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Sleven, When I would commute to work, I had a van mate who sold CBD oil. It sounded like the new snake oil, good for both humans and animals. Anxiety, pain, neuralgia etc. He said it worked for his anxiety. CBD isn't cheap either. The THC has to be processed out. I've never used it myself.
My brothers use Cannabis, one is partially paralyzed, he can still get around but has to use a cane and drags a leg. My other brothers knees are shot (overweight). IDK maybe it's more of a fad than anything. I know a lot of folks use cannabis now. I started growing Cannabis in my garden this year. You harvest only the female plants and kill the male plants. One plant got to 7 ft tall, I got over a Kilo of cannabis from it. Made all my neighbors happy as clams.
It could be a Disney moment; "Dumbo with the Feather" idea. If you believe it will work it usually does.
With regards to Vascepa however, the numbers didn't lie (Cholesterol) when my TGs dropped substantially without a change in diet. Even when I wasn't taking a statin they dropped. The Herpes Simplex disappeared. The aches and pains were gone. I'm still able to get an erection (Big benny), without the little blue pill. :D)
I still can't believe how good Pete Carroll looks at 70....he must be on Vascepa too. He jumps around on the sidelines like a 30 year old. Or maybe he has a young good looking wife like I have. Got to keep up with the missus.
Remember the Red Green Show ; "If they don't find you attractive at least they'll find you handy."
Agreed, today's price exceeded my expectations as well. Finally got some life.
Az Cardinals may be in the hunt for another quarterback. Kyler Murray torn ACL, may not start next season. Derek Carr's (Raiders) name is being mentioned. JJ Watt also retired. Maybe a new Head Coach as Kliff Kingsbury hasn't lived up to expectations. Of course it's the NFL. In the old NFL coaches names like Lombardi, Shula, Landry, had jobs until they quit or retired. Today it's coaches like Reid, Belichick, Pete Carroll (70), Arians, that are the old guard now. The next generation? Who's going to stand out?
Active NFL coaches with the most wins:
Bill Belichick: 324 (293 regular season, 31 playoff)
Andy Reid: 254 (237 regular season, 19 playoff)
Pete Carroll: 166 (155 regular season, 11 playoff)
Mike Tomlin: 164 (156 regular season, 8 playoff)
Mike McCarthy: 157 (147 regular season, 10 playoff)
Sleven, you know I was just kidding about the bribes, right? We know that never happens.
So, one of the important aspects of Vascepa that I've experienced is; That it does help with inflammatory issues. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8961629/
I've personally experienced this in my clinical study of 1. Before getting on Vascepa;
I used to get Herpes simplex (Cold sores) annually particularly around the mouth area. Not anymore...
My knee due to a football injury used to hurt (no longer). As for other joint pain or arthritis conditions to speak of. I have none of the above. I'm 71.
Although not an inflammatory issue; My anxiety/panic attacks have diminished, although Cannabis helps as well. However, I only take a few puffs of weed about every two weeks.
My mother passed away with Dementia, so I'm her son, who inherit's her genes. My dad was fine, I was joking with him the day before he passed. Other than forgetting where I put stuff or why I went from one room to the next to get something (baffled). Nothing so far?
I need to research this excerpt from EISAI's blurb, unless someone more knowledgeable in chemistry/biology wants to step in?
"a humanized immunoglobulin gamma 1 (IgG1) monoclonal antibody directed against aggregated soluble ("protofibril")* and insoluble forms of amyloid beta (Aß) for the treatment of Alzheimer's disease (AD)."
Monoclonal antibody? https://www.cancer.org/treatment/treatments-and-side-effects/treatment-types/immunotherapy/monoclonal-antibodies.html
Aggregated soluble Protofibril? https://www.nature.com/articles/srep38187
amyloid beta...I think I can find out the definition to this one. https://www.nature.com/articles/s41598-017-06377-8#:~:text=Protofibrils%20of%20the%2042%20amino,the%20pathology%20of%20Alzheimer's%20disease.
Sounds like EISAI developed an antibody or vehicle for the antibody to attack amyloid plaques? Maybe Mother nature has already been there done that with EPA?
LEQEMBI sounds pretty safe, no restrictive side effects.
VASCEPA is cheaper by far, even paying full boat (without insurance or discounts) $1000 for 90 days. Of course the generics and their buddies will be chomping at the bit if BRAVE comes in strong.
Yes, imagine that! A lot of greenbacks must have been exchanged... :D)
Well, shut my mouth....
Pretty pricey; $26,500 per year, 100 mg/mL injection for intravenous use, administered every two weeks. What's not to like. If it works.... Yowza!!!
https://investors.biogen.com/news-releases/news-release-details/fda-approves-leqembitm-lecanemab-irmb-under-accelerated-approval
Marzan, January 10th, San Francisco
https://investor.amarincorp.com/news-releases/news-release-details/amarin-present-41st-annual-jp-morgan-healthcare-conference
JonSnow; pure speculation and gut feel on my part. I've been wrong before. Keep in mind we're in a recession whether we think we are or not. I would think (IMHO) when Karim speaks next week and provides any kind of updates at the Healthcare Conference? perhaps, perhaps not? I think the markets, especially Tech markets are in a wait and see period.
What are the catalysts for Amarin to surprise us with? We know everything Michael Yee knows, cash burn, stabilized scripts, Mineral oil issue (dead), EU status (waiting for updates), HN settlement (details not made public), combo pill (?), Evaporate EPA updates from Doctors Nelson and Budoff. What else? BRAVE study (2024), Lawsuit against Hikma (?) Australia? China (don't hold your breath). Funny nobody's talked about South America, Africa, Middle East?
I don't disagree with you, there's a lot to digest. I think we're in a wait and see, might as well take some money off the table. I still have a few shares left :D)
Thanks North, years ago when I was trading with a broker, he said if a stock goes up on no news it's usually a good sell indication. IMHO, Michael Yee's upgrade is just such an opportunity, unless of course the JP Morgan San Francisco Healthcare Conference is going to provide anything new on the horizon.
Life is a crap shoot.
For more detail see scxj post # 397071 and or panton post # 397045
Thanks panton
You're a bigger idiot than I thought;
"Putins invasion of Ukraine and the cut off of a cheap gas supply forced economic hardship on the EU countries affecting among other things their ability to fund their healthcare systems."
It wasn't the placing of missiles in the Ukraine was it? You Kalifornia Kool-Aid Kids will believe anything the Liberal media publishes.
Joe didn't have to apply pressure on Western Europe for oil sanctions against Russia did he? Causing an energy crisis in the US and EU.
Let's keep the topic on the effects of Vascepa rather than blather on about topics that are out of our control or that you know little about.
We all know that Vascepa has proven itself over and over. That it's a proven CVD drug when combined in conjunction with a statin. To place so much Hope on other studies (Mitigate) is nonsense. This Cytokine storm theory might very well be, trying to prove that Vascepa is a preventative drug for this condition is subjective at best. I've been taking Vascepa all along and I've gotten Covid twice. Did Vascepa help with Covid inflammation? How would I know? Vascepa is not a cure-all like we all think it is. It is wonderful for lowering Cholesterol and getting heart attacks, there-in lies the value. Not in some political grandstanding.
Personally; I am looking forward to the Brave study results
Ha ha, I'm too cheap for that, I grow my own. I did buy a pretty cool gadget called the "Mighty"made by Storz & Bickel. Pricey but works really well.
I could make brownies I guess.
Thanks LB, I took two hits off the Albuterol (inhaler) and took my first dose of Paxlovid. I think the Albuterol helps a lot. I've had worse chest congestions before. I had Bronchitis when I was younger, most confuse Bronchitis with Croup. Bronchitis is the more serious condition. Either one is terrible, especially as a parent when your young child can't breath.
No smokin the strange stuff for a while until I get over this. :D)
Although I am craving a Pepperoni Pizza about now....maybe I'll re-primer the jeep?
Yeah, imagine that? Highly recommended by clinicians. 3 tablets twice a day for 5 days. Two pink ones and one white one. What a scam. Cheaper than Mucinex OTC however.
Just got out of the clinic. I was tested positive for Covid. They suggested I take an experimental drug called PAXLOVID. I asked if it was “free” :D) Gonna give it a try.
Hmmm, getting off the cruise ship on Tuesday, I started feeling nauseous, stuffy head, slight sore throat.
Yesterday things started getting worse. Went to get a COVID test (no results yet). Runny nose, tired, stuffy head. Last night was terrible... went to bed early, restless sweats. Woke up this morning with stuffed up nose and upper chest congestion. Scheduled an Immediate care visit this morning.
I've had one J&J shot in April 2021, no booster, no mask unless required by the places we visit.
I've been taking Vascepa normal 4 g dose.
Good luck to your parents.
I beg to differ. However, I can see your point, there's articles out there that support your point. All I can say is there's always under currents in the energy markets. deals done behind closed doors or on golf courses. Lets compare notes; I worked for an AZ Utility. California Utes had excess Renewables (Photovoltaic and Wind), so much so that they paid (my usta) both utilities in the Phoenix and region to take it the excess renewables. At least that's what my management presented to us during "All Hands" meetings. "It's complicated."
Look up a guy named Tom Styers (Billionaire) who is a proponent of Renewable Energy (California). He pushed a Proposition 127 (AZ elections 2020) that would have (if passed) required AZ utilities to increase their Renewables (Solar, wind) to 50% of baseload by 2030. There were dire consequences involved if this Proposition would have succeeded, loss of jobs for one.
https://www.energy.ca.gov/data-reports/energy-almanac/california-electricity-data/2021-total-system-electric-generation
I just got back from a trip to the Caribbean, Aruba, Curacao, Bonaire etc. On these islands (Aruba and Curacao being desert islands) and the other islands we visited, relied on Wind generation. They also use Desalination (Reverse osmosis) to supply each island with water. They pump and store (using gravity for pressure), as I saw quite a number of water storage (tank farms). Albeit electricity and water are very expensive there. So, it is feasible to produce water using renewables.
So, if my notes seem plausible, why wouldn't California build more Renewables if that's what they want? Heck, they shut down their Coal and Nukes except for Diablo Canyon. United Arab Emirates (UAE) are utilizing Nuclear Plants to desalinate ocean water. California has the whole Pacific Ocean to utilize? Keeps your hands off our water (Colorado). :D)
Let's end our discussion here, as I don't want the babies to start crying and whining.
Centene has a market share of 9.1% in the United States according to Google. I searched using largest health insurance companies in the USA
What California needs to do is use their excess Electricity to desalinate. Of course they’re so f__ked up in that state as they’d have the tree huggers suing the crap out of them for destroying the environment.
California gets some not most of their water from the Colorado River. Don’t forget Arizona and Nevada take water out of the Colorado too (a lot of water). By Congressional directives.
I’m back from vacation, doesn’t look like I missed a lot. The “closed” to the public settlement didn’t do much for the share price I see? With Amarin’s track record with court proceedings, you can’t blame them for putting this case behind them. Now unto bigger fish.
You're spot on ORBAPU, it was the donut hole effect. Apparently, I reached the $4200 retail limit for drug coverage for 2022. So, I ended up paying 25% of Retail price for Vascepa. At least now I won't need to get another script filled for almost 5 months as I got a new 90 day script today. It's a wash as my co-pay is $500, but I won't need to pay until nearly May 2023.
I probably could have waited to fill my script. Mail order for Vascepa should be around $70 for (3) 90 day refills according to my Humana Plan. If I'm reading it right.
My agent said the new Retail Gap has been raised to $4,660 for 2023.
Thanks for your help.
Nuke
Don't know, I changed to a Medicare Advantage Plan 2 weeks ago? Maybe it's already gone into effect? It shouldn't have, but who knows? Guess I'll call the agent who sold me the Plan.
Got my 4th script of Vascepa before the end of year. I paid $244 for it, no explanation from CVS. They said Insurance perhaps? I paid my deductible ($500) for my first script of 2022, then I paid $9, $56 and now $244 it doesn't make sense? BCBS offices are closed for the holiday, are you kidding?
Let's look forward to a better New Year. Amarin should do well in January, I'll be looking forward to the HealthNet settlement news and the Healtcare conference in San Francisco.
https://finance.yahoo.com/news/amarin-present-41st-annual-j-120000099.html
Brave Study response; Remember I sent them a email concerning Fish Oil Vs Vascepa? I got a reply from the University of Wisconsin. Names were changed to protect the grumpy.
Feel free to contact the contact Kelsey sent me. I'll be away from the board for 2 weeks over the Holidays (aka Holy Days), "thank God the people said." :D) enjoy the Holidays everyone. Grumpy
Hi Michelangelo,
Thank you for contacting the Wisconsin Alzheimer’s Disease Research Center. This information has been forwarded to the BRAVE study team at our center.
In addition, to contact the Brave study in the future please contact Hannah Zylstra at hzylstra@wisc.edu or the BRAVE phone number: 608-256-1901 ext 17152.
Have a wonderful day,
Kelsey
Kelsey Shuda | she/her/hers | Outreach Specialist
Wisconsin Alzheimer's Disease Research Center
3330 University Ave | Suite 200 | Madison, WI 53705 | Mail Code: 9210
Phone: (608) 265-0548 | Email: klshuda@medicine.wisc.edu
Web: adrc.wisc.edu/ | Follow us: Facebook | Twitter | YouTube | Podcast
I think if we did one of our famous “Polls” there would be a resounding “no confidence.” Outcome concerning the IRS. “They should be an agency for the people.”
Sure, there’s going to always be people who take advantage, cheat on their taxes ect. But goodness gracious, this has been so one-sided it’s comical.
I think folks need to get out more often and see the world. Yes, we’re fortunate to live here. We have so much.
Once people dig deeper then they would realize these are fleeting times.
First, they’d have to admit to making a mistake? I’ve never seen that ever. They lost my return last year along with my extension, so now they’re charging me a penalty for late filing and interest on back taxes. Plus they’re taking whatever amount they think they should get per month instead of something people can afford to pay? And I can’t even get in contact with them to discuss my issues?
Really? That’s an efficient and user friendly agency?
Let’s wait and see shall we? I’ve never received an interest payment on top of any income tax return…ever!
Capt; Hate to rain on your parade, but I'm afraid you won't see any interest accrual. Unfortunate.
Great job Duke, What happened with the Four (4) kids? The curious want to know?
Part of the 87,000 added headcount I'll bet. Don't forget we're a friendlier, helpful IRS.
Understand, you got help, that's fantastic!! Last year was another story.
My lessons learned is pay the taxes dummy.
Duke; agree, it's criminal is right. Sadly, the IRS doesn't give a rats. But wait, they're only doing what Congress has allowed them to do right?
Think about this one, taxpayers pay taxes upfront usually payroll, Social Security, IRA withdrawals ect. If you owe and file for an extension on your tax return (April 15 to October 15), guess what? You pay an interest charge on the money owed. Does the IRS pay you the same interest rate on the money they've withheld from your paychecks for the entire year? ....... CRICKETS
Higher lows and Higher highs, except the Colorado kind…. :D)
Almost forgot; The IRS taxes you for taking all the risks, as they still get their "cream off the top." Their cut.....regardless of the risks you take. I realize ROTH accounts help, but it has it's limitations, the IRS doesn't want to miss out on their cut, that's why they limit you on the amount you can set aside.
Did I mention Required Minimum Distributions (RMD's)? The IRS wants it's piece of flesh. You can't die and leave your children an inheritance. Of course your estate is taxed as well?
Hmmm? So, when I volunteer and give my services to my community and use my God given knowledge and training for the good of my community, I should send them a bill?
Problems I have with the IRS? They were established in 1862 to pay for war expenses. They've now morphed into an "All Powerful" Agency who can take your house and property without remorse. They can garnish your wages regardless of your predicament. They crush small businesses who have a hard time making payrolls. They still want that payroll tax and whatever kind of taxes they can bilk an employer out of. They still tax the crap out of you when you live abroad. You have to essentially secede from being a US Citizen in order to escape their clutches. "They tax you for dying." They're like a pariah that never goes away. You know the old saying; "Nothing is ever constant except "Death and Taxes." If you think your free, think again. All we can ever hope for is to leave this earth debt free and not be a burden to those we leave behind. The IRS is always there waiting and watching.
If you want to get in contact with the IRS forget about it, they don't respond to phone calls or emails. You can't really setup any kinds of appointments, believe me I've tried. The common man has no chance in resolving issues with them. Their word is law. They don't want to hear about your problems. All they want is their piece of flesh.
Do you now understand my gripe with the IRS?
I mentioned Banks as well who are #3 on my list. These scumbags make Danny DeVito (Matilda), look like a cub scout. They entice people into getting Cash back credit cards. They love putting people in debt and keeping it that way. Credit scores, mortgage insurance, really? Credit card interest rates 20% plus? What's not to like about money lenders? They make Ebenezer Scrooge look like a philanthropist. They're almost like drug dealers, except they push money.
Agreed; IMHO we are seeing accumulation occurring, just pull up the Historical on AMRN. At least Yahoo is good for something; Their definitely not good for much else. They're the new Twitter for anti-Freedom of Speech.
https://finance.yahoo.com/quote/AMRN/history?p=AMRN
I thought kiwi would leave once the Baker Brothers sold?
Speaking of insurance companies, they are in my “Top 3 of my most hated organizations.”
In order:
#1 - the IRS
#2 - Insurance companies
#3 - Banks (money lenders, credit cards, mortgage holders ect.)
Did you know? My insurance company raised my rates by 25% this month for a combination of things. My mortgage lender automatically increased my house replacement cost from $278k to $351k, this increased my insurance premium by ($23 per month). The second thing, I just turned 71 years, my insurance company increased my premium ($63 per month) because I’m now an unsafe driver according to their actuarial tables. Then of course they tout the “inflation” factor which allows them to adjust their rates anyway they want. A win-win for them. I do understand the increases, but to the tune of 25%? I’ve also learned the “birthday” thing is not consistent, most insurers charge the “teenage driver” rates when folks turn 75. I’m shopping around for a better deal. My Social Security didn’t increase by 25%, come on Joe, throw us a bone.
1.28 AH.... Nasdaq was up a whole 1.08 points today. Keep em rockin Super Joe
Are you English? Brits use the "Bloody" term a lot, given the inference it has a wide spread connotation. Cheese factory? You mean have a little Whine with your cheese? Understand your point.....