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Because time waits for no one, it is paramount we get to the Clinical Trials in Australia (2015).
IF it is true that the Flucide Clinical Trials are delayed by a year, from 2015 to 2016, that represents a minimum burning US $2 million a quarter doing, what again? Drowning mice/rats in FluCide?
Vaccines? it is 20th century technology rehash and no match to NanoViricides, Inc. 23rd century nanotechnology today!
KMBJN, from what I've read seems you are right on target.
KMBJN, interesting problem Dr. Anil Diwan and his team are faced with. I don't know if there is a high concentration of receptors over the worm-like Ebola virus surface area. If so, why not increase the dose for low-toxicity Ebolacide to something like a tablespoon whereby many EbolaCide nanomachines would quickly attach, and collectively envelope and destroy the Ebola virus structure, in the trillions, in a matter of hours. I know, in the mind all things are possible. Somehow I am confident Dr. Anil Diwan and his team will find the answer to the deadly problem.
Some people in West Africa have survived the virus with conventional anti-viral drugs but far more have died.
Rawnoc, I did not include a link to that simply because you guys don't include a link to support your statements. The year 2013 is water under the bridge and it was on the 2nd half of 2013 when the construction of the cGMP Pilot Plant actually started. Today the new state-of-the-art cGMP Pilot Plant is operational and scientists inside are racing to get it validated.
I am optimistic about NanoViricides, Inc. (NNVC). Are you optimistic about any company stock?
daBoze, we are constructing a railway that will take FluCide to the Clinical Trials in Australia (2015) and ultimately to FDA review/market. However, FluCide GLP full tox study, is the one station in which the "train of therapeutic drugs" will not be slowing down or stopping for again. The BigKahuna explains...
It may take a few of our EbolaCide nanomachines to bind and destroy one Ebola virus structure...to destroy the Ebola virus in the trillions, in a matter of hours! Dose, two or three teaspoons of EbolaCide?
viralzone.expasy.org/all_by_species/207.html
ExPASy
Molecular biology. Filamentous 970 nm long for Ebolavirus. Diameter is about 80nm.
Some people learn by association, and repetition of facts. Some are fast learners and some are slow. The board will indulge you and repeat to you the facts as many times as necessary.
We have a new 5kg cGMP Pilot Plant in Shelton, CT. that is now operational and scientists are racing to get it validated. Once validated it will have capacity to produce FluCide for the Clinical Trials (2015) and EbolaCide for outbreaks affecting about a 1000 people.
Houston Medical Center Considers Ways to Prevent Ebola
Hopefully this could be used to curb the outbreak...they may have doses for up to 20,000 patients.
Successful treatment of advanced Ebola virus infection with T-705 (favipiravir) in a small animal model
Highlights
• T-705 suppressed replication of Zaire EBOV by 4 log units in cell culture.
• Mice lacking the type I interferon receptor (IFNAR-/-) were used as in vivo model.
• In this model, T-705 administration prevented a lethal outcome.
• Treatment was effective even if initiated at day 6 post infection.
Abstract
Outbreaks of Ebola hemorrhagic fever in sub-Saharan Africa are associated with case fatality rates of up to 90%. Currently, neither a vaccine nor an effective antiviral treatment is available for use in humans. Here, we evaluated the efficacy of the pyrazinecarboxamide derivative T-705 (favipiravir) against Zaire Ebola virus (EBOV) in vitro and in vivo. T-705 suppressed replication of Zaire EBOV in cell culture by 4 log units with an IC90 of 110 µM. Mice lacking the type I interferon receptor (IFNAR-/-) were used as in vivo model for Zaire EBOV-induced disease. Initiation of T-705 administration at day 6 post infection induced rapid virus clearance, reduced biochemical parameters of disease severity, and prevented a lethal outcome in 100% of the animals. The findings suggest that T-705 is a candidate for treatment of Ebola hemorrhagic fever.
Ebola has no cure, no medical treatment—and in this deadly West Africa outbreak, doctors can only isolate victims and find those they had come into contact with to track the virus' spread.
Misinformation is running rampant in the countries that have been affected. Scores of newspapers urged residents of Liberia to "Burn all bodies." A pastor who claimed to have a cure for Ebola prompted Nigeria to decree that anyone spreading similar scams could face jail time. Street protests broke out in Kenema, Sierra Leone, when angry crowds attempted to burn down the city's Ebola treatment center in an effort to eradicate the virus.
To make it clear: There is no cure for Ebola.
Read more:
http://www.thewire.com/global/2014/08/why-there-may-never-be-a-cure-for-ebola/375452/
We don't have a cure for Ebola at NanoViricides, Inc. but we likely have the most low toxicity, effective (able to bind to the Ebola virus) and fast acting anti-viral nanoviricides that will destroy Ebola virus structures, in the trillions, in a matter of hours. To paraphrase Dr. Seymour, CEO of NanoViricides, Inc.,...yes, but more news are forthcoming!
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Non one other than NNVC bashers are talking about dropping FluCide tox studies in favor of EbolaCide. Tox studies for FluCide are advancing and are essential for EbolaCide.
drkazmd65, I believe the zMapp drug is as good as the immune system of the subject/host to the Ebola virus. If the subject/host to the Ebola virus has a compromised immune system your chances of survival are also compromised.
And vaccines?, dime a dozen! It is 20th century technology re-hashing!
We should all become vocal, about NanoViricides, Inc. technology, at every chance we get, everywhere we go.
I expect EbolaCide to be as effective as FluCide. If zMapp can attach/bind to the virus and human cells to flag and stop the virus from replicating, EbolaCide will attach/bind to the Ebola virus to destroy it, in the trillions, in a matter of hours. In other words, EbolaCide will be the "kiss of the dragon" to the Ebola virus, in the trillions, in a matter of hours!
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We estimated the possible effects of the next influenza pandemic in the United States and analyzed the economic impact of vaccine-based interventions. Using death rates, hospitalization data, and outpatient visits, we estimated 89,000 to 207,000 deaths; 314,000 to 734,000 hospitalizations; 18 to 42 million outpatient visits; and 20 to
47 million additional illnesses. Patients at high risk (15% of the population) would account for approximately 84% of all deaths. The estimated economic impact would be US$71.3 to $166.5 billion, excluding disruptions to commerce and society. At $21 per vaccinee, we project a net savings to society if persons in all age groups are vaccinated.
At $62 per vaccinee and at gross attack rates of 25%, we project net losses if persons not at high risk for complications are vaccinated. Vaccinating 60% of the population would generate the highest economic returns but may not be possible within the time required for vaccine effectiveness, especially if two doses of vaccine are required.
Excerpt from Scott Gotliebb article on Ebola experimental drugs --- Forbes magazine
Also, remembering Patrick Cox's article, brought to the board by 'leifsmith'...what if Ebola were to mutate in the wild and become airborne? That adds to the risk of not taking action.
Yes, I get your point. Thank you mdphd1.
If Dr. Anil Diwan and his team are confident enough in a "...NNVC's new configuration for anti-Ebola cide [that]resolves with >90% rescue of subject animals..." then it would make a whole lot of sense to spend some of our treasure to test in BSL-4 lab like that of ViroClinics. I do know that BSL-4 is costly but do not know how much in dollars and cents. Risk/reward must be good enough to go forward on this high profile outbreak. It then makes more sense to me now Dr. Seymour's reply to you on Ebola, "Yes but more news are forthcoming". And yes, WHO would not be able to ignore such glowing results.
Thank you drkazmd65! When possible, please read the handbook (follow the link at the very bottom of my post).
Repost at will...
How much money is needed to test our EbolaCide in-vivo? Just how experimental is experimental? Tekmira's vaccine and Mapp Pharmaceuticals drug were in clinical trials when they were enlisted for the fight against the Ebola virus. These market companies were hand picked, bank rolled by governments, in order to conduct the research and development of their drugs and now the World Health Organization (WHO) says it will allow employment of experimental drugs in the fight against Ebola. But how experimental is experimental? Phase 1 clinical trials, pre-clinical, etc...what are the rules to qualify as experimental and receive money?
If we are 10,000+ investors/traders strong, for those investors that are proactive, here is the link to contact the approachable WHO. You may have your questions but for example, will the WHO finance BSL-4 efficacy tests of Ebolacide and once succesful, will they pay for the manufacturing/production of Ebolacide? What are the rules/regulations? Once again keep in mind that our government and the WHO has hand picked companies and helped them along in their development, awarded them millions, tens of millions, hundreds of millions. It is time these government entities pay our small company for development low-toxity, effective and life saving nanoviricides. Fair is fair. After all, the money they use is taxpayers money (taxpayers debt) to protect and save the lives of who else but taxpayers as well as non-taxpayers.
Expensive Biosafety Level Labs
And where is the FDA on all of these WHO deliberations? Why quiet? Remember it was CDC's Frieden who stated that Ebola's arrival to the U.S. was innevitable. He also said, "What we're doing at CDC is surging our response," said Frieden on Sunday. "We are going to put at least 50 public health experts in this region in the next 30 days because actually we do know how to stop Ebola."
Why would FDA bet on Frieden's claim? He will be fired if he turns out to be wrong? That would not be conforting if any single American dies in the U.S. for some government agency not being proactive. Why be hessitant at this point? They were not when they made an exception for toxic Cannabis (no Clinical Trials required).
Kevin Donovan, director of the Pellegrino Center for Clinical Bioethics at Georgetown University Medical Center, told National Geographic that he would recommend distributing any available drugs first to aid workers.
"Because if we allow the people who are treating it to be wiped out, there's no one left to treat it," he said. (Related: "Q&A: American Virus Expert in Africa's Ebola Zone: 'This is Like War.'")
WHO blunders
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larson1, that NYU doctor is a political hack...
Any announcement on full tox study and we will start testing some serious rocket engines!
If character assasination of Dr. Anil Diwan, President NanoViricides, Inc. and/or Dr. Seymour CEO NanoViricides, Inc. is the plan in order to slip in the idea that the full tox is delayed, that is not going to work.
Around year 2011 - 2012, some posters here were saying 10-20 years before clinical trials on any nanoviricide drug and here we are, moving forward to meet our goals for this year and Clinical Trials in Australia (2015). Our broad-spectrum FluCide to fight Influenza has been found to have excellent profile:
But we've been proactive...
More about the small private company that developed the Ebola drug:
Some sense of proportionality.
Leave it to a government mouthpiece in a classical cya action to tell the world whose fault is it. It seems this historian from Sierra Leone did not get the same memo:
Ebola is bioterrorism and it also means war!
There is no money to be made, by any biotech, in Ebola however, if the government steps in to do its job and protect the people/citizens it should do it by setting up a contest with rules, prizes, incentives, and results. It is in this way possible for biotechs to engage in the fight/war against the bioterrorist agent, Ebola.
The government threw $400 million at a biotech for smallpox vaccine. I am not suggesting throwing money at any biotech but keeping government as honest as possible by setting up a results driven contest with rules and prizes/incentives. People benefit from the added protection against disease, biotechs compete for revenue/profit and government does not continue spending more that it is necessary.
I am not so sure NanoViricides, Inc. would engage in that competition but it is another fast track to establish our technology and one drug in our antiviral pipeline of drugs. At this point in time, moving FluCide to the Clinical Trials (2015) is our main objective.
I'd like to know the cost in the millions/billions to government, funded by taxpayers, this Ebola (bioterrorism agent) is going to cost the western world now that that we know is out of control. War as usual means at some point more taxes to be paid.
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"...the Secret Service calls the vicepresident's transportation the "Wilmington Shuttle," describing one golf outing with the president that racked up $12,406 in taxpayer expenses, according to the Daily Mail. ~ Ronald Kessler
Interesting that Scientists would state the following:
Instead of having the WHO, or other government entity, solely select recipients of $100 million, to find a cure/drug for Ebola, why not let the market forces decide?