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I don't think whether primary endpoint PFS meets or not is important enough to scare people away from taking/adding positions if OS shows significant improvement via HR, and landmark 2-, 3-, 4- and 5-years survivals compared to placebo, later vaccined patients, etc
Yes the short may have an hour of confusion and deception impacting stock price in a significant way. It will be transient.
We have well passed PFS days when it was meaningful. Of course I believe we will meet PFS target in a statistically significant way.
Get dry powder ready!
No worry this stock is a retail stock despite somebody claims to have the control of 100 million shares/warrants, or at least those self-claimed long hedges have not done their parts yet to maintain/protect their positions.
I have been buying more again ever since the price had dropped to low 0.80s.
Today I get a bit greedier and my buy order has yet to be filled around 0.77, missed the first wave down to 0.76. May raise my bid later depend on situation.
the beauty of this stock is that we have had no big fish onboard yet. Bigger or the guy claimed he would have to file 13f in the future when warrants convert are just like most posters in this board, better at lip work
so we will be rise exceptionally huge when topline data is released because at that time we will truly have some bid fish swimming in nwbo pond/ocean
until then, happy to add
Look at the pathetic volume. you are lawyer you should be able to comprehend.
These jerks should pass big volume trading to each other to make it real
Grade F for their job.
I could be only quickly enough to catch 9k shares at 0.833, then the price went up.
too old and not enough time to watch every dirty move
[Sorry not directly in reply to you bio]
Shout from the rooftops: Topline data any day within 6 trading days!
In Lindas we can believe!
Because of the science, the data we have known, and ironically the market.
Yes the market has awaken. Dynamic has changed. Naked short wolfpack has broken up among themselves!
Gap up tomorrow. Yes you right I am talking about nwbo.
[some people never change until it's too late]
I know it's premature to express my deep appreciation to Linda Powers and her brilliant leadership for guiding this trial into fruition as we are awaiting topline data announcement anytime now ("later in the month of September")
God forgives and blesses I said it now!
If it is not for the publication of the interim blinded data in Journal of Translational Medicine in 2018, and the subsequent updates, I have not been so assured and ease in continually adding shares to my already large position whenever share prices were weakened. And the fact is now I have been able to average up!
Nobody is and should be happy for having gone through those dark days when the company has had to go through repeated deteriorating dilutions as if there would have been no end of it.
We now know how extremely hard for Linda to lengthen the trial not by months but years while maintaining the integrity of the trial because it's important and vital to bring the effect of immuno-oncology (IO) agents such as DCVax-L into full strength in treating cancer patients, which requires years of following up.
In effect, most other small biotech companies with phase 3 trials for GBM have failed due to a variety of reasons. For one important reason, I think it's because their leaders' lack of steel will, long-term vision and vulnerabilities to the market force which has been always hostile to promising small biotech companies. It seems we are an exception, a pleasant exception because we have an exceptional leader; all other big pharms have also failed in their trials of various agents in treating GBM patients despite very resourceful because their treatments are either unsafe and/or ineffective. We are only one standing!
Thanks to Linda we have come a long way and only a few yards away from reaching our first milestone goal: prove both the safety and efficacy of DCVax-L for GBM patients.
Again God forgives and blesses!
Hi marzan, I think this time the AF + hedge fund combo won't work simply because nwbo has had so many investors who are really committed because of science for which AF and friends don't understand.
Regardless nwbo will have a cult following by a very large number of retail investors plus perhaps dozens of small long hedge funds.
In my decades of biotech investment, I have never ever come to know so many retain investors who have been unbelievably knowledgeable on how DCVax works, its MOA, and what's the status of GBM clinical trials and treatments, and the current best cares/standard cares, etc.
These investors will not be easily shaken off and let go their collectively huge numbers of shares in case disinformation/fake news/deceptive analysis is released by any of the naked short wolfpack.
In addition, AF's appeal as frontman for short hedges has been severely damaged ever since he left the street due to several high profile bad calls and aftermath consequences. If ever naked short hedges want to conspire with him in the future, the effect will be temporary in my opinion.
We are educated with knowledge of DCVax. Next will be the mainstream media after topline data are released.
Actually the share price movement since around 1 September has been a testament that the wolfpack has been broken, and they will run for the hills. I like to see a stampede aka squeeze, not only for my profit but most importantly for GBM patients!
Definitely not small fish like you and me. Use your imagination. Most who have done their DDs think DCVax-L Phase 3 trial for GBM will be successful, meaning FDA approvable, but there are some who think otherwise.
Some of those who think otherwise have been much more resourceful and bold, let alone they may have other agenda other than making money.
The trading history and pattern of deteriorating endless dilutions in the past tell the story; AF, the never ending forces who have turned good news into bad; the few proliferate posters who have never ever said a single word good about the company; our own SV Les who despite unlikable by many who have talked with him has repeatedly claimed hundred of millions of naked short shares; and CDEL if you watch trading everyday which has been in the ask with lower price at any opportunist times with 100 share lots when volumes are low and recently 1000 share lots when volumes increase.
Yes anybody's selling order may be directed to CDEL or any other MMs, but its strange lots and never ending lowest ask price, meticulously and painstakingly opportunistic timing tell a story: you would think CDEL likes to lose money, right? It has definitely lost a lot of money when share price has been appreciated in recent months from low 20 cents to today's 80 cents, and CEDL has been always at the lowest ask. Even a rock know CEDL has been losing money for fun, and yes CEDL never adjusts. Does that tell a story of naked shorting and stubbornness.
No point to argue, we will know soon enough when Topline data is announced.
Most people don't believe, but it's actually very prevalent for hedge funds to have significant naked short positions in most small biotech companies in the face of a binary event regardless what the share prices are.
That's your lawyerly statement? I bought today around 0.86, and then 0.84 because as I said a few days ago: anything below $1 is no brainer.
[Have averaged up almost daily!]
[Notice when we are up volumes are up and when we are down volumes are down. CDEL is just a pathetic MM, constantly putting out 1k lots at lower price at the ask]
Definitely the buying pressure is here and strong so if larger buyers are not materialized today, they will be tomorrow risking aftermath of topline data announcement.
I am expecting to see some familiar names missing the days ahead. Nothing wrong with some profit taking, but some turning into a sour grape is pathetic.
Average up!
Gap up late this afternoon! Some old timers have been replaced by new comers, which has always been the case in high-profile stock appreciation history.
Get ready for gaping up!
That shorted number is a peanut. the wonder is the naked shorted shares which is believed to be around 200 million large. Though disputable, we will see!
marzan I believe we don't need to go through the usual Nasdaq listing process/procedures as we are former Nasdaq listed company and it seems very clear Linda has been preparing for uplisting/back to Nasdaq for some time. The recent up-to-date filing is evidence.
After positive topline data which will be announced within two weeks, there will be no obstacle to go back to Nasdaq. For instance, no investors will complain to have a reverse slit of stock 1 for 4 or 1 for 10 to make the stock price to $4 or $10 per piece if the stock price is $1.
I personally think if the results are positive enough, the stock price will be well above 1 and may readily reach $4 and $5 in a short time thanks to the current general crazy market environment and widespread awareness of humans own immunization system which can do wonder.
GLTY and GLTA longs.
[With short squeeze which we are definitely having one, big or small, the share price may easily go above $10 in a few days]
Yesterday's filing (D form) may suggest it has something to do with acquisition, partnership, etc. Because of the date mentioned, ie, late August, people are quick in making a conclusion that it is related to Flaskworks acquisition. The fact is nobody knows for sure at this time, and there is reason why the filing doesn't specify.
Now today's 8-K/A which seems to show merely a fiduciary responsibility of CEO Linda to the investors of the company in regards to one resolution of the early shareholder meeting on compensation as if the company has been always up to date with SEC and its shareholders.
So what gives. Regardless, we will find out soon, and most important thing is there are only 10 days left for trading in September.
Topline data will be announced "later the month of September" literally means any day of the remaining days in September.
Com'on flipper44.
Is this Linda's statement clearer than would be expected:"...later this month of September, we will be expecting to unblind, unvell, and announce, finally, the results of our 13-year long Phase 3 trial of DCVAX for Glioblastoma brain cancer."
Twelve trading days left in September. If you want 100% correct, you can choose the 30th of September.
Nobody can outsmart the market, which Linda knows and we all know. In the things regarding NWBO, admitted or not we have to deal with the naked short wolfpack, let alone a vast army of traders who think they have ultimate mastered the market.
Shorts have to pay back; "smart" traders have to pay back, and yes good luck to patients.
Nothing wrong with me flipper44. I am well and sound. Just interested to point out some subtle observation if I am not that busy.
this is the last post of mine. GLTA
[Can I say it again, we are just experiencing a mini-gap up today. More to come]
Today we are in the stage of a mini-gap up warm up. Still far away to reach $2 for those self-claimed "leveled" investors to load up all the way to $10.
Well I am sorry I didn't buy more enough to help you guys to reach that goal as quickly as possible so you guys have to continue your "leveled" opinion in this board a bit longer. I do appreciate your honesty though.
Finally, after a repeated endless 1k shares offer at ask by CDEL at 0.599, the ask was forced to move up. CEDL may come up with a price for its next endless 1k shares offer in order to damp enthusiasm, but it's okay in a warming up stage, we can just move step by step with tons of patience.
For folks who think we have a functional market economy governed by rules of law, they are at the front of the corporation ladder, like the guy blue bashing something, never in the position of executive ranks (not a mom and pop business of course).
Meaning, if you want a big piece of a penny stock, there is no obstacle for any major Wall Street institution to have it, such as the $5 limit, OTC limit, etc, but all these are to fool retail investors, or the masses. SEC will be a guarantor!
Be prepared.
Really. No flip flop. I did not see you in the land of 10s and 20s cents. It doesn't matter anyhow and shorts are killing themselves.
No need for us who have average up. We compete with shorts in the way down and up regardless.
Positive topline within two weeks
Gap up tomorrow!
In a lawyer's mind [you are one of them, aren't you?]:
"...are expected to be unblinded and announced later this month."
Meaning:
...are expected to be unblinded and announced later this month [to the general public]
See the difference?
Bought 50k more shares today at around 0.555. Yes I am prepared to short NVCR when the pig is fatty enough, meaning when NWBO substantially rises in price again. Then start to short, depending on situation, may short more
In the meantime, at a price below $1, NWBO is a buy!
Done my posts today. I am going to take a break.
Good weekend NWBO longs
The manipolators MM/Naked wolfpack has been working hard to make a trend of downward price movement in recent days so some smart ones think they could sell now and buy later for cheaper shares while other smart ones would be waiting on the sideline thinking the bottom has not been reached.
While doing that, MM/Naked wolfpack are pumping up NVCR for short when DCVax-L trial results are published
Greedy, a purely and totally greedy bunch! There are only 12 trading days left for September!
Each individual investors have their own situations and conditions. For me there is no brainer to average up until $1 - this is my view at the time being.
And which is based on not super results but a controversial one, ie, longs believe it will be approved while shorts (if there are genuine) think it will not garner approval.
But I believe the trial results will be positive enough to get all four countries approval.
Care to point me to where I have said that? I did say that when price fell under $1, then $0.5, let alone in teens.
In all these price ranges, I have not said it but bought increasingly more shares. Now I am in black, up six figure paper profit at least.
Still committed for a long term gain with the vast majority of my shares.
[As a matter of fact, I have been averaged up all the way from the jump out the teens to most recently at around 0.63, 0.61, 0.59]
[I believe a big surprise is in the making, a big positive surprise to be exact]
I know that flipper, but as many posters have pointed out if for a failed trial, there would be no rash to get in and present.
The way the company put LL and B in that presentation shows it's unlikely a failed trial, particularly on top of the fact we have had lots of blinded data, and pretty much know how SOC has behaved over the years. All points out to a successful trial.
Other question?
The market via MMs, led by CEDL which has been always on top of the ask for quite a while, has set a perfect stage for Linda Powers.
The losers list will soon be extended from the short to the various bottomfeeders, including those who have a long learning curve, and who practice laws in message boxes, etc.
Buying at this level is a no brainer thanks to Linda's failure to attract a strong financial backer who would have no tolerance to any market manipulation. All Linda's dozens or so existing financiers are just some broken arrows, vulture in nature without enough resources, let alone guts. Bigger can just tweet, besides that not much of open market buying. That's the opportunity Ladies and Gentlemen.
When you see a Form 4 or two, that would be too late for cheap shares.
Again because of that, buying at this level is a no brainer. Manipulation has happened often. It's not because we are trading on OTC but it's because we have not yet secured a strong financial backing. For this reason, thank you all who have tried to contact big wall street sharks.
Whatever and however you think that the prestigious conference would not accept Drs L and B to present P3 DCVax-L results in its plenary session in the form of a late breaker fashion on 1 Sep without having a peek at some significant positive results.
Before a significant financial baker onboard, it's no brainer to buy.
From sharpie510's post above:
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=158195899
It does seem the company has locked the data or is about to lock the data. Otherwise the unblinded data would not come out of the 13-year old trial like what Les said in the video aired on 8 September:
https://www.biztvclub.com/tv/search/video/6a63a72571be4a60f2ed7d4b91dcdcd8
Listen to 24-30 marks.
So it seems the company may acknowledge DL either via a news release or a filing or by Linda during her attendance the meeting on 12 Sep.
Or it may simply not acknowledge it publicly, and elect to only announce topline data.
But it does seem or is confirmed by Les topline data will be announced this month.
It also does make me wonder why Linda will be presenting on 12 Sep meeting without unblinded to data. Normally she would be quiet during such a special period awaiting topline data/unblind.
In 8k dated 1 Sep, Linda says
"The phased buildout of our Sawston, UK facility and now our acquisition of Flaskworks are major building blocks towards achieving these goals. These steps, along with others in process, have been years in the making to reach fruition at the same time as we are reaching the results of our Phase 3 clinical trial of DCVax-L for Glioblastoma."
Can that statement serve as an update or indication maybe what we expect the next is not DL but Topline data?
plus, the company had talked about what venue and time the company will determine to present findings of the trial in consultation with PI and other experts after the company is unblinded.
Now it seems LL and Bosch will be presenting on 20 Nov, preceded by LP's presence/speaking on 12 Sep.
Is the above also indication that the data has been locked pending public reporting?
I would say either way, ie, the company will report DL or the company will directly report Topline data bypassing DL announcement, is likely.
Honestly, I like this ambiguity since I plan to hold the vast majority of my shares for a long term, and because it irritates traders and shorts.
Bought a little above 50K more shares ranging from 0.628 to 0.635. Thanks.
Seem the price drop again. back to buying
And it seems the whole Dutch Real Estate has been frozen releasing full time of its many lawyers to flood BB/MB
Believe or not, we are about to have the reading of DCVax-L P3 trial for GBM
That is just beginning as the now still conceptual MOA is proven and verified by the trial data
Many doors open for approval of many other solid tumors because of the proven MOA
That's a sure thing. The timing of course is anybody's guess. Definitely not days nor years.
For anyone who has a target price of a few dollars, you will be soon shown the door out.
Bye then
Criminal activities committed yesterday around 10:44am by those who wanted to stop the momentum which has been built up beginning around 2 September.
By implementing that rogue/criminal nature transaction which dropped the share price from 0.60s to 0.005 in a moment, it brutally disrupted the intense momentum in the beginning of the morning trading, preceded by some desperate short selling to bring the price down and hold it at around 0.60s. Sensed they would fail badly they initiated that rogue/criminal transaction.
Big boys including MMs trade stocks using own proprietary algorithms (computerized programs)based on own parameters. In normal time, a strong upsurging momentum would accelerate as the algorithms are all set to detect and execute changes/momentum, and the opposite is true in a downward trend, and in that case, instead of accelerated price increase it would be accelerated price drop.
So it seemed the evil force succeeded yesterday stopping the upsurged price movement by suddenly and brutally changing the conditions in which all these algorithms were working at that moment all the way back to the beginning of the morning, ie, competing with each other for shares which saw prices increasingly accelerated.
I expect after SEC takes action to get the bottom of it, we will be able to find out who are behind that rogue/criminal transaction, and how SEC penalize those responsible.
Flipper is right. Without that transaction, we might see $1 yesterday. The evil force may delay our ascending temporarily, the upsurging trend has been carved in stone.
Tuesday gap up!
Nobody will be in a rash to present "failed" results. It's no coincident that Linda Powers pulled the trigger to buy Flaskwork, and Linda Liau (PI of the trial) and Bosch (CTO of the company) will both present in the Plenary Session on the trial results, making it ready in the last minutes submitting a late breaking abstract on 1 September.
Since then we see price has been rise substantially as the market started to smell something positive.
Remember what Linda said in a previous update: After the company is unblinded, the company would consult with PI, committees of experts for comments, and will determine the venue and time to present detail trial results.
Smart forces are buying while shorts are scrambling. At the time being the market still seems orderly except today's unexplained sudden drop from 0.60s to 0.05
That orderly market reaction will not last long as the general market comes to know what is really happening.
Gap up Tuesday!
Just submitted mine.
Get the dry powder ready for any unexpected and unwarranted drop of price.
And continually average up if possible
A huge gap up Tuesday!
Pity of those "smart" ones who sold for a penny or two profit
the smartest ones make some money while the dumbest ones lose money all the time. The one who make real money are those who can sense change and consensus.
Watch late this afternoon how the naked short wolfpack are scrambling to cover, and if they are they are lucky as the general market has not yet been ticked with headline of positive Topline data
For the dumbest ones, they are aiming to cover in dollars land.
But remember many long suffering longs are competing with each share available at this low price too
So are increased numbers of new investors
The old tricks of the short may not work beginning from today!
Not traders as you said. It's obviously the short (the wolfpack naked short) who sense an opportunity at close to the end of market at a hugely down day for the three big indexes.
The wolfpack are actually covering shares all day today and yesterday in almost all time. Then today they sensed the opportunity of big market down day and investors who have been buying too probably left at the time when the market was close to end.
They could just sell some shares at lower price, and waited; if there were buyers come right away willing to buy shares at or above the price they just sold, the short would know time was not right. But today seemed after the short tested sell, no serious buyers came.
So they were able to pain the floor at lower price for today so they hoped tomorrow they can continue their orderly covering at lower price.
It never changes that shorts are the most snaky ones on the market, but they can only get away when the market condition is not in our favor.
Now I think the market condition is actually in our favor. Who knows Linda would not drop another or two unexpected news at any time on top of expected Topline day announcement after Labor Day.
Technically and practically statisticians can know the general results almost right away after data lock, from a few hours to a day!
Nobody knows whether the database has been locked, and nobody knows whether Linda has had a peek at the results.
Too many unknowns and speculations at this stage all are in favor for higher share price.
One more million the "selling for profit" should be taken care of
We are heading higher from that
Big Pharms want a piece of it if not the whole. They have the right brains who see the huge potential of this revolutionary cancer fighting vehicle called DCVax, not only DCVax-L
They are onboard start competing shares with the shorts
Next, the general market will be wakened up
More shares will be grabbed and held
Shorts will have no way out who can only buy in the open market
Squeeze or not, they will be burned badly and they deserve it!
Short covering is just beginning, volume is higher than before but still not higher enough (forget that 12 million reg short, there are much much more the so-called naked shorts)
That's actually not all. It's just beginning!
Not all pharmas which want to buy nwbo can be assured in its acquisition or which want to be part of can be assured to be part of it. There are ways to offset those deficiencies
One way is to buy the stock of the said company either directly or indirectly, but mostly via an existing financial vehicle in the Wall Street.
Then you have all this awakening, chattering, etc about this company suddenly rising from nowhere for most potential investors as price and volume continue spike
Even purely technical an interesting story is unfolding!
So Flipper what he is if not short, or one working for naked wolfpack since he has been working hard for 24/7 for years after tens of thousands of post in this tiny board?
Lots of people are living in alternative world these days! Like no shorts, no naked shorts from the same persons who are part of it.
You must know I almost never reply to those people, let alone those in the lower ladder of the wolfpack. It's a wast of time and useless!
CDEL has given him a break. He will be back soon after break posting in coordination with xxx, xxxx, xxxx, and you know who they are
CDEL has been acting as lead of the wolfpack recently
I said this on 21 Aug: "Although I don't like it I expect naked short wolfpack will start to cover, there is simply no any other way out.
For all the vulture hedges collectively, you are as pathetic as the naked short wolpack." in the post: https://investorshub.advfn.com/boards/read_msg.aspx?message_id=157793331
Now share price is up with significantly large volume compared to the past, indicating the short wolfpack is indeed covering, which I hated to see it's happening, more of preferring it happens when topline data is announced as I said multiple time in the past.
Well be happy things come this way!
Now as the wolfpack is covering in a still "orderly" manner, we only need some fuel in the already burning fire.
If only Linda's financiers either true friends of the company or those vultures can put some money in the working buying in the open market, that orderly manner will turn into what we have known as squeeze.
A $1 a share is in the reach very quickly before topline!
How could this trial (pivotal phase 3 DCVax-L for GBM) fail?
1) control arm outlives treatment arm? (very unlikely for GBM according to what have been known from literature and myriad of presentations from treating doctors);
2) No separation between control and treatment, and/or early and late (crossover) vaccinated patients? (very unlikely according to supposed mechanism of action of DCVax-L, and the suggestion of Dr. Linda Liau in her various presentations);
3) PFS messed up due to pseudo-progression? (may be true initially, but corrected after adjudication. More importantly, as the last patient in the trial lasts five years, PFS really doesn't matter anymore because it is just a surrogate for OS);
4) Treatment effects if any cannot be detected in a statistically significant way, ie, the p value being greater than 0.05? (may be likely due to crossover, but the efficacy can be backed up by comparing to similar external data and some immunogenetics data showing distinct immune-reactions before and after vaccination, etc.);
5) Not a pre-specified group or subgroup shows any statistically significant benefits? (very unlikely); and
6) All of the above or a combination of some of the above? (mostly unlikely)
A quick rough recap on what we have known today before unblinding:
1) mOS for all patients in the trial: about 23.1 months from surgery (compared to the standard of care: 14-17 months); and
2) One year mOS: 89.3 %; two year mOS: 46.4 %s; three year mOS: 28.2 % (based on 2018 updated data); and five year mOS: about 15-17% for all patients according to Les from his recent discussion (compared to standard of care which is about 5% at five years).
Conclusion: DCVax-L will be at least approved for treating GBM based on landmark long-term overall survivals (there are other ways for DCVax-L to get approved as well).