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Big D, re. points 1&2, it's been my understanding that the 9.38 million UPS loan to be used to purchase, deliver and install the US manufactured plant equipment and machinery, leaves just a little over 3 million needed to complete the new state-of-the-art pharmaceutical facility, estimated at a total cost of 12.45 million USD.
Are you including the Alembic loan of 2 million due the end of this year in the 5 million NEXIM loan currently being sought?
Bowdrie? am i correct? I've been around a little while myself.
MY mistake, you are right. .0345
This PR will make my day when it comes out.
Diamond Dog, i am referring to the last run to .035
Pandey,,Noted. then i suppose you caught message #65736. I am just catching up on reading a large number of posts now.
I spoke with Steve Burg today. He said to me, the Nigerian banks are soundly committed to providing the guarantees. But nothing is finalized with them just yet, and that he will PR them immediately upon securing them.
Drifter, i haven't read all the post's here today, but are you and i the only ones concerned with the topic i brought up last night in post #65736 concerning the Nigerian bank guarantees?
As i stated, where the last run to .035 was due to the 9.38 million loan news, where many misinterperated it to include the long awaited guarantees, and hence the subsequent drop in pps when these buyers discovered it wasn't so.
Point being, This is where the current focus should be, on being concerned about those secured guarantees, in getting the pps back up to .035 and beyond in the near future.
TDD814u, the source of my information is part of a link that i will post here in the next day or two.
I am putting a post together here that will show the board a broader, near future range of clientele for Nicosan.
TDD814u, the latest figures to date on gross national income in Nigeria is 117 USD per month, per capita. Pitiful but true.
Conservatively speaking, i would estimate the 4th quarter revenues to be near the three quarters of a million dollar mark.
I had estimated this 3rd quarter to be close to the 100k mark.
Not big dollar amounts at any rate. But 4th quarter revenues will show beyond any shadow of doubt, barring sales distribution problems at this time of limited pre-facility capacities, that Nicosan is either exploding in demand, or only moderately gaining customer/sales, and patient momentum, as this 6000 patient figure to date would indicate.
1000 patients the first 3 months of sales.
Another 5000 patients in just over the last month? A moderate increase.
Will sales explode into the 20,000 capacity of Dr Pandey's estimate through the remainder of 2006?
Lets say, quite likely. Conservatively speaking.
WMBZ-SC, you may want to refer your sister to this post.
Sickle cell is in many nationalities including African Americans, Africans, Arabs, Greeks, Italians, Latin Americans, and those from India.
You can be Caucasian and have sickle cell disease or trait.
All races should be screened for this hemoglobin at birth.
The number 1 deciding little detail in point that got this stock to run to .035 the last time was the 9.38 million dollar loan announcement that was partially misunderstood by many in that one crucial little detail was overlooked.
The all important guarantees from Access Bank, and Diamond Bank that had not yet been, nor have yet been obtained, causing the quick and subsequent sell off of this stock,
This should still be considered at the forefront in what to watch for in respect to what is going to drive the pps considerably higher any time soon here.
Big D was on this subject a little while back with a call to Steve Burg, responding by saying they were sending someone over this very afternoon to look into acquiring the guarantees.
Nothing to my knowledge has been posted in the following up of this since that day Big D posted it.
I think some of your concerns expressed here have merit, and that some people here, whom are not willing to acknowledge that they do, is likely more the going concern within your own conscience than your actual stated points of contention.
It's always been that, attempting to make a mountain out of a molehill has always been futile. Nonetheless for arguments sake notwithstanding, some do listen to what you say, and are not totally ignoring you.
Fatbacker,,every cause has an effect
True enough, some for the better, some for the worse.
Those who give to charity, specifically the food banks and soup kitchens, are doing a great service and can pat themselves on the back for doing so.
Many of these charitable souls through no fault of their own subsequently go unaware of the greater effect they have helped create.
The general vicinity in which these food banks and more specifically, the soup kitchens are located, are a magnet for thousands of homeless drug addicts who permanently deluge the immediate neighborhoods of these free food destinations, bringing with them all the associate negative aspects for property owners in these immediate neighborhoods, and leaving them to fend for themselves is an all too glaring example of how one man's good is another man's evil.
Not to go any deeper into the subject here. But only to make a point in general.
I'm sure many of the real people here, the real posters, those who confine their posts to what's real in the true sense of the word, getting a little tired as to how quick their valid statements and opinions become buried and forgotten here leaving many with no alternative but to repeat themselves almost to the point of redundancy.
As we all know, or most of us should, the root factor in all of this is greed.
Greed driven by fear going up, and Greed driven by fear going down.
It is indeed quite amusing as to how this stock at this stage can be manipulated and played like any other run of the mill otc.
The common denominator with this product NICOSAN is that it is today's answer in treating SCD.
This Biotech winner is going to leave these lowly bottom feeder pps and this current level of invading stock bums far behind.
Xkem at 2 plus pennies with phase two studies complete, with an approved market of 5 million at the door is a gift that many here are either blind to see, have very little to invest, or have underlying motives and refuse to acknowledge this simple truth. MMs operate to their advantage using the boards misinformed, disgruntled, and/or self serving like puppets on a string. A who's who in the basher/pumper zoo made up almost entirely of non-connected individuals, many with their own personal agenda's, along with one or two professionals with multiple aliases.
Bashers want to buy, and buy low.
Pumpers want to sell, and sell high.
Smart., RE. Biotechs valued, based on future earnings.
This is very true of Biotechs, and especially so of those that have reached this stage.
Effectiveness of the product approved for sale, in this case Nigeria, where the largest number of SCD sufferers reside in one country, and upwards of 5 million there alone, is first and foremost the deciding factor in validation of Xkem and their success, in conjunction with their being an emerging Biotech.
Putting aside all arguments for a moment here on this MB. Consider those SCD sufferers currently being treated with Nicosan, free of the pain and the effects of recurring episodes.
Ask how they feel? Ask Investor Relations for this answer.
This is what is truly astounding about XKEM.
Will this board degenerate into a bashers paradise?
Fear and Greed abound here in a multiple of varieties.
Media.
You are bang on in your understanding of the otc in general, but your understanding of Biotechs, with the gauranteed near term outcome, as Xechem's will be with it's proven effective product Nicosan ( as will be the noted highlights of the upcoming 10qsb and the next 2 and 3 quarterlies as well, world calamities notwithstanding ) is either showing your lack of understanding of Biotechs in general, or a possible not so hidden personal agenda of your own.
Foxwoods, re. your post, effect that Nicosan has on sickle cells as far as the antisickling properties changing blood cell shapes in providing clues for fighting disease.
Red blood cells have receptors that open and close under normal circumstances. The body converts carbohydrates to glucose in the bloodstream, these receptors regulate the inflow of blood sugar to the cells where it can be metabolized and turned into energy.
I have just caught your post late here and will try to get back to you on this subject.
Implications for research in finding a cure for Diabetes through herbal extractions such as those related to Nicosan specifically is a deep subject, one of which i will pursue for it's scientific research and value.
Bashers....The Devil's Advocates....assisting the dirty greedy market manipulators free of charge. The MMs know the bashers are out here self serving their own interests, assisting in creating the negative volatility the longs constantly struggle with.
A long is someone who has been caught up in the battle against volatility, while in many cases, watching the value of his shares erode. If all were to play the MMs game and bash along with the bashers, assisting these evil greedy shorters, there would be no company to speak of in short order as the shorty manipulators would drive the pps down to nothing and hold them there, much to their delight possibly driving the company into bankruptcy where they would never have to cover.
Bashers, there is no game without the defending longs, when the longs all disappear, you have no one left to play with, you disappear, the MMs win.
Since that is never going to happen here, count on this, unless a company is weak, which this one is not, what goes down, always always goes back up.
Always Always choose the strong companies to invest in, never a weak one. Choose XKEM and hang tough longs.
This one will turn on a dime and head back up soon enough. Although the bottom line in the coming 10qsb is important enough, a strong showing of public/customer approval for the product with sales totals to date nevertheless that will reflect repeat customer sales, times the number of those treated, will have it's impact on the investing community in terms of what is indeed real and what is truly yet to come, and what is to be dispelled in the speculative sense.
Nefarious market participants, market makers, online brokers and hedge funds notwithstanding.
Flippers will always surf the chops, but the longs will ride this one in on a tsunami.
6 months ago.......................................................
i give you 6 months to live...................
but doc,,,,,i can't pay what i owe you in only 6 months..........
okay then,,,i give you another 6 months
This earlier post of mine might help you some #60682
As well, your questions concerning storing the raw materials to produce Nicosan.
How Where and Duration. I posted a contact link earlier.
SHESTCO. Admin. at their Gamma Irradiation Facility should be able to answer your questions perfectly. http://www.shestco.org/contact_us.htm
Sheda Science and Technology Complex (SHESTCO): Contact us
2nd time in 2 days while i was typing a post it submitted before i was done typing it. Could have been my fault, not quite sure.
In addition to my last post, i would like to add,the gradual increase in customer/patient sales of Nicosan will eventualy snowball when the supply will be able to meet the demand, a huge and never ending demand as all SCD sufferers will need to be treated using Nicosan daily for the rest of their lives.
The 6000 patients treated so far as stated here and the current mood on this board would almost indicate a misunderstanding of the gravity of this entire undertaking.
Have some of you here forgotten that this can only go forward and not backward in the number of users of nicosan there will be in very short order.
All of these estimated 6000 patients are now permanent users for a permanent condition of which the endless and necessary regular daily use thereof must be kept up to keep the debilitating effects of SCD permenantly at bay.
In short these are repeat customers for life, not one pop one shot
An Ice Cold Stethoscope.
Stay Calm
Take a Deep Breath
It's Nothing Serious
Your in Good Health Xkemer
Don't Panic
Awareness Initiative Health
About Nigeria....There is Reason to Believe. http://www.nigeria.gov.ng/fed_min_health.aspx
Welcome to Nigeria- Federal Ministry of Health
Infrastructure Accessibility Evolution.
NAFDAC intervention, to oversee and regulate approximately 800 pharmaceutical outlets in 6 geopolitical zones totaling approx. 4800 outlets throughout Nigeria.
Each zonal drug distribution center (zddc)is to be headed by a qualified superintendent pharmacist, a must requirement.
Entry of pharmaceuticals into the marts will be controlled and restricted to drugs that have satisfied all NAFDAC requirements for safety and efficacy.
NAFDAC NICOSAN ZDDC and history in the making.
In addition to my last post, so as not to confuse anyone, concerning getting SCD under control permanently, may i state, Nicosan used regularily on a daily basis, will do just that.
Something to think about in terms of numbers as to how many SCD sufferers will ultimately be treated regularily and use Nicosan.
All of you here need only ask yourselves this simple question.
If i was afflicted with this terrible, terribly painful disease, would i not be more than a little anxious in getting it under control PERMANENTLY and as quickly as possible.
Nicosan will do just that.
Taken from the abstract of 2002 from the National Institute for Pharmaceutical Research and Developement you posted earlier.
"one oral dose of 12mg/kg Niprisan daily"
Apart from causing headache, which was reported by 9 patients while taking Niprisan, there were no important adverse effects.
As a counter measure to prevent headache from slightly high dosing.
To date it has been determined that the most effective daily dosage of Nicosan consists of four capsules for adults and two capsules for children. The daily doses should be administered in two divided doses with one-half of the daily dosage taken twice daily. Preferably the seperate divided doses will be taken in the morning and again in the evening.
The thing i was getting at was the cost of the facility to complete being short 3 million not holding up completion of the facility that far along where creditors are concerned and the rest of the funding that will be needed,
Three million dollars shy of the mark is peanuts at this point in time of the undertaking to bring Nicosan on line to full production and the stage the building of the new manufacturing facility is currently in, with the total cost of the project estimated at 12.45 million and 9.38 million coming from the US loan.
The expanded pharmaceutical facility once completed, will enable Xechem Nigeria to produce commercial scale quantities of Nicosan to meet the needs of millions of people afflicted with this terrible disease.
The new facility completion and subsequent commercial scale production of the proven effective product Nicosan in treating SCD is now a gaurantee.
This is a boitech, everything that has transpired to make this a reality has been necessary, everything yet to be completed must first be completed without putting the cart before the horse.
Education increased knowledge and awareness is the key to ever increasing sales in Nigeria.
A computer for all Nigerians (cani) launched this year should be vigorously supported.
http://www.africa-interactive.net/index.php?PageID=1796
Nigeria: kick start of Computer for All Nigerians Initiative - AfricaNews EN
In response to your post from yesterday, i came across something related to your question recently that i should have bookmarked and i'll be dambed if i can find it again. Just one of those things you happen to come across the deeper you go into research. I was actually going to bookmark it and then i got sidetracked with something else and forgot it and lost it. I have only recently gotten back into xkem, so many irons in the fire, so little time. Will try to get back to you on that.
Another question that came up on the board concerning the a/s and how it will be used caught my attention. It has been my understanding that much of it will be used to lure highly skilled professionals to this region of Nigeria, considered difficult to get them to relocate without the added incentive. The shareholdings of current and future staff would not likely be sold anytime soon subsequently swelling the o/s and that is good for xkem overall.
Had to wait till today to post again as i am just a striker newbie here and am only allowed 3 posts a day and ran up my total yesterday, just to explain why all the responses in one here.
Silverfox you were interested in the shelf life of Nicosan. I could give approximations but i'd rather you contact the Administration at the Sheda Science and Technology Complex Gamma Irradiation Facility. Here's the link. Ask your operator for assistance.
http://www.shestco.org/contact_us.htm
Sheda Science and Technology Complex (SHESTCO): Contact us
Tests of Niprisan/Nicosan have conclusively shown that the product protected the red blood cells of sickle cell patients against sickling when such cells were exposed to low oxygen tension. This effect lasted over 48 hours while the protection was about 91%. Furthermore, laboratory data clearly indicated the dose dependant reversal of already sickled red blood cells using the product. This reversal also lasted for over 48 hours and the effect was 100%. Scientific justification for safety evaluation tests was warranted and conducted. The data obtained clearly shows the product to be very safe. Carcinogenicity and Mutagenicity evaluation was also conducted and the obtained results indicate the product to be devoid of adverse effects.
Clinical trial phase 1 was conducted using staff of the Nigerian National Institute for Pharmaceutical Research and Developement (NIPRD) as volunteers. The clinical parameters of the blood chemistry, the liver functional status as well as kidney functional status were assessed. It was thus determined that the product had no adverse effect on the volunteers regarding all the parameters studied.
Throughout the phase 2 clinical trials laboratory testing of blood chemistry was conducted and evaluations recorded from approximately 500 patients coming from different parts of Nigeria, three clinics were established by NIPRD for the trials.
From the data obtained it has been determined that the product had no detectable adverse effect on the kidney, liver and the blood chemistry. The values recorded for these parameters fall within normal range. On the average about 90% of the patients involved in the clinical trials did not experience any major sickle cell disease crisis since they entered the clinical trial program. Even the few patients (10%) who have experienced crisis reported that such crisis were less frequent and less severe as compared to their experiences before they joined the clinical trial program.
The patients had improved appetites accompanied by appreciable weight gain. There was less incidence of anemia and jaundice, most likely due to the reduced rate of destruction of the red blood cells. Patients whose tests indicated 60-90% sickling with sodium metabisulphite at the beginning of the study, such tendencies had completely disappeared after about 8 months of using the product.
It will have it's impact.
Just figured out how to post here without linking on as a reply. Im just new to this mb.
Nicosan-an alternate medicinal treatment for SCD. A medicinal herbal preparation comprized of 100% organic herbal ingredients.
A phytochemical ethanol/water extract of about 15.8% by weight of piper guineenses seeds, about 18.4% by weight of pterocapus osum stem, about 13.2% by weight of eugenia caryophyllum fruit, about 31.6% by weight of sorghum bicolor (caudatum) leaves, and about 21.0% by weight of potash.
Piper Guineenses seeds are removed from the mature fruit of the piperaceae family and air dried. They are harvested and hand picked from october to december and used to prepare an ointment for treating joint pains.
Pterocapus Osum stem is utilized in the making of cosmetic powder and dyes for clothes.
Eugenia Caryophyllum fruit a tropical evergreen tree one or two seeded berry, harvested from september to february, utilized it acts as a stimulant and antiseptic and is a mild anaesthetic. The tannin content of this fruit is postulated to be the major contributor to the anti-sickling properties of this product.
Sorghum Bicolor (caudatum) leaves from a semi arid tropical cane like grass with wide husk like leaves tolerant to waterlogging and can be grown on a wide range of soil types and is adaptible to a wide range of enviromental conditions. Harvested in the fall as a field crop and the protein breakdown inhibitor, cytokinins.
These various raw materials are weighed, mixed together and then subjected to cold water extraction for 24 hours. The fluid containing the extract is then decanted and filtered and the residue is discarded. The filtrate is freeze dried for 48 hours using a Finn-Aqua Lyovac GT3 freeze dryer to provide a dry powder containing the active drug materials extracted from the initial mixture.
The powder containing the active drug materials and inert additives may then be formulated into capsule dosage form.
It has been determined that the most effective daily dosage consists of four capsules for adults and two capsules for children. The daily doses should be administered in two divided doses with one-half of the daily dosage taken twice daily. Preferably the seperate divided doses will be taken in the morning and again in the evening.
That's about the size of it in one small bottle.
This is my first post on ihub, i have been out of xkem for a few months now and have recently made a killing in uranium stocks. I am quite familiar with xkem and have posted on various message boards in the past. I have encountered much negativety on the other boards , most of it i believe to be self serving in a number of different varieties. XKEM with all it's resiliency will not be denied, least of all by those self serving individuals, i've always maintained this stance.