JL, Nice clear summary.

Cheers

JL, I have some technical questions regarding data to add to the V Website. Can you drop me a contact note to hypchlor@yahoo.com so I can get it right before posting.

Cheers, Hypo

JL, I agree and will be a participant.

Cheers

FFS, Well Done!!

Cheers

Hornett, Great page start. In due course I'll put together "Experience with Vascepa" for posting.

Cheers,Hypo

Rapid,

My experience suggests that while on V you can reduce the Simvastatin mG level and achieve the same lipid levels.

Of course that is in my body chemistry but worth a try. My experience was that change required 1-2 months to settle in. You are in the early days so worth the monitoring effort.

Cheers,Hypo

North.

I have taken V for 4.5 years with Zocor at 20 and 10 mg dose. I dropped to 10 mg dose when I realized my total Cholesterol numbers were stable at 170 +/- 10. The reduction was a test of this stability. LDL numbers are and have been 100 +/- 10.

In the last 6 months I returned to 20 mg dose, Doc's request....no change in Cholesterol figures so I have returned to the 10 mg level.

All these figures date back to 2005.

Cheers,
Hypo

BB, Thanks for that!!
Cheers, Hypo

Biob, Would you please post the specific link as I cannot find it on AMRN site.

Cheers, Hypo

AMEN, ZIP

Happy Thanksgiving to all

Hypo

Jl, Excellent anecdotal summary.

JL-Confirmed heart doc V ignorance

Discussion of Vascepa during my appointment 10/16/18
Q- Are you attending AHA meeting in November in Chicago?
Doc – No
Q – Are you familiar with the 6 year Reduce-It Vascepa trial?
Doc – No
My A - I described the trial.
Q - Did you get the message I sent to your office regarding the initial trial results?
Doc – No
My Response – The result of the trial was a 25% reduction in CV events. I have been on Vascepa for 5 years.
Doc Q – Who prescribed it?
My A – Doc G.
Doc Q – Why?
My A – At my insistence. It helped reduce my Simvastatin dosage 40mg to 10 mg. Also, eliminated Rosacea and Dry Eye problem; inflammation issues.
Doc – I prescribe Lovaza when necessary
Response – Vascepa is better than Lovaza. Lovaza is not at all the same type of medication
Doc – Does your insurance cover Vascepa?
My A – Yes
Doc – Hmmm. Maybe I’ll prescribe

Cheers, Hypo

JL, 76 is a bloody great round for all but a very few. Congrats!!!

An illuminating read for those who have not seen Motorhead's SA article.

https://seekingalpha.com/amp/article/4210747-amarin-street-factored-amarin-worth-80

Cheers, Hypo

Jl,If I may speak for others, we all look forward to your event review upon your return.
Hope you are able to speak with some of the principals.
Cheers,
Hypo

WOW JL

Hard Work involving some "Fun" as well.
Cheers

JL, I am in complete agreement with your thinking.

Below is a partial post after initiating V consumption. There has been no change from that time.

A) During my May, 2013 lipid check with Dr. Mark R. Goldstein, a lipid specialist formerly with Cleveland Clinic, Vascepa was discussed. We agreed to add Vascepa to my lipid control regimen (2gm early morning and 2gm in the evening at dinner) and reduce the Zocor dose by halving the 40mg tabs to 20mg. I also discontinued the daily baby aspirin.
B) Present Lipid data range for 2 tests post Vascepa, test 1 at 6 weeks from start and test 2 was 5 months from start.
a. Test 1
i. HDL – 59
ii. LDL – 102
iii. Total Cholesterol - 173
iv. Trig’s – 60
b. Test 2
i. HDL – 59
ii. LDL – 97
iii. Total Cholesterol - 165
iv. Trig’s - 43
C) Physiological changes
a) Dry eye; My left eye had sufficient irritation to cause me to use “No More Tears” 2-3 times per day; changes began within 2 months after starting Vascepa. That problem is, for the moment, history.
b) Rosacea; I have been fighting Rosacea on my nose for over 3 years. My dermatologist gave me Sodium Sulfacetamide (SS) to treat the small “blisters” that occur topically. This does not rid you of the affliction. After Vascepa use for about 3 months the incidence of blistering began to abate. That condition seems to have stabilized where I have rare minor topical treatment requirements.
c) Muscles and low back; Sore muscles and back stiffness have been standard morning fare for several years. The low back problem is a disk that will eventually require attention. These aches and pains are not gone but I would estimate an 80 to 90% soreness reduction.

Cheers,
Hypo

JL, Very interesting revelation with high order prospects.

Cheers

sts, Your quote is different from the article I have. Is it from the original presentation?

Cheers

Zip
You have the credentials to suggest to the author that this type of trial be performed. What say you?

Cheers

To all,
Has anyone read the cover article in the July 1, 2018 issue of Ophthalmology Times?

The DREAM Study headline "From Dream To Reality" with the sub-line "NEI Study provides level 1 evidence on omega-3 fatty acid supplementation for dry eye." Author - Cheryl Guttman Kruder; reveiwed by Penny Asbell, MD.

This publication was given me by my eye doc. It is not my field.

It failed to produce favorable results. It did not use Vascepa.

The supplement contained 2,000 mg EPA & 1,000 mg DHA. Placebo was refined olive oil.

Cheers, Hypo

Chris

I have had the same experience as JL on the Dry Eye issue in my left eye but to a less severe extent.

I started taking V in May 2013 after a discussion with my PCP who specializes in lipid management. I was on 40 mg Zocor at the time. Our agreement was that I cut the Z in half and take Vascepa as well. There was no change in my lipid panel with the reduction in Z.

We then cut down to 10mg of Z....again not change in the lipid panel, all good numbers. That's where I am today.

I'm now discussing the prospect of taking Red Rice Yeast rather than the Simvastatin. Data from my research suggests it may be sufficient to manage my Cholesterol issue.

I also noticed, as did JL, that the dry left eye was no longer a problem.

Separately, I was wrestling with Rosacea about every month or two. That went away in the same time frame as the DES.

Cheers,
Hypo

Well understood. Thanks JL.

Cheers, Hypo

JL, Then the regimen is twice per week at 85? Didn't see that in your current posts.
Curious cause I'm on the daily dose without issues but your early posts suggest it is not beneficial at that level.
Or is it nit picking by an old goat?

JL, I read the article.

But I’m confused as to the link between aspirin’s function and that of V. I use excerpts from your posts listed below to illustrate my point.

Aspirin is a prototypical NSAID that effectively inhibits the COX enzymes COX1 and COX2 through the irreversible modification of the enzymes’ active sites. This occurs through a transacetylation reaction; the acetyl group of aspirin migrates to and covalently modifies the enzymes to block their catalytic activities. In platelets this occurs even at low doses (80–100 mg/d), because they lack nuclei and cannot resynthesize COX1, and platelets are thus inactivated for their lifetimes. Aspirin at a typical dose of 650 mg covalently modifies COX1 and COX2 in all tissues, which similarly inhibits prostaglandin synthesis. NSAIDs other than aspirin do not transacetylate the COX enzymes but bind with sufficiently high affinity that the enzymes are competitively inhibited. The mechanism of action of high-dose salicylate is distinct, as it lacks an acetyl group and neither covalently modifies COX1 or COX2 nor binds with sufficient affinity to effectively inhibit the enzymes.

From 4/4/13 JL post 3758
For the first ten days I continued my morning aspirin as normally if I do not take it I feel sluggish..Ten days ago I stopped the aspirin going on the theory that aspirin is non specific blocker of COX receptors, blocking the expression of both good and bad eicosanoids...Since EPA and AA react on the same receptors, EPA expressing mainly "good" eicosanoids, and AA "bad"..The good being defined as those raising cyclic Amp levels, and the bad elevating pro inflammatory leukotienes, thromboxanes etc..The aspirin would inhibit the production of good eicosanoids which are essential to feel your best...Well that is pretty much what happened..Stopping the aspirin lead to a heightened sense of well being, less underlying anxiety, more energy, more clarity..

From 5/27/15 JL post 50165
aspirin or other NSAIDs may block some of the effects of EPA on the COX and LOX eicosanoid receptors and have a neutralizing effect. This is dose related. Small amounts of aspirin, less than 40mg may trigger Resolvin effects. I do this twice a week.

Are you on the same aspirin intake regimen as noted above?

I have been taking V since May 2013 and stopped aspirin at the start of taking Vascepa.

Cheers, Hypo

Watershed Disruptions

This link is about Energy and Cars...

But does this same phenomenon apply to Vascepa and its impact on medicine?
Based on the data presented on this board, I believe it will.

HYPO = > 90%

JL, Thanks
A really good explanation.
Cheers

JL I believe you've nailed it.

"The mistake most people are making is they are underestimating Vascepa...because what is the reality is very hard to accept...It's very similar to the Wright Brothers. Most peoples' thinking includes a process which concludes that if it has never been done..it is impossible to do.."

Cheers

Raf, Thank you

Well and clearly stated!!

Some on this board offer excellent insights with JL being one of those of particularly strong notability.

Hypo

JL, Thank you for sharing this very excellent summary.
Cheers, Hypo

Excellent post JL. But a question. Has this data been expanded upon to confirm the LDL "clearance" suggestion? Six years years since the article was presented allows for further development of this thought.
Cheers, Hypo

JL, On my background.

Not a Chem E. but an engineer without formal training. I have spent the last 50 years in various aspects of the chlor/alkali industry, bottom up. Always made it my business to know more about what I was working with than the other guy. I'll send along material under separate cover for the flavor.

Cheers, Hypo

Wow, JL, that link will keep me busy for a bit.

I really enjoy understanding totally new technology, Sodium Ferrate, graphene etc.

The fun is understanding the underlying function and how it can be applied elsewhere.

Happy Turkey Day

Cheers....

JL, your statements are causing some serious confusion for me as follows.

First, what is EC NO release? Endothelial Cell = EC? NO = Nitrous Oxide?

In membrane chlorine/akali cells the brine (salt solution, aka blood) feed is treated with an ion exchange resin to remove residual calcium to a 20 ppb level or lower. In the electrolysis process the chlorine (Cl) is separated anodically from the NaCl (salt) and departs the anolyte compartment as a gas in the depleted brine solution. The sodium, some water and some residual calcium are transported across the Nafion membrane to the catholyte solution where the caustic (NaOH) is concentrated to a controlled level.

Here is why I must be missing something.

The calcium ion is positively charged therefore will be drawn through the membrane to the negative cathode but the transport is not at all successful; it precipitates in the structure of the membrane causing pluggage degrading transport performance and increasing the operating voltage.

The surface of the endothelial vessel lining is negatively charged. Logic suggests that the calcium - as part of the lipid structure - should be inclined to deposit in the porosity of the endothelial lining (a sophisticated membrane) rather than be rejected as is suggested by the title statements. This further suggests there is a variation (reversal) in the polar electrical conditions either in the vessel wall or in blood chemistry that prevents deposit formation in/on the vessel wall.

A: Does vessel wall inflammation result in isolated changes in endothelial wall polar condition or capability? Does the addition of EPA result in a return to more effective vessel wall polar capability?

B: Is reduction of existing deposits as previously board discussed a similar polar variation function on the deposits, vessel wall and/or in the blood chemistry? Brought about by the addition of EPA?

For all of my searching I can find no data on the polarity of EPA at any concentration let alone in the purified Vascepa form.

Apologies for being so verbose.

Cheers, Hypo

BB, Thanks

BB, Thanks. But that was my point for testing. In 3-6 months DES and Rosacea should be in the line for FDA label acceptance. Seems I'm not clear on the requirements but then it's way out of my field.

Cheers

BB, Thanks. But what duration of test is required for FDA approval? That is the key to label expansion, right?
Cheers

On alternate indication approvals

There appears to be a vast market for EPA but how to speed the approval process for ancillary indications?

I have no clue what is required to meet FDA clinical studies requirements. But common sense tells me for the less serious indications such as DES, Rosacea, et al. requirements are relatively short term vis a vis the R-I trial now in progress.

In my mind it raises the question of what can also be done short term by the AMRN Asian affiliate, Eddingpharm, to expand the sphere into these indications. That assumes some effort is not already underway. Taiwan would seem an excellent starting place, Hong Kong second and China, despite its population, a VERY distant 3rd.

Let’s also hope Amarin patent attorneys are buried with potential new patent apps for the indications being discussed on this board.

What say you???

Cheers

JL, On V Indications

When I started on V the DES I was experiencing in my left eye went away in less than 2 months. A very good thing...

But another inflammatory problem I had was regular bouts with Rosacea every month or so. This was treated with antibiotics by my dermatologist. Within 3 months this problem went away. Since initiating the 4 gram V regimen this problem has been eliminated.

I do not know the incidence of Rosacea in the population but it seems this is another prospective indication for Vascepa albeit less prominent than those you have listed.

Cheers