I am not a professional advisor. Seek professional advice before investing or trading.
Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
Sorry... my response may not be entirely clear... by "over speculating" I was referring to specifically it being the inhaler. But they do indeed appear to be gearing up for some production.
Possibly a dot... just cautious of over speculating... but nonetheless a good find.
Hahaha doesn't surprise me :)
How long have you and FitBit been working together on this board? You guys should know by now we are not phased by your nonsense. You should try somewhere more effective.
Hahaha... your next project should be to resolve all the unsolved murder mysteries over the past 10 years LOL :D There isn't anything anyone could ever hide from Guy! :)
I'm ready for fireworks... go ahead an drop that Atom bomb!
All Caps Jason clarified that it is a different and separate document... not a change or an update. I am just not able to focus on it right now.
LOL... it seems to be an almost entirely different paper. It will take some time to comb through this to compare the two versions and draw conclusions... and I won't have time to do it today. Hoping one of you guys/gals can shed some light on it.
Wow. What a perspective.
We are expecting/assuming the 102 interim patient data is going to be unmasked today (yesterday/tomorrow)... so they're seeing the data for the first time! The DMC will review and make a recommendation to the fda... we have to wait for all that to transpire before we know anything, so being a fly on the wall would allow us to know now... assuming we can understand English as a fly.
I have found our center of gravity to be at .556 (others will challenge me), where we should continue to gravitate towards until PR hits.
Hopefully days, probably weeks. Hopefully I'm wrong. Maybe Javitt will mention it verbally before its official.
I have updated our "Google 24-Hour News Search" link to include the term "SamiAir".
Use this daily to check for news in the past 24-hours...
https://www.google.com/search?rlz=1C1CHBF_enUS704US711&biw=1680&bih=939&tbs=qdr%3Ad&tbm=nws&ei=MGKZX5XcAq6AtgX79ZToAg&q=%22aviptadil%22+OR+%22rlftf%22+OR+%22RLF-100%22+OR+%22relief+therapeutics%22+OR+%22samiair%22&oq=%22aviptadil%22+OR+%22rlftf%22+OR+%22RLF-100%22+OR+%22relief+therapeutics%22+OR+%22samiair%22&gs_l=psy-ab.3...28252.36883.0.38624.15.14.1.0.0.0.129.1427.10j4.14.0....0...1c.1.64.psy-ab..0.0.0....0.vqHpaLJ72Iw
The actual SOFA & Rothman values can be found on Table 2 of the following document. Additionally, the following statement was made in the paper.
Is that what you were looking for?
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3665228
In order to identify potential referral bias and confounding based on severity, Rothman score and WHO ordinal scale upon admission, together with Sequential Organ Failure Assessment Score (SOFA), at time of ICU admission was compared between aviptadil-treated and control patients (Table 2). Rothman index is a continuous predictor of impending mortality that is implemented as part of the electronic medical record system.
At hospital admission there were no significant differences in age gender, or Rothman index. At ICU admission, however, the Rothman
index (16.5(SD 23.7) vs. 56.9 (SD 26.1);P<0.001) and SOFA score (10.6 (SD3.7) vs. 4.3 (SD 2.2); P<.001) for aviptadil-treated patients was significantly worse than for control patients (Table 1 – detailed data reproduced in online Table 1a).
Hahaha won't we all lol
Quicker indeed :D
Some things I pulled out of the preprint... pretty amazing.
Important Note: Compared to the control group patients, the Aviptadil patients were coincidentally in significantly worse condition. Their “SOFA score” (which measures organ failure) was significantly worse, and the “Rothman index” (which predicts mortality) was also much worse. Aviptadil patients were already at a disadvantage over the control group, but still managed to produce the following results.
Enrolment
45 patients enrolled - All had the highest possible risk for mortality
21 were selected for Aviptadil in June & July
16 were already on ventilators
5 were already on ventilators and ECMO
24 were selected for the control group in May - Aug
11 were already on ventilators
13 were already on ventilators and ECMO
Results
19 of 21 (90%) Aviptadil patients survived to day 28
4 of 24 (19%) in the control group
4 of 5 (80%) Aviptadil patients on ECMO were removed
3 of 13 (23%) in the control group
15 of 16 (94%) Aviptadil patients on vent were removed
1 of 11 (9%) in the control group
10 Aviptadil patients returned home/care facility
2 in the control group
15 of 21 (71%) Aviptadil patients had 100+ point improvement in oxygenation
4 of 30 (13%) in the control group
Aviptadil Patient Stats
• 9-Fold advantage of survival P<.001
• 9-Fold advantage of recovery from respiratory failure P<.001
• 8 times more likely to return home or a care facility on Aviptadil
• 3-fold improvement in oxygenation
• 17 of 21 saw improvement in both lungs, 2 saw improvement in 1 lung, and 2 showed no improvement
• 2 Patients developed hypotension, which was treated
• 4 Patients developed diarrhea, which was treated
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3665228
Thank you. Likewise. May we all benefit from all of our work to keep each other informed and on our toes!
Nice work! Thanks for sharing all of that... wow. Talk about a rabbit hole. It's almost as deep as Guy's patent hole. lol.
I nominate BOTH of you for... the Edison Award! :D
1) This preprint says we are entering the Tech Watch program, which was misworded this morning. Tech Watch is the initial entry point to "start the process" to prepare a request for BARDA funding:
"Based on these findings, aviptadil has been selected for inclusion in the Corona Virus Tech Watch Program administered by the US Department of Health and Human Services."
https://papers.ssrn.com/sol3/papers.cfm?abstract_id=3665228
(bottom of page 11)
AND
2) There was a nomination for the Edison award that was pulled back. No big deal here, as I think anyone can be nominated (for $1000 I believe).
https://edisonawards.com/
I think so. But certainly much progress is being made at high velocity behind the scenes, causing some other-missteps this morning... I have no doubt about that.
Ok... you asked a fair question, but I still think its a mixup. I could be wrong, but here's where my head is...
There are some confusing terms in the FDA, so let's clear that up first:
EUA - Emergency Use Authorization - this is what we're currently waiting on the fda to approve for us.
EAP - Expanded Access Protocol – currently approved and allows us to use the drug at clinical trial hospitals only on patients who are too sick to get into the trials.
FTD - Fast Track Designation - we already have this and it recently was "just granted" in June... this basically gives us more access to the FDA in terms of meetings and such.
So... we already have FTD (fda meetings) and EAP (treat sick patients at CT locations only)... but this EAP is too limited because it only helps a very small number of patients, so we're waiting on EUA (so we can use the drug at every hospital in the U.S.).
Now... if you (or maybe others reading this) didn't know all the differences with the above terminology, then I would suggest neither does the NYPost... what they seem to have done is mix the terms...
They took:
"Fast Track Designation" --and-- "Emergency Use Authorization"
and came up with a new term:
"fast-track emergency use designation"
(no such thing)
And when you combine that NYPost mistake with the other posting mistakes from this morning, it looks like they're all related. But in this case, I think NYP is a separate mistake. I could certainly be wrong... where there's smoke, there's fire... and today there seemed to be quite a bit smoke. I just don't know if NYP had anything to do with it.
Here's the Fast Track from June...
https://relieftherapeutics.com/newsblog/32-neurorx-and-relief-therapeutics-announce-fast-track-designation-granted-by-the-fda-to-rlf-100-aviptadil-for-the-treatment-of-respiratory-distress-in-covid-19
Ummm... actually... no I'm not sure. Let me take a closer look.
I'm just a bit concerned they NYPost may have mixed up some terminology... Neuro or Relief would have put out some official PR on this, and THEN the NYP would have reported off the official PR... not the other way around IMO.
Tomorrow is when the 102 interim trial results are unmasked... but that doesn't mean we will know the results or get an announcement/PR out of it... doesn't mean you can't enjoy the Scotch though :)
Thanks for the nomination, but I'm not interested. We all should have enough DD and self policing by now to get by with minimal moderating. The ones who have been moderating and who have recently stepped up to moderate have gotten us off to a great start. Much appreciated.
I think the terminology "just granted" is a very "relative" term and I've seen this several times before, so they're probably just regurgitating info from Relief's source announcements/publications.
Now as far as the "emergency" part... I'm not sure, but I doubt these guys have any "inside scoop" that we wouldn't see everywhere else. It's not likely how the news will break.
Oh WOW! Who updated our board's info??? Muuuuuch better... thank you! Now we look legit. Thanks to whoever did our first version (it served us well) and thanks for updating the new fresh version. The waiting is over... now NeuroRX can start their announcements and PR campaign... we're ready on our end ;)
lolol welcome back I suppose???
What? Seriously?
LOL... beat him at his own game :D
288 huh? I just don't know what to say about that... I'm speechless. Literally. I.. ummm... do you... ummm... could... WOW!
I think we've all been grounded by J-Belfort's big brass bull story (and his many other contributions), which was what gave me the idea. These quotes will be helpful as new investors come to look at what we have.
Quotes - Here's to all the strong longs!
What Investors Are Saying About RLF-100 and Relief Therapeutics
RLF-100 Quotes Captured by Uncle Gee Gee
“LISTEN...IF YOU ARE NOT ON FIRE FOR RLFTF THEN YOUR WOOD IS WET MY FRIEND!!!!!”
All-Caps Jason
“This company’s Texas Hold'em Hand is stacked with Aces...all of the Aces.”
aGuyUS
“I don't see much in the way of competing therapeutics yet… VIP right now sounds like the Holy Grail.”
DD Police
“Show me any other med that can heal and clear lungs out so quickly, with precision, at such a high rate.”
Tiger Money
"How about we WALK down there and get ALL of that RLFTF money."
J Belfort’s Big Bull
"There is no Fountain of Youth, but we have something in the same neighborhood."
(Old) James
“Wow. That's what I call big pharma in the making.”
Pcilliterate
”I can't think of a better cause to contribute my money towards. Proud to be a part of this historic endeavor.”
Uncle Gee Gee
“VIP in its Natural 28 amino acid chain is the most efficient at doing what it is supposed to do.”
aGuyUS
“It is time for the fda to start saving lives.... no brainer here.”
Tiger Money
“If you are not ALL-IN with RLFTF, then you have not done enough due diligence in my opinion.”
Uncle Gee Gee
“THEY ARE BUILDING A PHARMA EMPIRE”
All-Caps Jason
“Everybody is getting giddy across the internet. :)”
tiggerifficm4
“This might be the therapeutic we are looking for to kill #COVID19. Keep your eye on this one..”
Bill (Bill01234567890)
“Hey this is covid CURE baby! Everyone want to own some shares. Who will miss it?”
Andy2018
“They are putting all the pieces in place. Management knows exactly what to do and is doing it.”
Charliebee
“RLFTF is ticker for the U.S. RLF-100 is the drug that will save the world.”
Stonk Doctor
“I don’t think you want to wrangle with the $RLFTF crew.... You’re better off walking away than picking a fight.”
Bill (Bill01234567890)
“Huge things about to happen. Opportunity of a lifetime!! Bombs about to drop!! Just follow the breadcrumbs!! This is gonna be a game changer for covid and whoever owns $rlftf”
Pennywise
“The leadership team is top-notch. They’re focused. They’re making steady, precision progress. When it’s GO-TIME… the world will know!”
Uncle Gee Gee
“$RLFTF People are actually recovering! This should be in the market already!! FDA APPROVAL IMMINENT !!!!”
Karen Gartner
“The question now prevailing: Is there anything Aviptadil doesn't improve?”
elllk
“I mean I saw the market size and pricing opportunity in Javitt's presentation, but seeing it like this...holy shit man!”
Confused investor Pedro
“Some of them may even think this complicated venture could one day yield a Nobel Prize somewhere in there...”
Elllk
“As good, or better than gold. Way better than gold, it’s life.”
Chromosomesix
“Let’s focus on what we know: We have money needed for trials; we have a partner for manufacturing and distribution; we have EUA on deck for approval; we have potentially game changer data coming out soon...that alone should help everyone be patient, as we navigate the current environment.”
dmsrz8
“Who knows if/when another similar virus should happen to hit the world. I'm sure EVERYONE would feel a whole lot more at-ease, knowing we have therapeutics such as RLF-100 already approved and ready.”
KILLAZILLA
“THERE IS NOT ANOTHER DRUG PENDING OUT THERE THAT EVEN MAKES ONE OF MY EYEBROWS RAISE”
All-Caps Jason
“In regards to stock investors, rlftf is going to get the entire Pizza…”
King James
“$rlftf - gonna be the biggest covid play”
Pennywise
“There are currently 7,000+ patients with COVID-19 on ventilators with potential of >25,000 by the new year. We need #RLF100 now!”
Stonk Doctor
“RLF-100 showed dramatic improvements in virtually all patients. It is a statistical blowout for those who understand statistics…”
DD Police
“…everything is showing that maybe we aren't drunk and actually hit the investment of the decade that could help the world get out of a health crisis?”
Confused investor Pedro
“NOT JUST A COVID PLAY...IF YOU READ THE MATERIAL AVAILABLE NEURO RX AND R/T ARE GOING TO REVOLUTIONIZE RESPIRATORY CARE...ASTHMA INCLUDED....THIS IS A HOLD FOR ME.”
All-Caps Jason
“We (investors) are partners in the emergence of a new world leader in the treatment of Covid-19 and perhaps all diseases that affect the lungs. It is exciting and gratifying to be a part of the solution to this crisis.”
Charliebee
“Humanity took a swing at its enemy (Covid-19) yesterday, and Relief Therapeutics is mounting an attack that will result in our enemy’s total annihilation.”
Uncle Gee Gee
“I HAVE BEEN IN BIOTECH STOCKS LOOOONG BEFORE COVID....I HAVE READ EVERY PUBLICATION ABOUT EVERY TREATMENT POSSIBLE.....I HAVE A FILE ON RLF100 4 INCHES THICK”
All-Caps Jason
“Guys, we might have the best therapeutic stock in the world right here for COVID-19. The science is legit.”
King James
“WHY WOULD ANYONE INJECT VIRAL RNA INTO THEIR BODY? Especially since therapeutics are available that stops the virus and the cytokine storm...#AVIPTADIL #RLF100”
Mike Irwin
“BARDA is stockpiling up-to 6mm doses of vaccines and therapeutics. NeuroRx/RLFTF entered manufacturing for 1mm doses. 2+2=4”
Bill (Bill01234567890)
“The principals spent all this time quietly building the foundation. The VIP drug was a miracle of nature from the beginning, and remains such.”
(Old) James
“Do you guys all feel like we're part of history in the making?”
Devon
“SOC = Everything AND the kitchen sink! We're NINE-FOLD better than all of THAT! Take SOC and UNFOLD it 9 FREAK'N TIMES!!!”
Uncle Gee Gee
“The demand is so great now with the pandemic, and this is going to be a global solution with an IV and an inhaler form.”
King James
“…dang near 100% of patients on vent/ecmo die! On Aviptadil, damn near all the same population live!”
Mike Irwin
“I have to tell you… I don't think Dr. Javitt or any of them at Neuro or Relief are in it for the money. I think it's a lot deeper and more personal. They don't seem to me like money-hungry cash rob’n parasites like most companies.”
pat
“I DID A LOT OF DUE DILLIGENCE IN MID JULY...YOU COULD SEE THEN THIS WOULD BE A MAJOR PLAYER....ITS FERMENTING...THAT IS THE BEST WAY I CAN DESSCRIBE IT.”
All-Caps Jason
“I like Javitt. I like what management is doing. I like our political ties. I like our professionalism. I like our partnerships and strategy. And most importantly I like our amazing results.”
The Referee
“I really think that RLF-100 is the best long term solution for Covid, and it alone will allow us all to get back to normal”… “So much so, that it makes the vaccine unnecessary. You test positive, you get inhaler, you turn it into mild cold and recover quickly. The whole world will want it.”
DD Police
“I HAVE BEEN IN BIOTECH STOCKS LOOOONG BEFORE COVID....I HAVE READ EVERY PUBLICATION ABOUT EVERY TREATMENT POSSIBLE.....I HAVE A FILE ON RLF100 4 INCHES THICK”
All-Caps Jason
“RLF100 isn't going to nudge anywhere... we're going to blow past everyone. Once we are released into the medical field, it will become very clear who has the right solution, and all these other clowns will be sent to the circus by the medical community.”
Uncle Gee Gee
“NeuroRx was the best-affordable-dream-Big-Pharma-experienced-team that they could get. Look at the executives and FDA experience these grey heads got. We're in the best shape. I've never seen anything like this before.”
King James
“When I heard the story of the double lung transplant survivor I was ecstatic. BUT THEN TO SEE THE VIDEO OF HIM AND HIS FAMILY... to see him walking down the hallway... I WAS BLOWN AWAY even more!”
pat
Hmmm... The new website is sporting a new logo that represents perhaps an exclusive focus on the lungs, which could indicate the intention to build-out the other potential VIP lung applications... just a speculative observation.
lol you are the patent master ;)
New website providing a bit of detail around the patent...
"Relief holds a patent covering potential formulations of RLF-100TM in the United States valid until at least July 2029, with extension opportunities up to five years as well as in the EU and RoW (Great Britain, Germany, Turkey, Spain, Switzerland, Netherlands, Denmark, Ireland, Austria, PRC and Mexico) valid until at least 2026, excluding extension opportunities comparable to the U.S."
Try another browser AND/OR try holding down the SHIFT key when clicking sometimes helps force it???
Yeah... if you are done moderating, can you please assign aGuyUS or someone to moderate more regularly?