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Endonovo Therapeutics, Inc. (ENDV) Reports First Patient Enrollment in Clinical Study for Treating Traumatic Brain Injury Using its Electroceutical Therapy
June 14, 2018 8:33 AM
Endonovo Therapeutics, Inc. (ENDV) today announced that the first patient has been enrolled in a clinical study at the University of New Mexico Health Sciences Center that will evaluate the effects of Pulsed Electromagnetic Fields (PEMF) on reducing brain injury, blood-brain-barrier and inflammation biomarkers in the cerebrospinal fluid and blood in patients with brain injury who are or have been fitted to an external ventricular drain. Funding for the study has been secured via the Company's senior secured Series C Preferred Stock financing.
"The initiation of this study represents a significant milestone for Endonovo," said Endonovo CEO, Alan Collier. "We believe our technology, whose proven mechanism of action is the suppression of inflammation, has the potential to change the treatment of central nervous system disorders where neuroinflammation propagates injury such as ischemic stroke, Alzheimer's disease and Multiple Sclerosis."
"After completing two PEMF safety studies on volunteers and patients with brain injury currently submitted for publication, we have consented and studied our first severe traumatic brain injury patient for the PEMF study and collected brain fluid and serum samples for four days post-injury," said Edwin Nemoto, PhD, University of New Mexico Health Sciences Center, School of Medicine, Department of Neurosurgery.
About the Study
The randomized, double-blind, placebo-controlled, clinical study is an extension of a safety trial that will be open to all patients who have or are fitted with an external ventricular drain (EVD) to remove excess cerebrospinal fluid (CSF). The study will enroll 48 patients with brain injury and will assess the effects of PEMF on suppressing the release of brain injury, blood brain barrier and inflammatory biomarkers in the cerebrospinal fluid and blood for up to one week after severe TBI with neurologic outcome follow up at one and three months. CSF will be collected at baseline and then every 8 hours until EVD is removed. CSF samples will be analyzed for biomarkers, such as IL-1ß, IL-10 and S100 and other outcomes such as ICP, tissue oxygenation, blood flow, vital signs, and variables specific to individual diagnoses will be measured. Patient outcomes will be compared within and between groups.
About Traumatic Brain Injury
Traumatic brain injury (TBI) can happen when a sudden, violent blow or jolt to the head results in damage to the brain. As the brain collides with the inside of the skull, there may be bruising of the brain, tearing of nerve fibers and bleeding. If the skull fractures, a broken piece of skull may penetrate the brain tissue. Causes include falls, sports injuries, gunshot wounds, physical aggression, and road traffic accidents. Primary brain injury is irreversible as it occurs at the moment of impact and involves immediate neuronal damage from axonal shearing. After the initial injury, secondary injury may result from hypoxia, hypotension, and intracranial hypertension, all of which cause cerebral ischemia and neuroinflammation. Therefore, treatment of TBI is concentrated on preventing or attenuating secondary injury by appropriate medical intervention or therapeutics. Chronic traumatic brain injury (cTBI) represents one of the largest unmet medical needs in the U.S. healthcare market today, with a current pool of approximately 5.3 million patients incurring costs estimated at more than $60 billion per year. Furthermore, each year an estimated 1.7 million people in the United States suffer a traumatic brain injury. In the United States and elsewhere, it is a major cause of disability and death. Yet, despite its cost and clear lack of treatment, not a single drug has been approved for traumatic brain injury.
$RBIZ...“Based on customer feedback in Q2, Verus continues to back its previous forecast of $100M in annual revenue following a full business transition and receipt of adequate financing.”
$RBIZ...“Based on customer feedback in Q2, Verus continues to back its previous forecast of $100M in annual revenue following a full business transition and receipt of adequate financing.”
Over 1 million share bid at .0023 held strong. Should move up very soon.
$ABCE
Exactly and it will open up markets across the nation...
Got a few myself
“We are beginning to see a number of changes in our market as our time in business and reputation as a quality provider has helped our firm with a larger number of higher quality projects, and we expect this trend will continue in the future as we expand our markets,” said Charles O’Dowd, President of ABCO
ABCE .003 hit
Heck yeah $ABCE
Agreed!
Nice call there my friend
People must not like money because this one has major move written all over it and still quiet.
$RBIZ
Should easily move back into 2’s without news...
Sweet....
Check out our newest press release.https://t.co/EVsbWGGVcU
— ABCO Energy (@ABCOEnergy) June 12, 2018
I am as well. Think we hear something soon.
$ABCE
$ABCE very nice
Looking good...8’s back up!
Quite a winner .0004 to .001 huh?
No 6’s sold in a long time. Holding tight
Nice! I like it. Breakout board is very important. Brings eyes. Good call!
250 million shares loaded yesterday
No selling at 7...sweet
Trademarks! Awesome $HVCW
Big runner here?
Because people talk about a stock on Twitter doesn’t mean it’s a pump and dump. That’s absurd. Is Tesla a pump and dump?
Very nice move .0004 to .001! Thanks
Heavy loading? Big runner?
$HVCW winner?
Buyout???!!!
About to get interesting again...
Why am I still with TDameritrade?
10 million bid....nice
$HVCW was able to consolidate loans and push off the maturity date to June of 2019...most sub pennies dream of getting a deal like this done. Says much about this company imo.
Nice day here for sure
$ABCE
Attitude Beer Announces New Operating Partnership With World of Beer Corporate ParentPress Release | 12/27/2017
Attitude Beer Announces New Operating Partnership With World of Beer Corporate Parent
PR Newswire
NEW YORK, Dec. 27, 2017
NEW YORK, Dec. 27, 2017 /PRNewswire/ -- Harrison Vickers', Attitude Beer Holding Company subsidiary, announced today that it has reached an agreement with the operating and marketing units of the chain of World of Beer taverns, to manage its taverns in Connecticut and Massachusetts. The deal as structured, allows for World of Beer to take over the daily operations of the taverns which should dramatically improve efficiencies and top line sales. Additionally, the 9% royalties previously paid under the old agreement with NEWOB will be eliminated, thereby driving significant benefits to the bottom line of the business. Further, World of Beer has become an equity partner in both the West Hartford CT and Cambridge MA tavern operations.
Jeff Canouse, CEO of Harrison Vickers stated, "This transaction puts our taverns on much firmer footing. The increased efficiencies from the experienced operators and marketers at World of Beer, along with the significant economic improvement to our bottom line, should position the Company well for the coming year and beyond."
World of Beer is at the forefront of the craft beer movement with 50 brews on tap and more than 500 in its cooler from around the globe in 77 locations worldwide. “Continued momentum of craft beer consumption in America remains strong and has proven to be a sustained trend,” CEO and President Paul Avery says.
World of Beer is a chain of taverns with 55 locations in 16 states as of May 2014 and is headquartered in Tampa, Florida. Each World of Beer sells more than 500 beers including almost 50 on tap and offers burgers, wings, soups, sandwiches, flatbreads and main course entrees such as salmon and steak. [1]
Major loading?
Massive accumulation???
Major accumulation?