it for some time to come!
You got that right!
Some of my shares are so old they’ve grayed and wrinkled, ba dump dump!!!
My shares are so old….
How old are they Johnny?
My shares are so old they’re approaching their Required Minimum Distribution!!!
I’ll stop now mercifully, or is that Murcidencel!
So did Merck, BM, and all the other important companies presenting in the two Expert Theatres at ASCO.
It’s called getting the word out!
Were they playing Sweet Home Chicago or
Damn Right I Got The Blues?
Think Chatgpt and how it lit up the AI arena that has also been very promising for 15+ years!
Clarity of the true power!
Keep your eye on the Bon Jovi character!
Like the sub, I occasionally surface while mostly waiting for a victorious conclusion.
Pray you never have to make good on that statement. Nobody should have to succumb to GBM, not even a worst enemy.
Look to the new promise and hope in the science of dcvax and combo cocktails of synergistic treatments, like the history of HIV treatment from early death sentences to chronically treatable malady.
Except for the successful DCVax L phase 3 trial, and the early combo indications, and about 50 long term survivors, there is nothing else imminent other than DCVax!
Hopefully this isn’t a smoke and mirrors event for the mRNA which is years away and doesn’t create the strong memory effect in the immune system that DCVax does.
So in summary, DCVax is now, and even the combo treatments that promise >50% response rate is now or as soon as approved!!!
I’ve been critical of the Moonshot program in that it hasn’t mentioned DCVax yet and would be grossly disappointed in the moonshot and President Biden if that continues given the first family’s terrible loss to GBM.
I thought you hear “I buried AF” when you play the ASM in reverse?
This won’t be very scientific, but I hear the earth move under my feet, the walls tumble-ing down….. oh never mind, it’s just gas
Seriously, there is an overall DCVax/nwbo buzz level that was pianissimo and has been in crescendo building towards a boisterous chorus in fortissimo, and a glorious finale!
And you know it ain’t over until the “adipose laden” lady (or gentleman) sings!
The real news and mentions are of a positive nature, and the various ucla presentations and upcoming ASCO theatre presentations will keep adding to the inevitable conclusion that DCVax enables a new and much more efficacious set of cancer treatments!!!
If I were a rich man
La La La lalala lalalalalala
Don’t worry, it’s gonna be all peaches and cream
Soft talk and suspicion
There’s gonna be an exhibition
And we gonna all find out
After ASCO, it’ll all be peaches and cream!
Seems like the one post a day inspires you to make it thoughtful and interesting. Of course anything Clapton doesn’t hurt
That might qualify as a threefer as in
1 + 1 => 3
Call me simplistic, however wouldn’t you expect safety concerns to be identified during the preliminary combo testing and the ongoing combo, now morphed into phase 2 trial?
If dcvax made things worse wrt the pd1 (I.e., keytruda, etc) reactions and safety events, I would think the good doctors at ucla would have raised the concerns by now.
Again simplistically imo they are likely not seeing significantly worse safety than with pd1 alone and might be seeing somewhat better possibly.
My memory is fuzzy about Dr LL presentations such as those in NY, Pa, and other venues where she talked about the combination treatment some.
Perhaps our friends on the board with better memory or more recent viewing of the Dr L presentations can remind us what if anything was said regarding combo safety empirical observations?
The optimist in me thinks the combo safety is or can be better than pd1 treatment alone.
We sure see that efficacy of response is remarkably better!!!
Yes, your understanding is in synch with what I had implied, and I wasn’t even thinking of applying the iclc in the same injection as the DCVax but was only considering separate administration of the DCVax and iclc, hence my point of where you draw the dotted line and what you call it is at least secondary to the result for the patient.
Murcidencel has a nice ring to it, as it sounds like mercy being delivered by dendritic cells to patients and their families!
Thanks for showing me the shortcomings of my overly simplistic message. Truly!
Friends, let’s not forget the message from a certain Mr William Shakespeare:
A rose by any other name would smell as sweet!
I would expect our wonderful doctors to apply the best practices and iclc is an element in the best practice. Whether grouped into the “vaccine “ or not.
Good point!
Aren’t all Canadian dollars a little short compared to American dollars ?
This is the year Scotty!
I can hear the theme music already:
Well next thing you know Old Horse’s a millionaire
The kin folks said, Horse move away from here
And he packed up his bags and moved to Cherokee
County, that is
Avalon, swimming pools, golf courses….
I’m over 12, probably 13-14 years. It all seems like a blur now. But we’re all waiting in good company together, if you filter out the perma negative narrative crowd.
I am still hopeful that I’ll be in one of the generations that will benefit from the generational wealth that will be created by nwbo in the not too distant future
I’d gladly wait for Gal Gadot
Any price movement is whatever the big dogs want it to be. They play and run the rigged game, so they move it down and trigger cheap share sells, then let it go up a little to get more retail money in, then work it down again, etc.
It’s plain to see that there is a major disconnect between current stock price and the value of a cancer platform of DCVax’ potential with a successful phase 3 and approved production!
The manipulation will be broken however until then the stock price is what the big dogs program it to be!
As if ?
Call it the Ground Hogs Day stock because they manipulate the sp every day whichever way they want because they control the game.
Look forward to the manipulation being broken sooner than later and in this year!
Looks like the groundwork to establish the efficacy of the set of DCVax-L + Checkpoint Inhibitors (Merck, Bristol Myers, etc.) where DCVax plus iclc is the enabler of heretofore unobtainable favorable response rates!!!!
For one thing, if nwbo paid for the equipment and facilities then additional non DCVax work would be consuming these items and you would think that is to be compensated plus a return.
I suppose the current law suits against major market makers and hedge funds, and the hundreds of fines they have been ordered to pay are specious and don’t demonstrate the reality?
And it’s not nwbo’s suit only, there are numerous other cases and penalized violations. So who’s flinging the BS?
In the market, value and price can differ, especially when artificially kept down!
The army of paid mercenaries who “work “ round the clock including weekends and holidays, and the alleged spoofing for years on end, along with the other manipulative measures, have clamped the share price down.
Soon however that suppression will finally be broken, and retail won’t shed any tears for the cabal as the cabal doesn’t concern themselves with the suffering and dying cancer victims of all ages, children through grandparents!!!
I used to say I would whack someone on principle but not for money. The cabal is all about the money and not troubled about who suffers and dies terribly.
Grazie!
I’m invested in nwbo close to 20% of my life, so I guess I’m a patient investor and now we are one more milestone to first approval!
I believe there will be many approvals to come and a great many human beings who will benefit from DCVax and what will evolve from DCVax!
And btw, I’m sorry if you find my comments preachy, however your sermon might not be more or less better so let’s agree to disagree and please don’t be upset. There are many things of greater importance than my or your opinion of managements.
You’re right, I’m not sure what point you’re trying to make. What, that if dcvax was in the hands of other management, for whom this isn’t personal and who wouldn’t have Linda’s unique set of skills and intelligence, that you know “they” would have been better and faster?
In the words of one of the Bush Presidents, No, not gonna say it, it wouldn’t be prudent !
In my opinion other management would have folded long ago when faced with the various orchestrated attacks.
Oils well that ends well, a tsk tsk tsk
Where are the other managements who have made the breakthrough?
More than 400 failed attempts and 17 years since current SOC and nwbo stands alone and is still standing.
That’s the objective assessment, not backseat driving and Monday morning quarterbacking planting coulda shoulda woulda if only narratives!
Management is pulling off a great success not made any lesser an achievement given the constant forces trying to undermine nwbo at every opportunity.
Done, next?
When manipulation and slap of the hand penalties are the daily routine that keeps filling the coffers of all players in on the rigged casino, the golden goose keeps laying the eggs and everyone except us naive retail benefit.
Although I’ve been investing for more than 55 years, I’ve been unaware of the real structure of the markets until the last 8 months or so. I mean I thought I understood before that but I had no real idea of the nitty gritty details of how the game works and is controlled by the big dogs.
Changes my whole outlook on the markets and regulators, watchdogs, politicians and industry players. NWBO is the last non blue chip or other mega company investment I will make. It might be my biggest winner, which would make a nice poetic justice finish!!
Fool me a couple of times, shame on you.
Fool me again, shame on me!