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You're projecting the largest quarter ever when scrips are down significantly? Something reminds me you were off by maybe $10M for Q1 - maybe didn't take into account non-cash based exec comp? Is that in this estimate?
$635/mo for 1 g caps and $730/mo for 0.5 g caps - holy crap that's expensive! Wonder if that has any ties to reality or if whomever is offering it for sale is making a killing? Don't know if it's legal either - who is offering this for sale?
A merger is not an acquisition - it's combining two companies at some ratio of valuation, like shareholders of X get 0.6 shrs of the combined company and shareholders of Y get 0.4 shrs on the new company. It's essentially a merger of equals, or similar companies that compliment each other and could gain cost savings by combining and eliminating overlapping functions. My biggest winner of all time was formed by combining two tech companies, which then did a 1:4 RS - up almost 600% in that one. AMRN could never duplicate that success, unfortunately, unless they start putting V in smart phones ;>)
Capt, you rock - I love it!
It would be especially pleasing if you place us ahead of Mike Yee again as we are still laughing at his reaction last time!
R-IT did not have multiple studies indicating success was in the cards - there was only one, JELIS - all others were mixed O3's that pointed towards failure, which is why jerks like Nissen refused to believe R-IT results were valid - they went against the findings of nearly every preceding O3 trial.
So somebody took the time to OCR the entire transcript - that would take your avg. PC days - unless it was originally published as text in a PDF, not an image. Reason I mention that is I've seen multiple posts that showed screenshots of testimony, meaning whomever had the files could not copy/paste text. A lot of the research papers on various health topics I've seen are also non-searchable image files, not true PDFs - I can OCR a page or two if needed, but it takes about 20 sec/pg. Oh, and almost all of the formularies linked here by various people are not searchable - they're rather odd - my PDF app can copy text within one of those files, but search does not work - why insurers would make formularies non-searchable is beyond me.
I'm confused - you wrote:
Have no idea how many witnesses/experts were called, but a double spaced transcript of 7 hours worth of testimony must take a boatload of single sided pages. For instance, a CD can hold ~ 80 mins of music (wavs, not mp3's) - 7 hours would fill 5 1/4 disks.
They wouldn't answer questions about a BO, period - unless they had already announced someone made an offer that became public, or they said they'd hired a banker to look at options to sell the company. Any still secret BO talks would never be disclosed.
10b5-1 plans were created so execs could buy/sell stock during quiet periods - if there are no F-4's it's because quarterly RSU and options haven't vested this month - they last vested end of June, so the next batch won't vest until end of Sept. That's only true for certain awards, not all of them - in any case, if someone has awards vesting end of July, we wouldn't see F-4's until the first few days in August.
Trial transcript is ~140k pages?!? That would mean depositions might be a million pages - even if you could get your hands on them I doubt you could guess how Hikma planned to attack the patents - clearly Covington didn't sniff out their plans in real time as depositions were occurring.
I think he was asking whether you could deduce what the defense would focus on during the trial from depositions, not whether you could predict what the judge or jury would decide. Given the depositions in this case took what, 2 years, and transcripts were probably hundreds of thousands of pages, I'm not sure you could tease out the defense's plans ahead of time unless they spent a ton of time on a couple issues, making it obvious. When the Allies were prepping France for invasion in WW2, they bombed the entire coast from Normandy to Calais so the Germans couldn't guess where the landings were going to take place - if I were a legal team I'd do something similar, spread out my lines of questioning among many different targets to not tip off the plaintiffs of my plan of attack.
I may have mentioned it in passing - but learned something about this outbreak today that the MSM and CDC is not talking about because it's not PC - there was a male gay pride event in Provincetown right before the outbreak occurred (Bear Week) - infections occurred mainly in packed bars and behind closed doors - 85% of those testing positive were males:
https://twitter.com/search?q=provincetown%20bear%20week&src=typeahead_click
Not being homophobic, just posting the facts - if this had been a swingers gathering they would have had the same result.
I get a "no preview available, file is in owner's trash" error - but I was able to see it yesterday, not my browser's problem.
Nevermind - I see you replaced it with a new file. BTW, you won't get an answer to #14 unless you end it after the first sentence - the rest is proprietary info, they won't speculate about new indications or formulations. Add my vote to #4 and #5.
Kura was important because of it's lack of statistical value - AMRN got one patent based on V reducing Apo(b) levels and Kura was a key for them overturning the USPTO's original rejection for obviousness - Kura did not prove or even suggest anything about Apo(b), and it's even stated in the written text of the paper (not stat sig diffs) - forget the table, it's not even relevant, unless your last name is Du.
Refill rate dropped dramatically AFTER R-IT results came out? On what planet does that make sense? Only in the universe of AMRN could that happen.
Might be KM putting his stamp on marketing - that was a really stupid commercial, a waste of precious cash. Might be saving money on ads to support the rollout in the EU too - not gonna be cheap, and those employees won't be making AMRN any money until mid 2022 - at least the extra 400 hired in the US were able to go out and try to increase sales right after R-IT approval, although it doesn't appear that most of them are earning their keep, partly because AMRN sales strategy sucks.
A drug that combats CV19 with anti-inflammatory activity should not have different results for various strains unless a variant causes different medical problems, something not in evidence. Vaccine efficacy is a different animal to treatment efficacy. I hope we see V helps at least a little bit, but I'm not counting on it - may not be enough severe cases to get stat sig data - and I don't believe V will have any efficacy in preventing infection, MOA doesn't match.
And yeah, scripts are depressing, worse than last year and no growth in the combined market. Even worse, check out this plot by Captbeer - the refill rate dropped by -23% AFTER the R-IT results came out - how the hell does that make sense?
That says exactly what I claimed - Kennedy is staying on until a replacement is found.
Kennedy ain't gone, at least not that we know of - they haven't announced a replacement for him yet. If CFO leaves for another job within the same company is that really material? Would appear not if Kalb is now in Germany and not doing CFO functions.
Baloney - I've seen PRs from multiple bios after CMOs left - most recently at MRNA.
CMO quits and AMRN stays silent - guess JT is still in control until Monday, or KM is following his "say nothing" playbook - god help us if the latter is true, nothing will change. Who's next to go? Kalb? Ketchum? Berg? How about ALL OF THEM! Think about how many RSUs and options will vaporize should they all leave - millions. KM may be cleaning house.
You're obviously not talking about poor black urban areas filled with elderly people lacking transportation options - there are no pharmacies in those neighborhoods, they don't even have a grocery store, only corner convenience and liquor stores. Only way to get them vaccinated is to bring it to them, and cities are doing that, mobile vaccine clinics, but many blacks still remember Tuskeegee and don't trust the government.
Ask Lamar Jackson, who is in the most important season of his young career, how depending on previously getting infected worked out for him as far as protection against Delta - hint: he's going to miss half of training camp. So is our best RB - those asshats have put the season's success in danger because they were too ignorant to get vaccinated - over 90% of the roster DID get vaccinated. If I were one of them I'd be beating Lamar in the head and face with a herring for being so stupid and selfish.
Yes, that's him - he did it within 48 hours of Du's decision being made public.
I see others have answered so I won't repeat - don't know how you pin all the blame on JT though - I blame Covington. And I still say Mori was a sideshow, Kura was the most important as far as patents go, and Du screwed that up bad - Covington couldn't respond, never knew about it until Du had issued her decision and the cropped table showed up.
Best in class drug but a vanishingly small market - about 1.5M in the US have lupus, 2%-3% go on to develop severe kidney disease that AUPH's drug treats, active lupus nephritis - that's only 45k people - not surprised sales aren't good - might stay that way too. Did they get orphan drug status, is the drug expensive enough for them to make money while GIA? I doubt their reps would face the same resistance AMRN reps face (it's just fish oil), but still could be a hard sell with such a small target population. If I wanted to place a spec bet on a biotech it would be IBRX or NRXP - have already gotten as much IBRX as I want.
Unfortunately Delta infects a large number of vaccinated people in MA after a town held some kind of festival where indoor crowds w/o masks were frequent - the unvaccinated attendees apparently turned into super-spreaders:
https://www.cdc.gov/mmwr/volumes/70/wr/mm7031e2.htm?s_cid=mm7031e2_w
Educate yourself - mRNA vaccines are still 85% effective against preventing infection from Delta and 95% against preventing hospitalization or death.
He's head of the cardio division at the Cleveland Clinic, a much more prestigious job than working for AMRN in any capacity (like replacing Bhatt). But I *have* seen someone act that way - my old company bought out our only local competitor and chose not to hire all of the engineers that worked there - one of them had a PhD but he was a pompous a-hole and nobody liked him - I knew him because that company had done some work for my dept. while I was working as a Fed employee. He didn't get hired, but did go to work for the Fed agency, where he eventually ended up being appointed to consult on a major program I was working on for the Feds - he HATED my company for dissing him and made my life a living hell, the jerk - questioned everything I did and made me do all kinds of extra unnecessary work to prove I knew what I was doing. The asshat probably cost the program over $100k for me to do work beyond the scope of the contract, something he really wasn't authorized to do.
I don't recall Nissen ever saying anything nice about R-IT, he jumped on the rise in hs-CRP and LDL in the MO group instantly.
I don't call being kept out of the hospital and possibly the morgue "no benefit" - despite Delta infecting vaccinated people, it still protects all but the weakest from the hospital. The Feds are saying they may require vaccinations for Fed employees and possibly Fed contractors, or masks plus weekly tests if you refuse the vaccine. That's nothing compared to the NFL's rules - if you're not vaccinated, you cannot eat team meals (get a boxed one for takeout), must wear a mask at all times when at team facilities or you get an instant $14k fine, you're not allowed to dine with others on your own time, you're isolated to the team hotel for away games, and if there's a forfeit of a game due to an outbreak EVERYONE loses their game paychecks (1/18th of salary). Coaches and staff are 100% required to get vaccinated - if you refuse you get fired - happened to a Viking's coach a couple days ago. If I were a 325 lb lineman I'd threaten everyone on the team with a beating if they refused a vaccine - can you imagine missing the playoffs by one game because some diva wide receiver refused a vaccine, got infected, and wiped out the entire WR corps for 10 days? Talk about selfish! Having previously been infected doesn't protect you either - if you had a mild or asymptomatic infection you didn't develop a strong immune response and can get reinfected, especially by Delta - just happened to someone on the Orioles, he got it last year and caught it again last week.
Afraid to answer, but then you went and answered anyway, LOL? Don't worry - you don't have Part D, not breaking any laws - you're just required to have drug insurance, and your wife's benefits provide it, and her plan allows coupons. The pharmacy would reject the coupon if you tried to use it with Medicare Part D because the Part D insurer would deny the claim.
Thnx. And after reading what I wrote again:
There's no MO involved in PREP-IT, is there? They don't say what the placebo is on clinicaltrials.gov - but I'd like to see how Nissen can spin positive results against CV19 to blame the MO if that's the placebo. The entire world would be exposed to his bias against AMRN and V if he makes a stink over a potentially life saving therapy as safe and cheap as V.
Congress may eventually get around to doing something about the thieving PBM's in the next 3.5 yrs - they know the rebates BP must give PBM's are not being shared with patients to lower drug costs, they're just pocketing the money themselves, which raises costs for everyone.
Well then you should remember that Bhatt didn't even think of looking at Mori until someone on this MB did the analysis and proved Mori's conclusions were wrong - that analysis was sent to AMRN, which sent it on to Bhatt. Not that I'm blaming Bhatt for ignoring Mori's errors - he was not involved in getting those patents approved, and it's rare that a scientist will independently take exception to a peer reviewed article and do his own analysis to prove it wrong.
I dunno about that - Hims & Hers sells DTC but doesn't take insurance, although Capsule does. Amazon Pillpack also works with all major PBM's, no different than getting a script at CVS. PBM's aren't being cut out as middlemen, so I don't see the value for BP owning their own pharmacy - pharmacy margins are very low.
Viagra and Nexium are the only medications being offered for sale directly to the consumer according to that article - I confirmed you can buy generic viagra right from PFE, but you're paying cash and bypassing insurance - not affordable for most brand drugs. Will admit I'm surprised it's even legal - you'd think PBM's would be screaming bloody murder over being bypassed like this, but since it's so limited they probably don't care - Nexium is available as an OTC generic too, so IMO that one doesn't even count. Don't think this would be terribly cost efficient for drug makers either.
Bhatt's Mori paper did not exist during the trial, only came out months after Du ruled.