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Aurinia Pharmaceuticals Inc (AUPH)

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Last Post: 5/20/2022 5:34:49 PM - Followers: 225 - Board type: Free - Posts Today: 8

Aurinia is a late-stage biopharmaceutical company providing novel products specifically engineered to treat a limited, targeted patient population suffering from serious disease states for which there is a high unmet medical need.

*Aurinia Pharmaceuticals Inc.





Candidate & Indication Development Stage
Preclinical Phase 1 Phase 2 Phase 3 Market
VOCLOSPORINLupus Nephritis (LN)
Preclinical Phase complete
Phase 1 Phase complete
Phase 2 Phase in progress
Phase 3 Phase not started
Market Phase not started

Aurinia is committed to working in areas of high unmet medical need and is poised to deliver the first approved therapy in the U.S. and Europe for the treatment of lupus nephritis, or LN.

The Voclosporin Advantage

Voclosporin, an investigational drug, is a novel and potentially best-in-class calcineurin inhibitor (“CNI”) with clinical data in over 2,000 patients across indications. Voclosporin is an immunosuppressant, with a synergistic and dual mechanism of action that has the potential to improve near- and long-term outcomes in lupus nephritis (LN) when added to standard of care mycophenolate mofetil (MMF). It has been granted “fast track status” by the U.S. Food & Drug Administration (FDA).

Voclosporin Could Transform the LN treatment Landscape

Voclosporin has the potential to become a best in class medication and the first approved treatment for LN in the U.S. and Europe, effectively altering the current treatment paradigm for the disease.

Advantages of Voclosporin Combined with Standard of Care (SoC)

Our clinical data suggests that adding voclosporin to the current SoC of MMF for the treatment of lupus nephritis (LN) will yield superior results to using the standard of care alone.

Additionally, voclosporin may prove to be an ideal therapy for lupus nephritis due to advantages such as:

  • Improved efficacy
    Increased safety
    Oral administration
    Improved average time to renal response or remission
    Improved duration of renal response
    Reduction in steroid burden
    Potential first line add-on to MMF
    Fewer toxic immunosuppressants required
Benefits of Voclosporin

Potential Benefits of Voclosporin

In clinical trials, Voclosporin has been shown to be especially effective in the presence of low dose steroids with rapid reduction of LN inflammatory markers and overall improved renal stability.

The list of potential product benefits includes:

LN Critical Need Voclosporin (based on AURA Results)
Control of Active Disease
Rapid Disease Control
Lower Steroid Burden
Impact on Extra-renal disease
Convenient Treatment Regimen

In previous studies, over 2000 patients have been treated with Voclosporin with no abnormal or unexpected SAE’s

Well Characterized Safety Profile

Efficacy of calcineurin inhibition has already been established. Voclosporin has a well-characterized safety profile (over 2,000 patient exposures across multiple years) across indications.

No new safety signals were observed with the use of Voclosporin in LN patients; Voclosporin was well-tolerated and renal function remained stable in clinical studies. The overall safety profile is consistent with other immunosuppressive drugs.


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News News Alert: Statement of Changes in Beneficial Ownership (4) 05/20/2022 12:12:08 PM
#15344   Can't stress how important EU approval for Lupkynis rosemountbomber 05/20/22 05:34:49 PM
#15343   Check this out guys… Jesspro 05/20/22 04:18:41 PM
#15342   Checkmate! good game! SOC Cosa 05/20/22 04:15:23 PM
#15341   Re-emergence of GF triggered this good news. Jesspro 05/20/22 04:12:12 PM
#15340   This is porn for big Pharma companies looking Ganz 05/20/22 03:04:50 PM
#15339   I just hope Aurinia can hang in there too simple 05/20/22 02:21:07 PM
#15338   Aurinia Pharmaceuticals touts long-term benefit of Lupkynis for greggors 05/20/22 01:14:59 PM
#15337   Thanks Jess- You do a truly excellent job moosedogger 05/20/22 09:22:55 AM
#15336   Anti viral effect of Voclosporin… Jesspro 05/19/22 05:11:28 PM
#15335   Held up nicely today, need volume to get Cosa 05/19/22 04:46:18 PM
#15334   Bingo Ganz 05/19/22 12:18:58 PM
#15333   Options expiring this Friday. They are going Cosa 05/18/22 07:48:08 PM
#15332   Give it a little time Moose. These other Jesspro 05/18/22 04:17:39 PM
#15331   Time is Nephrons moosedogger 05/18/22 12:27:09 PM
#15330   But PG's history of false statements suggest fairly zzaatt 05/18/22 10:14:08 AM
#15329   sleazy slimeball is an excellent description. obviously the cervelo 05/17/22 06:47:48 PM
#15328   I still think the pandemic is one of Jesspro 05/17/22 06:43:27 PM
#15327   GF very active these days. Remember guys, it’s Jesspro 05/17/22 06:36:55 PM
#15326   .....PG is trying to position the price north. moosedogger 05/17/22 05:42:54 PM
#15325   Hi everyone, longbear 05/17/22 04:54:57 PM
#15324   By golly, I think we have a substitute biotech_researcher 05/17/22 04:28:31 PM
#15323   My opinion only and take it with a Pablo Bio 05/17/22 11:17:38 AM
#15322   My opinion only and take it with a Pablo Bio 05/17/22 11:17:34 AM
#15321   A BO, without a doubt and when we Ganz 05/17/22 11:05:58 AM
#15320   AUPH is a great company that has lost zzaatt 05/17/22 10:35:00 AM
#15319   Thank you for the reply, AUPH is Pablo Bio 05/17/22 08:49:28 AM
#15318   Aurinia Pharmaceuticals Announces Presentations at the 2022 ERA moosedogger 05/16/22 07:47:03 AM
#15317   How do you see AUPH in the next moosedogger 05/14/22 12:32:34 PM
#15316   zzatt unless you have been a ceo or cervelo 05/13/22 06:42:26 PM
#15315   Good luck to you also and thanks. How Pablo Bio 05/13/22 10:11:11 AM
#15314   Pablo- Hollywood Beach Boardwalk.... moosedogger 05/13/22 08:55:58 AM
#15313   Thank you, will look into those also. Pablo Bio 05/13/22 07:59:13 AM
#15312   Welcome to both boards. We had ARIA too, north40000 05/12/22 04:46:00 PM
#15311   Cheers also, just retired and joined the Pablo Bio 05/12/22 04:36:55 PM
#15310   Pablo- Just goofing around; couldn't resist. moosedogger 05/12/22 03:35:44 PM
#15309   Because he did well with ARIAD. Pablo Bio 05/12/22 02:58:57 PM
#15308   "We need an Alex Denner Savior here." moosedogger 05/12/22 02:56:46 PM
#15307   We need an Alex Denner Savior here. Pablo Bio 05/12/22 02:31:48 PM
#15306   He cant. He never has. Newbie1421 05/12/22 02:11:37 PM
#15305   Nice moose Ganz 05/12/22 11:59:37 AM
#15304   Jess, Lupy or Limpy?? Good to see your biotech_researcher 05/12/22 11:47:45 AM
#15303   we will keep dropping until management does something[/colo zzaatt 05/12/22 10:02:08 AM
#15302   we will keep dropping until management does something. cervelo 05/12/22 09:19:58 AM
#15301   Like to see the Whales return for a greggors 05/11/22 07:08:55 PM
#15300   Accumulating for the next ride up! The Cosa 05/11/22 06:55:33 PM
#15299   Also liked this from Lunacy: moosedogger 05/11/22 11:33:28 AM
#15298   with the present administration ruining all things good cervelo 05/11/22 10:31:33 AM
#15297   From current issue of Barron's: moosedogger 05/11/22 09:07:24 AM
#15296   This is an interesting post re payers covering Lupkynis: moosedogger 05/11/22 08:36:01 AM
#15295   nferna- thanks for posting Lunacy's comments re yesterday's moosedogger 05/11/22 08:30:01 AM
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