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Vanilla, may I suggest that you take your abundant energy and bombard the IR department with your questions and anxieties
Right now you are barking up the wrong tree adressing your co-investors wont change a bit - except fowling the general atmosphere so people with a new found curiosity for what RELIEF is all about get turned off and turn away before getting to the real DD done on this board!
Kindly write to these adresses or call in telling the girls you are an online blogger
:
Contact:
RELIEF THERAPEUTICS Holding AG
Raghuram (Ram) Selvaraju, Ph.D., MBA
Chairman of the Board
Mail: contact@relieftherapeutics.com
For media inquiries contact:
MC Services AG
Anne Hennecke / Brittney Sojeva
Tel.: +49 (0) 211-529-252-14
Mail: relief@mc-services.eu
I am working on MAC Os...
Thx Deckard! Unfortunately the link open BUT the page remains white:
https://fnih.org/what-we-do/programs/activ-partnership
Do you have another link?
Page Not Found
Sorry
The page or document you are looking for does not seem to exist.
Thank you for that effort. Unfortunately I am also no expert on the calcium and gaba channels and receptors..
But IF(!?!) AVIPTADIL could substitute it that would be a huge benefit to mankind and an amazing market oportunity!
Glad to hear that you are one of the 35% that have no side effects but a positive reaction that betters your life!
It might have well today that yo do not take it daily (which most patients with a chronic conditions are supposed to do because usually it takes 2 -3 weeks to build u up an depot effect..)
on an as needed base.
All the best!
Another source seems to confirm this - but with Google Translate there are numerous variants in translation:
https://translate.google.com/translate?hl=en&sl=zh-CN&u=https://www.163.com/dy/article/G64NTL59053469JX.html%3Ff%3Dpost2020_dy_recommends&prev=search&pto=aue
Do we have any native chinese speakers on this board to check sources?
Good Day! Was VASCEPA approved in China over the weekend?
This is a shady source but the statement is an exceptionally affirmative:
Vascepa's approval is an important milestone in cardiovascular prevention. It can help more patients with chronic cardiovascular diseases, reverse coronary plaques (soft plaques), and reduce the risk of cardiovascular malignant events.
https://www.reddit.com/r/Amarin/comments/mf78hp/vascepachina_approval/?utm_source=share&utm_medium=ios_app&utm_name=iossmfFul Text:
Vascepa was successfully introduced in Boao Lecheng.
News from New Hainan Client, Nanhai Net, Nanguo Metropolis Daily on March 27 (Reporter Su Guizhu) On March 27, Hainan Free Trade Port International Cardiovascular Academic Exchange Conference and Lecheng Pioneer Zone’s first cardiovascular drug Vascepa expert seminar It will be held at the Boao Yiling Life Care Center, and 40 experts in the field of cardiovascular and cerebrovascular participation from home and abroad will participate in the seminar.
The successful introduction of Vascepa in Boao Lecheng, after 55 days, achieved China's first prescription in Boao Yiling. It is a great blessing for first-age members and for cardiovascular patients across the country. This new medicine and good medicine will become a boon for domestic cardiovascular treatment in the future, benefiting 330 million people with cardiovascular diseases, and truly enabling Chinese people to enjoy world-class medical services without going abroad.
Vascepa's approval is an important milestone in cardiovascular prevention. It can help more patients with chronic cardiovascular diseases, reverse coronary plaques (soft plaques), and reduce the risk of cardiovascular malignant events.
At present, the introduction of international new pharmaceutical equipment in Boao Lecheng is developing rapidly, which has effectively promoted the construction of Hainan Free Trade Port, and has implemented the application of data research work for some new drugs and special drugs in the real world to promote the transformation of its big data results. Boao Yiling Cardiovascular and Metabolic Disease Prevention and Treatment Center has also established a special medical team to provide guarantee for the smooth implementation of this new drug, and carry out comprehensive collection of patient feedback on clinical use, data statistics, real-world data research, etc. for cardiovascular disease Optimization of clinical pathways for chronic diseases.
Professor Ma Changsheng, appointed chairman of the Cardiovascular Branch of the Chinese Medical Association and director of the National Cardiovascular Disease Clinical Medicine Research Center, said that with the aging of our country’s population and changes in residents’ lifestyles, cardiovascular disease has become a threat to the lives and health of our residents. Major public health problems, among which stroke and ischemic heart disease are the main cardiovascular diseases. Solving cardiovascular diseases will effectively slow down the growth of chronic diseases in my country. He hopes that in the future, the first age of Boao can be used as a base for cardiovascular diseases to provide safe and effective treatment methods and treatment methods for cardiovascular patients nationwide.
Heart Alliance and Yiling Group formally signed a strategic cooperation agreement.
At the meeting, the Heart Alliance and Yiling Group formally signed a strategic cooperation agreement, and the Boao Sino-French Rehabilitation Medical Center was awarded the "National Standardized Heart Rehabilitation Center Construction Center".
It is understood that the Heart Alliance is a medical scientific research consortium co-founded by cardiovascular experts in my country and will provide high-quality professional services to cardiovascular doctors and patients across the country.
The Center for Cardiovascular and Metabolic Disease Prevention and Treatment is an important part of the Yiling Life Health Care Center. It is led by Professor Yue Hongwen, a postdoctoral fellow from Johns Hopkins University in the United States and a well-known cardiovascular expert from Beijing Fuwai Hospital of the National Center for Cardiovascular Diseases. It is a cardiovascular and metabolic disease prevention center integrating prevention, medical treatment, and scientific research.
The center introduces global innovative drugs and functional nutritional foods such as Vascepa ethyl eicosapentaenoate soft capsules, Di Jero cardiovascular functional medical products, etc., to bring clinical treatment drugs with better treatment effects and lower residual risks to domestic patients Program.
According to the "China Cardiovascular Health and Disease Report 2019", there are currently 330 million people suffering from cardiovascular disease in China. The purpose of this conference is to conduct full research and discussion on the future development and clinical effects of Vascepa, an innovative drug in the field of international blood lipids, through academic exchanges, while leveraging the preferential policies of Hainan Free Trade Port and Boao Lecheng Pioneer Zone , To provide assistance for real-world data research, accelerate the listing of this product in China, and benefit more people.
Looks like Peg is mixing up RLFTF with BRPA...
NeuroRx is a seperate legal entity that works as a contractor of sorts for RLF on a "crop sharing" base. Later on it intends to merge with BRPA in SPAC deal..
Has got nothing to do with RLF's plans on uplisting - if there are any or maybe not , we don't know
All the best for your Mom!
And try to read up on some of the trials and bring some info as most cardiologists are still not aware of it due to a beak down in the information campaign due to COVID19 measures.
There is one cardiologist and intensive care specialist posting on iHub as >Hindukush< that might be able to guide you on what information to be prepared to show:
https://investorshub.advfn.com/boards/profilea.aspx?user=718139
IF(!) there was going to be a few positive remarks about the inhaled VIP trial going on this would be the icing on the cake as this will probably be the biggest market for AVIPTADIL worldwide as it is much easier available and cheaper to produce than most a other meds!
Given the alarming rise in medical debt it is a necessity and needs to become a household name!
https://finance.yahoo.com/news/medical-debt-america-health-care-133404914.html
Thank you Ellk! This is truly amazing find as it has far reaching implications for the future application of AVIPTADIL to various a other medical conditions!
Do you believe AVIPTADIL/ZYESAMI could potentially substitute for Gabapentin and other anticonvulsant medication by blocking calcium channels and/or glutamatergen receptors?
Since Gabapentin (or Neurontin in the US) is prescribed for a very wide range of indications from seizures over neuropathic pain to psychiatric disorders whilst being quite toxic and only effective in 35% 0f patients this could possibly be the second most important future indication if this could be shown in trials!
Changes, there are several thousand pages of clinical studies and articles in Journals like NEJM about VASCEPA!
It has been clinically proven to reduce strokes, heart attacks etc. by 35 to 40 % dependent on the length of time it is taken - it gets better the longer it is in use - and most importantly in you case it is also called the liquid stent as it reduces plaque in coronary blood vessels by up to 65 % within 6 months!
What maybe most important for your Mom's condition is that it does work as a powerful anti-inflammatory agent almost rightaway.
For those reasons KAISER PEMANENTE is doing a trial on some 16.000 cardio patients that already receive the medication on how it fairs for them re:COVID19 .
Since this is highly relevant for anyone interested in how to combat COVID19 I will try to produce a short dossier sometime next week if you are interested
https://www.nejm.org/doi/full/10.1056/NEJMoa1812792
https://apnews.com/press-release/globe-newswire/science-business-products-and-services-drug-approvals-western-europe-e504fce27a14b5a1923ff48c52e990dc
https://amarincorp.com/therapeutic_focus.html
Changes, did you get to read my reply on the cardio medication for your Mom before some eagerbeaver thought saving a live is OffTopic...
Take a lead from the vaccines trials:
NO trials were allowed with children until only very recently AFTER millions of doses had been given safely to adults!
And now we have St.Jude's children hospital (yes - that St.Jude you see on CNN all the time) involved in an inhaled trial besides UCI is almost unbelievable... certainly unimaginable to me up to now.
Was the FDA asleep at the wheel on this?
Unlikely..
This is the one foundation on which I rest well at night
A little unofficial celebration might be in order:
Thank you Ellk! This is truly amazing in it's far reaching implications!
In my younger days I would have probably exclaimed FARFRIGGINOUT
Do you believe it could potentially substitute for Gabapentin and other anticonvulsant medication by blocking calcium channels and/or glutamatergic receptors?
Since Gabapentin (or Neurontin in the US ) is prescribed for a very wide range of indications from seizures over neuropathic pain to psychiatric disorders whilst being quite toxic and only effective in 35% 0f patients this could possibly be the second most important future indication if this could be shown in trials!
Outstanding finds that you produce,Elk - Thx a lot!
What ever happened with the share price ?
Was the rule 60/24 motion struck down or die GSK lose?
I barely have time to even look into this most valuable community board on the whole internet - left alone posting... - but this is of utmost important as it has been shown that COVID19 virus herds can be encapsulated in the brain as they somehow penetrate the blood brain barrier that usually shuts out most infections
https://kstp.com/coronavirus/new-study-shows-some-covid-19-patients-end-up-with-damage-to-brains-february-15-2021/6014166/
If(!?!) VASCEPA could work it's wonder on this it could be a total sensation putting us all over the news (provided Mr. Thero does not stomp it out before it catches)...
So far the only substance showing efficacy is a naturally occuring peptide that has been synthesized and is being tested in clinical phase III trials both in Europe and the USA lately as a therapeutical intervention for critically ill patients with severe ARDS due to COVID19 as it coincidentally not only restores damaged brain neurons but also restitutes damaged lung alveolar cells type II but is also showing antiviral properties specifically to COVID...
It is amazing that the 2 most promising drugs on the horizon both are synthesized from all naturally occurring molecules!
https://www.researchgate.net/publication/309491952_The_effects_of_vasoactive_intestinal_peptide_in_neurodegenerative_disorders
https://pubmed.ncbi.nlm.nih.gov/15282712/
The drug named AVIPTADIL in EUROPE is already in use in the university teaching hospital of Freiburg for sarcoidosis and pneumonia and is available as ZYESAMI in the USA under an Emergency Use Protocol from NeuroRx for critically ill COVID patients in case you need it.
@whalatane knows a lot more about that than I do
Good Day Changes, where have you been? Here is something sinister but I believe you posted a link about the neuro-regenerative efficacy of VIP that could restore degenerated brain function due to a stroke.
Also you had an article on the effect of COVID19 on the brain, right?
Do you still have that link?
Spooky stuff:
https://www.nytimes.com/2021/03/22/health/covid-psychosis.html
You're absolutely right which is why I propose one more time to form an AdHoc Shareholder special interest group demanding a seat at the table!
Reiterating our helplessness time and again is not god for my health but getting pro-active like our heroes @marjac and @Hinukush and ALL other activists e.g. Biobill is both possibly financially rewarding and mentally and emotionally uplifting!
In all Valeurs ?
(or Names as our cousins from the colonies like to call it..?
Laissez les bon temps rouler
Belfort, where art Thou?
Did you jump ship?
Wrote several times on the consequences for RLF regarding this language in BRPA's SEC-filing:
Cher Belfort, Ca va?
Have you become an absentee owner or have you sold your holdings?
In any case, what do you make of this language in the SEC filing?
It is suspiciously close to the 10m$ that RLF raised recently... :
Form: S-4 Date Filed: 2021-01-27
Page 44 /33
In the event that NeuroRx terminates the Merger Agreement in order to enter into a definitive agreement with respect to a Superior Proposal, NeuroRx is obligated to pay to BRPA a termination fee in the amount of $10,000,000 within three (3) business days of the notice of such termination.
Any idea?
Any idea?
Those patients admitted to EAP are basically doomed - mostly comatose and on external oxygenation.
ANY PATIENT'S SURVIVAL ON DEATH ROW IS A MIRACLE!
And if it helps to save lives it is a MUST DO for a doctor!
There you have it Vanilla - I can use CAPS too
Well,Belfort, I guess selling off 25k shares in a matter of minutes is an answer too...
Cher Belfort, Ca va?
Have you become an absentee owner odr have you sold your holdings?
In any case, what do you make of this language in the SEC filing?
It is suspiciously close to the 10m$ that RLF raised recently... :
Form: S-4 Date Filed: 2021-01-27
Page 44 /33
in In the event that NeuroRx terminates the Merger Agreement in order to enter into a definitive agreement with respect to a Superior Proposal, NeuroRx is obligated to pay to BRPA a termination fee in the amount of $10,000,000 within three (3) business days of the notice of such termination.
Any idea?
He really did! Please go ahead and ask him why not us!
Vanilla, did you share your concerns with Dr. Javitt or the german IR desk ( who is apparently apparently speaking english) in a civil manner?
They do seem to be responsive!
I am eagerly waiting for you to report on that exchange!
Or do you just want to vent some anger with an audience of fellow victims?
"My name is Fit and I'm an Aviptadilic"
Dear Marjac, let me say how deeply grateful I am for your tireless effort as well as Hindukush, BioBill and all the other acitivists whilst I was dealing with health challenges like so many here but without access to VASCEPA in EUrope yet...
Are you by any chance aware of the 18th century playwright and philosopher Heinrich von Kleist who wrote a harrowing novella titled MICHAEL KOHLHAAS about an individual from the 16th century starting a revolution for having been slighted and having been denied just remedies before the law?
His revolt was started under the motto:
„Fiat iustitia et pereat mundus“
Somehow our fight reminds me of that drama and I certainly hope that you will be instrumental to deflate a bloated system and bring a crippling blow to that ongoing effort to invalidate patents
Warm Regards,
Ratna
Ouch...this means that the Fabulous Baker Boys are now below 10% ownership given that Shares Outstanding number 392.54M and we have a Float of 357.3M...
Why would they give up the leverage that comes from being above this meaningful level
go back to my other posts Ria
EUAs do NOT need proven decrease of mortality (which is difficult even in high powered trial)
ALL they need to prove is safety and a possible benign effect!
There have been EUAs given to other therapeutics for reducing Length of Stay for just one (1!) day!
So the red tape makes no sense at all which is why I suggested to Wamu to look at legal leverage if you can prove you are personally damaged by this artificial delay.
Of course that only holds water if it is the FDA dragging its feet and not RLF or NeuroRx
Hey DJ, no I am not! Wish I were so since I went to school in California...
Why are you asking?
you can answer again via PM.
Go sue them! Team up and find a lawyer to create and file an emergency injunction on grounds of "willful omission of help" e.g. which under european codified law is actually a criminal offence.
The only legal detriment to not give an EUA would be safety concerns which are proven to be 100% unwarranted with Aviptadil that has an unparalleled safety profile.
It is useless to complain about the FDA if there might be legal remedies
This is pre trial results and they are moving on to phase I....
I had no time to check into it, so you might want to read up on it yourself and bring back your findings to this board?
https://ampiopharma.com/
As for the mode of action nor even what substance it is I have not read up.
From a quick glance I suppose that they are blocking the inflammatory process with their compound which seems to be an "immunomodulatory agent with anti-inflammatory effects"
So I am looking forward to your research
One thing I am fairly sure of that it does not have the strong regenerative and tissue restoring powers of VIP
Pegs, it is not that hard to find out. You can either check my past posts where i I reported on this several times and so did Changes4 or you can go to clinical trials.gov...
https://www.clinicaltrialsregister.eu/ctr-search/search?query=Aviptadil+
This is the professor conducting the research:
Kontakt
Prof. Dr. Joachim Müller-Quernheim
Ärztlicher Direktor
Klinik für Pneumologie
Universitätsklinikum Freiburg
Telefon: 0761 270-37050
joachim.mueller-quernheim@uniklinik-freiburg.de
https://www.uniklinik-freiburg.de/presse/publikationen/im-fokus/2019/neue-therapien-bei-knoetchen-im-koerper.html
https://www.uniklinik-freiburg.de/presse/pressemitteilungen/detailansicht/2058-hormon-inhalation-stoppt-schwere-nebenwirkung-von-immun-krebstherapie.html
BTW
contrary to the hateful comments on CNBC,FOX etc. about socialist medicine in Europe (which I suppose expresses their eternal fear that even poor people shall get treatment when fallen sick and the rich will have t pay for them..) medical treatments in Germany are no cheap if you do not have a german health insurance plan. I estimate it at roughly 45% of US cost for equivalent treatments. Some US insurers might cover you anyway given the savings but you need to work this out beforehand
are you aware of this trial by any chance ?
Ampion demonstrated an improvement in all-cause mortality in COVID-19 patients compared to standard of care (SOC). A lower all-cause mortality rate of 8% is observed for the Ampion treatment group, compared to 21% in standard of care alone.
Patients who received Ampion required less hospitalization time. The average hospital length of stay was 7 days for the Ampion group compared to 11 days for standard of care patients.
Patients who received Ampion required less oxygen than standard of care alone, and 86% of Ampion patients were stable or had improvement compared to 75% of SOC patients.
More patients who received Ampion were stable or had improvement on a scale of clinical improvement compared to standard of care alone. By day 5, 86% of patients who received Ampion were stable or had improvement compared to 75% of standard of care patients. This trend in improvement with Ampion treatment is noted as early as day 2 and continues to day 5.
Adverse events were the same between Ampion and standard of care, and no drug-related serious adverse events have been reported.
In commenting on the preliminary positive results in the AP-014 Phase I clinical trial of inhaled Ampion, Dr. David Cornutt, MD, Chairman, Department of Emergency Medicine, Regional West Health Services, and a Medical Monitor on the study, said, "The scientific findings we have reviewed thus far are fascinating and very encouraging. While we are still looking at preliminary data from a small sample size, the safety signals look strong, and I look forward to moving into the efficacy phases to come."
https://www.marketscreener.com/quote/stock/AMPIO-PHARMACEUTICALS-IN-13421507/news/Ampio-Pharmaceuticals-nbsp-Details-Early-Positive-Results-for-Inhaled-Ampion-in-COVID-19-Respirato-32718378/
Good Luck and speedy recovery Pegs!
BTW
numerous patients from Russia,Dubai and the USA present themselves at the university hospital here as it is a world leader in many areas as it is cost efficient relative to their domestic hospitalization expenses. That is why they have a concierge and translation bureau here for international patients if you ever have to go that route.
Sad but so true!