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Open Label Extension Study for Patients With Early Alzheimer's Disease (AD) Enrolled in Study ANAVEX2-73-AD-004
Estimated Primary Completion Date : July 31, 2024
Estimated Study Completion Date : July 31, 2024
https://classic.clinicaltrials.gov/ct2/show/NCT04314934
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Anavex is hiring
Senior/ Principal/ Statistician
Anavex Life Sciences · United States · 2 days ago · 64 applicants
No longer accepting applications
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The pediatric Rett syndrome EXCELLENCE trial using Anavex's blarcamesine was NOT a failure.
THAT IS A FACT!!!
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I expect that the Anavex 3-71trial for the treatment of schizophrenia should be full enrolled by or before summer 2024 and completed by or before the end of 2024.
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ABSOLUTELY GREAT HUGE NEWS exactly as expected!!!
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AVXL
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1:30 PM EDT today!!!
https://www.anavex.com/post/anavex-life-sciences-to-present-at-the-noble-capital-markets-virtual-healthcare-equity-conference
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Tesla Semi has been pushed ‘well beyond expectations’ by a new customer
https://electrek.co/2024/04/17/tesla-semi-pushed-well-beyond-expectations-new-customer/
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LOL
Carbon in the atmosphere is without a doubt one of if not the most important cause of global warming and Tesla is one of if not the most important companies working to reduce global warming by reducing carbon in the atmosphere.
GOD bless,
Crudeoil24,
Crude oil and coal contribute hugely to the amount of carbon in the atmosphere. That is one of the most important causes of global warming caused by the greenhouse effect.
We (humans) must convert to green renewable energy resources and uses.
Tesla is one the main leaders in this effort to curb and reverse global warming to to carbon in the atmosphere.
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Tesla set to roll out awesome new Sentry Mode feature
https://www.teslarati.com/tesla-sentry-mode-remote-viewing-feature/
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Tesla teases huge Spring software update: here’s what’s in it
https://www.teslarati.com/tesla-spring-software-update/
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Thursday 18 April 2024
Noble Capital Markets Virtual Healthcare Equity Conference. Christopher U Missling, PhD, President & Chief Executive Officer is scheduled to present at 1:30pm ET, TRACK 2 on Thursday, April 18th, 2024.
https://www.anavex.com/post/anavex-life-sciences-to-present-at-the-noble-capital-markets-virtual-healthcare-equity-conference
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To curb global rising temperatures, Canada mandated last December that all light-duty vehicles sold by 2035 cannot produce tailpipe pollution.
The ruling carries benchmarks of 20% of all passenger cars, SUVs, crossovers, and light trucks sold by 2026 to be zero-emission vehicles (ZEVs) and 60% by the end of the decade.
https://www.thecooldown.com/green-business/canada-zev-mandate-evs-zero-emissions-vehicles/
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Tesla FSD 12.3.3 Drive Without Intervention … Almost
https://cleantechnica.com/2024/04/15/tesla-fsd-12-3-3-drive-without-intervention-almost/amp/
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Do you know what orders of magnitude means
10X is one order of magnitude increase
100X is two orders of magnitude increase
1,000X is 3 orders of magnitude increase
10,000X is 4 orders of magnitude increase
orders of magnitude is plural meaning more than 1
Anavex 3-71 (formerly known as AF710B) is orders of magnitude more potent than donepezil (Aricept)and other agonists acting either on the M1 or the s-1 receptors, respectively,” Fisher said.
Quote:
First, s-1 receptors. They are strangers to published AD drug development, though pharmaceutical industry research on compounds active in the CNS comes across them frequently. First identified in the 1970s, these receptors were studied pharmacologically until Austrian researchers cloned the gene (Hanner et al., 1996). In the years after, scientists learned that many endogenous peptides, for example, pregnanolone and neuropeptide Y, interact with these receptors, and subsequent knockout and other biological studies showed they act as chaperones associated with the endoplasmic reticulum (Hayashi and Su, 2007). Unusually for chaperones, a slew of endogenous ligands that act as agonists or antagonists operate the s-1 receptor, Tangui Maurice at INSERM in Montpellier, France, told the audience in Zuers.
The s-1 receptor’s role in neurodegenerative diseases is poorly understood. One mutation appears to cause juvenile ALS (Al-Saif et al., 2011), but beyond that, data on its genetic contribution remain sparse (see AlzGene listing).
The receptor is ubiquitous. Besides neurons, astrocytes, oligodendrocytes, and Schwann cells, the liver, spleen, heart, kidney, intestine, and other organs express it. It is a transmembrane protein that lives in the ER, particularly at touch points with mitochondria. There, it modulates calcium and influences the composition of lipid rafts. The receptor becomes active in response to ligand binding and in conditions of ER stress. It protects mitochondria by influencing production of radical oxygen species and expression of the anti-apoptotic gene BCL2. It also sits in the plasma membrane, where it interacts with receptors ranging from TrkB, the muscarinic acetylcholine receptor, to sodium and potassium channels. “The s-1 receptor is an important activity-dependent signaling modulator of multiple intracellular pathways in the cell,” Maurice told the audience in Zuers.
How can the s-1 receptor influence myriad functions in cells? It does so by way of cooperating with other receptors. At least in some cases, it forms heteromers with them, said Abraham Fisher, Israel Institute for Biological Research, Ness-Ziona (e.g., see Navarro et al., 2010). This constellation is how the s-1 receptor may work as a target for certain drugs. For example, haloperidol treats schizophrenia by acting on the dopamine D2 and s-1 receptors; fluoxetine treats depression through a combined effect on the serotonin and s-1 receptors, and donepezil treats AD through an effect on a cholinesterase and the s-1 receptor.
In Zuers, both Fisher and Maurice presented their respective efforts at finding small molecules that tickle this receptor in a way that might treat AD better than current drugs do. Fisher introduced AF710B, a bicyclic heterocyclic spiro-compound that he said selectively activates both the muscarinic M1 receptor and the s-1 receptor. In detailing its effects on a list of phenotypic parameters—it increases sAPPa secretion, decreases tau hyperphosphorylation and GSK-3ß activity, decreases Bax, and increases BCL2 expression in mitochondria—Fisher emphasized that the former two effects come through the M1 receptor and the latter two through the s-1 receptor. Unlike previous compounds Fisher developed, which were mainly M1-selective orthosteric agonists, AF710B is an allosteric M1 receptor agonist. Its heteromer-specific effects differentiate it from other M1 agonists and modulators. Fisher claimed that the new compound is exquisitely potent, acting as a cognitive enhancer in rats at 1 to 30 micrograms (not milligrams) per kilogram body weight. According to Fisher, the compound is orally available with a safety margin of more than 50,000 times the minimally active dose. “Those are orders of magnitude more potent than donepezil and other agonists acting either on the M1 or the s-1 receptors, respectively,” Fisher said.
Fisher proposed that the compound has a unique mechanism of action, whereby it sensitizes the M1 receptor through heterodimerization with the s-1 receptor in the membrane of the ER, adding, however, that heteromerization of these receptors has not been formally proven. “We are looking to license it for drug development,” Fisher said.
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Anavex Life Sciences Reports Publication of ANAVEX®3-71 in Clinical Journal Confirming Pharmacokinetic Dose Proportionality of ANAVEX® 3-71 in Humans
https://www.anavex.com/post/anavex-life-sciences-reports-publication-of-anavex-3-71-in-clinical-journal-confirming-pharmacokinet
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Anavex Life Sciences Announces U.S. Phase 2 Clinical Trial of ANAVEX®3-71 in Schizophrenia
https://www.anavex.com/post/anavex-life-sciences-announces-phase-2-clinical-trial-anavex-3-71-schizophrenia
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Anavex Life Sciences Initiates Placebo-Controlled U.S. Phase 2 Clinical Trial of ANAVEX®3-71 in Schizophrenia
https://www.anavex.com/post/anavex-life-sciences-initiates-placebo-controlled-u-s-phase-2-clinical-trial-of-anavex-3-71-in-schi
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Tesla (TSLA) gets “Buy” rating and $298 price target from RBC Capital
https://www.teslarati.com/tesla-tsla-buy-rating-298-pt-rbc-capital/amp/
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Anavex 3-71 (formerly known as AF710b)
"...AF710B, its exceptional brain penetration and target engagement can be implied from the very high potency of the compound in in vivo studies. Notably, AF710B functions as a cognitive enhancer in the PA test involving trihexyphenidyl-treated rats at unprecedented low doses of 1–30µg/kg, po (Fig 1E). The effects of AF710B on cognition are enantioselective since the enantiomer AF710A is not active at 1 and 10 µg/kg, po (Table 1 and ?and2A).2A). Strong enantioselectivity of AF710B vs. AF710A was consistently observed in vitro and in vivo (Table 1). How does AF710B pharmacodynamics overcome existing compounds? We found that AF710B is the most potent cognitive enhancer and with the highest safety margin vs. a variety of compounds tested by us in the trihexyphenidyl model under same experimental protocols as tested for AF710B, including, inter alia, AF710A, AF102B, AF267B, AF292 and donepezil..."
"...In summary we identified AF710B as a novel comprehensive therapeutic agent to ameliorate cognitive deficits, synaptic loss, amyloid and tau pathologies, neuroinflammation, and neurodegeneration in AD and perhaps additional related protein aggregation diseases. AF710B appears to be a highly effective treatment for AD, when compared with competing drugs (Table 2 A,B). A drug like AF710B that works in extremely low doses provides far more dosing and testing options for future Alzheimer’s disease therapeutics...."
Tesla Undercuts Average US Car by Almost $5,000 in EV Shakeout
https://www.bloomberg.com/news/articles/2023-02-21/tesla-undercuts-average-us-car-by-almost-5-000-in-ev-shakeout?utm_medium=cpc_search&utm_campaign=NB_ENG_DSAXX_DSAXXXXXXXXXX_EVG_XXXX_XXX_COUSA_EN_EN_X_BLOM_GO_SE_XXX_XXXXXXXXXX&gad_source=1&gclid=EAIaIQobChMIu6Gfqu3FhQMVW3FHAR12fgc7EAMYASAAEgJzLvD_BwE&gclsrc=aw.ds
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American Academy of Neurology (AAN) Annual Congress April 13-18, 2024
https://www.aan.com/events/annual-meeting?gad_source=1&gclid=CjwKCAjwt-OwBhBnEiwAgwzrUqCDxaUFz8QYgvam7QNMSxUP0R4RXre9JQzp-ByCA4Hc4FCZQUx_0xoCjTEQAvD_BwE
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AVXL going up SOON!!!
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Look at the number of shares bought during the last 90 minutes of trading today.
It seems like some people expect ABSOLUTELY GREAT NEWS this week and possibly starting tomorrow.
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Tesla Giga Texas packed with Model Y Quicksilver and Cybertruck units
"...On Monday, drone operator and Giga Texas observer Joe Tegtmeyer shared a video from the Austin plant, showing multiple lots full of the Cybertruck, and one with several of the the Quicksilver Model Y. The video seems to show around 340 Cybertrucks across multiple exterior parking lots and 87 of the Model Y units, not counting a few that are scattered around other vehicles...."
Expect ABSOLUTELY GREAT NEWS regarding AVXL this week possibly beginning tomorrow!!!
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“…On March 20, Cybertruck posted an image to X, formerly known as Twitter, of the Gigafactory Texas team posing outside its warehouse with the caption, "Produced over 1k Cybertrucks' worth of 4680 cells at Giga Texas last week!"…”
Anaheim Police to deploy Tesla Model Y cruisers this week
https://www.teslarati.com/anaheim-police-tesla-model-y/
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Pantheon and Syntagon combined give Anavex the production process control and capacity to produce Blarcamesine for commercialization and worldwide distribution and sales.
https://patheon.com/
https://www.syntegon.com/company
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YOU are and were WRONG.
The 2018 article about Dr. A. Barrie Pittock PhD was about him starting the Phase 2b/3 trial.
Stop spreading FUD.
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Expect ABSOLUTELY GREAT NEWS regarding AVXL this week!!!
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Michael Haber completed the Anavex blarcamesine Phase 2b/3 trial and his still taking blarcamesine
https://www.9news.com.au/national/dementia-pill-clinical-trial-anavex-2-73/797ff055-d7e4-441d-b9a7-677ab52a9806
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YOU said and I quote:
"...Hint! Retrospective!
Five years ago, the acclaimed academic noticed he was becoming forgetful and was struggling with simple tasks like reading maps. Brain scans confirmed he was in the early stages of the degenerative condition.
Now, Dr Pittock is participating in a trial with Australian researchers and sees it as one of his final contributions to science.
"I want to be useful. I wanted to do something that had some practical value to humanity," he said.
That would be 2013, yes its that long ago Anavex were running a small open label P2 trial in Australia...."
Vanguard Group Inc. Purchases 41,193 Shares of Anavex Life Sciences Corp.
https://www.defenseworld.net/2024/04/13/vanguard-group-inc-purchases-41193-shares-of-anavex-life-sciences-corp-nasdaqavxl.html
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Tesla Model Y & Model 3 Cost $10,000 Less Than Average New Car Price
https://cleantechnica.com/2024/04/12/tesla-model-y-model-3-cost-10000-less-than-average-new-car-price/
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The EXCELLENCE pediatric trial was NOT a failure.
The real world results out way to slight miss on the statistical significance.
The FDA will review all of the evidence before they will call the EXCELLENCE pediatric trial a failure.
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"...He has never lost his passion for life after the diagnoses, and in 2018 took part in a ground-breaking trial to try and advance a cure for Alzheimer's..."
Expect GREAT NEWS regarding AVXL next week!!!
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American Academy of Neurology (AAN) Annual Congress April 13-18, 2024
https://www.aan.com/events/annual-meeting?gad_source=1&gclid=CjwKCAjwt-OwBhBnEiwAgwzrUqCDxaUFz8QYgvam7QNMSxUP0R4RXre9JQzp-ByCA4Hc4FCZQUx_0xoCjTEQAvD_BwE
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