Amarin Corp Plc (AMRN)

[hypo]

JL, I read the article.

But I’m confused as to the link between aspirin’s function and that of V. I use excerpts from your posts listed below to illustrate my point.

Aspirin is a prototypical NSAID that effectively inhibits the COX enzymes COX1 and COX2 through the irreversible modification of the enzymes’ active sites. This occurs through a transacetylation reaction; the acetyl group of aspirin migrates to and covalently modifies the enzymes to block their catalytic activities. In platelets this occurs even at low doses (80–100 mg/d), because they lack nuclei and cannot resynthesize COX1, and platelets are thus inactivated for their lifetimes. Aspirin at a typical dose of 650 mg covalently modifies COX1 and COX2 in all tissues, which similarly inhibits prostaglandin synthesis. NSAIDs other than aspirin do not transacetylate the COX enzymes but bind with sufficiently high affinity that the enzymes are competitively inhibited. The mechanism of action of high-dose salicylate is distinct, as it lacks an acetyl group and neither covalently modifies COX1 or COX2 nor binds with sufficient affinity to effectively inhibit the enzymes.

From 4/4/13 JL post 3758
For the first ten days I continued my morning aspirin as normally if I do not take it I feel sluggish..Ten days ago I stopped the aspirin going on the theory that aspirin is non specific blocker of COX receptors, blocking the expression of both good and bad eicosanoids...Since EPA and AA react on the same receptors, EPA expressing mainly "good" eicosanoids, and AA "bad"..The good being defined as those raising cyclic Amp levels, and the bad elevating pro inflammatory leukotienes, thromboxanes etc..The aspirin would inhibit the production of good eicosanoids which are essential to feel your best...Well that is pretty much what happened..Stopping the aspirin lead to a heightened sense of well being, less underlying anxiety, more energy, more clarity..

From 5/27/15 JL post 50165
aspirin or other NSAIDs may block some of the effects of EPA on the COX and LOX eicosanoid receptors and have a neutralizing effect. This is dose related. Small amounts of aspirin, less than 40mg may trigger Resolvin effects. I do this twice a week.

Are you on the same aspirin intake regimen as noted above?

I have been taking V since May 2013 and stopped aspirin at the start of taking Vascepa.

Cheers, Hypo