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TOP GUN RSS Feed

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Moderator BooDog
Assistants drugtester alfaspider

Small group working towards one common goal...


All posts are to keep within the IHUB TOS.

 

Usefull links:
https://listingcenter.nasdaqomx.com/Material_Search.aspx?mcd=LQ
NASDAQ
https://listingcenter.nasdaq.com/assets/continuedguide.pdf
site for researching listing requirements and such.

http://www.venturelawcorp.com/listing_requirements_nasdaq.html

 Kitco Gold, silver spot and other metals
http://www.kitco.com/charts/livegold.html

http://www.kitcosilver.com/

Orangequant's Synthetic Trendlines
http://www.orangequant.com/

European clinical trials and marketing
https://en.wikipedia.org/wiki/CE_marking
https://www.ema.europa.eu/en/human-regulatory/research-development/clinical-trials-human-medicines
https://eur-lex.europa.eu/LexUriServ/LexUriServ.do?uri=CONSLEG:2001L0083:20070126:en:PDF Containes Annex 1.  May get updated in the future so be sure that you're using the most current directive.
https://www.ema.europa.eu/en/human-medicines-regulatory-information
 

http://www.centerwatch.com/clinical-trials/overview.aspx

http://stoxline.com/



Up listing

https://listingcenter.nasdaq.com/assets/initialguide.pdf


p53 mutations in cancer...
http://www.nature.com/ncb/journal/v15/n1/full/ncb2641.html



Keeping it simple and ethical.

 

The more you learn how to make decisions for yourself the more $$$ you'll make. Whichever strategy you use on an initial investment sets the tone on whether you'll make money or end up taking a loss. It takes time. Having good stocks that pay dividends is always a good long term choice imo. But getting in at the right time counts. That's where technical analysis pays off. There are a gazillion sites that offer assistance in this area, for a fee. More often, brokers are offering short training sessions, Scottrade offers some quick training sessions, for free. Guessing others do as well. There is PLENTY of free online information as well, and in the library.
Building a plan and investing with a diversified portfolio keeps the $$$ somewhat safe. Then, having some cash available for short term swing trading can bring in some profits. Short term trading has its higher tax implications and higher risk of course. Need to learn the technicals, and how to read the fundamentals. A short watch list of a dozen or so GOOD stocks taking turns swinging when they're set up or just adding at the right time to strengthen long term stocks.
The idea is to be independant of others influencing your decisions. Know how/when to cut the cord on something that isn't working, and keeping the winners. A plan to buy something short term can certainly turn into a long term hold if it's paying off imo.
I am not an investment advisor.
 
 
Some online and other useful books...

Toni Turner is very easy to read and understand without putting you to sleep.

A Beginner's Guide to Day Trading Online by Toni Turner www.toniturner.com
"Short Term Trading in the New Stock Market"

A Beginner's Guide to Short Term Trading by Toni Turner (for swing and position trading which i recommend)

How I made $2,000,000 in the Stock Market by Nicolas Darvas www.darvastrades.com (a good complimentary website to his trading style since he is not on this earth anymore to have his own official website)

The Candlestick Course by Steven Nison www.candlecharts.com

Trend Following by Michael Covel (some of the biggest traders in the world are Trend Followers including John Henry, Jerry Parker, Ed Seykota, The Turtles, Richard Dennis, William Eckhardt, Bill Dunn, Keith Campbell etc.) www.trendfollowing.com

Reminisces of a Stock Operator by Edwin Lefevre (about the legendary Jesse Livermore and how he thought about trading)

Market Wizards by Jack D. Schwager (about other traders mindsets)

New Market Wizards by Jack D. Schwager (same as above)

The Micro Cap Investor: Strategies for Making Big Returns in Small Companies by Robert Imperiale

The Guide for Pennystock Investing by Donny Lowy

Making Dollars with Pennies by R. Max Bowser

Penny stock Winners by R. Max Bowser

Mastering Microcaps by Daniel P. Coker


Bowser is old and out of date but his strategies/research techniques are fundamentaly good imo.

Thanks for reading, and as always feedback is welcome!!

 

CTIX board
F1ash Monday, 01/25/16 09:25:44 AM
Re: None  
Post # of 138140    
This 9 minute video might help to understand P53 - P21 relationship as it relates to Kevetrin.

http://m.youtube.com/watch?v=-3Di4OgAhmc
 
slcimmuno Member Level Tuesday, 04/14/15 11:02:32 AM
Re: frrol post# 97715  
Post # of 97735    
thx frrol. that was an excellent post by O Neb. a keeper. along with the U of Colorado p53 researcher not being impressed with aprea, reinforces how Kevetrin is different, likely better, than the competition. bring on leo's biomarker update and the D Farber presentation at ASCO 2015.

thx too Infinity and rr. below some links to various MDM2-p53 articles, some of which i'm sure have been posted before. the first seems the best overview based on my cursory review --- comprehensive and gets to the MDM2-MDMX interplay. still learning up on the science.

///

Targeting the MDM2-p53 Protein-Protein Interaction for New Cancer Therapeutics (2012)
http://1drv.ms/1GGSt04

xxxxxxxxxxxxx

MDM2-p53 Interaction in Peadiatric Solid Tumous: Preclinical Rationale, Biomarkers and Resistance (2014) (Note: this has been posted before / refs Kevetrin) (PDF)
http://www.ingentaconnect.com/content/ben/cdt/2014/00000015/00000001/art00010?crawler=true

Targeting MDM2-p53 interaction for cancer therapy: are we there yet? (2014) (abstract only)
http://www.ncbi.nlm.nih.gov/pubmed/24180275

Small molecule agents targeting the p53-MDM2 pathway for cancer therapy. (2012) (abstract only)
http://www.ncbi.nlm.nih.gov/pubmed/23059763

Targeting the MDM2–p53 interaction as a therapeutic strategy for the treatment of cancer (2010)
http://www.dovepress.com/targeting-the-mdm2ndashp53-interaction-as-a-therapeutic-strategy-for-t-peer-reviewed-article-CHC
http://www.dovepress.com/getfile.php?fileID=6660 (PDF, Full)

Targeting the MDM2-p53 Interaction for Cancer Therapy (2009)
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2676446/

The MDM2-p53 Interaction (2003)
http://mcr.aacrjournals.org/content/1/14/1001.full
 
slcimmuno Member Level Wednesday, 04/15/15 04:32:26 PM
Re: None  
Post # of 97977    
4 Part Vid Intvw w FDAs Richard Pazdur (Head Onc guy)
bodes well for Kevetrin if results are as good as we think they might be. the interview covers a lot of ground. he mentions "there's not going to be one drug that cures 8 cancers." maybe. maybe not. but that's the p53 dream. well worth a listen -- hearing the scoop straight from the FDA's regulatory top dog.

Cancer "Rocket Docket"
http://bcove.me/ndarcfh0

Patient Power
http://bcove.me/uawobpqd

Precision Medicine
http://bcove.me/xamojt6a

Compelling Case (pediatrics)
http://bcove.me/rtyf8t0p

The Gatekeeper to New Cancer Drugs
Dr. Richard Pazdur is the world's most important cancer drug regulator

Dr. Richard Pazdur, director of FDA's Office of Hematology and Oncology Products, tells BioCentury why FDA is racing to approve new cancer drugs. Dr. Pazdur says new targeted drugs and immunotherapies with unprecedented efficacy are the payoff from 20 years of basic science. He calls for greater patient engagement in drug development, says compassionate access should be improved, and predicts rapid uptake of biosimilars.

------------------------------------------------

vancomycin and clindamycin
 
https://www.morningstar.com/news/pr-news-wire/PRNews_20160121NY03914/allergan-announces-fda-approval-of-updated-label-for-new-dosing-regimen-for-dalvance-dalbavancin.print.html
 
http://www.duratatherapeutics.com/news-media/press-releases/detail/7514/fda-approves-durata-therapeutics-dalvancetm-for-the
First and Only IV Antibiotic for ABSSSI With Once-a-Week Dosing for Two Weeks
CHICAGO, May 23, 2014 (GLOBE NEWSWIRE) -- Durata Therapeutics, Inc. (Nasdaq:DRTX) announced today that the U.S. Food and Drug Administration (FDA) has approved DALVANCETM (dalbavancin) for injection for the treatment of adult patients with acute bacterial skin and skin structure infections (ABSSSI) caused by susceptible Gram-positive bacteria, including methicillin-resistant Staphylococcus aureus (MRSA). DALVANCE is the first and only IV antibiotic approved for the treatment of ABSSSI with a two-dose regimen of 1000 mg followed one week later by 500 mg, each administered over 30 minutes.

 

What's involved with a CSR

An Insider’s Insight into Clinical Study Reports

http://www.niche.org.uk/asset/insider-insight/Insider-Clinical-Study-Reports.pdf
Citrati Monday, 01/04/16 11:19:58 AM
Re: None  
Post # of 1377    
Thought some might find these 18 principles from Steve Burns interesting.

Psychology

New Traders are greedy and have unrealistic expectations. Rich Traders are realistic about their returns.
New Traders make the wrong decisions due to stress. Rich Traders can manage stress.
New Traders are impatient and look for constant action. Rich Traders are patient.
New Traders trade because they are influenced by emotion. Good Traders use a trading plan.
New Traders think they can stop learning. Rich Traders never stop learning about the market.

Risk

New Traders act like gamblers. Rich Traders operate like a businessperson.
New Traders bet the farm. Rich Traders carefully control trading size.
For New Traders outsized profits are the #1 priority. Rich Traders know that managing risk is the #1 Priority.
New Traders try to prove they are right. Rich Traders admit when they are wrong.
New Traders give back profits by not having an exit strategy. Rich Traders lock in profits while they are there.

Methodology

New Traders give up. Rich Traders persevere until they are successful.
New Traders hop from system to system when they lose. Rich Trad