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Part of trying to be transparent is sharing the realities of the slips in schedule and their estimated impacts on the schedule.
Anyone who has been a project manager is well aware of this, and the scrutiny is in understanding and evaluating the rationale given.
In this latest update it appears the rationale for getting to today’s state is reasonable and was largely if not totally a dependency on the CRO and sites completing the work, not NWBO.
The next step is largely independent as well, followed by last steps NWBO is directly involved in accomplishing. In the PR they do not give the most optimistic estimates for the remaining steps to be completed and likely not the worst case either, so September for completion is reasonable imho and can change again for later or earlier.
Anyway that’s how I see it FWIW.
Senti yes indeed every vacuum becomes an attack point. We have seen this a number of times like the cherry picking pseudo proggression, reason for the halt, etc
Is it coincidence or a very lucky guess that Scotty calls .27 pre market and the other pessimistic posse are around to jump on board, and the sp happens to hit .28 same day? Reminds me of an orchestra being led by the conductor imho, pianissimo at first with the first statement of the theme, then gradually building to a rousing fortissimo for the climax.
Same lowball 0.05 yesterday after hours. I guess someone is setting traps in case a market sell order is placed?
It would be very nice timing if a positive announcement is forthcoming tomorrow GBM Awareness day. Also might get extra awareness of dcvaxL if news is released.
It’s the shares that are donated that counts as a donation of the value of the shares, I assume at the day of donation, and you don’t pay tax on the shares donated.
You can also set up some kind of account into which you donate money and/or shares and you can disburse donations to charities over time out of that account.
I nibbled on shares during the afternoon but picked up shares at 35 cents mostly.
It’s difficult because I had requested the non paraffin media and told it would be only to find out after the fact that paraffin was used. I guess trying to get it in writing might have been good, and reminding the oncologist and also directly discussing it with the surgeon might have helped. My mom didn’t have GBM so it would have been a long shot for her to get dcvax but I wanted the tissue in case it became possible.
So F = Flounder, apparently
Au contraire (sp?) the patients will find where they can access the new treatment if the efficacy is there and lowest adverse side effects to boot!
In the immortal words from When Harry Met Sallie, I’ll have what Sir Pumpernickel is drinking!
Eeeehhhhhhh What’s up doc?
Good point! I tried to interest my mother’s oncologist several times regarding Dcvax as a possible treatment and that nwbo was doing their presentation at ASCO, to no avail, not even a response. This oncologist worked at two of the leading cancer centers and was involved with personalized medical treatment and trials, however I conclude that since not involved in Dcvax trials and Dcvax not being established as an available treatment, the oncologist wasn’t interested in the Dcvax direction as practical for my mom. As an aside, I had requested that my mother’s cancer tissue from her kidney that was removed be stored in non-paraffin media, however it wound up being stored only in paraffin thus not supporting a Dcvax treatment possibility without removing more tissue again.
I imagine this experience is more the norm, and hopefully will be changed if Dcvax-L is approved.
Excellent analogy for what us longs have been feeling. I do think there has been an element of the carrot motivation and personally think that the tactic was to motivate staying in and raising funding rather than losing support by telegraphing a longer road ahead. However that may be my imagination and the truth might be more innocent or righteous.
I have had similar thoughts about Kennedy and Biden and McCaine cases of gbm. Why they were not dcvax treated. Perhaps their doctors recommended approved approaches over “unproven.”
The fact that the trial was allowed to keep treating patients that were already in progress eliminated safety concerns.
And then LP makes her comment about “good being made into bad” paraphrasing the actual comment.
“From my heart and from my hand
Why don't people understand
My intentions, Ooh, weird science
Magic and technology
Weird Science
Things we never seen before
Weird Science
Not what teacher said to do”
The science will hopefully determine the outcome assuming the foul play doesn’t have an ace in the hole.
Nice reply with actual data basis, POW! WACK! Holy Bayesian Batman!
Certainly
You think I’m funny
I amuse you
I make you laugh like a clown!
(Ok, not Goodfellas, Pope of Greenwich Village, I think, but Pesci)
For a pumpernickel you sure have a rye sense of humor
Next you gonna tell me Santa Claus isn’t real, why don’tcha :(
And prolonging and saving some lives from certain death sentences!
Words of experience, thanks and GLTA. The light at the end of the tunnel is getting close and it’s not looking like an upcoming train but it will be over when it’s over.
Thanks for the replies!
My biggest lost opportunities have been due to not chasing stocks that jumped up and keep jumping up.
It’s a flaw that I wait for them to come back down but the great ones keep going up without retracing significantly lower.
I never got in on Netflix, Amazon when they were in the $30’s price range. The other thing is I grew up when earnings and P/E ratios, and margins and ROEs were to be considered when evaluating company stocks.
Now and in the recent past a lot of the stocks that have been running up have losses. Development biotech stocks never have earnings during clinical trial phase so I know I’m gambling despite the best efforts to do due diligence.
I guess it’s hard to teach an old dog new tricks :)
Thanks LF !
Any clue why the huge 125% jump premarket after a huge gain yesterday? Stage1 clinical biotech so product may be years away?
The system has some quirks and gaps as well.
For example my mom first got the drug free since she was included in a trial before the drug was approved.
Then after a number of months the drug was approved but the insurance would not cover any of it because the drug was not on the insurance formulary yet - sure, it was just approved.
That left her with no option other than continue and pay in full, or not continue getting the drug.
For another cancer drug insurance denied it because the drug was indicated for another cancer, and ignoring that the oncologist prescribed it based on genetic analysis of the cancer that was surgically obtained and thus targeted her cancer’s makeup.
Fortunately the hospital has liaisons with the drug companies and helped us submit for financial aid from the drug companies and was able to get the drugs by the good graces of the drug companies for a limited time period. Had her income been a bit more she would have been out of luck.
I wonder how much of these insurance gaps Dcvax will face or whether by nature of being biologic get some better positioning for coverage?
Yes, 125k - 175k seems good, and 125k or less is even better.
I remember some drug that cures a cancer being talked about as cost effective at over $400,000 for the treatment that stands a high chance of curing the patients instead of the typical ongoing high cost drugs to try to keep the cancer chronic but managed.
You lucky youngster, I got in around 55 and now 65 years old. There have been times I wondered if the trial was going to outlast some of us seniors :) needless to say I’m not looking to invest in other new clinical stage biotechs facing long development cycles. Hoping NWBO is the big winner we long time longs have believed in all these years.
Skitahoe
God bless you!
Regarding placental and umbilical cord blood and stem cells, the Doctor that built Celgene started a new company, Celularity, to research, bank, and derive treatments based on the stem cells I believe. Sounding more and more interesting but his new company isn’t publicly listed.
Regarding whether dcvax would be affordable, I can offer that my mother was taking tiny little cancer pills that cost $40,000 per month (30 pills) when approved. So 3 to 6 months of the pills will probably cost more than the dcvax treatment and the pills need to be taken longer term with less prospect of cure or longer term efficacy.
Dcvax should be cost effective especially if the production is made closed system automated. And of course if it isn’t just priced at the high end of what the market will be thought to bear.
Good one and I like that song and Paul Simon!
So maybe you can call me Al.... so long as you don’t call me late for dinner :)
The moment of truth is nigh as far as DL and unblinding, because the messaging leaves a little wiggle room, not multiple months of it. The trial results and then what the approval agencies conclude from them are separate matters.
Now I wouldn’t be surprised if there is up to about a month+ of time between DL and statements of statistical results per the steps outlined in the PR. I would think running the statistical analyses will be quick, but putting out results to NWBO and then external release of some form could take some review time, although it could also be quick.
Call me naive, call me a wishful thinker, you can call me Ray, or you can call me Jay, or you can call me RayJay, but you don’t have to call me Mr Johnson. And don’t call me late for dinner sorry it’s silly time
Iwasadiver
I’ve been feeling for a long time that you “sound” like you know or have known NWBO management by some means. Or maybe you, like myself, have developed a feel for them based on years of integrating their presentations, interviews, statements, etc., that may be closer or further from the realities.
Anyway, I value your contributions and insights.
I personally don’t buy the Fud re LP, and instead think she is probably the smartest person in any room she’s in, and committed to getting dcvax as far as she can more for the fight against cancer and the financial rewards secondary.
I have gotten similar vibes from you. You may have in fact made such supportive posts, as after all the posts I read things are starting to blur.
Anyone seeing the firming of the share price since around 11:30am?
Is this just usual action or does anyone have insights?
Thanks in advance
Thanks for setting me straight about the options vesting details.
Sorry for your family loss.
I pray we see cancer effectively beat in this decade.