Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
Register for free to join our community of investors and share your ideas. You will also get access to streaming quotes, interactive charts, trades, portfolio, live options flow and more tools.
mrp, I think he has seen the data; he states it is "... robust clinical data ..."
Thanks, hnbadger.
Has he spoken at this venue before? Do you think we'll receive news before the 13th?
Thanks, Doc. The next question is: will the Strong Responders' percentage be the same?
avxllent, thanks for your post. I thought that all weekend as those on the other side seemed very, very active this past weekend with posts continuing each day, all day long, even though it was a holiday weekend.
sokol, participants continue their SOC and added blarcamesine.
For both groups (30 and 50 mg), there were ~2 of out 3 taking DPZ, with the rest being DPZ-naive.
Tred, this is what I found:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4517678/#:~:text=In%20AD%20dementia%2C%20the%20mean,050%20to%20%E2%88%92.
As to those over 60 who experience amyloid issues, I found this:
https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3280058/
Tred, not sure if the blood test will have a correlation bias between 1) amyloid and 2) AD [if 1) = Y, then 2) is Y] or if the intent is to determine other biomarkers than amyloid that will predict Alzheimer's. I'll let the Board know what the results are in 4-6 weeks.
Steady, here is the AlzMatch Study/APT Web information on its blood draw, of which I had earlier in the week.
How can a blood test advance Alzheimer's research?
Tred, my thought is biomarkers are going to be examined and I'll learn what they indicate. My Mary is doing so, too.
Phase I trial results ... see link below.
https://www.reuters.com/business/healthcare-pharmaceuticals/bayer-says-parkinsons-stem-cell-therapy-improves-symptoms-initial-trial-
2023-08-28/
Or, Investor, as you pointed out, Anavex might look at the 48-week data (which is ending now in mid/late August) of the OLE. With that data, there might be sufficient evidence that the OLE primary and secondary endpoints are being met and could be used for the AA, given that the OLE trial, if acceptable, does not need to be completed to be used in the AA decision.
IMO, the secondary endpoints will be where the "Strong Responders" carry the day.
You are correct it is funny, but we don't have an "x12" poster ... we have, however, a "12x" poster. ;)
george, do you know what "~" means?
If you do, then ~230,000 is acceptable!
abe, ~230,000 shares were retained by TGD.
bas, if Investor were correct with the highlighted phrase below, then the read-out s/b occurring now as 48 weeks from mid-September 2022 is ~ August 20th, 2023. If the read-out is done now, that might prove to be the trial needed for AA approval, given the un-stated desire by the fda to have such a trial in progress.
Pazzo, it is a 96 week OLE, which ends in July2024, therefore everyone had to have been enrolled by mid-September 2022. My take is that 450 is a solid number.
Please provide quote.
Jeffrey Cummings, an Anavex SAB member, is quoted.
https://www.biopharma-reporter.com/Article/2023/08/15/vaxxinity-alzheimer-s-treatment-shows-promising-results-in-early-trial
FYI - A webinar sponsored by Eisai on September 7th. I wonder if HH will present.
https://webinars.endpts.com/alzheimers-disease-using-deep-human-biology-learning-to-guide-next-generation-treatments/?source=Early-Edition
Sorry for the interlude, but I went to a funeral of a fellow Cursillista.
Pass on any further comments.
Then, you need to review the definition of "past".
I think you mean ...
The other word gives the impression that the approval opportunity was missed ... and I know you don't mean that.
Tred, it's what happens to a "fair" moderator.
1:41, but you did not run spell check. ;)
Investor, it took you 3 minutes and 51 seconds to post your reply to falconer, whose post was not in reply to any of yours. So, do you have these retorts in a pipeline to quickly sort through and copy or are you able to read a post as it is being written?
To read, analyze and reply to that post so quickly is amazing ... unless you are the bot that many think frrol is ... or his twin bot.
Please provide said "single post."
Unfortunately, there are only 14 pages in this link, Doc.
Also, it is questionable how much assistance DPZ provides after 6 month or 26 weeks.
https://www.beingpatient.com/how-does-aricept-work-in-the-brain/#:~:text=Aricept%2C%20also%20known%20as%20Donezepil,usually%20for%20around%20six%20months.
I thought this remark is noteworthy:
FYI from Endpoints
Notable paragraph
https://endpts.com/new-alzheimers-drug-raises-hopes-along-with-questions/
bas, does Cramer join the smear campaign tonight?
AVXL Short Interest
SETTLEMENT DATE SHORT INTEREST AVG. DAILY SHARE VOLUME DAYS TO COVER
07/14/2023 16,728,610 623,329 26.837529
06/30/2023 16,739,768 1,148,109 14.580295
06/15/2023 17,739,562 1,165,885 15.215533
05/31/2023 16,508,942 763,358 21.626736
05/15/2023 15,901,191 937,267 16.965487
04/28/2023 14,379,183 798,137 18.015933
04/14/2023 15,594,970 981,502 15.888883
03/31/2023 15,887,617 1,275,882 12.452262
03/15/2023 15,677,855 1,171,753 13.379829
02/28/2023 16,320,041 850,227 19.194922
02/15/2023 17,125,449 1,160,761 14.753639
01/31/2023 16,719,384 1,128,968 14.80944
01/13/2023 18,368,256 1,504,154 12.211686
12/30/2022 18,252,546 1,422,909 12.827627
12/15/2022 15,780,885 7,073,260 2.231062
11/30/2022 11,914,762 1,787,726 6.664758
11/15/2022 10,167,456 986,389 10.307755
10/31/2022 10,105,713 985,598 10.253382
10/14/2022 10,043,451 718,819 13.972156
09/30/2022 10,260,594 936,366 10.957888
09/15/2022 9,737,900 683,304 14.251197
08/31/2022 9,102,975 706,411 12.886231
08/15/2022 8,428,105 784,854 10.738437
Thanks again, Moon ... hopefully, they haven't been in either of the last 3 administrations ... er, make it 5.
Thanks, Moon. I certainly get the impression that TGD believes Rett approval is as close as an NDA filing.
P.S. Who are KOLs?
george, how is T's post nonsense?
Many wait for your answer.
Thank you, raja. Nice to know your view is positive.
Peace
Sorry, for the initial truncated post.