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Again
The complete misunderstanding of
our company..
We were not formed nor created nor funded to be taken over or merged ..
I only read your teeet through someone else reply as I have you on ignore..
We are not an M&A target by design.
Blarcamesine and a3-71 are human health drugs whose potency reverses dementia..
The actual potency is derived from a properly agonized human cellular chaperone cell , the sigma one ligand,
Which we are learning balances calcium
Channels creating cellular homeostasis..
We already are big Pharma..
Institutional investors jump off cliffs with the herd of Tetonka ..
Anavex is about to change the human health dynamic..
But you already know this..
Because all the shares are fake as hell short sakes
There is no inventory on the selling side because the shares don’t exist
What a scam the mm run
250,000 shares?
What a joke
Sorry it’s like talking to
Imen Hell.. you can find his video on YouTube just not the ones warning you about dangerous medicines that cause blood clots and kill young people
It’s like talking to hell
And it lends to a perception that anavex is not leading the AI - precision driven DNA modeling treatment and clinical proofing ..
Is proofing even a word?
We are leaders in technology use..
Leaders
Even if doing manually..
Talk about misconception of what
Data driven AI precision medicine is
All about..
It would be more than a decade to see same data if not for computers and AI!
Actually.. we would never see this data if not for AI and computers..
I make misstatements all the time..
But this was a doozy
No I believe you..
I mistaken.. didn’t know that..
But maybe I purposefully trying to mislead!
Maybe I have ulterior motive!
Lying to trap people into buying scam stock!
Haha
Thought the snow would melt today so we could play gold tomorrow.
Made tee times
Called my friends
But although it’s 50 degrees
The ground is so cold from arctic blast
That all my plans for tomorrow which seemed reasonable based upon
temperature are for naught.
Didn’t try to lie, didn’t plan on not being able to play..but I will be working upon other aspects of life fulfillment until the snow melts..
The best laid plans of mice and men..
And that happened without people making money if I dont play golf tomorrow..
Thank God no one actively to destroy my financial value..other than democrats
A transition strategy to a Big Pharma..
Reasonable..
That could be another
positive after peer reviewed
And revenue
Thx Doc this does help
A fool asks for vinegar instead of the wine he already has in his cup!
How would the market react to anavex losing its CEO?
You think TGD would have any issue finding another path? Making more money? Still being the largest single shareholder of anavex!
Do people think before they write
utter pablum?
It’s hard to understand how they ever accumulated the wealth and intelligence to be here..
When I don’t have people on ignore it means they haven’t trashed the
Company or our ceo..
So it’s nice to get the backstabbers in front of us..
Frustrating that patients are not the first order of business for all here and
getting them access..
Oh well each must answer..
God may offer abundance but judgement is never as a collective ..we all have a choice of good or evil
Peace be upon you
I would be more upset at your fellow longs
who have traded momentum at every turn and then not supported share value except to sell momentum again and again!
Your fellow longs have betrayed our MC
by selling calls and “trading shares” in a coordinated manner using “ technical analysis” and Facebook as their communication and launch pad..
If you want to be disgusted by someone..
Anyone who has sold their anavex shares at a high price is more guilty than TGD..
He hasn’t sold a single share!
So as the saying goes..
Go Find Yourself
Plex do you think TGD has an ordered plan that builds upon itself for patient access and government approval?
I think he does
I think the Voucher for RSS May come into play as well.. also, leading with more complete TLR for AD trial.. or maybe
Peer revieviewed article has to lead way and it got delayed..
There is a plan.. our SP does suck it should be 10 times higher..
Don’t be sore
Buy more!
Patience for the patients
Angst and aggression build upon
Inflammation and we all know
inflammation is bad especially for CNS disease.
TGD and Anavex have told us all that
Makes sense for their plan to aggressively pursue access.
That is all we need to know..
Largest short position in history..not helping MC .. we don’t need money..
Patience for patients..
It’s a beautiful drug..
But the real beauty is the
Sigma One Ligand Chaperone!
What a Homeostatic Comductor!
The Beethoven of human health
The Mozart of bio health
Except the weeks when anavex announced
Universe changing data from Rett syndrome, Parkinsons dementia and Alzheimer’s clinical trials.. those weeks
Geoerge was spot on.. I am sure I missed a couple
The PDD 2 data release focused on high dosage and was incredible!
I never saw low dosage results..
Which means probably very small..
Guessing Alzheimer 2b/3 the same..
So of 320 dosed
200 close or same as placebo..
120 super responders same or better than when started..
So that equals. 2.6.. average overall??
Regulators are gate keepers
That Gate is revenue & access
Regulators are at the top of the
Info Chain and Planning Chain..
You do NOT want to kiss them off..
So yeah.. investors and the public
are not Anavex’s number 1 concern..
Nor should they be at this point..
Than you don’t understand dilution
Do we have news?
Peace!
This has not been a topic or concern for management since phase 2a results..
I will leave it at that
My other guess..
Many participants stopped taking DZP
During and after trial.. I guess few if any OLE participants still take DZP..
That would be a great question for DrMacfarlane or TGD..
These are notable points..
But again..
I go back to the person who
knows OLE data for hundreds of patients for multiple years.. and he says two things:
1. High Dosage is THE common denominator.. NOT DPZ Naievete, NOT S1r wildtype..
2. Expect results similar PDD high dosage..
I posted the PDD high dosage results ..
I will go with the person at the helm who actually KNOWS the data..
Merry Christmas!
So don’t you think the PDD
Participants had the same DZP
usage? The company has not said DZP is a negative factor.. ever..
I am going with over 100 super responders in High Dosage group ( out of 160)
Think it could be closer to over 125!
The high dosage is the key..
That is why I reposted the PDD data
I Believe you about chart..
We also have to consider the
jabbed and what percentage have been reacting horribly to that experimental
…..”medicine”… and covid..
So .. it is my contention that
the High Dose of Blarcamesine empowers
the S1r system of somewhat healthy people.. you don’t have to be terribly
healthy for your body to express enough S1r that Blarcamesine on high dosage will cause that expression to expand!
What we don’t know yet..
Is does the broader expression of S1r on high dosage mean that New Cellular S1r are being created through exosomes/ mRNA ?
This to me is the super freak question!
Is Blarcamesine so succesful and the S1r so powerful that we will identify MORE cells with S1r apparatus than BEFORE high dosage?
No one has answered this question and I don’t know if even Anavex knows the answer..
They know S1r expression increases
but is that due to
Agonization? Propagation?
Or BOTH!
Power
I was under the impression DZP is no longer widely prescribed..
These are good numbers.
Think we wil be higher .. but these are exceptional
Patients who finished ANAVEX 2-73-PDD-001 were invited to continue or start treatment with Anavex 2-73 in ANAVEX 2-73-PDD-EP-001 (NCT04575259), a 48-week (almost one year) extension study of the therapy’s long-term safety and efficacy, as well as potential treatment effects on gut bacteria. It is due to be finished in June.
How much data does anavex have from OLE trials? All they need
Interesting.
Early modeling thought they would
Be adjuvants.. didn’t work..
Early super responders were Naieve..
Avxl said no connection.
But that was a guess..
Just as this is a guess.
Many patients have stopped DZP so
I think you are wrong on both counts..
That DZP stops Blarcamesine and that
our super responders will be fewer ..
I have guessed 80-90% of high dose
will be super responders..
This would mean according to the average 2.25 point increase overall response of dosed and average of placebo 4.5 that 30mg and non responders were very close to placebo..
high Dose will be proved to be key..
Just as it was in PDD..
Everything else wii fade away into background..
Doesn’t seem old
They know OLE data of high dosage for hundreds for multiple years..
We need access to this
Miraculous Drug
It was a small sample of 40/40/40 I think
But WOW!!!!!
Kids
Did we miss this report?
I did!!!!
https://parkinsonsnewstoday.com/news/anavex-2-73-high-dose-improves-pdd-patients-subscores-mds-updrs-phase-2-trial-update/?cn-reloaded=1
Can anyone believe this?
Dose-dependent increase in scores for episodic memory — the ability to remember new shared information and personal experiences — was also reported. While the placebo group scores fell by 20.82 points, the scores for those treated with Anavex 2-73 rose by 21.40 points, a 44.22-point improvement in episodic memory scores.
44 point difference! Miraculous!!
More recent data confirmed these cognitive and sleep benefits and also showed the therapy’s high 50 mg dose led to a 10.98 points drop in the MDS-UPDRS total score, indicating an easing in disease severity across several measures. At the same time, the total score in the placebo group rose by 3.53 points, representing a 14.51-point difference and an 18.9% relative improvement over 14 weeks.
n MDS-UPDRS Part I, measuring non-motor experiences of daily living including cognition, mood, psychosis, and sleep issues, 12 out 13 items assessed improved (92.23%). MDS-UPDRS Part II examines motor experiences of daily living, from speech and eating to doing hobbies, and 10 out of 13 items improved (76.92%).
Or for MrN to lose Caesar share
Speculation:
So if 120 respond 80% at their baseline or better..zero decline..
Then My hypothesis is of the 200 patients left ( 40 in high dose and 160 in 30 Mg )
100 responded to 2.25 or to overall average increase and 100 responded
Very close to placebo..
Think titration to highest dosage as soon as possible is key to expanding
The super duper responders ..
Don’t know if lower dosage will be seen as providing benefit because everyone will want to titrated to highest possible dosage as quickly as possible..
These are all guesses and IMO…
So if 200 responders combined 40 high dose and 160 30 Mg average 3.6 point increase ( mental decline)..
Let’s say 80% responded..so 160 of 200
Scored the overall 2.25 average score increase..this means 40 dosed patients
Would have to increase by 10 points twice the placebo historical decline in ad..
So.. we did not see and 80% response rate in non high dosed nor in high dosed non responders..
Thinking with as much as TGD focused on high dosage equaling common denominator the 40 high dose did respond ..
And the 160 30 Mg patients saw some slowing of symptoms over and above placebo..
Guessing of the 200 dosed low responders
They still average better than placebo..but since placebo 4.5 drop.. guessing
the 120 high dosed super responders really lift up the numbers..
The OLE of PDD and AD should show the titration to higher dosage
the dosing at night and biological evidence of higher S1r expression over time will make over 80% of all participants super duper responders..
We will get a feel for these numbers from PDD OLE