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For those here actually interested in some new Vaccine news around the world, there is a lot going on with many others. These are but a few of those. GO IPIX get these full results released please. What was the delivery system and amount of drug used for best results or cautious results? Thank you Board for your support here.
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8159019/
https://emergexvaccines.com/
https://emergexvaccines.com/emergex-announces-approval-to-initiate-phase-i-clinical-trial-of-its-next-generation-covid-19-vaccine-candidate/
To me news of these latest test results mean something totally different to the company versus someone holding shares of stock. This testing gives the company and others data/information about "B" and its usefulness. It is not all bad news folks. Yes if you own shares it turned out bad but if you are a scientist it gives you new data points and knowledge, that is why folks do tests to start with. They all learned something from these results, stockholders learned how to get mad and run. But holding is not fault of those who have stayed. It is the hope that this Brilacidin will have its day in court and in the sun to help humanity with ailments not now being handled very well by these MRNA vax machines. I for one am sitting tight as I understand what tests do, they drive you to the area you need to go to they allow you to know what not to do and what to do, they give you hope as to the proper use of your drug and where it can benefit humans in our society. Hate gets you nothing but more hate. Try some patience versus MacDonald's syndrome. Thanks all stay the course good things will come here.
As a company putting together a PR with results I won't say good or bad as we don't know all those details yet, they should have sent out the Friday PR on the same day within the hour, that way trading would not have sunk so low unless they had some internal intentional reason for doing so. I did not find the first PR bad news as some here felt from reading it. Poorly worded I will give you that, so next time don't rush to put out something that simply read badly. Thanks all, GO IPIX and LONGS.........
Thank you JTFM love it here. Be safe out there. GO IPIX LONG and STRONG....
The first bold print why not share the counts of the data per patient count here? 40 of XYZ or 60 of ABC etc. etc. Puzzles me. Second bolden statement then why test patients in this difficult population/situation of this type of patient's to best see promising results the use of this Brilacidin? If you knew it was difficult to achieve said results? Baffles me. Third bolden why Leo do you compare yourself to these other two dolts if you feel what you own is far superior than them in all the related subject matter put out over all these months? Baffles me. There should be no comparison to these others. Fourth bolden comment about the antiviral aspects/prospects of Brilacidin via NIH and academic researchers? From where?
What of the US Government testing of Brilacidin against these other (20) different virus streams, why would they do so if they saw zero promise here folks? To me if these results are (4) dead of (40) or (60) in a severe condition from Covid and we know nothing of existing health conditions with those patients and for all we know IPIX knew nothing of those patient conditions either here. Alot of items are missing here folks, this is not the end to this story for sure. To me no improvement over a placebo this means it does not matter if you are deathly ill from Covid nothing will save you. I will say at this time we had a Co-Worker on a ventilator two weeks ago and on a Friday was put on it. His Doctor prescribed Ivermectin to be used on this person that day and by Monday morning he was sitting up in his bed eating food and no I don't know what that means except it happened. On that Friday they felt he had no chance of making it. Just saying.
The last bolden comments. Not sure what they mean by the normally 6.67% die from this patient population. Assuming over 58 plus years old and sever Covid symptoms. I guess. Again missing components of counts and numbers as to what they mean on a graph or chart would be nice you put out this PR and it to me is a big nothing burger, except you could not save severely ill Covid patients, that is it.
WAKEFIELD, MA / November 11, 2021 / ACCESSWIRE Innovation Pharmaceuticals (OTCQB:IPIX) (“the Company”), a clinical stage biopharmaceutical company, today reported topline results from the Company’s Phase 2 clinical trial of Brilacidin in hospitalized patients with moderate-to-severe COVID-19. Brilacidin is being developed for treatment of COVID-19 under FDA Fast Track designation.
Brilacidin did not show a difference compared to placebo in reducing Time to Sustained Recovery Through Day 29, the study’s primary endpoint based on clinical status. Clinical status endpoints contain a degree of subjectivity that may impact outcomes of COVID-19 trials. Additional analysis of topline and all study endpoints is ongoing.
“Though disappointed with these topline results, treating moderate-to-severe COVID-19 is an exceptionally difficult patient population,” said Leo Ehrlich, Chief Executive Officer at Innovation Pharmaceuticals. “Companies, such as Merck and Regeneron, also did not show clinical benefit in these groups of patients, although both went on to refocus their development efforts in mild-to-moderate COVID-19 and achieve success. Regarding our Brilacidin antiviral program in general, collaborations with NIH scientists and academic researchers to explore Brilacidin’s broad-spectrum antiviral activity in different viruses are ongoing. Initial feasibility work to formulate Brilacidin for potential prophylactic use via inhaled delivery, to leverage Brilacidin’s unique virucidal and blocking antiviral properties, also is underway. There are many paths to pursue in the antiviral space. We believe Brilacidin holds tremendous promise as a differentiated antiviral drug candidate and plan to continue its development in this area of great opportunity and unmet need.”
Topline safety data showed Brilacidin was generally well-tolerated, with frequency of treatment-emergent adverse events similar between study arms. The number of patients who died totaled eight, four each between active and placebo. In the Brilacidin group, one patient who died did not complete the treatment regimen and withdrew from the study. The overall mortality rate (6.67%) in the trial was approximately one-half of what is typically observed in this patient population.
I agree with you here. It would have been nice to have a further detailed PR today concerning those that walk out of the hospital in good condition, those that remain in the hospital and their condition, those that died of other causes altogether. Again this is supposed to have been an AnitViral use here but this was a test for moderate to severe related patients. That is a high hurdle to jump over here as now we have seen. But to me the negligence of the PR in not pronouncing any good news about these tests leaved me puzzled. Not enough information and the wording leaves the reader to believe nothing good came from this testing. Which is not great of course, see the PPS now. Be that as it may I was here solely as a small investor to hope some good for humanity would come from this so I for one am sitting tight here. Other good things may come forth here and I am ready for that news to come. GLTA here. By the way for those shorts here who bought recently this is the OTC and is really a buyer beware stock. Thanks. Wish the PR had other news it did but not really related.
Patience all this is not McDonald's you're burger is not quite ready for you yet. GO IPIX.......................
A couple of reminders here for longs and newcomers to IPIX Know what we own folks. Do not lose faith by any negative posters here. Its all good. Gee why would the Government want to check how Brilacidin will perform against these others virus’s?? Things that make you go hmmmmm…………………….. But we know why don’t we folks. Good night all.
+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++
The Company is also pleased to report Brilacidin has been shipped to two academic laboratories for planned in vitro testing of Brilacidin in over 20 acutely infectious viruses, including Ebola, Marburg, Nipah, West Nile and Zika, through a collaboration with U.S. government scientists. The goal of this testing is to further inform the spectrum of Brilacidin’s antiviral properties.
+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++
Today the Company announced and anticipates reporting topline results the week of November 8th from its Phase 2 clinical trial of Brilacidin for treatment of moderate-to-severe COVID-19 in hospitalized patients
+++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++++
Dr Degrado, IPIX science advisor, is acknowledged by his peers as a leading researcher in the field of proteins, peptides
and defensins as well as defensin based pharmaceuticals.
Brilacidin is based structurally on a defensin peptide, Magainin. Attempts to make Magainin a therapeutic failed to to the structural weakness in its peptide core.
Dr Degrado and his team used biochemical and supercomputer enhancement to produce a new pharmacologically stable compound with superior antibiotic, anti-inflammatory and now antiviral capabilities, Brilacidin.
Having Dr DeGrado give a portion of a named lecture in his field is an honor .
Having Dr Degrado as IPIX's scientific advisor gives IPIX and Brilacidin scientific and academic credibility that is priceless.
Brilacidin research is just beginning to open its multiple possible uses as a pharmacologic agent.
Remember shareholders this evening it is morning in Russia/Moscow/St. Pete areas that is. So they may have some news perhaps?
A shout out to you DrBones, much appreciated. GO IPIX.........
https://rupharma.com/arbidol/
I had never heard of this before.
Anyway GO IPIX..........
Anyone here heard of this drug.
https://en.wikipedia.org/wiki/Umifenovir
Umifenovir, sold under the brand name Arbidol, is an antiviral medication for the treatment of influenza infection used in Russia[4] and China. The drug is manufactured by Pharmstandard (Russian: ????????????). Russian and China studies have shown it to be effective and it is approved in both countries while, it is not approved by the US FDA for the treatment or prevention of influenza because it was never applied for FDA approval since the drug company is in Russia not the US.[5]
Chemically, umifenovir features an indole core, functionalized at all but one positions with different substituents. The drug has been shown in studies to inhibit viral entry into target cells [6] and stimulate the immune response.
Umifenovir is manufactured and made available as tablets, capsules and syrup
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC7187825/
https://www.barchart.com/stocks/quotes/IPIX/opinion
88% BUY. What say you folks. Go IPIX.... GO Leo.....
Just a reminder to newbies here. Why would FDA approve such a move?? Things that make you go HMMMMMM............. KNOW WHAT YOU OWN FOLKS.
he Company has received individual patient Expanded Access (compassionate use) requests for Brilacidin to treat critically ill COVID-19 patients who are not responding to prior therapy. Expanded Access was implemented by the FDA and Congress to address physician applications for access to potentially lifesaving drugs, prior to FDA approval, for patients in their care when available treatment options have failed. Following receipt of such requests, the Company has supplied Brilacidin to relevant hospitals for individual patient use, with the FDA granting the treating physician permission for the emergency administration of Brilacidin. In addition to Brilacidin's antiviral profile, Brilacidin's immunomodulatory and anti-inflammatory properties may be particularly beneficial in treating COVID-19 in hospitalized patients.
GO IPIX............GO LEO...........
Perfectly great week of trading action on IPIX this week folks nice up and down action, nice healthy pull back on Friday, this bodes well for those that missed this boat the MM'S just helped their buddies get cheaper shares so they can also enjoy the ride up. I find this trading action very healthy here prior to news coming out soon. A lot of new buyers in here and most longs are all still here too. I think it was a great week for all here. New eyes now on IPIX as well. PFE had to come out with some more BS product as they knew this was coming along. Just like Car manufacturer's do get their product out a week prior to their competitors no different here. Pfizer holds all the cards in this game they have been there and done that. And on top of that they are REALLY, REALLY afraid of IPIX taking control of their profit margins soon. KNOW WHAT YOU OWN, BUILD IT AND THEY WILL COME. GO IPIX...GO LEO...
Looking forward to a climb on Friday to $ .75 and then Monday/Tuesday Boom Time, not that this week has not been great for us longs here, it has. Better days are ahead for shareholders and humanity here in my mind. A lot of good will come from all this background quiet noise I call it. Glad to be onboard here on a WINNER!!!!!!!!!!!!!!!!!!
Glad to know this was a fake trade here that someone is out to simply hold down this dam that is about to break full force. What a joke MM"s are there is no place in the world for this type of stock manipulation. Least of all a company with such great prospects for humanity as a whole. Oh that is right MM's who control pricing are not humans. Sorry, lost my mind for second. GO IPIX.... GO LEO.
My earlier predication this week of $ .75 by weeks end is holding up so far, we shall see how this week ends up. Hope it is actually higher but I will take $.75 PPS Friday afternoon. Thanks to all for your input here. Back to lurking. GO IPIX.... GO Leo.............. Good things are ahead of this little firm.
IPIX - Innovation Pharmaceuticals Stock Price - Barchart.com
IPIX - Innovation Pharmaceuticals Stock Barchart Opinion - Barchart.com
https://stockcharts.com/acp/?s=IPIX
Good times are coming and ahead for all longs here. GO IPIX... GO LEO....
I believe this will gain a little each day this week building up to news next week, is my guess. Maybe $.75 by week's end in my humble opinion. GO IPIX.
Alex Zhavoronkov Thank you for sharing this news.Congratulations on your continued success. It is exciting to see new companies embrace AI in their drug discovery and development. Based on our understanding of evolutionary biology and virus structure, we have established a robust AI-enabled Monoclonal Antibody Program. As a result, we have been able to fast-track our Monoclonal Antibodies for HIV and SARS-CoV-2.
AI has multiple uses it would seem here. GO IPIX...... Leo..........
Note the purpose of the CI, Efficacy and Safety. And 106 patients here.
https://i.redd.it/uhg1tfah06i61.png
https://www.sciencedirect.com/science/article/pii/S0882401021002023
Promising role of defensins peptides as therapeutics to combat against viral infection
Author links open overlay panelSubhash SinghSolankiaParulSinghbPoonamKashyapaManish SinghSansicSyed AzmalAlibd1
https://doi.org/10.1016/j.micpath.2021.104930
1.6. Defensins against SARS-CoV The lectin-like human a defensin 5 (HD5) and HD6 peptides protect intestinal infections. Lectins are proteins or glycoproteins that specif-ically bind to carbohydrates present on the glycoproteins surface. 2019- nCoV S-proteins and its intestinal receptor ACE2 both are glycosylated proteins. HD5 binds to the ligand-binding domain (LBD) of ACE2 gly-coproteins and masks its availability to enter the 2019-nCoV virus. This interruption between viral glycoproteins and cellular receptors activates the adaptive immune antigen-presenting phagocytes cells and interferes with nuclear enzymes that prevent viral cellular replication (Park et al., 2018). Human neutrophil peptide-4, bovine beta-defensin 1, HD5, HD6, rat neutrophil peptide 1 (RNP-1), RNP-2, chicken avian beta-defensin 5 (AvBD5), AvBD6, and channel catfish beta-defensin peptide have the antiviral activity against the Middle East Respiratory Syndrome Coro-navirus [3]. HNP1-6, HD5-6, and HBD2-3 defensins remove the viruses by getting in the way of viral entry, membrane destabilisation, immune-modulating, downregulating receptors and ligands such as ACE2, CD4, CCR6 CXCR4, CXCL & CXCL5, lysosome fusion, inhibiting essential proteases, central dogma enzymes, and post assembly of virion particles [37,70]. Bio-computational designed Brilacidin is a synthetic non-peptide defensin mimic drug that destabilises the viral membrane by its amphipathic & hydrophobic nature, and its immunomodulatory prop-erty influence the expression of IL-1ß, IL-6, TNF-a cytokines, and cAMP& PDE4/PDE3 pathways which are associated with bronchodilator and anti-inflammatory effects of COVID-19 disease. The smaller size, more effective antimicrobial activity, bioavailability, low enzymatic degra-dation and toxicity, natural and low-cost production make the Brilacidin a most potent drug against SARS-CoV-2 than the known antiviral drugs. Dalbavancin, Telavancin, Oritavanci, and Roflumilast are other Brila-cidin like drugs used for MERS, SARS, and SARS-CoV2 viral inhibitions [71]. Rhesus macaque’s leukocytes express ?-defensin1 (RTD-1) and RTD-2 antimicrobial peptides in response to viral infections. HD5-6, HNP1-6, HBD2-6, and retrocyclin-2 inactivate the various enveloped and non-enveloped virion particles by interrupting virus pre and post-entry steps, chemokines, and cytokines immunomodulation, chemotaxis of immune cells [72].
ClinLine
Registers: Research Institutions Researchers
HomeClinical Trials RegistryIPI-BRIc-201
IPI-BRIc-201 Protocol
Protocol name
Double-blind, placebo-controlled, randomized, multicenter Phase II trial to evaluate the efficacy and safety of Brilacidin in patients hospitalized with COVID-19
Therapeutic area
Anaesthesiology and resuscitation, Infectious diseases, Oncology, Therapy (general), Surgery, Cardiology, Pulmonology, Toxicology
Start and end date of CS
17.12.2020 - 31.12.2021
RCR number and date
705 17.12.2020
Organization conducting CS
Innovation Pharmaceuticals Inc. (Innovation Pharmaceuticals Inc.)
Name of LP
Brilacidin
Dosage form and dosage
solution for intravenous administration, 50 mg / ml
City
Barnaul, Kirovsk, Moscow, Nizhny Novgorod, Ryazan, St. Petersburg, Saratov, Yaroslavl
Country of development
UNITED STATES
Organization engaged by the developer of the LP
iPharma LLC, 143026, Moscow, the territory of the Skolkovo Innovation Center, Nobel Street, 7, Russia
Phase KI
II
Type of KI
ILYICH
Purpose of KI
evaluation of the efficacy and safety of Brilacidin in patients hospitalized with COVID-19
Number of Medical Institutions
20
Number of patients
138
Where the study is conducted
1
KGBUZ "City Hospital No 5, Barnaul"
Region
Altai Krai
City
Barnaul
Researchers
Martynenko T.I
2
GBUZ LO "Kirov MB"
Region
Leningrad
City
Kirovsk
Researchers
Klinov A.S
3
ICB NO 1
Region
Moscow
City
Moscow
Researchers
Nurmukhametova E.A., Bystritsky D.A
4
GBUZ "GKB NO 52 DZM"
Region
Moscow
City
Moscow
Researchers
Fomina D.S
5
FEDERAL STATE INSTITUTION "CCB with polyclinic"
Region
Moscow
City
Moscow
Researchers
Lomakin N.V
6
GUZ GKB NO 15
Region
Moscow
City
Moscow
Researchers
Gordeev I.G.
7
EVDOKIMOV MGMSU of the Ministry of Health of Russia
Region
Moscow
City
Moscow
Researchers
Vertkin A.L., Rogova I.V
8
GBUZ "Research Institute of SP named after N.V. Sklifosovsky DZM"
Region
Moscow
City
Moscow
Researchers
Zhuravel S.V
9
First Moscow State Medical University named after I.M. Sechenov of the Ministry of Health of Russia (Sechenov University)
Region
Moscow
City
Moscow
Researchers
Moiseev S.V., Smolyarchuk E.A.
10
GUZ NO GKB NO3 (NGC)
Region
Nizhny Novgorod Oblast
City
Nizhny Novgorod
Researchers
Makarova A.E
11
GBU RO "OKB"
Region
Ryazan Oblast
City
Ryazan
Researchers
Ivanova A.Yu
12
St. Petersburg State Budgetary Institution "Nikolaev Hospital"
Region
St. Petersburg
City
Saint Petersburg
Researchers
Nigrieva Y.N
13
St. Petersburg State Budgetary Institution "City Mariinsky Hospital"
Region
St. Petersburg
City
Saint Petersburg
Researchers
Mamonov A.G.
14
S-PB GUZ "City Hospital No 38 named after N.A. Semashko"
Region
St. Petersburg
City
Saint Petersburg
Researchers
Popov A.V
15
St. Petersburg State Hospital "City Hospital No. 15"
Region
St. Petersburg
City
Saint Petersburg
Researchers
Goloshchekin B.M
16
St. Petersburg State Budgetary Institution "City Pokrovskaya Hospital"
Region
St. Petersburg
City
Saint Petersburg
Researchers
Khmelnitsky O.K
17
Saratov State University named after V.I. Razumovsky of the Ministry of Health of Russia
Region
Saratov Oblast
City
Saratov
Researchers
Schwartz Y.G.
18
GBUZ YAO "YAOKGVV-MC "Healthy longevity"
Region
Yaroslavl Oblast
City
Yaroslavl
Researchers
Mozheiko M.E
We all have something here to look forward to and on the positive side are the below observations which all bode well for investors here.
Brilacidin approved by FDA for compassionate use, which means what no major side affects or deaths from its use, and possibly little to no side affects either to authorize this to move forward. So why did FDA approve this use unless it was good news or some good/great results that they had no choice.
If any bad news existed such as deaths or failure to provide comfort and relief or deliver as promised it would be known pretty much by anyone in the know here and would leak out as bad news thrives in our world today.
Results are forthcoming soon here just need to know what you own here. Assuming good results based on the above observations.
Military involvement would be kept quiet until they had what they needed to support their efforts and of course Leo will accommodate them for a small stipend/fee here. All good stuff folks.
BP keeping their mouths shut as they don't know what to do when this hits the market as a working therapeutic my guess is they are lining up quietly and do not think for a moment they know how small Leo's team is either, they do most assuredly and wonder WTF did I not know this existed, dang it all to heck.
A BP buyout I do not think is in the cards assuming Leo is in for the long haul here with other potential life saving uses here and being concentrated not solely on COVID issues only, others are out there as candidates for relief as well and Leo knows that and believe me so do the BP boyz.
This is a long term hold for those who have been here awhile you will prosper with those holds.
I would love to hear the meetings and phone calls Leo must be getting here watching BP firms squirm to get a piece of this, or try to dismantle it altogether, hence the testing in Russia kept it away from manipulators amongst those scurvy bastards. If I were Leo I would milk this until the cows run dry if he in fact makes any such deal.
Perhaps the play here is deal with them all as Brilacidin may have potential benefits with all their drug lines thing about that for a brief second folks, what now that is impressive.
Cancer, indigestion issues, COVID, the normal flu season, Nipha virus, variants abound or are still being created by A holes, eblola??? One stop remedy right here folks.
to all those who wish to day trade this buyer beware and invest only what you can afford to lose here. This is not a day trade stock folks. Pennies at this point are foolish trades unless buys are being traded. Sells at these levels is simply foolishness.
GO IPIX............... GO LEO you know what you are doing. Keep it up.
I heard on Japanese news today that Thailand is going to begin accepting out of country visitors again without quarantine restrictions, this bodes well here for Thai Airways. GLTA here.
Just in case no one has seen this yet.
https://www.japantimes.co.jp/news/2021/09/27/national/science-health/sotrovimab-japan-panel-approval/
If the media and the BP folks and others would get off of their high horses for a minute IPIX and "B" may have a shot, but all those folks are making a lot of money on things that are a 1/2 a band aid approach versus a total fix. Not sure how they will spin this "B" when it comes around here, they hold sway and regardless of the results they are beholding to each other media=BP=D.C.=CDC=FDA=NIH=WHO. Money talks shiite walks.
This is how I see it. GLTA here, long holder here hoping for great things as you all are, but it is really up to those I have mentioned herein. GO IPIX.
I had heard a small news clip this week on the radio and it is the next virus that IPIX's "B" needs to tackle as it is next up, 75% death rate. NIPAH Virus.
https://www.bbc.com/future/article/20210106-nipah-virus-how-bats-could-cause-the-next-pandemic
GLTA here, GO IPIX need Brilacidin now.
"The Sting", this is that movie folks. GLTA with your sound investments sell em if you hold em.
Nothing simple about this set up, anyone seen the movie about Paul Newman and Robert Redford running a con on criminals, this is no different. MZ is a stooge for others here folks, this all was a rich set up.
Must be a great company here all Liberals and criminals use its services and those who aim to provide more strife in the world, TWTR loves these folks. Good Luck providing more strife in the world. Love you baby. GO TWTR.
Yes and they will get one from the BP companies not this one I am afraid after holding two years now. Sad but true learn a lesson folks money talks no matter what you have and shiite walks. Just the way of the world, swallow your pride and move on from here. Nothing coming I am afraid. I hope someone can help the future lives of humans that need such a drug but I am afraid it is not in our cards now. Just what I call stringing along we are on a hook and cannot get off, now you know what a fish feels like.
Would like to know the financial arrangements with Samsung Biologic's. Anyone here know?
Thanks. GO ENZC... still here lurking/long.
So it means actually of this evidence what exactly? That it works only for a short period of time only and what is that time frame? Seems like most news stories are incomplete with all the information. Like for kids 5 to 11 what is their rate of infection and how many have died to have to force them to get a shot? What are those numbers versus long term affects of this vaccine in their little bodies? No one ever says, they just say get the shot. GO IPIX need you more than ever now that the kids will be indoctrinated into this do it or else culture that has been allowed to occur.
Starting to fly again to certain countries slow and steady wins this race folks, I am long here on TAWNF no issue here flew this airline many times, loved it then and it will come back big time, watch out above. GO TAWNF....