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There isn’t anything on enrollment or much at all regarding proof of phase 3. I believe it’s happening but would love to see what’s going on as well as who this mystery financier is.
Welcome back as well
How do we know it’s being manipulated. Any buying pressure is met with someone dumping.....who is beyond me
I have been out of the country on business and pleasure for the last 40 days plus thought I would come back to a very good scene
What I would like to know I understand it’s been filed now we’ve got finding that has enrollment actually started I can’t find any info on that yet
Also it looks like there’s so much manipulation going on that is pathetic here we sit with 61 eyepiece and patents and we can’t get over 2 1/2 cents I want another stock that only has about two patents and they were $.59 last week and today they’re $1.50 plus on news on good news of phase 1 now go figure if we’re not being played with I don’t know what’s happening then
When I’m wondering is why we’re not contacting the SEC or something to see who’s manipulating this stock it’s terrible the way were being treated we’ve got to get to the bottom of this somehow
Post by TimGDixon » Tue Jun 21, 2022 2:35 am
Re: Can Always Ask Tim Part 2
I know there is a lot of pent up anticipation from Bio but as several people have stated; we won't have any updates for a bit. Venvalo has a bunch of followup to do which will include NDA's for sure so I give you all fair warning that you may hear silence for a bit.
Two of the greatest ever!
https://forum.therapeuticsolutionsint.com/viewtopic.php?p=5198&hilit=bio#p5198
I have a very high pile of TSOI shares, and my wife has a smaller pile. We're just waiting, cause in time we'll be really happy with our piles. And just the same, we'll be happy with the way this company is helping people with their health. Keeping people alive. Making their life a lot better than before. This is cutting edge, and we're really glad we're part of it. IMHO TSOI is leading a new way.
Hmmmm! TSOI and the market makers art of deception doesn’t exist in my book! I am happily loading hundreds of thousands of shares daily by the giant spoonful!! The reality check amongst stock investors worldwide is getting ready to present itself in a way that will echo for centuries to come! All I can say now is a legendary excerpt from some previous IHub poster from many days gone by which stated “loving the dd here”…
$TSOI Authorized Shares 3,500,000,000 06/02/2022
Outstanding Shares 2,547,356,759 06/02/2022
Restricted 1,216,830,128 06/02/2022
Unrestricted 1,330,526,631 06/02/2022
Held at DTC 1,287,078,804 06/02/2022
OS >16,571,994
Restricted >12,000,000
Unrestricted >4,571,994
DTC >4,571,994
4/29/22-03/04.21 TSOI SECURITY DETAILS Share Structure
Market Cap Market Cap 65,800,404 05/02/2022
Authorized Shares 3,500,000,000 04/29/2022
Outstanding Shares 2,530,784,765 04/29/2022
Restricted 1,204,830,128 04/29/2022
Unrestricted 1,325,954,637 04/29/2022
Held at DTC 1,282,506,810 04/29/2022
O/S >25,786,585
Restricted >19,000,000
Unrestricted >6,786,585
DTC >7,536,585
TSOI SECURITY DETAILS Share Structure
Market Cap 63,125,954 04/06/2022
Authorized Shares 3,500,000,000 03/31/2022
Outstanding Shares 2,504,998,180 03/31/2022
Restricted 1,185,830,128 03/31/2022
Unrestricted 1,319,168,052 03/31/2022
Held at DTC 1,274,970,225 03/31/2022
TSOI 01/12/22-3/03/22 SECURITY DETAILS + 2021
Share Structure
Market Cap Market Cap 66,382,452 03/07/2022
Authorized Shares 3,500,000,000 03/03/2022
Outstanding Shares 2,504,998,180 03/03/2022
Restricted 1,185,830,128 03/03/2022
Unrestricted 1,319,168,052 03/03/2022
Held at DTC 1,274,310,225 03/03/2022
Pink Current, AS: 3.5B, OS: 2.5B, US: 1.3B
Outstanding Shares Updated:
?? 2,312,158,342 (2022-01-12)
?? 2,504,998,180 (2022-03-03)
Difference: +8.3% (+192M)
TSOI SECURITY DETAILS Share Structure 12/17-03/04/21
Market Cap Market Cap 51,734,134 12/17/2021
Authorized Shares 3,500,000,000 12/17/2021
Outstanding Shares 2,311,123,860 12/17/2021 >16,927,248
Restricted 1,014,553,256 12/17/2021 >10m
Unrestricted 1,296,570,604 12/17/2021 >6,927,248
Held at DTC 1,252,872,777 12/17/2021 >7,927,248
TSOI 11/15/21 Authorized Shares 3,500,000,000 1/15/2021
Outstanding Shares 2,294,196,612 11/15/2021
Restricted 1,004,553,256 11/15/2021
Unrestricted 1,289,643,356 11/15/2021
Held at DTC 1,244,945,529 11/15/2021
Share Structure Update 10/18/21
Market Cap Market Cap 87,926,139 10/21/2021
Authorized Shares 3,500,000,000 10/18/2021
Outstanding Shares 2,274,932,452 10/18/2021
Restricted 990,553,256 10/18/2021
Unrestricted 1,284,379,196 10/18/2021
Held at DTC 1,240,681,369 10/18/2021
O/S NO change
Restricted NO change
Unrestricted NO change
Held @ DTC >5m
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=166066740
Authorized Shares 3,500,000,000 09/23/21
Updated O/S 2,274,135,577 09/23/21
Restricted 989,756,381 09/23/21
Unrestricted 1,284,379,196 09/23/21
Held at DTC 1,235,681,369 09/23/21
https://www.otcmarkets.com/stock/TSOI/security
as of 09/08/2021 $TSOI SECURITY DETAILS Share Structure
Market Cap Market Cap 177,382,575 09/15/2021
Authorized Shares3,500,000,000 09/08/2021
Outstanding Shares 2,274,135,577 09/08/2021
Restricted 1,094,756,381 09/08/2021
Unrestricted 1,179,379,196 09/08/2021
Held at DTC 1,129,681,369 09/08/2021
Share Structure 8/25/21
Market Cap Market Cap 201,463,566 08/31/2021
Authorized Shares 3,500,000,000 08/25/2021
Outstanding Shares 2,273,135,577 08/25/2021
Restricted 1,100,756,381 08/25/2021
Unrestricted 1,172,379,196 08/25/2021
Held at DTC 1,129,681,369 08/25/2021
TSOI Updated SS 9/01/21 http://investorshub.advfn.com/uimage/uploads/2021/9/1/jofddScreenshot_2021-09-01_174143.png
TSOI Share Structure
Market Cap Market Cap 138,081,770 08/11/2021
Authorized Shares 3,500,000,000 08/03/2021
Outstanding Shares 2,263,635,577 08/03/2021
Restricted 1,093,801,208 08/03/2021
Unrestricted 1,169,834,369 08/03/2021
Held at DTC 1,129,681,369 08/03/2021
TSOI Share Structure
Market Cap Market Cap 77,985,701 07/27/2021
Authorized Shares 3,500,000,000 7/09/2021
Outstanding Shares 2,259,800,077 07/09/2021
Restricted 1,092,501,208 07/09/2021
Unrestricted 1,167,298,869 07/09/2021
Held at DTC 1,119,045,869 07/09/2021
Float 303,593,877 08/16/20
7/9/21 TSOI SECURITY DETAILS
Share Structure
Market Cap 74,563,501 07/08/2021
Authorized Shares 3,500,000,000 06/02/2021
Outstanding Shares 2,252,673,740 06/02/2021
Restricted 1,088,601,692 06/02/2021
Unrestricted 1,164,072,048 06/02/2021
Held at DTC 1,092,456,980 06/02/2021
Float 303,593,877 08/16/2019
Par Value 0.001
TSOI SECURITY DETAILS 5/19/21
Share Structure
Market Cap Market Cap 116,553,339 05/25/2021
Authorized Shares 3,500,000,000 05/19/2021
Outstanding Shares 2,252,673,740 05/19/2021
Restricted 1,107,101,692 05/19/2021
Unrestricted 1,145,572,048 05/19/2021
Held at DTC 1,075,956,980 05/19/2021
Float 303,593,877 08/16/2019
TSOI SECURITY DETAILS
Share Structure
Market Cap 148,566,113 05/10/2021
Authorized Shares 3,500,000,000 05/04/2021
Outstanding Shares 2,251,001,716 05/04/2021
Restricted 1,107,101,692 05/04/2021
Unrestricted 1,143,900,024 n05/04/2021
Held at DTC 1,050,534,956 05/04/2021
Float 303,593,877 08/16/2019
Share Structure
Market Cap Market Cap 173,270,990 03/12/2021
Authorized Shares 3,500,000,000 03/04/2021
Outstanding Shares 2,243,571,019 03/04/2021
Restricted 1,279,963,335 03/04/2021
Unrestricted 963,607,684 03/04/2021
Held at DTC 805,734,684 03/04/2021
TSOI.... Authorized Sharesn 3,500,000,000
Outstanding Shares 2,243,571,019 03/04/2021
Restricted 1,279,963,335 03/04/2021
Unrestricted 963,607,684 03/04/2021
Held at DTC 805,734,684 03/04/2021
Float 303,593,877 03/04/202
Unrestricted 1,296,570,604 12/17/2021 >6,927,248
Held at DTC 1,252,872,777 12/17/2021 >7,927,248
TSOI 11/15/21 Authorized Shares 3,500,000,000 1/15/2021
Outstanding Shares 2,294,196,612 11/15/2021
Restricted 1,004,553,256 11/15/2021
Unrestricted 1,289,643,356 11/15/2021
Held at DTC 1,244,945,529 11/15/2021
Share Structure Update 10/18/21
Market Cap Market Cap 87,926,139 10/21/2021
Authorized Shares 3,500,000,000 10/18/2021
Outstanding Shares 2,274,932,452 10/18/2021
Restricted 990,553,256 10/18/2021
Unrestricted 1,284,379,196 10/18/2021
Held at DTC 1,240,681,369 10/18/2021
O/S NO change
Restricted NO change
Unrestricted NO change
Held @ DTC >5m
https://investorshub.advfn.com/boards/read_msg.aspx?message_id=166066740
Authorized Shares 3,500,000,000 09/23/21
Updated O/S 2,274,135,577 09/23/21
Restricted 989,756,381 09/23/21
Unrestricted 1,284,379,196 09/23/21
Held at DTC 1,235,681,369 09/23/21
https://www.otcmarkets.com/stock/TSOI/security
as of 09/08/2021 $TSOI SECURITY DETAILS Share Structure
Market Cap Market Cap 177,382,575 09/15/2021
Authorized Shares3,500,000,000 09/08/2021
Outstanding Shares 2,274,135,577 09/08/2021
Restricted 1,094,756,381 09/08/2021
Unrestricted 1,179,379,196 09/08/2021
Held at DTC 1,129,681,369 09/08/2021
Share Structure 8/25/21
Market Cap Market Cap 201,463,566 08/31/2021
Authorized Shares 3,500,000,000 08/25/2021
Outstanding Shares 2,273,135,577 08/25/2021
Restricted 1,100,756,381 08/25/2021
Unrestricted 1,172,379,196 08/25/2021
Held at DTC 1,129,681,369 08/25/2021
TSOI Updated SS 9/01/21 http://investorshub.advfn.com/uimage/uploads/2021/9/1/jofddScreenshot_2021-09-01_174143.png
TSOI Share Structure
Market Cap Market Cap 138,081,770 08/11/2021
Authorized Shares 3,500,000,000 08/03/2021
Outstanding Shares 2,263,635,577 08/03/2021
Restricted 1,093,801,208 08/03/2021
Unrestricted 1,169,834,369 08/03/2021
Held at DTC 1,129,681,369 08/03/2021
TSOI Share Structure
Market Cap Market Cap 77,985,701 07/27/2021
Authorized Shares 3,500,000,000 7/09/2021
Outstanding Shares 2,259,800,077 07/09/2021
Restricted 1,092,501,208 07/09/2021
Unrestricted 1,167,298,869 07/09/2021
Held at DTC 1,119,045,869 07/09/2021
Float 303,593,877 08/16/20
7/9/21 TSOI SECURITY DETAILS
Share Structure
Market Cap 74,563,501 07/08/2021
Authorized Shares 3,500,000,000 06/02/2021
Outstanding Shares 2,252,673,740 06/02/2021
Restricted 1,088,601,692 06/02/2021
Unrestricted 1,164,072,048 06/02/2021
Held at DTC 1,092,456,980 06/02/2021
Float 303,593,877 08/16/2019
Par Value 0.001
TSOI SECURITY DETAILS 5/19/21
Share Structure
Market Cap Market Cap 116,553,339 05/25/2021
Authorized Shares 3,500,000,000 05/19/2021
Outstanding Shares 2,252,673,740 05/19/2021
Restricted 1,107,101,692 05/19/2021
Unrestricted 1,145,572,048 05/19/2021
Held at DTC 1,075,956,980 05/19/2021
Float 303,593,877 08/16/2019
TSOI SECURITY DETAILS
Share Structure
Market Cap 148,566,113 05/10/2021
Authorized Shares 3,500,000,000 05/04/2021
Outstanding Shares 2,251,001,716 05/04/2021
Restricted 1,107,101,692 05/04/2021
Unrestricted 1,143,900,024 n05/04/2021
Held at DTC 1,050,534,956 05/04/2021
Float 303,593,877 08/16/2019
Share Structure
Market Cap Market Cap 173,270,990 03/12/2021
Authorized Shares 3,500,000,000 03/04/2021
Outstanding Shares 2,243,571,019 03/04/2021
Restricted 1,279,963,335 03/04/2021
Unrestricted 963,607,684 03/04/2021
Held at DTC 805,734,684 03/04/2021
TSOI.... Authorized Sharesn 3,500,000,000
Outstanding Shares 2,243,571,019 03/04/2021
Restricted 1,279,963,335 03/04/2021
Unrestricted 963,607,684 03/04/2021
Held at DTC 805,734,684 03/04/2021
Float 303,593,877 03/04/2021
JadiCell for COVID-19 (Phase III ongoing #19757)
JadiCell for COPD (IND #28508)
JadiCell for Chronic Traumatic Encephalopathy (IND #27377)
JadiCell for Idiopathic Pulmonary Fibrosis (Late Preclinical)
StemVacs Dendritic Cells for Breast Cancer (IND #28508)
StemVacs-V iPSC Derived Tumor Endothelial Targeting Vaccine (Late Preclinical)
Bio next week Post by TimGDixon » Fri Jun 10, 2022 6:18 pm
Most of you know next week BIO happens and Venvalo Group will be there to present the following opportunities on our behalf in One-on-One meetings for out-licensing and collaborative/partnerships. There will be no recordings as these are pre-arranged one on one meetings that are rapid so you can get maximum exposure. This is where pharma biopharma shops and something like 3,682 companies will be present.
JadiCell for COVID-19 (Phase III ongoing #19757)
JadiCell for COPD (IND #28508)
JadiCell for Chronic Traumatic Encephalopathy (IND #27377)
JadiCell for Idiopathic Pulmonary Fibrosis (Late Preclinical)
StemVacs Dendritic Cells for Breast Cancer (IND #28508)
StemVacs-V iPSC Derived Tumor Endothelial Targeting Vaccine (Late Preclinical)
https://forum.therapeuticsolutionsint.com/viewtopic.php?p=4624&hilit=Venvalo+Group#p4624
No news after the bio conference. Hmmm.
Previous studies have shown correlations between inflammatory cytokines in the blood and suicide. The causative effects of these molecules on suicidal ideation is seen in cancer patients who take similar molecules for hyperstimulation of immunity, which also results in suicidal ideation. Products developed by Therapeutic Solutions International such as NeuroStilbene™, NanoStilbene™ and QuadraMune™ have been shown to reduce inflammatory markers.
"It is extremely exciting to be at the ground floor of a paradigm shift" said Howard Leonhardt. "I look forward to assisting the Company in accelerating solutions for this terrible condition. Additionally, we will explore synergistic interaction with various companies from the Leonhardt Ventures portfolio."
"Suicide has historically been treated as a stigma. With increasing advancement of science, we realize it is a biological abnormality and should be addressed the same way we address other conditions" said Timothy Dixon, President and CEO of the Company. "Psychiatry is the only discipline of medicine that does not base its drug prescriptions by detailed evaluation of the organ they are treating. It is interesting that only in psychiatry that treatments are given without actually assessing physical changes that the intervention is accomplishing. Technologies we are developing will provide a biological basis for the practice of psychiatry as it relates to suicide prevention."
https://www.prnewswire.com/news-releases/therapeutic-solutions-international-launches-campbell-neurosciences-division-aimed-at-biologically-identifying-and-repairing-suicide-prone-brains-301110221.html
Leonhardt Ventures / Brain
https://leonhardtventures.com/brain/
Bioelectric Stimulation
https://cerebracell.com/
If you want to know what is farther ahead with TSOI ,
then follow the science, and enter the library :
https://forum.therapeuticsolutionsint.com/viewtopic.php?t=219
I'm talkin 'bout the waay beyond the front burner DD below on this list :
USPTO, FDA, SEC verified company
61+ patents and patent applications
5 Investigational Drug Applications
Phase 1/2 Solid Tumor Cancer
Phase 1/2 CTE
Phase 1/2 Breast Cancer
Phase 1/2 COPD
Phase 3 Lung Failure
Retail sold online @ Amazon & Walmart
If you really know your DD ,
then cross the R and D river with your MSCs from JadiCell , and venture into Transcranial Magnetic Stimulation, as well as Bio electric stimulation .
Campbell NeuroSciences ,
And Howard Leonhardt.
That’s my thinking as well. Hopefully a run like last year do some of us can exit stage left
BigBadWolf years away my friend, years away. imo
Happy Father’s Day to al the great fathers out there
Worth repeating. TSOI facts.
Thanks, Wolf.
Lets just stick with $TSOI FACTS:
USPTO, FDA, SEC verified company
61+ patents and patent applications
5 Investigational Drug Applications
Phase 1/2 Solid Tumor Cancer
Phase 1/2 CTE
Phase 1/2 Breast Cancer
Phase 1/2 COPD
Phase 3 Lung Failure
Retail sold online @ Amazon & Walmart
Re: Lotsa excitement and anticipation Post by TimGDixon » Wed Jun 15, 2022 4:43 pm
Re: Lotsa excitement and anticipation when the conf began....
Whats exciting about this is that its all coming back and this means new partnerships and collaborations and research and papers getting published and new and novel medicines being purposed and thats a really great thing... and then on top of that the potential for business that results in companies getting bought and patents getting licensed and money flowing.. its all good.
https://forum.therapeuticsolutionsint.com/viewtopic.php?t=218
Lets just stick with $TSOI FACTS:
USPTO, FDA, SEC verified company
61+ patents and patent applications
5 Investigational Drug Applications
Phase 1/2 Solid Tumor Cancer
Phase 1/2 CTE
Phase 1/2 Breast Cancer
Phase 1/2 COPD
Phase 3 Lung Failure
Retail sold online @ Amazon & Walmart
Last day of Bio Convention https://investorshub.advfn.com/boards/read_msg.aspx?message_id=169128949
oh the possibilities/potential of those One on One Partnership Meetings
I've been frustrated with the MM's quite a bit over the years.....but this manipulation is ridiculous....wow!
Can you share the link to phase 3 IND please.
Yes, a good close, hopefully it continues tomorrow.
JadiCell for COVID-19 (Phase III ongoing #19757)
JadiCell for COPD (IND #28508)
JadiCell for Chronic Traumatic Encephalopathy (IND #27377)
JadiCell for Idiopathic Pulmonary Fibrosis (Late Preclinical)
StemVacs Dendritic Cells for Breast Cancer (IND #28508)
StemVacs-V iPSC Derived Tumor Endothelial Targeting Vaccine (Late Preclinical)
Bio next week Post by TimGDixon » Fri Jun 10, 2022 6:18 pm
Most of you know next week BIO happens and Venvalo Group will be there to present the following opportunities on our behalf in One-on-One meetings for out-licensing and collaborative/partnerships. There will be no recordings as these are pre-arranged one on one meetings that are rapid so you can get maximum exposure. This is where pharma biopharma shops and something like 3,682 companies will be present.
JadiCell for COVID-19 (Phase III ongoing #19757)
JadiCell for COPD (IND #28508)
JadiCell for Chronic Traumatic Encephalopathy (IND #27377)
JadiCell for Idiopathic Pulmonary Fibrosis (Late Preclinical)
StemVacs Dendritic Cells for Breast Cancer (IND #28508)
StemVacs-V iPSC Derived Tumor Endothelial Targeting Vaccine (Late Preclinical)
https://forum.therapeuticsolutionsint.com/viewtopic.php?p=4624&hilit=Venvalo+Group#p4624
TimGDixon
Re: Bio next week
Quote
post Fri Jun 10, 2022 7:30 pm
“Whats attractive is the serial numbered ind and the fact you don't have to buy the whole damn company to get it. StemVacs-V is applicable in any cancer. The IND is a heavy piece of lifting and having it authored, filed and an issued ind # is most of the hard paperwork.”
3
12:42 PM
$TSOI
Unparalleled progress (literally)…yet stock oppression continues for over 6 months now….confounding…
TimGDixon
Re: Interesting times...
Post Wed Jun 15, 2022 6:24 am
Its a pain in the butt but if for example we needed to take a shareholder vote this is how you go about it and its just the cost of business. If someone is accumulating shares for their own investment who cares but if there is a operation to hold the price down so that can occur then thats stock manipulation. I don't who has that kind of power.
[In the 125 trading days between dec 1, 2021 and may 31, 2022 a total of 790,730,918 shares traded at an average price of 0.0245 in average dollar volume of $19,393,529].
You don’t say…??
forum.therapeuticsolutionsi...
https://forum.therapeuticsolutionsint.com/viewtopic.php?p=4942&hilit=shareholder+vote#p4942
$TSOI Carnitas y cervezas muy frias
very cold beers & twice cooked pork
Yankee haha. I’m a pulled pork dude. Haha tacos all day.
Man he won’t work the grill. I’m sure the party will be nice but if it all comes to fruition then somebody else has the grill. But I get it.
Lets all keep it real my friend ... good time or bad times, Tim vill be working the bbq grill. I have a craving for that much talked about Tomahawk Steak yu yankees like to talk about alot
Big things coming here I believe
Probably the most straight up dude here. Totally agree
Lets make sumthing klear here:
1. Bil n kimchi are here
2. Milanire netvork continues to add
3. We not gong
4. We are velly excited about interim jadicell results
5. Vhile we vsit for tsoi opportunities, ve ovserve others., ve still here, buy dips, vait for our yankee doodle day
Bio next week Post by TimGDixon » Fri Jun 10, 2022 6:18 pm
Most of you know next week BIO happens and Venvalo Group will be there to present the following opportunities on our behalf in One-on-One meetings for out-licensing and collaborative/partnerships. There will be no recordings as these are pre-arranged one on one meetings that are rapid so you can get maximum exposure. This is where pharma biopharma shops and something like 3,682 companies will be present.
JadiCell for COVID-19 (Phase III ongoing #19757)
JadiCell for COPD (IND #28508)
JadiCell for Chronic Traumatic Encephalopathy (IND #27377)
JadiCell for Idiopathic Pulmonary Fibrosis (Late Preclinical)
StemVacs Dendritic Cells for Breast Cancer (IND #28508)
StemVacs-V iPSC Derived Tumor Endothelial Targeting Vaccine (Late Preclinical)
https://forum.therapeuticsolutionsint.com/viewtopic.php?p=4624&hilit=Venvalo+Group#p4624
Venvalo Group and Dr. Boris Reznik to Present TSOI at BIO International Convention
in
One on One Partnership Meetings June 13-16, 2022·San Diego Convention Center
Credit goes to Cents
A very good presentation, This should be shared to many people.
Looking forward to the Convention
updates would be nice
my basic immune boost from QM helped me with the second time i had c19 .
Less green stuff in my lungs.
I have been using QM for over a year. I noticed I do not use my inhaler anymore to treat my asthma. No more associated chest pain!
Love what TSOI has been doing I never thought about foods healing my body until I bought this stock. Therapeutic Solutions is on the right track with JadiCell and QuadraMune plus all the other products
check out William Li he is on the same path as TSOI would be nice to see him
on the roster of doctors with our company
Thanks for the update
Nice Cents, I didn't see it. Thanks for the information.
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Preclinical Data Suggests QuadraMune™ Prevents Stress-Induced Suppression of Neurogenesis More Effectively than Prozac
OCEANSIDE, Calif., Dec. 9, 2020 /PRNewswire/ -- Therapeutics Solution International, Inc., (OTC Markets: TSOI), announced today new data suggesting the possibility that QuadraMune™ may mediate neuroprotective activity through preserving the ability of regenerative brain cells to proliferate subsequent to psychological stress.
The experiments, which involved exposing mice to established stressors, demonstrated that specific areas of the brain associated with production of new brain cells are damaged by stress. In agreement with previously published research, administration of fluoxetine (Prozac™) protected the brain from stress-induced damage. Surprisingly, QuadraMune™ administration appeared superior to Prozac™ at stimulating proliferation of new brain cells.
"QuadraMune™ which is currently in a clinical trial for prevention of COVD-191, has also been demonstrated to possess anti-inflammatory activity in other clinical trials, suppressing cytokines such as IL-62, which are known to be involved in depression3 and suicide4" said Kalina O'Connor, Director of Campbell Neurosciences and co-inventor on the patent. "Given major depressive disorder causes a significant risk for suicide, we are highly interested in exploring the use of QuadraMune™ for preventing suicide."
"Although much enthusiasm has been generated over the planned distribution of the COVID vaccine, at present little is being done to address mental health issues that are being exacerbated by the current pandemic" said Dr. James Veltmeyer, co-inventor of the patent, and Chief Medical Officer of the Company. "If current results are reproducible, the possibility that a nutraceutical would concurrently boost immunity while preserving mental health is highly enticing."
"It has not escaped us that COVID-19 is associated with increased inflammatory cytokines in the blood of patients, cytokines that also predispose to depression" said Famela Ramos, Vice President of Business Development for the Company. "It may be that the recent increase in suicides and suicide attempts is related biologically to activities of the coronavirus. It will be interesting to examine whether QuadraMune™ may modify putative negative mental effects of the virus."
"An estimated 17.3 million adults in the United States had at least one major depressive episode. This number represented 7.1% of all U.S. adults" stated Timothy Dixon, President and CEO of the Company. "We believe the Mission of our Company is not just providing a return on investment to our shareholders, but also increasing the quality of life for Americans. We are extremely pleased to report this unexpected finding with significant potential implications to advancing non-toxic means of helping patients with this terrible condition."
1 QuadraMune(TM) for Prevention of COVID-19 - Full Text View - ClinicalTrials.gov
2 Therapeutic Solutions International Announces Positive Preclinical and Clinical Evaluation of Nutritional Supplement QuadraMune™, Designed to Protect Against COVID-19 | BioSpace
3 Ting et al. Role of Interleukin-6 in Depressive Disorder. Int J Mol Sci. 2020 Mar 22;21(6):2194.
4 O'Donovan et al. Suicidal ideation is associated with elevated inflammation in patients with major depressive disorder. Depress Anxiety. 2013 Apr;30(4):307-14.
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