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A middle aged, over weight, man discovers he is losing his remaining vision. To help him cope, a natural competitive bodybuilder challenges him to take on a physical transformation and enter the world of competitive bodybuilding.
Supplements and sunlight give optimal protection from breast cancer:
By Stephen Daniells, 16-Dec-2010
Some sun exposure and vitamin D supplements may be the most effective means of reducing the risk of breast cancer, suggest findings from a French study.
Numerous studies have linked vitamin D levels to a reduction in the risk of certain cancers, including breast cancer, but much debate has focused on the means to boost vitamin D levels – supplements or sunlight.
According to new findings published in Cancer Epidemiology, Biomarkers & Prevention, a combination may be the best approach. Data collected over a decade of study from 67,721 women indicated that postmenopausal women living in sunny climes combined with high dietary or supplemental intakes of vitamin D were at a significantly reduced risk of breast cancer compared to women with high sun exposure and low intakes of the vitamin.
On the other hand, no associations were observed for dietary and supplemental intakes of vitamin D alone, report researchers led by Pierre Engel from Inserm (Institut National de la Santé et de la Recherche Médicale).
“Although, our results do not support a linear dose-response relationship of both UVR dose and dietary vitamin D on BC risk, our findings suggest that a threshold of vitamin D exposure is required to prevent BC; this minimal amount is likely to vary with individual ability to metabolize or synthesize vitamin D from both sources,” they said.
D and the big C
The link between vitamin D intake and protection from cancer dates from the 1940s when Frank Apperly demonstrated a link between latitude and deaths from cancer, and suggested that sunlight gave "a relative cancer immunity".
Since then there have been numerous studies suggesting associations between vitamin D and lower risks of certain cancers.
Vitamin D refers to two biologically inactive precursors – cholecalciferol (D3) and ergocalciferol (D2).
Both D3 and D2 precursors are hydroxylated in the liver and kidneys to form 25- hydroxyvitamin D (25(OH)D), the non-active 'storage' form, and 1,25-dihydroxyvitamin D (1,25(OH)2D), the biologically active form that is tightly controlled by the body.
There is growing evidence that 1,25(OH)2D has anticancer effects, but the discovery that non-kidney cells can also hydroxylate 25(OH)D had profound implications, implying that higher 25(OH)D levels could protect against cancer in the local sites.
The association between vitamin D and breast cancer is still ambiguous, however, according to results of a recent meta-analysis published in the European Journal of Cancer (doi: 10.1016/j.ejca.2010.03.037).
New data
According to findings of Dr Engel and his team, such ambiguity may be related to a combination of dietary, supplemental and sunlight exposure as the source of raising vitamin D levels.
The French researchers documented 2,871 cases of breast cancer over the 10 years of their study. While no relationship was observed between dietary and supplemental intakes of the sunshine vitamin, the risk of breast cancer for women residing in regions with the highest average daily UV exposure (living below a latitude of 46°N) combined with high dietary vitamin D intakes was 32 percent lower, while the risk for high UV exposure and high supplemental intakes was reduced by 45 percent.
“Considering that, in France, mean vitamin D dietary intake is low, and 25(OH) vitamin D serum concentrations are mostly below the 30 ng/mL recommended threshold, our results suggest that an increase in overall vitamin D intake should be encouraged by food and health agencies, possibly through fortification of foods,” concluded Dr Engel and his co-workers.
Jury–in or out?
The recent meta-analysis, which reviewed and summarised ten trials investigating the association between serum vitamin D (measured as 25(OH)D levels) and the risk of breast cancer, concluded that the data to date “show ambiguous evidence”.
“Data is still sparse and in depth analyses … especially measuring repeatedly 25(OH)D at different time points before diagnosis, are highly desirable to enable more precise estimates and a better understanding of the role of vitamin D in breast cancer development and prevention,” concluded the authors of the meta-analysis.
Source: Cancer Epidemiology, Biomarkers & Prevention
Published online ahead of print, doi:10.1158/1055-9965.EPI-10-1039
“Joint effects of dietary vitamin D and sun exposure on breast cancer risk: results from the French E3N cohort”
Authors: P. Engel, G. Fagherazzi, S. Mesrine, M-C. Boutron-Ruault, F. Clavel-Chapelon
so that article say vegans have low brain function? lol j/k...creatine is great...used it during my football playing/weight lifting days all the time..
Creatine may beef up brain function: Study
By Stephen Daniells, 13-Dec-2010
Related topics: Research, Proteins, peptides, amino acids, Cognitive and mental function, Energy & endurance
Supplements of creatine, most commonly associated with sports nutrition, may boost cognitive function in vegetarians, a group at risk of low creatine levels, says a new study.
Creatine, an amino acid-like compound, was first identified in 1832 for its presence in muscle. It has been the subject of about 70 randomized, controlled trials over the last 12 years or so, with the majority investigating creatine’s performance-enhancing benefits. The compound is mostly found in animal products like meat.
The role of creatine in brain functioning has been reported previously, but no data has been presented examining the effect of creatine supplementation in vegetarians, a group with lower muscle levels of creating.
According to new results published in the British Journal of Nutrition, vegetarians showed improvements in their memory after five days of daily creatine supplements. No such improvements were observed in meat-eating omnivores.
“To date, the findings are too preliminary to allow the role of creatine in the brain and the impact of its supplementation on cognition to be established. However, the present and previous reports that supplementation influences cognitive functioning, and the evidence that creatine supplementation influences basic brain physiology, suggest that the topic will repay further examination,” wrote David Benton from the University of Swansea and Rachel Donohoe from London Ambulance Service NHS Trust.
Study details
Benton and Donohoe recruited 121 young women, both vegetarians and omnivores, and randomly assigned them to receive either a daily placebo, or a daily creatine supplement (creatine monohydrate, 20 grams per day, Isostar Creatine, Wander Limited, UK) for five days.
A battery of cognitive tests were performed by the women, both before and after the five days of study, with results showing that memory improved by about 40 percent in the vegetarians consuming the creatine supplements, compared with placebo.
Furthermore, creatine supplements also reduced the variability of the women’s in the responses to a choice reaction-time task in both vegetarians and omnivores.
On the other hand, no improvements were observed in any group concerning measures of verbal fluency and vigilance.
“The results can be viewed as creatine supplementation selectively influencing a demanding task that placed greater physiological demands on the brain, as it was only the monitoring of eight lamps that benefited from creatine,” wrote Benton and Donohoe.
“The consumption of the placebo was associated with a poorer performance when tested for a second time, a decline prevented by consuming the creatine supplement. That the nature of the pre-existing diet did not influence the response to supplementation with the reaction time task suggested a more general effect,” they added.
Biologically plausible?
In terms of a mechanism, the UK-based researchers point to creatine in the form of phosphocreatine, a compound that acts as a reservoir of high-energy phosphate. The formation of phosphocreatine is controlled by the enzyme creatine phosphokinase. In the brain, the enzyme is concentrated in the synaptic regions, and therefore the researchers suggest that creatine’s role in the brain is in neurotransmission.
“The uneven distribution of creatine phosphokinase indicates that rather than having a general function, it is important in some aspects of functioning rather than others,” wrote the researchers. “The high concentration in the hippocampus is of particular interest, given the known importance of this area of the brain in memory. [Previous reports] that creatine supplementation improves memory and the present finding that memory benefited from supplementation are consistent with these physiological data.”
Source: British Journal of Nutrition
Published online ahead of print, doi: 10.1017/S0007114510004733
“The influence of creatine supplementation on the cognitive functioning of vegetarians and omnivores”
Authors: D. Benton and R. Donohoe
Nice one on potatoes...
The Winter I Had to Live Almost Completely on Potatoes ... And Loved It
Everything you could want to know about the potato, which, it turns out, is an amazing food.
AlterNet / By Carol Deppe 26 COMMENTS
November 19, 2010 |
http://www.alternet.org/story/148926/the_winter_i_had_to_live_almost_completely_on_potatoes_..._and_loved_it?page=entire
Chris Voigt, executive director of the Washington State Potato Commission, is currently eating nothing but potatoes for two months, 20 5.3 ounce potatoes a day. When I read about it, my reaction was, Hey, what's so hard about that? Last winter, I ate pretty nearly all potatoes for about six months. It was a feast all winter! Voigt is doing his diet to help publicize the nutritional value of potatoes as well as to protest the fact that the USDA has excluded potatoes from its list of approved foods for the WIC (Women, Infants, Children) food voucher program.
I was doing my diet for more traditional reasons: I was short of cash. I needed whatever I could scrape up to keep the utilities turned on. So the garden needed to provide the food. And not just vegetables, either. Staple foods. I'm both highly allergic to wheat as well as gluten intolerant. And I'm sensitive enough so that I can't eat other grains that are milled on the same mills as wheat, which includes nearly all the corn, oats, and other grains that would be gluten-free otherwise. Grains milled on dedicated mills are a specialty item, and are expensive. So the cheap foods so widespread in our culture are not available to me. I need to be able to grow my own staples. And the staple food it is easiest to provide from a garden here in maritime Oregon, as well as much of the rest of the temperate world, isn't grain or beans. It's potatoes. Good thing, too! There is no food I would rather mostly survive on for serious periods of time than the potato.
Potatoes are unique compared with other roots and tubers because they are an excellent source of protein as well as carbohydrate. Potatoes can be thought of as being honorary grains. Since a bite of wheat might kill me from anaphylactic shock before the ambulance arrived, I tend to look at it the other way round. Potatoes are the standard. I view grains as honorary potatoes. Potatoes and grains are comparable as sources of protein. A boiling type of potato, for example, with 2.1 grams of protein per 100 grams fresh weight, has 10.4 percent protein per unit dry weight. Brown rice with 7.5 percent protein in the bin, has 9.6 percent protein per unit dry weight. (Many people don't realize potatoes are a high-protein food because they are used to seeing numbers that compare the levels of protein in wet potatoes with those of dry grain.) Pasta varieties of wheat have protein amounts comparable to those of rice and potatoes. Bread varieties of wheat have higher protein contents. But grain protein is low in the essential amino acid lysine, so is not as usable to fill our protein (actually essential amino acid) needs as is the same amount of potato protein. In addition, we don't absorb wheat proteins as well as those of rice or potatoes. Taking these factors into account, the potato is about as good a source of protein as the higher-protein grains, and is superior to lower-protein grains such as rice or standard commercial hybrid corn. Of annual crops, only beans are better sources of protein.
If I am eating nothing but 2,000 calories per day of potatoes, for example, which is about 5.8 pounds of potatoes (taking boiling potatoes as the standard), I would get 55 grams of protein. The RDA for protein for adult women, adult men, and pregnant or lactating women is 46 grams, 56 grams, and 71 grams per day respectively. However, RDAs are set at somewhat above the needs of the average person so as to cover most of the population, including those with above average protein needs. This means that 55 grams of protein per day would be adequate for many but not all people. Those for whom the protein was a bit short would not be very short. A little milk or an occasional egg or bit of cheese, meat, or fish along with the spuds would be all that was needed.
Potatoes are also unusual for a root or tuber crop in containing serious amounts of vitamin C. A 2,000-calorie allotment of freshly harvested potatoes would contain about 680 milligrams of vitamin C. The vitamin C levels drop during storage. But even after 6 months of storage, 2,000 calories of potatoes would provide about 230 milligrams of vitamin C, still well over the RDA. That amount of potatoes would also provide more than the RDAs for several other important vitamins and minerals-thiamin, niacin, B6, folate, iron, phosphorus, potassium, magnesium, manganese, and copper. It would also provide significant amounts of many other vitamins and minerals, including 184 grams of calcium.
An all-potato diet comes as close to being nutritionally balanced as any all-one-food diet you can imagine. It isn't a complete diet, however. Most notably, it lacks fat, including essential fatty acids. It also lacks Vitamin A/carotene. (It may also be low in calcium. Calcium needs are controversial.) I was also eating kale, cabbage, sauerkraut, carrots, winter squash, and eggs from my free-range (backyard) laying flock, however. In addition, once or twice a week I bought a bit of cheese, meat, or canned fish to eat along with my spuds. And I bought and used butter as well as a full range of spices. So I wasn't short on vitamin A/carotene, fat, essential fatty acids and other vitamins and minerals.
The store-bought foods weren't nutritionally essential, given the eggs and garden. But I wasn't trying to prove anything by depriving myself more than economically necessary. I was just trying to get through some hard times and stay maximally functional in the process. Eating well helps a lot. No single food can provide a complete diet. But a serious potato patch, a modest vegetable garden, and a few free-range layers in the backyard can provide a complete diet. My laying flock are ducks, incidentally, because ducks are better adapted to year-round free-ranging in the maritime Northwest. They are the ecologically ideal livestock for our region. They love cold rain and lots of large slugs. Chickens are miserable and unproductive in cold rain and can't eat large slugs. If I lived in a region where the ground was frozen for large parts of the winter, necessitating keeping the birds indoors for months, I would keep chickens instead. Chickens are a better confinement animal.
As staple crops, we also grew polenta corn, corn-bread corn, and dry beans of several kinds. But except for an occasional batch for variety, I was saving those other foods for after the potatoes ran out. We also had plenty of winter squash of gourmet varieties. But we had got burned out on winter squash the year before when we grew 1,500 pounds of one variety as part of a breeding project. It's pretty easy to eat half a ton of potatoes and enjoy doing it. It turns out it isn't all that easy to eat half a ton of squash. Gourmet varieties or not, we got too sick of squash to get over it in just a year.
Chris Voigt prepared for his two month 20 Potato Per Day ordeal, and an ordeal it clearly was to him, by pigging out on foods he expected to miss, resulting in his gaining weight just before starting his diet. I began my Nearly All Potato Winter right after Nate finished harvesting, and we stood in our attached garage gloating over an entire wall of shelves full of bags of potatoes-about 1,200 pounds, of 18 varieties. "Whatever else," I said happily, "We're going to eat well this winter!"
"I can hardly wait to make a batch of hash-browned Azul Toros!" Nate said.
"I can't wait to sink my teeth into a baked Amey Russet!" I responded, continuing, "And I really can't wait to begin taste-testing the new varieties!"
Happiness is 1,200 pounds of gourmet-quality potatoes tucked away for winter.
Meanwhile, Chris Voigt, at the one-month half-way mark in his 20 Potato Per Day Diet, has lost 13 pounds. This is in spite of his diet including potato chips and more fat than he planned originally, though he is clearly trying to limit fat. His energy levels are fine, he reports. He isn't finding it easy, but he seems to think his diet is working. And so it is, if the purpose is to prove that even huge amounts of potatoes without much fat or fatty toppings are not fattening. But the stated purpose was to demonstrate that potatoes are nutritious. For that, Voigt needed to be able to maintain his weight on the diet. And he hasn't. At the rate he is losing weight, if he were to stay on his diet for another 16 months he would vanish entirely.
Voigt's diet has also slipped a bit. He started off planning to eat only potatoes and seasonings, with just a little fat. He did allow certain things with no nutritional value, such as coffee, tea, diet soda, and artificial sweeteners. He allows potatoes in all forms, including French fries, chips, jojos, instant mashed potatoes, dehydrated potatoes, and potato starch. He could, undoubtedly, gain weight on the diet if he wished by simply eating more potato chips and French fries and fewer fresh potatoes minimally dressed. But he is obviously trying to limit fat.
By mid-point, Voigt's diet includes more fat as well as occasional doses of potato chips, chicken bullion, little packets of fast-food hot sauce, and even some fast-food fries. There are, in addition, clear signs of desperation. "Pickles" made by soaking sliced raw potatoes in pickle juice. A concoction of "potato ice cream" made from riced potatoes, cocoa powder, and artificial sweetener. By now Voigt's diet is a nearly all potato diet, just as mine was from the beginning. Voigt's non-potato component, however, is of relatively low dietary and culinary value. My non-potato components turn each meal of potatoes into a feast as well as ideally complement the spuds nutritionally.
Chris Voigt's diet is partly aimed at publicizing his objection to the fact that potatoes are excluded from the foods that can be purchased by those on the USDA WIC program. Potatoes are the only fresh vegetable, fruit, root, or tuber excluded. Why isn't obvious. It's fresh potatoes we're talking about allowing or not allowing WIC participants, not frozen French fries. And while you can do fattening things with spuds, you can do so with bread also. So why are only the spuds disbarred? When Voigt inquired, he was told that Americans already eat enough potatoes. This reason doesn't work for me. Bread is not excluded just because people already eat plenty of bread. Cereal is not excluded just because people already eat lots of cereal. I think there genuinely is an unfair and inappropriate bias against the potato. In fact, in the popular diet and nutrition press, potatoes often seem to get a bad rap.
Some of the bad rap for potatoes comes from recent diets that feature lots of fats and as close to no carbohydrates as possible, such as the Atkins diet. I don't think such diets are healthy. And if they were, I don't think I could tolerate them for very long. A second problem is guilt by association. Potatoes fried in lots of oil are fattening. Potatoes drenched with large amounts of butter or sour cream are fattening. Oil, butter, and sour cream are fattening. Potatoes aren't. Boiled potatoes have only about 80 calories per 100 grams fresh weight. (100 grams is slightly less than 1/4 pound.) Baked potatoes run about 90. Mashed potatoes with milk and butter are still typically only 90-100. The same weight of bread, depending upon the recipe, has about 240-290 calories per 100 grams. A single slice of bread is about 80-110 calories. Most common unsugary cereals range from about 100-400 calories per 100 grams. Even cooked brown rice with no butter or fat is about 120. A single tablespoon of butter or other oil or fat, however, has about 100 calories. So putting a tablespoon of butter on 100 grams of spuds more than doubles the calorie content.
There is one legitimate nutritional concern about potatoes however. Potatoes have a high glycemic index. We digest them as fast or faster than almost anything, and turn their carbohydrates into pure glucose, blood sugar, the sugar our bodies are designed to run on. A food that is maximally easy to digest and whose carbohydrates are turned almost totally into exactly the form that our bodies can use most easily-shouldn't this be considered the epitome of excellence in a food? Why are all the foods that are harder to digest or that contain or turn part of their carbohydrate into other less directly useful sugars be considered superior? By this reasoning, a food that is so hard to digest that it provides no food value ever and raises blood sugar not at all should be considered best. (Rocks, anyone? Yum yum!)
I prefer to view the high glycemic index of potatoes as proof positive that they are the epitome of excellence in a food. Practically speaking, of course, if you eat a large amount of potatoes all at once with no fat or other ingredients to slow down your digestion, you'll get a big spike in blood sugar. That can be problematic for some people, people with carbohydrate sensitivity, of whom I am one. The big spike in blood sugar can cause the addition of sugars to proteins where they don't belong. In addition, it can trigger a spike in insulin production that may then drive your blood sugar down to below normal levels, resulting in hunger, shakiness, and food cravings shortly after eating. I have such problems if I don't pay attention to what I eat. That doesn't mean I eliminate potatoes from my diet. Instead, I learn how much potato I can eat at what times of day without getting the sugar jags and shakiness that indicate a blood sugar spike.
Of course, additional lower-glycemic-index foods eaten along with the potatoes also slow down the digestion. And in addition, we can also avoid blood sugar spikes by spreading our potato intake out in time. Two smaller meals of potatoes may work fine even though the same amount of spuds in one meal might cause problems. If we take these kinds of factors into account as well as our individual reactions, even those of us with serious carbohydrate sensitivities can make full use of potatoes and other foods that have high glycemic indexes. (I make no recommendations for diabetics, as I am not knowledgeable enough about that.)
Even those who aren't concerned about glycemic indexes often seem to discriminate against the potato. I think it is a result of subtle biases. Grain was the staff of life in Europe prior to the Little Ice Age. Climate change and unpredictable weather associated with the Little Ice Age made it much more difficult to grow grain, with widespread resulting famines and disease. The potato, a New World crop, was introduced in this period, and became one of the major saviors of European peasantry. Potatoes were easier to grow and much higher producers of both carbohydrate and protein per unit land or per amount of labor than any other temperate-climate crop. They are also much easier to process and cook than grain. But above all, potatoes were much more reliable than grains in the face of unpredictable, stormier, wetter, colder, or more erratic weather. In the Little Ice Age, peasants increasingly ate potatoes. Only the upper classes could still eat mostly grain.
When the USDA denies WIC-program women, infants, and children their potatoes, in spite of the potato's known excellence as a food, in spite of how much we all like it, I think I detect a subtly Euro-centric as well as classist message: "The right way to eat is like upper-class Europeans, not like New Worlders or peasants." The problem is bigger than failing to recognize that Americans are not all Europeans, that even most European-Americans now embrace food traditions from many lands and cultures, and that most of us are closer to being peasants than to being medieval European royalty. To reject the potato is to be several hundred years out of date. Rejecting the potato represents a failure to learn some of the most important climate-change lessons of the Little Ice Age. I think the USDA should revisit its potato policy.
It's fall again. Once again the shelves in the garage are full of bags of potatoes, this time about 1,600 pounds of potatoes of 23 varieties. Now we have plenty of polenta corn and cornbread corn, enough to eat it year round instead of needing to hold back until the spuds run out. But our corn is still mostly on the ear, still being processed. The squash patch was a bust this year. In between the coldest summer I've ever experience and a rototiller that quit at the wrong time, the squash patch really just didn't happen. There are plenty of duck eggs. And there are lots of dry beans this year, enough to eat good amounts through the year. And we have finished processing our dry beans and have started eating them. They go great with potatoes. Best of all, there are another half dozen new potato varieties to try out, to cook with all possible methods, to taste test, to explore, to discover the special virtues of. Happiness is 1,600 pounds of potatoes tucked away in the garage, with another half dozen new varieties.
L-Leucine Essential To Your Basic Health!
L-Leucine (C6H13NO2) is an essential branched-chain amino acid (BCAA) that's broken down in fat structures. The other two essential BCAA's are L-Valine and L-Isoleucine.
L-Leucine can not be made by the body, and must be acquired through food or dietary supplements.
It can be found in nuts, brown rice and whole wheat bread products.
What does it do and what scientific studies give evidence to support this?
L-Leucine comprises about eight percent of the total amino acid count in your body's protein structures; it is the forth most concentrated amino acid in skeletal muscle tissue.
As one of the three BCAA's, L-Leucine is essential to your basic health. It has athletic applications.*
L-Leucine has many beneficial effects on sports performance. It helps preserve lean muscle tissue, it supplies the body with energy when under stress (i.e. when engaging in athletic activity), it preserves muscle glycogen (glucose stored in muscle tissue used to power muscular contraction), it maintains nitrogen balance, and it enhances thinking abilities that can decline as physical activity becomes more intense.*
The effects of L-Leucine in the diet are profound.* As the strongest of the BCAA's, L-Leucine is what's known as a "limiting nutrient" - meaning that you must have enough L-Leucine in proportion to other amino acids in order for your body to make use of what you eat.* Simply: If you suffer from an L-Leucine deficiency, your body will not be able to make use of the protein that you give it - no matter how much protein you consume.* And, unless you have enough L-Luecine, the money you spend on quality food and dietary supplements will be wasted.*
To make the most of what you eat, you need two parts L-Leucine and two parts L-Valine for every one part of L-Isoleucine. You'll fail to get optimal results if you fall short of meeting this exact ratio.*
Learn more about the benefits of L-Leucine on Clayton South's Health Facts.
Who needs it and what are some symptoms of deficiency?
L-Leucine is an essential amino acid. Therefore, everyone needs Leucine to maintain basic health.
How much should be taken? Are there any side effects?
As discussed above, L-Leucine should be dosed at two parts L-Leucine for every two parts L-Valine and for every one part of L-Isoleucine.
Strictly adhere to label directions.
No side effects have been reported, and this BCAA is generally considered to be safe for healthy persons.
Leucine supplements could help prevent muscle loss
A leucine-rich diet could reduce age-related muscle loss, say French researchers who have reported positive results on rats.
By supplementing the diet of young (8-month) and old (22-month) rats with 5 per cent leucine, the scientists from INRA's Human Nutrition Research Centre in Auvergne showed that muscle loss was repressed in the older rats.
The study also found that elevated levels of peptidase enzymes and proteasome subunits characteristic of old muscle were suppressed in 22-month old rats chronically fed a leucine-supplemented diet.
A natural balance exists in adults between muscle breakdown and buildup. After a meal muscle loss slows down and synthesis doubles. However, as we get older this balance is upset and muscle breakdown begins to dominate. Annual muscle loss for people over 40 can be as much as two per cent.
The researchers established that muscle loss does not slow down after feeding in older animals, so there is excessive loss.
"Thus the defective postprandial down-regulation of in vitro proteasome-dependent proteolysis [breakdown of contractile muscle-protein] in 22-month-old rats was restored in animals chronically fed a leucine-supplemented diet," wrote Lydie Combaret and colleagues in the December issue of the Journal of Physiology (vol 569, issue 2, pp 489-499).
A diet rich in protein, and therefore also leucine, has previously been shown to increase weight loss in highly active people. Professor Donald Layman from the University of Illinois, author of this earlier report, explained that "the diet works because the extra protein reduces muscle loss while the low-carbohydrate component gives you low insulin, allowing you to burn fat".
He also pointed out that the average American diet contains 4 or 5 grams of leucine, "but to get the metabolic effects we're seeing, you need 9 or 10 grams".
The demand for leucine and other amino acids is growing thanks to trends in the animal feed market but human nutritionists are becoming increasingly interested in amino acids and peptides for food use too.
Amino acids are already widely used in foods in Japan but with tryptophan supplements coming back on the UK market, and ingredients companies developing peptides for lowering blood pressure and other applications, amino acids like leucine may start to see increasing demand in Europe also.
Pharma-grade Vitamin K ingredient enters supplements market
By Stephen Daniells, 04-Oct-2010
Viridis BioPharma/Synergia Life Sciences has announced a 10-fold expansion of its vitamin K production facility, a move which sees the company’s pharmaceutical-grade ingredient’s availability extended to all dietary supplements.
The ingredient – MenaquinGold – is said to be manufactured to drug standards by Viridis BioPharma/Synergia Life Sciences in a dedicated GMP, Indian FDA-inspected facility in Mumbai. According to the companies, it is the only natural K2-7 from natto fermentation that is made as a drug and sold to large multinational pharmaceutical companies.
The ingredient is distributed exclusively in North American by Nu Science Trading. Talking to NutraIngredients-USA, Dale Kriz, senior managing director, Nu Science said that the ingredient had only limited availability for dietary supplement manufacturers because “demand for the product in the pharmaceutical sector was growing rapidly and thus supply was controlled”. However recent expansion at the Mumbai production facility has led to a widening in availability to the US supplement and food markets as a whole, he added.
A move towards pharma-grade?
Kriz said that supplement manufacturers were becoming more quality conscious following the introduction of GMPs. “We are seeing an increase in demand for documentation and certificates to show that the product is produced under the right quality standards.
“With this in mind, the pharmaceutical grade materials we use for MenaquinGold are of the highest quality standard and thus customers can rest assured that they are putting the safest and most efficacious products on the shelves and in the hands of consumers,” said
“Having participated in the development of more than five prescription formulations with vitamin K2-7, Nu Science Trading and Viridis BioPharma have extensive knowledge in the area of formulation and ingredient stability of vitamin K2-7,” said Kriz.
Kriz added that the companies have developed a 2500ppm granulated oil powder which reportedly offers high process stability and versatility, and is said to be the “only one of its kind on the market today”.
The ingredient’s stability has been checked under ICH guidelines and is Kosher certified, added Nu Science.
K forms
There are two main forms of vitamin K: phylloquinone, also known as phytonadione, (vitamin K1) which is found in green leafy vegetables such as lettuce, broccoli and spinach, and makes up about 90 per cent of the vitamin K in a typical Western diet; and menaquinones (vitamins K2), which make up about 10 per cent of Western vitamin K consumption and can be synthesised in the gut by microflora.
Menaquinones (MK-n: with the n determined by the number of prenyl side chains) can also be found in the diet; MK-4 can be found in animal meat, MK-7, MK-8, and MK-9 are found in fermented food products like cheese, and natto is a rich source of MK-7.
In NutraIngredients-USA’s recent focus on vitamin K, Francis Foley, president of Xsto Solutions – exclusive US distributor of Kappa’s recently launched K2Vital synthetic vitamin K Product Line – estimated the vitamin K market in the US at $10 million in raw material sales (vs finished product sales).
“What is really impressive is the growth in Vitamin K supplementation, estimated to be (my personal estimate) over 15 percent per year. We feel the K2 market can double to $20 million in less than five years,” said Foley.
The number of dietary supplements launched containing vitamin K has been relatively stable over the past four years. According to data obtained this week from Mintel’s Global New Products Database (GNPD), in 2007 86 products were launched, while 95 and 91 were launched in 2008 and 2009, respectively. So far this year 38 dietary supplements products have been launched containing vitamin K.
Branded domination
The market is dominated by branded ingredients: NattoPharma offers MenaQ7, Blue California offers Vitamin K2-All Trans, PL Thomas has Vitamin K2-MK7, and Kappa/ Xsto offers K2Vital.
Adding to this will be the wider availability of Viridis BioPharma/Synergia Life Sciences’ MenaquinGold.
Commenting on the price of the MenaquinGold ingredient, Kriz said that, despite being manufactured to pharmaceutical grade, the ingredient “is extremely competitive in pricing. We are right on par with other supplies of natural K2-7 and in most cases can even present the buyer with cost savings and provide them with a superior product,” he said.
Meta-analysis dismisses benefits of glucosamine, chondroitin
By Stephen Daniells, 17-Sep-2010
Glucosamine and chondroitin, two of the biggest hitters in the joint health segment, do not work for reducing joint pain or impact the narrowing of joint space, says a new meta-analysis.
Despite the apparent null effects, scientists state in the British Medical Journal that sufferers of osteoarthritis may continue using the supplements due to the ‘perceived’ benefit on joint health.
“Some patients, however, are convinced that these preparations are beneficial, which might be because of the natural course of osteoarthritis, regression to the mean, or the placebo effect,” state the reviewers, led by Prof Peter Jüni from the Institute of Social and Preventive Medicine at the University of Bern in Switzerland.
In addition, the reviewers support the safety of glucosamine and chondroitin supplements and “see no harm in having patients continue these preparations as long as they perceive a benefit and cover the costs of treatment themselves”, they added.
However, when it comes to paying for such supplements, Prof Juni and his co-workers are clear that consumers should shoulder the cost, and not national health services or insurance companies.
“Coverage of costs by health authorities or health insurers for these preparations and novel prescriptions to patients who have not received other treatments should be discouraged,” they stated.
Aging populations
As populations age, the burden of osteoarthritis is growing. Over 20 million Americans suffer from osteoarthritis, and it is reported to be second only to ischemic heart disease as a cause of work disability in men over 50. According to the Center for Disease Control, the direct and indirect costs are estimated to be approaching $90 billion. Elsewhere, the figures are equally worrying, with approximately seven million people in the UK alone are reported to have long-term health problems associated with arthritis.
The market for joint health ingredients is dominated by glucosamine – now a $2bn (€1.47bn) global blockbuster. It is most commonly blended with chondroitin so the two have become linked in the minds of many consumers.
Selective science
Professor Juni and his co-workers searched the literature for “large scale randomised controlled trials in more than 200 patients with osteoarthritis of the knee or hip that compared glucosamine, chondroitin, or their combination with placebo or head to head”. Of the 58 potentially eligible studies, only 10 met the inclusion criteria. This provided the reviewers with data for 3,803 people with knee or hip osteoarthritis. All studies used doses of at least 800 mg/day of chondroitin and at least 1500 mg/day of glucosamine.
According to the results, there were no clinically relevant effects of chondroitin, glucosamine, or their combination on perceived joint pain or on joint space narrowing
“We believe it unlikely that future trials will show a clinically relevant benefit of any of the evaluated preparations,” wrote the researchers.
Despite such statements, any unanswered question may be answered by the ongoing Long Term Evaluation of Glucosamine Sulphate Study (LEGS). The “industry independent” randomised trial involved 600 patients assigned to one of four groups: chondroitin sulphate, glucosamine sulphate, glucosamine plus chondroitin, or placebo. “First results will become available at the earliest in November 2011,” said Prof Juni and his co-workers.
Limitations and ‘convenient exclusions’
Commenting on the meta-analysis, Daniel Fabricant, PhD, vice president of scientific and global government affairs at the Natural Products Association (NPA) said he did not think the researchers "did a complete job of reviewing all the data at hand or all of the appropriate data given the tool (Bayesian statistics) they chose to use".
"Bayesian statistics, when used properly are allow for the inclusion of observational study data to compare those data along side with RCTs. Bayesian analysis is not predicated on randomization, and can be used to analyze data from observational studies in exactly the same way as for randomized trials... A powerful tool for certain but without looking at all the studies its sort of like driving a corvette and never taking it out of second gear."
Dr Fabricant also said that the reviewers "would be wise to be more discreet in their description of earlier RCTs, especially those with subgroups that did show some improvement. Blanket statements about efficacy are rarely accurate, especially given trials on OA which as they authors state have been conflicting.
"So, when the authors state that more research isn’t needed in this area, that wouldn’t seem to be the most prudent conclusion given that over 20 million Americans suffer from OA in some form and have few options when it comes to relief from OA," he added.
Andrew Shao, PhD, senior vice president, scientific & regulatory affairs for the Council for Responsible Nutrition (CRN) told NutraIngredients-USA that the investigators “conveniently excluded a large portion of the evidence base” on the effects of glucosamine and chondroitin
“The majority of published studies involving glucosamine and/or chondroitin are positive,” said Dr Shao. “Even the GAIT trial, with a 60 percent placebo effect showed that Glucosamine and Chondroitin were effective at reducing pain in knee osteoarthritis patients with moderate-to-severe pain – and outperforming the Rx drug Celebre,” he added.
“Furthermore, both glucosamine and chondroitin are approved drugs for osteoarthritis in various countries in Europe. This surely would not be the case if they were ineffective.
“We also must recognize that consumers have voted with their wallets - choosing to continue to derive benefits from glucosamine and chondroitin supplements, with the category experiencing significant year over year growth over the past decade. If these were ineffective, then we would not observe this kind of growth.
“The bottom line for consumers is that overall the evidence indicates that glucosamine, chondroitin or the combination is effective for improving mobility and joint discomfort in osteoarthritis patients, while also demonstrating a strong safety profile. Consumers should continue to feel confident in choosing glucosamine and chondroitin,” said Dr Shao.
Source: BMJ
Published online ahead of print, doi: 10.1136/bmj.c4675
“Effects of glucosamine, chondroitin, or placebo in patients with osteoarthritis of hip or knee: network meta-analysis”
Authors: S. Wandel, P. Juni, B. Tendal, E. Nuesch, P.M. Villiger, N.J. Welton, S. Reichenbach, S. Trelle,
Fish oils may help to activate anti-diabetic genes: Study
By Nathan Gray, 25-Oct-2010
Polyunsaturated fatty acid fish oils may activate genes that regulate fat cell differentiation and glucose homeostasis, according to new research on mice.
The new study published in Journal of Nutritional Biochemistry suggests supplementation with fish oils activates the transcription factor PPAR?, increasing regulation of adipocytes and helps to maintain glucose homeostasis.
“We demonstrated that adipogenic genes and glucose metabolism genes were elevated in PPAR? transgenic mice when fed fish oil. This transgenic mouse model provided direct evidence to demonstrate PUFA, especially EPA and DHA, regulate glucose homeostasis through interaction with PPAR?,” wrote the researchers, led by Dr Yu-Hsiang Yu from the National Taiwan University
Vital roles
Peroxisome-proliferator-activated receptor ? (PPAR?) is considered an important transcription factor in regulating fat cell (adipocyte) differentiation, and is also known to play a vital role in maintaining glucose homeostasis. The transcription factor is a target for many anti-diabetic drugs as activation promotes glucose dispersal.
Activation of PPAR? occurs through the binding of specific ligand molecules; however, polyunsaturated fatty acids such as arachidonic acid, eicosapentaenoic acid (EPA) and docosahexaenoic acid (DHA) are also known to have a high binding affinity for PPAR?.
Previous studies suggest that polyunsaturated fatty acids (PUFA) and their metabolites are able to regulate PPAR? activity, demonstrating that DHA treatment increases PPAR?-responsive gene expression in a cell model.
However, most research demonstrating PPAR? activity uses in vitro cell models and there is currently no direct evidence available to demonstrate that polyunsaturated fatty acids are able to activate PPAR? in vivo.
The authors said the current experiment was designed to determine the potential for PUFA, particularly EPA and DHA, to activate the function of PPAR? in vivo.
Wild-type and transgenic mice – with over expressed PPAR? –were supplemented with either fish oil or PPAR? ligands (rosiglitazone) for four months to investigate whether fish oils have similar effects to true PPAR? ligands in vivo.
Results
Dietary rosiglitazone fed mice had a significantly lower feed intake, but had no significant effect on body weight or fat pad weigh, whereas fish oil supplementation did not significantly decrease feed intake, but significantly decreased body and fat pad weight, found the researchers.
Dr. Yu and colleagues reported that adipogenic genes (LPL, FAT, SREBP-1c and FAS) were markedly up-regulated by rosiglitazone supplementation. Fish oil supplementation increased LPL and FAT, but not SREBP-1c or FAS; however, stained muscle sections indicated no lipid accumulation in skeletal muscle.
Researchers noted that transgenic mice fed a fish oil supplementation had increased expression of adipogenic and glucose uptake genes, leading to reduced plasma glucose concentration.
Natural regulator
The authors suggested that polyunsaturated fatty acids, particularly EPA and DHA, may serve as a natural regulator of glucose uptake in vivo, stating that such effects are mainly mediated through PPAR? activation.
“Our data demonstrated that the PPAR?-regulated glucose metabolism genes, GLUT-4 and ADN were dramatically increased in skeletal muscle of PPAR? transgenic mice when fed rosiglitazone or fish oil, suggesting activation … by either ligand,” concluded the authors.
Source: Journal of Nutritional Biochemistry
Published online ahead of print, doi: 10.1016/j.jnutbio.2010.01.006
“The function of porcine PPAR? and dietary fish oil effect on the expression of lipid and glucose metabolism related genes”
Authors: Y.H. Yu, S.C. Wu, W.T.K. Cheng, H.J. Mersmann, T.L. Shen, S.T. Ding
Copyright - Unless otherwise stated all contents of this web site are © 2000/2010 - Decision News Media SAS - All Rights Reserved - For permission to reproduce any contents of this web site, please email our Syndication department: Administration & Finance - Full details for the use of materials on this site can be found in the Terms & Conditions
Multivitamin use linked to fewer heart attacks for women
By Nathan Gray, 14-Oct-2010
Women who take a daily multivitamin may be at a reduced risk of heart attacks, according to new research.
The study, published in the American Journal of Clinical Nutrition, observed multivitamin use to be inversely associated with myocardial infarction in women with no history of cardiovascular disease. The researchers noted that the association grew stronger with long-term use, and was not affected by how often supplements were taken.
“From a public health point of view, it is important to evaluate whether multivitamins should be recommended to prevent myocardial infarction,” stated the researchers, led by Dr Susanne Rautiainen, from the Divisions of Nutritional Epidemiology at the Karolinska Institutet, Sweden.
The new research shows correlation and not causation, however, and the researchers noted that further research must be completed in order to confirm or refute their findings. If such findings supported this study’s observation then it would be important to “clarify what composition of multivitamins (doses and ingredients included) and duration of use is needed to observe beneficial effects on myocardial infarction,” wrote Dr Rautiainen and her co-workers.
Frequent use
Multivitamin and mineral supplements are the most frequently used supplements in industrialised countries, where there is a common belief is that they ensure an adequate nutrient intake, which can help to prevent coronary heart disease
Most multivitamins contain a wide spectrum of nutrients, including antioxidant vitamins, B vitamins, and minerals such as magnesium and selenium – all of which have been inversely related to heart disease by previous research.
Despite the widespread use of multivitamins, the authors noted the limited data available on the relationship between multivitamin use and coronary heart disease incidence, with only one previously published randomized controlled trial on low-dose multivitamin supplements and heart disease incidence, which showed no significant effects.
However, some observational studies have associated multivitamin use with statistically significant effects on the risk of myocardial infarction, with a Dutch study finding a 51 percent lower risk of incidence in a prospective cohort study (American Journal of Clinical Nutrition, Vol. 69, No. 2 ). Additionally, an American study observed combined use of multivitamins and supplements of vitamin A, C, or E to be associated with a 25 percent lower risk of coronary heart disease mortality.
The new study prospectively investigated the association between multivitamin use and myocardial infarction in a population of over 30,000 Swedish women between 49 and 83 years old.
Lower risk
In women with no history of cardiovascular disease, the researchers observed that use of multivitamins alone – compared with no use of supplements – was associated with a 27 percent lower risk of myocardial infarction.
They found women using multivitamins together with other supplements had a 30 percent lower risk of myocardial infarction; however the use of supplements other than multivitamins was not significantly associated with such effects.
Researchers noted that the observed associations were similar among regular and occasional users of multivitamin supplements.
On the other hand, multivitamin use, alone or in combination with other supplements, was not statistically significantly associated with myocardial infarction in women with a history of cardiovascular disease.
The association between multivitamin use and myocardial infarction was seen to be stronger among women using multivitamins for more than five years.
Protective effect?
Researchers suggested the potentially protective effects of multivitamins on myocardial infarctions may the due to antioxidant vitamins – such as vitamin C and vitamin E –, and B vitamins and minerals included.
“Even if multivitamins contain low amounts of antioxidant vitamins […] they may be involved in mitigating the atherosclerotic process by scavenging free radicals,” suggested the authors.
Source: American Journal of Clinical Nutrition
Published online ahead of print, doi: 10.3945/ajcn.2010.29371
“Multivitamin use and the risk of myocardial infarction: a population-based cohort of Swedish women”
Authors: S. Rautiainen, A. Åkesson, E.B. Levitan, R. Morgenstern, M.A Mittlemanand A. Wolk
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Tea and coffee may reduce brain tumor risk: EPIC Study
By Nathan Gray, 19-Oct-2010
Daily intakes of more than 100 ml of tea or coffee may significantly reduce the risk of certain brain tumors, according to new research published in the American Journal of Clinical Nutrition.
The study is based on data from over half a million people in the European Prospective Investigation into Cancer and Nutrition (EPIC) study, and finds that people consuming over 100 ml of tea, coffee, or both, per day are at significantly lower risk of glioblastoma tumours (glioma) than those consuming less than 100 ml per day.
“In this large cohort study, we observed an inverse association between total coffee and tea consumption and risk of glioma,” wrote the researchers, led by Dr. Dominique S Michaud from the Department of Epidemiology and Public Health at Imperial College, London.
Poor prognosis
According to the American Brain Tumor Association, glioma's are tumors that start in the supportive tissue brain. The exact causes of gliomas are not known, however the prognosis for people once diagnosed with the type of tumour is usually very poor.
A recent US study found total coffee and tea consumption was inversely associated with risk of glioma, whilst experimental studies have shown caffeine can slow the invasive growth of glioblastoma tumours.
However very few large scale epidemiologic studies have measured the association between coffee, tea, or caffeinated beverages and glioma risk. The authors noted that the results of these studies “have been inconsistent”.
“Given the limited evidence suggesting that coffee and tea intake may reduce the risk of glioma, more studies are needed to address this hypothesis,” stated the researchers.
In the new study, the researchers examined the relation between coffee and tea intake and risk of glioma and meningioma.
Inverse association
A significant inverse association was observed for glioma risk when consuming more than 100 ml coffee and tea per day, compared consuming less than 100 ml per day.
However, the researchers observed no association between coffee, tea, or combined coffee and tea consumption and risk of either type of brain tumor when looking at data based on country-specific intakes.
No association was reported for meningioma risk with the same intake values for coffee and tea intake combined, or when a higher cutoff of 200 ml per day was used.
Potential mechanisms
“Given that we did not observe an association between coffee and tea consumption and meningioma risk, it is possible that the effect of coffee, if causal, is acting late in the process of carcinogenesis by preventing tumor growth,” suggested the researchers.
Another potential mechanism that may be implicated in the observed effects, involves the DNA repair protein MGMT. Higher activation of MGMT is believed to have a protective effect against development of several types of cancer, including colon cancer and glioma.
Coffee compounds kahweol and cafestol have been reported to increase MGMT activity in rats, whilst certain tea polyphenols are known to reactivate genes in cancer cells – including MGMT.
“These findings, if further replicated in other studies, may provide new avenues of research on gliomas,” they added.
Source: American Journal of Clinical Nutrition
Published online ahead of print, doi:
“Coffee and tea intake and risk of brain tumors in the European Prospective Investigation into Cancer and Nutrition (EPIC) cohort study”
Authors: D.S Michaud, V. Gallo, B. Schlehofer, A. Tjønneland, A. Olsen, K. Overvad, et al.
Copyright - Unless otherwise stated all contents of this web site are © 2000/2010 - Decision News Media SAS - All Rights Reserved - For permission to reproduce any contents of this web site, please email our Syndication department: Administration & Finance - Full details for the use of materials on this site can be found in the Terms & Conditions
Oat beta-glucan LDL effect linked to molecular weight and gut viscosity
By Jess Halliday, 26-Oct-2010
The ability of oat beta-glucan to lower LDL cholesterol is related to its molecular weight and viscosity in the gut, a new study has found – and manufacture using an extrusion process makes the beta-glucan more soluble and produces higher viscosity.
Beta glucan from oats is renowned for its potential to reduce LDL (bad) cholesterol. The FDA allowing a health clam on reduced risk of heart disease and the European Food Safety Authority (EFSA) recently published a positive generic (article 13.1) health claim on the cause and effect of oat beta-glucan lowering cholesterol.
However the authors of the new study noted that not all the research has drawn positive conclusions. This inconsistency seems to be down to the molecular weight of the beta glucan (MW), which effects viscosity of the gut contents, and its solubility. The higher the viscosity in the upper gut (small intestine) the greater the observed effect on LDL cholesterol.
The researchers said that the MW and solubility can be affected by normal methods of processing and storage. There have been concerns that high temperature and pressure processing would break down the beta-glucan molecules and make them lose their effectiveness. This now seems to be unfounded in the case of extrusion.
The team set out to test whether 3g high MW beta glucan would reduce LDL cholesterol, and whether the cholesterol lowering was related to MW and viscosity.
Their study involved 345 participants with high LDL cholesterol, who were randomly assigned to receive a manufactured extruded cereal with one of four different additions for 4 weeks: wheat fibre; 3g high MW beta glucan; 4g medium MW beta glucan; 3g medium MW beta glucan; or 4g low MW beta glucan. The doses were split across two servings a day.
The study was multi-centre, with participants in Canada, Australia and the United Kingdom. The source of the beta glucan used in the cereals was Oatwell oat bran, supplied by Swiss company CreaNutrition.
Once a week the participants gave a fasting blood sample and were weighed, had their blood pressure measured and changes in medication and any adverse effects were noted. The blood samples were analysed for total and HDL cholesterol, triglycerides, glucose, AST, CRP, urea and creatine, and LDL cholesterol was calculated. The participants also had to provide a diet record.
At the end of the 4 week period, the researchers found that the participants who took the 3g high MW, 4g medium MW, and 3g medium MW beta glucan was significantly lower than those that took the 4g low MW and the wheat fibre – by an average of 0.21, 0.26, and 0.19 mmol/L respectively.
“The physicochemical properties of oat beta-glucan should be considered when assessing the cholesterol-lowering ability of oat-containing products,” concluded the researchers. “An extruded breakfast cereal containing 3g oat beta-glucan/d with a high MW (2,210,000 g/mol) or a medium MW (530,000 g/mol) lowered cholesterol similarly by around 0.2mmol/L (5%) but efficacy was reduced by 50% when MW was reduced to 210,000 g/mol.”
Ruedi Duss of CreaNutrition, who was also one of the authors, told NutraIngredients.com that the study is significant because 1.5 g bioactive oat beta-glucan from an eligible oat source consumed twice a day as part of a normal diet has not been studied by any scientific group before.
“As far as we know this is the largest ever published international multicenter RCT trial based on bioactive oat beta-glucan ,” he said, drawing attention to the consistent results across three continents.
“And the study could also show non bioactive oat beta-glucan has no effect,” he said.
Source: American Journal of Clinical Nutrition
2010, Volume 92, Pages 723-732
"Physicochemical properties of oat beta-glucan influence its ability to reduce serum LDL cholesterol in humans: a randomized clinical trial"
Authors: Wolever, T., Tosh, S., Gibbs, A., Brand-Miller, J., Duncan, A, Hart, V., Lamarche, B., Thomson, B., Duss, R., Wood, P.
CoQ-10 is a very affective supplement that aids in heart health, as well as reduces free radicals. Make sure to take the Ubiquinol form. It's better absorbed than traditional CoQ-10. I love this company Biotics Research Corporation.
CoQ10 also aids in helping produce more energy, but the energy you get isn't in the form of stimulants. It gives more energy from a cellular form if that makes sense. I used to own a nutrition store, and I've been in the health care business for more than 12 years. I know a lot about supplementation and which companies to use.
Please feel free to PM me and ask me about any supplements.
Coenzyme Q10 Boosts Energy, Promotes Heart Health and Assists Weight Loss
by John Phillip, citizen journalist
(NaturalNews) Coenzyme Q10 is an amazing chemical cofactor which is required by every cell in the body to produce the energy we need to live. It's been shown to increase the level of energy to all muscles and is especially important to cardiac function as it increases energy production at an optimal rate. Coenzyme Q10 provides the necessary energy to fuel our immune system, as it mounts an attack against invading pathogens and improves the release of fat from storage by improving oxygen utilization. Our production of CoQ10 decreases as we age so it's necessary to supplement with the correct form of this enzyme to achieve the important health benefits.
Boost Energy and Improve Heart Health
The primary unit of energy used by the mitochondria of our cells is known as ATP, and Coenzyme Q10 is the only chemical facilitator which can be used by the body to make this critical fuel. A shortage of this coenzyme means our muscles don't function efficiently and the aging process is accelerated. Coenzyme Q10 is also a powerful antioxidant which has been shown to influence arterial elasticity.
The results of a study published in the journal Nutrition and Metabolism show that combining Coenzyme Q10 with other powerful antioxidants including Vitamins C, E and selenium significantly improved an array of cardiovascular risk factors including arterial function, blood pressure, blood sugar and protective HDL cholesterol. Billions of dollars are spent annually on pharmaceuticals which are largely ineffective at improving cardio biomarkers and have the potential to wreak havoc throughout the body.
Provides Critical Energy for Strong Immune System Function
Our immune system requires considerable energy to combat potentially lethal pathogens and rogue cancer cells. Coenzyme Q10 has been found to help boost our immune system when an invader is detected. The coenzyme works at the cellular level by providing critical support for our natural killer cells which are the first line of defense in detecting and removing viral and bacterial invaders.
Coenzyme Q10 has also been shown to lower levels of damaging systemic inflammation by down regulating the secretion of chemicals (NF-kappaB) which lower our immune response. Researchers have shown that increasing blood levels of the coenzyme can raise antibody response by 57% which improves the time it takes for our immune system to respond to an invader.
Burn More Fat and Assist Weight Loss Efforts
Coenzyme Q10 provides needed energy to improve the effectiveness of exercise as it increases oxygen utilization and fat metabolism. By improving the efficiency of how raw energy components are converted into ATP, coenzyme Q10 stimulates metabolic rate and controls how quickly fat is released from our white adipose tissue. Researchers have found that combining Coenzyme Q10 with regular aerobic exercise significantly increases fat release compared with just exercise alone.
The importance of Coenzyme Q10 to human health has been confirmed by a large number of scientifically validated studies. Benefits include improved cardiovascular and immune system health from the nutrient's ability to lower inflammation, increase antioxidant status and assist metabolic function. Most adults need to supplement with 100 mg each day to improve health and dramatically lower disease risk.
Amazing..keep it up!~
By the way my dog's tumor in her throat must be shrinking with the use of huge dose of http://www.polymva.com or I am hard of hearing. I will post my experience here as it evolves.
She wheezed very hard til we went to the vet Monday at 6:30 am ET. She was diagnosed with massive growth inhibiting breathing passages and warned that I should think about her potential suffering. Now in 36 hours of treatment every 2-3 hours....no wheezing.
I will post her results - good or bad.
I'll check it out~
Coenzyme Q-10 - Dosage & How to Take It
Orally
There is no "standard" dose of Q10 that a person requires.
In adults, typical dose used is 50 to 1,200 milligrams daily (in two or three divided doses). 100 mg is a commonly used dosage. Start with a low dose and slow increase to reduce chance that side effects that might appear.
For increasing sperm count, dosage of 200 mg daily has been used for 6 months. See Herbs to Increase Fertility for more information on remedies to treat infertility in men and women.
Topically (on the skin)
Creams containing various concentrations of Co Q10 are used to help treat wrinkles and signs of the aging skin.
Coenzyme Q-10 - Common Drug & Health Condition Interactions
Warfarin / Blood Thinners / Bleeding Disorder - caution
There has been some reports of Co Q10 increasing the risk of bleeding in those people taking blood thinners.
High Blood Pressure Medication / High Blood Pressure - caution
Co Q10 is suspected to lower blood pressure. Monitor your blood pressure when you are starting or stopping this supplement.
Blood Sugar Medications / Diabetes - theoretical
Coenzyme Q10 is suspected to lower blood sugar levels, but current research does not show this effect. Monitor your blood sugar when you start or stop this supplement just in case.
Cholesterol Medications - theoretical
Co Q10 may lower cholesterol levels. Have your doctor monitor your blood cholesterol levels if you are planning to take Co Q10.
Thyroid Medications - theoretical
Co Q10 is suspected to change thyroid levels, especially if you are taking thyroid supplements (such as Eltroxin, Synthroid, Levothroid, Levoxyl or Unithroid).
Coenzyme Q-10 - Suggested Benefits and Traditional Uses
Orally
•age-related macular degeneration (AMD)
•anti-aging benefits
•antioxidant benefits
•Alzheimer's disease / dementia
•angina
•asthma
•breast cancer
•coenzyme Q10 deficiency
•congestive heart failure
•diabetes
•enhance athletic performance
•enhancing the immune system
•extending life
•heart attack (myocardial infarction / MI)
•heart disease
•high cholesterol
•HIV / AIDS
•hypertension (high blood pressure)
•kidney disease and failure
•male infertility / enhances fertility
•migraine headaches
•muscular dystrophies
•Parkinson's disease
•reduces risk of high cholesterol medication use (statins)
•tinnitus
Topically (on the skin)
•photo-damaged skin
•wrinkles
Side Effects, Toxicity and Warnings
Co Q10 has very little side effects. Most are mild and disappears with stopping this supplement or lowering the dose.
Possible side effects of taking this supplement include heartburn, nausea, vomiting, loss of appetite, skin rash, insomnia, headache, fatigue, irritability and flu-like symptoms.
Co Q10 may lower blood pressure. Monitor your blood pressure when starting or stopping this supplement.
Safety - Research studies have been done on Q10 lasting up to 30 months with no evidence of danger. It has been used in children for up to 9 months with minimal risks.
Pregnancy and Lactation - There is no information available on using CoQ10 during pregnancy or lactation.
Take a very close look at CoQ-Quinol from premier research labs...Supposedly very absorbable and effective....tastes like crap though.
Facts about Coenzyme Q-10
What is it?
It is vitamin-like chemical that is found in practically all the cells in our body, especially the heart. It shows antioxidant properties and the body uses it the generate ATP, a storage form of energy. Coenzyme Q-10 levels drops after the age of 20 and after 80 years old, it can be lower than the levels found in you at birth.
Is has been used in Japan since 1974 to treat congestive heart failure.
Coenzyme Q10 is used extensively in Europe, Russia and Japan. The Japanese uses it to treat heart disease and is approved for use in treating congestive heart failure.
Some prescription medications are thought to lower the Co Q10 levels in our body. These includes:
?antipsychotic medications
?beta blockers
?diabetic drugs
?"statins" for lowering cholesterol such as Zocor, Mevacor and Crestor
?Alzheimer's disease medications
?heart medications
?cancer drugs
?"water pills" (diuretics)
What happens when you are having a Coenzyme-Q10 deficiency?
Research studies suggest that low levels of Co Q10 are found in people with heart disease, Parkinson's disease, cancer, diabetes, muscular dystrophy and HIV/AIDS.
As well, low levels of coenzyme Q10 might interfere with the energy production pathway in our body. The benefits of taking Co Q10 have not been clearly shown in research studies in humans.
Rooibos tea Rooibos is grown only in a small area in the region of the Western Cape province.[2] Generally, the leaves are oxidized, a process often, and inaccurately, referred to as fermentation by analogy with tea-processing terminology. This process produces the distinctive reddish-brown colour of rooibos and enhances the flavour. Unoxidized "green" rooibos is also produced, but the more demanding production process for green rooibos (similar to the method by which green tea is produced) makes it more expensive than traditional rooibos. It carries a malty and slightly grassy flavour somewhat different from its red counterpart.
[edit] Use
In South Africa it is common to drink rooibos tea without milk, but instead with a slice of lemon and sugar or honey to sweeten. The flavour of rooibos tea is often described as being naturally sweet (without sugar added) and slightly nutty. Rooibos can be prepared in the same manner as black tea, and this is the most common method.
Several coffee shops in South Africa have recently begun to sell "red espresso", which is concentrated rooibos served and presented in the style of ordinary espresso. This has given rise to rooibos-based variations of coffee drinks such as red lattes and red cappuccinos. Iced tea made from rooibos has recently been introduced in South Africa, Australia, and in the United States.
[edit] Nutritional and health benefits
Rooibos is becoming more popular in Western countries particularly among health-conscious consumers, due to its high level of antioxidants such as aspalathin [3] and nothofagin, its lack of caffeine, and its low tannin levels compared to fully oxidized black tea or unoxidized green tea leaves.[citation needed] Rooibos also contains a number of phenolic compounds, including flavanols, flavones, flavanones, and dihydrochalcones.[4]
Rooibos is purported to assist with nervous tension, allergies and digestive problems.[5]
Traditional medicinal uses of rooibos in South Africa include alleviating infantile colic, allergies, asthma and dermatological problems.[6][7]
[edit] Scientific study
Although human studies of rooibos are scarce in the scientific literature, animal studies suggest it has potent antioxidant, immune-modulating and chemopreventive effects. In addition, rooibos tea has not been found to have any adverse effects.[8]
It is often claimed that "Green" rooibos (see above) has a higher antioxidant capacity than fully oxidized rooibos. However, one study, using two different ways of measuring antioxidant activity, found conflicting data, with green rooibos showing more activity under one measure, and less activity using the other. The study also found conflicting data when comparing both forms of rooibos to black, green, and oolong tea, although it consistently found both forms to have less activity than green tea.[9]
In 2010, eleven poison dart frogs were raised at WWT Slimbridge by amphibian keepers in pint glasses of water, topped up with shop-bought Rooibos tea. Rooibos was used because it contains antioxidants with anti-fungal properties. This successfully protected the frogs against infection by chytridiomycosis.[10]
A recent study performed by Japanese scientists also suggests that Rooibos tea is beneficial in the treatment of acne. This is due to levels of alpha hydroxy acid, zinc and superoxide dismutase present in the herb.[citation needed]
[edit] Grading
Rooibos grades are largely related to the percentage "needle" or leaf to stem content in the mix. A higher leaf content will result in a darker liquor, richer flavour and less "dusty" aftertaste. The high grade rooibos is exported and does not reach local markets, with major consumers being EU, particularly Germany, where it is used in creating flavoured blends for loose leaf tea markets. In development within South Africa are a small number of specialty tea companies producing similar blends.[citation needed]
[edit] History
Through the 17th and 18th centuries, European travellers and botanists visiting the Cederberg region in South Africa commented on the profusion of "good plants" for curative purposes. In 1772, Swedish botanist Carl Thunberg noted that "the country people made tea" from a plant related to rooibos or redbush.
Traditionally the local people would climb the mountains and cut the fine needle-like leaves from wild rooibos plants. They then rolled the bunches of leaves into hessian bags and brought them down the steep slopes on the backs of donkeys. The leaves were then chopped with axes and bruised with hammers, before being left to dry in the sun.
The Dutch settlers to the Cape developed rooibos as an alternative to black tea, an expensive commodity for the settlers who relied on supply ships from Europe.[11]
In 1904, Benjamin Ginsberg, a Russian/Jewish settler to the Cape, riding in the remote mountains, became fascinated with this wild tea. He ran a wide variety of experiments at Rondegat Farm, finally perfecting the curing of rooibos. He simulated the traditional Chinese method of making very fine Keemun, by fermenting the tea in barrels, covered in wet, hessian sacking that replicates the effects of bamboo baskets.[12]
In the 1930s, Ginsberg persuaded local doctor and Rhodes scholar Dr. le Fras Nortier[13] to experiment with cultivation of the plant. Le Fras Nortier cultivated the first plants at Clanwilliam on the Klein Kliphuis farm. The tiny seeds were difficult to obtain, as they dispersed as soon as the pods cracked, and would not germinate without scarifying. Le Fras Nortier paid the local "volk", some of whom were his patients, to collect seeds. An aged Khoi woman came again and again, receiving a shilling for each matchbox filled with seed. She had found an unusual seed source: having chanced upon ants dragging seed, she followed them back to their nest and, on breaking it open, found a granary.[13] The attempts by Dr. le Fras Nortier were ultimately successful, which led Ginsberg to encourage local farmers to cultivate the plant in the hope that it would become a profitable venture. Klein Kliphuis became a tea farm, and within ten years the price of seeds soared to an astounding £80 a pound, the most expensive vegetable seed in the world. Today the seed is gathered by special sifting processes, and Klein Kliphuis is now a guest farm.[14]
Since then, rooibos has grown in popularity in South Africa, and has also gained considerable momentum in the worldwide market. A growing number of brand-name tea companies sell this tea, either by itself or as a component in an increasing variety of blends.
[edit] US trademark controversy
In 1994, Burke International registered the name "Rooibos" with the US Patent and Trademark Office, thus establishing a monopoly on the name in America at a time when it was virtually unknown there. When the plant later entered more widespread use, Burke demanded that companies either pay fees for use of the name, or cease its use. In 2005, the American Herbal Products Association and a number of import companies succeeded in defeating the trademark through petitions and lawsuits, and after losing one of the cases, Burke surrendered the name to the public domain.[15]
[edit] Legal protection of the name Rooibos
If passed by the parliament of South Africa[dated info], the Intellectual Property Laws Amendment Bill [16] of 2008 will provide for the protection and restriction on commercial use of the name Rooibos in that country. Similar legislation (protection of the names Champagne and Port for example) already exists in Europe. This is despite Rooibos South Africa's decision to contest the Burke trademark on the grounds that "rooibos" is a generic term, rather than claiming it as a geographic indication.
10 Reasons Why Flu Shots Are More Dangerous Than a Flu!
Submitted by Buzz Team on Wednesday, 20 October 201041
http://www.bewellbuzz.com/general/10-reasons-flu-shots-dangerous-flu/
Best and Worst: Top 10 Most Inflammatory and Anti-Inflammatory Foods!
Inflammation: A localized physical condition in which part of the body becomes reddened, swollen, hot and often painful, especially as a reaction to injury or infection.
We all know when something is inflamed. But, what about inflammation on the inside of our bodies? Internal inflammation can happen for a host of different reasons: high temperatures when cooking food, eating processed foods, sugar, trans fats, etc. A high level of inflammation within the body can cause many health problems. An easy way to combat this? Eat more anti-inflammatory foods and eliminate the inflammatory ones.
But, what is an anti-inflammatory food? More importantly, what is an inflammatory food? While you know healthy, whole foods from processed foods, none of us can see the true effect they have on our bodies (sometimes, until it's too late).
Often diseases such as diabetes, PCOS, excess weight gain, coronary heart disease and countless other illnesses can be contributed to the inflammation from various foods. Here is a list of some of the most anti-inflammatory foods.
TOP 10 ANTI-INFLAMMATORY FOODS
1. Wild Alaskan Salmon: Salmon contains anti-inflammatory omega-3s (wild is better than farmed) and has been known to help numerous ailments. Try and incorporate oily fish into your diet twice weekly. If you don't like fish, try a high quality fish supplement.
2. Kelp: High in fiber, this brown algae extract helps control liver and lung cancer, douses inflammation, and is anti-tumor and anti-oxidative. Kombu, wakame and arame are good sources.
3. Extra Virgin Olive Oil: The secret to longevity in Mediterranean culture, this oil provides a healthy dose of fats that fights inflammation, can help lower risks of asthma and arthritis, as well as protect the heart and blood vessels.
4. Cruciferous Vegetables: Broccoli, brussel sprouts, kale and cauliflower are all loaded with antioxidants. Naturally detoxifying, they can help rid the body of possible harmful compounds.
5. Blueberries: Blueberries not only reduce inflammation, but they can protect the brain from aging and prevent diseases, such as cancer and dementia. Aim for organic berries, as pesticides are hard to wash away due to their size.
6. Turmeric: This powerful Asian spice contains a natural anti-inflammatory compound, curcumin, which is often found in curry blends. It is said to have the same effect as over-the counter pain relievers (but without their side effects).
7. Ginger: Ginger contains a host of health benefits. Among them, it helps reduce inflammation and control blood sugar. Ginger tea is a great addition to any diet.
8. Garlic: Though a little more inconsistent (in terms of research), garlic can help reduce inflammation, regulate glucose and help your body fight infection.
9. Green Tea: Like produce, this tea contains anti-inflammatory flavonoids that may even help reduce the risks of certain cancers.
10. Sweet Potato: A great source of complex carbs, fiber, beta-carotene, manganese and vitamin B6 and C, these potatoes actually help heal inflammation in the body.
TOP 10 INFLAMMATORY FOODS
These foods have been linked to obesity, increased risks of numerous diseases and even death in some cases.
1. Sugar: Sugar is everywhere. Try and limit processed foods, desserts and snacks with excess sugar. Opt for fruit instead.
2. Common Cooking Oils: Safflower, soy, sunflower, corn, and cottonseed. These oils promote inflammation and are made with cheaper ingredients.
3. Trans Fats: Trans fats increase bad cholesterol, promote inflammation, obesity and resistance to insulin. They are in fried foods, fast foods, commercially baked goods, such as peanut butter and items prepared with partially hydrogenated oil, margarine and vegetable oil.
4. Dairy: While kefir and some yogurts are acceptable, dairy is hard on the body. Milk is a common allergen that can trigger inflammation, stomach problems, skin rashes, hives and even breathing difficulties.
5. Feedlot-Raised Meat: Animals who are fed with grains like soy and corn contain high inflammation. These animals also gain excess fat and are injected with hormones and antibiotics. Always opt for organic, free-range meats who have been fed natural diets.
6. Red and Processed Meat: Red meat contains a molecule that humans don't naturally produce called Neu5GC. Once you ingest this compound, your body develops antibodies which may trigger constant inflammatory responses. Reduce red meat consumption and replace with poultry, fish and learn cuts of red meat, once a week at most.
7. Alcohol: Regular consumption of alcohol causes irritation and inflammation to numerous organs, which can lead to cancer.
8. Refined Grains: "Refined" products have no fiber and have a high glycemic index. They are everywhere: white rice, white flour, white bread, pasta, pastries... Try and replace with minimally processed grains.
9. Artificial Food Additives: Aspartame and MSG are two common food additives that can trigger inflammation responses. Try and omit completely from the diet.
10. Fill in the Blank: Do you constantly have headaches or feel tired? Sometimes, you may develop an allergy to a food and not even know it. Coffee, certain vegetables, cheese... there might be a trigger you aren't even aware of. Try and take a few foods out to see how you feel and slowly incorporate them back in to see if there might be a hidden culprit lurking in your diet!
Best and Worst: Top 10 Most Inflammatory and Anti-Inflammatory Foods!
Clean Convenient Cuisine on 09.18.10 at 8:15 AM
http://www.chicagonow.com/blogs/clean-convenient-cuisine/2010/09/best-and-worst-top-10-most-inflammatory-and-anti-inflammatory-foods.html
http://www.biopharmasci.com/patients/nanogreens/default.asp
http://www.biopharmasci.com/patients/nanopro/default.asp
http://www.biopharmasci.com/patients/nanomega/default.asp
This is everything that I take, and the nutritional values and analysis are amazing.... I will live by these products, and it's the only supplements you will ever need.
If you know anyone with a low throid problem, be sure to investigate Thyrofood.
I have been using the product for 2 weeks after signing on for the http://www.quantafoods.com seminar
I called my naturopath to have him order and he has had numerous people comment what a great product it is. I have had a tremendous increase in energy after using it.
You can't order directly, but could find a professional naturopath in your area that recommends it through their pharmacy. If you join the association, I saw that you can also have it recommened through the QuantaFoods website Doctor.
Resveratrol shows metabolic benefits for obese: Study
Daily intakes of resveratrol – a compound from red wine – may improve the metabolic profile of people with obesity, according to a new study from Denmark.
Writing in the International Journal of Obesity, researchers from Aarhus University report that resveratrol changed the production of certain compounds called adipokines from human fat cells, and produced an anti-inflammatory effect.
The study is reported to be the first to in vitro suggest resveratrol has anti-inflammatory effects on adipokine expression and secretion in human fat tissue.
“Small interfering molecules such as resveratrol are in this matter hypothesized to possess beneficial effects and might improve the metabolic profile in human obesity,” wrote the researchers, before adding that the results need to be replicated in vivo.
Resveratrol’s rosy potential
Resveratrol, a powerful polyphenol and anti-fungal chemical, is often touted as the bioactive compound in grapes and red wine, and has particularly been associated with the so-called 'French Paradox'. The phrase, coined in 1992 by Dr Serge Renaud from Bordeaux University, describes the low incidence of heart disease and obesity among the French, despite their relatively high-fat diet and levels of wine consumption.
Interest in the compound exploded in 2003 when research from David Sinclair and his team from Harvard reported that resveratrol was able to increase the lifespan of yeast cells. The research, published in Nature, was greeted with international media fanfare and ignited flames of hope for an anti-ageing pill.
According to Sinclair’s findings, resveratrol could activate a gene called sirtuin1 (Sirt1 – the yeast equivalent was Sir2), which is also activated during calorie restriction in various species, including monkeys.
Since then studies in nematode worms, fruit flies, fish, and mice have linked resveratrol to longer lives. Other studies with only resveratrol have reported anti-cancer effects, anti-inflammatory effects, cardiovascular benefits, anti-diabetes potential, energy endurance enhancement, and protection against Alzheimer’s.
Metabolic syndrome
The new study sought to investigate if the compound’s anti-inflammatory benefits extended to the low-grade inflammatory state associated with obesity. This is “characterized by abnormal levels of circulating proinflammatory factors and an abnormal production of bioactive factors/adipcytokines from the adipose tissue”, explained the researchers, and these adipocytokines are “suggested to have direct implications for the development of the metabolic syndrome”.
Led by Jen Olholm from the Department of Endocrinology at Aarhus University Hospital, the researchers examined the effects of resveratrol (Cayman Chemical) on levels of adipcytokines – particularly interleukin 1beta (IL-1B) – in human adipose tissue explants.
When human fat cells were exposed to IL-1B, the researchers noted increases in the secretion of pro-inflammatory compounds, including IL6, IL8, MCP-1. However, when the cells were simultaneously exposed to resveratrol, a 16 to 36 percent reduction in the expression of these cytokines was observed.
From human cell to human being
“Our results show that resveratrol ameliorates the proinflammatory response in human adipose tissue and increases adiponectin expression changes, which is hypothetically beneficial, as adipose tissue from obese individuals with metabolic syndrome, expresses lower adiponectin levels and higher levels of proinflammatory adipokines,” wrote the researchers.
“We are aware that it is difficult to compare in vitro incubations and in vivo conditions, and especially it is difficult to know whether the concentrations used in our study are a meaningful in a clinical setting.
“It is known that orally administrated resveratrol is rapidly absorbed and then quickly metabolized, but the local concentration of resveratrol in different tissue compartments are unknown and it is also not known if glucuronidated resveratrol can be locally de-glucuronidated and thus reach a higher local concentration.
“However, the concentration used in our in vitro experiments (50 mM) is similar to most other reports on resveratrol effects in different cell types,” they added.
Source: International Journal of Obesity
Volume 34, Pages 1546-1553; doi:10.1038/ijo.2010.98
“Anti-inflammatory effect of resveratrol on adipokine expression and secretion in human adipose tissue explants”
Authors: J. Olholm, S.K. Paulsen, K.B. Cullberg, B. Richelsen, S.B. Pedersen
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Passion fruit peel extract may improve knee health
By Stephen Daniells, 12-Oct-2010
Extracts from the peel of purple passion fruit may reduce measures of pain and stiffness in people suffering from knee osteoarthritis, says a new randomized, double-blind, placebo-controlled trial.
Writing in Nutrition Research, scientists from Iran, the USA, and New Zealand report that, according to scores on the widely accepted WOMAC scale, 60 days of supplementation with the passion fruit peel extract reduced pain and stiffness of the knees by about 18 percent.
If additional studies support the effects of the passion fruit peel, it could see the extract emerge as a potential replacement for pharmaceutical non-steroidal anti-inflammatory drugs (NSAIDs). Some NSAIDs, which are among the most frequently prescribed medications worldwide, have been linked with gastrointestinal toxicity, increased blood pressure, and increased risk of cardiovascular disease.
“The ability for passion fruit peel extract to act as an anti-inflammatory agent, antioxidant, and MMP inhibitor may explain its reduction in osteoarthritis pathology in the patients studied in this double-blinded, placebo-controlled study,” wrote researchers led by Ronald Watson from The University of Arizona and Southwest Scientific Editing and Consulting, Arizona.
“The passion fruit peel extract supplementation should help patients to reduce their reliance upon NSAIDs that may have undesirable side effects in the treatment of osteoarthritis symptoms,” they added.
Aging populations
As populations age, the burden of osteoarthritis is growing. Over 20 million Americans suffer from osteoarthritis, and it is reported to be second only to ischemic heart disease as a cause of work disability in men over 50. According to the Center for Disease Control, the direct and indirect costs are estimated to be approaching $90 billion. Elsewhere, the figures are equally worrying, with approximately seven million people in the UK alone are reported to have long-term health problems associated with arthritis.
The market for joint health ingredients is dominated by glucosamine – now a $2bn (€1.47bn) global blockbuster. It is most commonly blended with chondroitin so the two have become linked in the minds of many consumers.
Study details
Dr Watson and his co-workers recruited 33 people with osteoarthritis in the knee and randomly assigned them to receive either placebo or the passion fruit peel extract (150 mg per day) for two months.
At the end of the study the researchers report that clinical symptoms of osteoarthritis, measured using the Western Ontario and McMaster Universities (WOMAC) Osteoarthritis Index, showed significant improvement in the passion fruit group, compared with placebo. In addition to the improvements in the pain and stiffness scores, the researchers note that physical function and composite WOMAC score improved by 19.6 and 19.2 percent, respectively.
Commenting on the potential bioactives, Watson and his co-workers pointed to the passion fruit peel extract’s “unique mixture of bioflavonoids with antioxidant and inflammatory activity”.
The study was funded by Southwest Scientific Editing and Consulting, whereas New Zealand’s Industrial Research Limited provided the extract. Researchers from both companies were involved in the study.
Source: Nutrition Research
Volume 30, Pages 601-606
“Oral intake of purple passion fruit peel extract reduces pain and stiffness and improves physical function in adult patients with knee osteoarthritis “
Authors: R. Farid, Z. Rezaieyazdi, Z. Mirfeizi, M.R. Hatef, M. Mirheidari, H. Mansouri, H. Esmaelli, G. Bentley, Y. Lu, Y. Foo, R.R. Watson
Bulgur Superpower: shrinks fat cells Bring on the carbs! Dieters who dined on whole grains lost more tummy fat than calorie cutters who ate refined grains, a study in The American Journal of Clinical Nutrition notes. Half a cup of cooked bulgur has more fiber (4 g) and fewer calories (76) than other grains.
How it works Fiber aids in keeping your body's insulin levels low—which researchers speculate may shrink fat cells, suggests a study from the University of Kuopio in Finland.
Blueberries Superpower: fuel fitness Fat-blasting cardio is an essential ingredient for sexy, sculpted abs—and antioxidants in berries enable you to step up crucial conditioning.
How they work "Antioxidants help improve blood flow—which delivers more oxygen to your muscles," says Leslie Bonci, R.D., director of sports nutrition at the University of Pittsburgh Medical Center. "Giving your muscles the oxygen they need makes exercise feel easier, so you may work out harder, longer and more often." Blueberries and blackberries top the antioxidant chart; try them on whole-grain waffles or in a turkey-lettuce roll-up.
Yogurt Superpower: flattens fast After you achieve the abs of your dreams, a bit of bloat can still have you reaching for a cover-up. Treat puffiness with probiotic-rich yogurt.
How it works One creamy cup encourages the growth of good bacteria in your gut—which crowds out other bugs that can cause bloating, says David Grotto, R.D., author of 101 Optimal Life Foods (Bantam). Add plain yogurt with a Live & Active Cultures seal (such as Dannon) to your torso-trimming grocery list.
Condé Nast Digital
Green tea Superpower: revs metabolism Everyone has a six-pack in there somewhere. Unveil yours by melting the fat covering it up. Drinking three cups of green tea a day may kick up your metabolism and erase 30 calories daily, a study in Medicine & Science in Sports & Exercise shows.
How it works The compound ECGC in green tea makes it easier for your body to fry fat. The extra burn can help you shed about 3 pounds a year, simply from sipping.
Avocado Superpower: fights fat If there were an Academy Award for Flat Abs, the monounsaturated fat in avocados would be the Meryl Streep of nutrients, winning nods year after year. Dieters who consumed monounsaturated fats lost more stomach bulge than those eating the same number of calories but less of the fats, a study in the journal Diabetes Care finds. And a study in the journal Obesity reveals that when monkeys ate trans fats, their waists were 30 percent bigger than those of simians eating monounsaturated fats.
How it works Blood sugar peaks can signal your body to store fat around your midsection, but monounsaturated fats stop the spikes, thwarting fat accumulation. Half an avocado contains 10 grams of the healthy fats. Dip veggie slices in 1/4 cup guacamole for a flat-ab snack.
The Melatonin Miracle
This Overlooked Hormone Holds a Little-Known Secret…
It Protects You from Disease, Boosts Your Bedroom
Performance and Keeps You Younger Longer
If you travel a lot on business, you’ve probably already discovered melatonin. It eases jet
lag and lets you get some precious sleep in those cramped airplane seats. But nature’s
sleep regulator holds another little known secret: It can peel years off your age.
This hormone holds not one but nearly half a dozen age-fighters. They can help you look
and feel younger longer. And melatonin can protect your cells against deadly diseases
like cancer and Alzheimer’s.
Today, I’ll tell you how you can add melatonin safely and easily to your anti-aging
program, and why you should.
The Anti-Aging Supplement that Works Wonders
Your body produces melatonin naturally. It’s the main hormone made by your pineal
gland. This is a tiny, pea-sized gland at the base of your brain. One of the most important
jobs this gland has is regulating your sleep cycle. It works like this: The pineal gland
monitors changing light levels throughout the day and when darkness falls, it excretes
melatonin to bring on sleep.
For decades, travelers have used melatonin to ease the transition between time zones with
great success. But melatonin holds other, more important health-enhancing secrets.
Melatonin is one of the best-studied and most effective anti-aging nutrients available
today. Surprised? Don’t be. For one thing, melatonin is one of the only oral supplements
that stimulates your body’s release of human growth hormone (HGH). This is the
hormone that keeps you looking and feeling young.
When you’re in your twenties, your body produces lots of HGH. But production slows
down as you age. When you reverse this decline, you reverse aging. In fact, studies show
improving HGH levels heightens energy, sexual performance, muscle gain, fat loss, and
skin appearance.1
And melatonin works well increasing HGH levels even at small oral doses.2 What’s
more, when you double the dose, HGH levels double.3 No wonder melatonin increases
lifespan in study after study.4
Melatonin is also one of the most potent antioxidants ever discovered. It destroys diseasecausing
molecules called free radicals at an incredible pace. And it does something most
other antioxidants can’t: It stimulates extra antioxidant enzymes that can protect against
everything from wrinkles to illness.
Bring Your Dying Cells Back to Life
One thing that causes aging and the diseases of aging is the death of cells. Your cells
depend on their energy powerhouses called mitochondria. If the mitochondria are
damaged, you fall victim to conditions like Parkinson’s disease, Alzheimer’s disease,
even cancer.5 Protect the mitochondria from damage and you keep millions more cells
alive. That means you’ll stay healthy and more youthful.
Melatonin is also quickly gaining a reputation as a cancer killer. In fact, it works so well
at blocking tumors, doctors are already using it to treat cancer. And the results are
promising. Melatonin enhances the effectiveness of other cancer treatments, reduces side
effects of those treatments, and increases survival rates.6
Melatonin may do more than just protect your body from age. Studies show it may
actually reverse it where it matters most: Your brain. (After all, what good is a younger
looking body if you’re not “all-there” to enjoy it?)
Studies have shown that melatonin can reverse aging in the brain tissues of mice.7
Obviously, that’s not the same thing as reversing brain aging in men, but with all of its
other benefits, there’s no reason not to try melatonin—and if it helps keep your brain
young in the process, so much the better.
As you can see, melatonin isn’t something you want to lack. Trouble is, you lose it as you
age.
Trouble Sleeping? Does Your Prostate Have You Getting Up in the Middle of the
Night? Melatonin can Help You Too…
Like Human Growth Hormone, melatonin levels fall sharply as you age. It’s a drop you
can feel. For example, one of the most common complaints I hear from older patients is
that they’re not sleeping as well as they used to. It’s often caused by a deficiency of
melatonin.
And, as a side benefit, just a couple of milligrams will work wonders if you’re suffering
from prostate trouble. Benign prostatic hyperplasia sufferers find they don’t have to get
up and go as often at night when they’re taking melatonin.
Putting Melatonin to Work for You
If you’re over 50, you should think about taking melatonin. There is to date, no evidence
to tarnish its perfect safety record.8
I recommend a small anti-aging dose of 0.5 mg a night. For jet lag, take 1 mg for every
time zone crossed.
If you have cancer, I recommend a much higher “antioxidant dose” of 20 to 40 mg every
night before bed. Of course, be sure to discuss this with your doctor first.
To Your Good Health,
Al Sears, MD
1 Klatz, R. Grow Young with HGH Harper Collins, NY: 1997
2 Forsling M.L., Wheeler M.J., Williams A.J., “The effect of melatonin administration on pituitary hormone
secretion in man” Clin Endocrinol (Oxf) 1993 Aug;39(2):193-9
3 Valcavi R, Zini M, Maestroni GJ, Conti A, Portioli I. “Melatonin stimulates growth hormone secretion
through pathways other than the growth hormone-releasing hormone.” Clin Endocrinol (Oxf) 1993
Aug;39(2):193-9.
4 Maestroni G.H.M., Conti A., Pierpaoli W. “Pineal melatonin, its fundamental rol in aging and cancer in
neuroimmunomodulation: Interventions In Aging and Cancer” Annals of the NY Academy of Sciences 1988
521:140-148.
5 Reiter RJ, Tan DX, Manchester LC, El-Sawi MR. “Melatonin reduces oxidant damage and promotes
mitochondrial respiration: implications for aging.” Ann N Y Acad Sci. 2002 Apr;959:238-50.
6 Lixsoni P. Melatonin and cancer treatment, in: Melatonin on the Promotion of Health by R.W. Watson
CRC. Boca Raton, 1999 pp. 175-190.
7 Okatani Y, Wakatsuki A, Reiter RJ, Miyahara Y. “Melatonin reduces oxidative damage of neural lipids
and proteins in senescence-accelerated mouse.” Neurobiol Aging. 2002 Jul-Aug;23(4):639-44.
8 Dean, Ward M.D. “Melatonin: Unique, Potent Life-Extending Nutrient” Vitamin Research News: Anti-
Aging Supplement Review and Update Part 3, August 2004, p 14.
Beat Cancer with Vitamin D
By Al Sears, MD
The recent announcement by the Canadian Cancer Society reinforced what I’ve known for years: Vitamin D is most effective way to prevent cancer ever discovered.
The landmark discovery revealed that vitamin D slashes your risk of all cancers by 77%.i
In this report, I’ll show you why that’s true. I’ll reveal vitamin D’s unique health-enhancing power and tell you exactly how to get the right dose you need to prevent today’s chronic killers.
It’s much easier than you think… The two best sources of vitamin D are cod liver oil and sunshine.
But the levels of vitamin D in your diet keep shrinking. And the media’s campaign to keep you out of the sun – and covered in sunscreen – cuts down your only other source of this critical nutrient.
Vitamin D Isn't Just a Vitamin…
By definition, a “vitamin” is an organic substance that’s required by the body, but can’t be made by the body. Vitamins must be acquired through the diet. A hormone, on the other hand, is a substance produced by specific organs and carried through the bloodstream affecting other organ systems.
By these definitions vitamin D isn't only a "vitamin." It's also a hormone. Your body makes vitamin D when the sun's ultraviolet rays strike your skin. Yet vitamin D can also come from the food you eat.
If you're deficient in vitamin D, genes designed to protect your health can't work properly, because they need vitamin D to switch them on.
Vitamin D plays a vital role in human health. To understand vitamin D’s significance in keeping your body well, it is important to understand how your body makes and uses it.
Your Body Uses Sunshine to Make Vitamin D
Your endocrine system produces vitamin D. The endocrine system is a series of ductless glands that regulate your body's functions by producing hormones and releasing them into the blood stream. The endocrine system creates vitamin D in three steps:
1.
Sunlight strikes pre-cholesterol molecules in your skin, transforming them into large quantities of cholecalciferol (vitamin D3). This is the naturally occurring form of vitamin D. It can also be taken as a supplement. The best form by far is cod liver oil.
2.
Your bloodstream absorbs this cholecalciferol and transports it to the liver where it’s converted to calcidiol (25-hydroxyvitamin D). Although this form of vitamin D doesn’t have significant biological activity, it’s vital in the next step of the vitamin D process.
3.
Calcidiol is then transported to the kidneys first and then to other tissues of the body where it is converted into the potent steroid hormone calcitriol (1,25-dihydroxyvitamin D). It is this form of “activated" vitamin D that goes to work protecting your body from disease.
Here's a flow chart of this process.
Ultraviolet light + pre-cholesterol in the skin
|
|
cholecalciferol (vitamin D3) + oxygen in the liver
|
|
calcidiol (25-hydroxyvitamin D… biologically weak) + kidneys/other tissues
|
|
calcitriol (1,25-dihydroxyvitamin D… activated form of vitamin D)
This final form of vitamin D is the most potent steroid hormone in the human body. It's active in amounts as small as a picogram. That's 1 trillionth of a gram.
We are just now beginning to understand how this complex system works
Vitamin D is Your Body’s Building Block
Your physiology is as linked to the sun as plants are. Plants use sunlight to photosynthesize chlorophyll. Your body uses a comparable process to photosynthesize vitamin D. Sunlight and vitamin D touch virtually every aspect of your biochemistry and physiology.
In fact, vitamin D is so important to your body, that soon after we began to move away from the equator, some of us began to develop fair skin. With fair skin, we could still synthesize vitamin D with the weaker northern sun. But for even fair-skinned people to produce vitamin D, they must still expose their skin to unblocked sunlight.
Let's look more closely at the vital role vitamin D plays in your health.
•
Autocrine cellular functions – this process occurs within cells and helps cells to regulate the expression of genes.
•
Paracrine cellular functions – in this process a cell produces hormones, growth factors, or other substances, which affect other local cells.
•
Genetic expression
•
Calcium Absorption
•
Cell growth
•
Immunity
•
Energy metabolism
•
Muscle strength and coordination
•
Neurotransmitter production
•
Apoptosis (cell death)
•
Reduction of C-reactive protein (CRP) and other markers of inflammation
•
Brain development
•
Insulin production stimulation
•
Modulates immune system function
•
Has an effect on myocardial contractility… in other words it helps your heart to beat properly.
•
Prevents inflammatory bowel disease.
•
Inhibits the blood pressure hormone rennin.
You see how varied the important work that vitamin D does in your body really is. Let's look more closely at two of the biggest benefits of
vitamin D—maintaining calcium levels in your blood and preventing disease in your genes.
Build Unbreakable Bones and a Disease-Proof Body
A primary role of vitamin D is to maintain normal calcium levels in the blood.
Vitamin D is necessary for good bone health. Of course, calcium is essential for the maintenance of bone tissue. What you may not realize is that when it comes to your bones—and more—calcium and vitamin D have a symbiotic relationship. If you're missing either one, the other can't do its job.
First, healthy calcium levels are crucial. Calcium controls innumerable processes in your body including responses in your muscles, bones and glands. In general, calcium:
•
Helps the central nervous system transmit nerve impulses.
•
Helps the muscles to contract.
•
Influences the secretion of insulin by the pancreas.
•
Regulates the immune system.
You get calcium from the food you eat, or from supplements. Your body needs vitamin D to absorb calcium and phosphorus from the intestinal tract. No matter how much calcium you ingest, without enough vitamin D your body can’t absorb it from the small intestine.
A Lack of Vitamin D Puts You at High Risk for Cancer
Your body’s first priority for calcidiol, the weak form of vitamin D, is to transport it to the kidneys to make calcitriol (activated vitamin D).
Activated vitamin D circulating in the blood keeps your blood calcium levels high. Calcium is essential for far more than just bones. Research shows that calcium and vitamin D deficiency in combination puts you at risk for a wide array of chronic diseases.ii
But your body needs calcidiol for a second vital function. After the kidneys have enough calcidiol, the rest goes directly to your cells, where it they convert it to activated vitamin D in a form that your tissues can use. This activated vitamin D goes to work on a cellular level fighting cancer and disease.
Why does this matter? If you are chronically short of calcidiol, your tissues won’t receive any. Think of it like a gas tank. When you keep your tank full of vitamin D, you ensure that it will flow to every part of the body that needs it. And it appears that the more calcidiol your tissues receive, the more activated vitamin D they will create.
Calcium and vitamin D work together to decrease the risk of malignancies in the colon, breasts and prostate and help prevent a wide range of inflammatory, autoimmune, and metabolic disorders.iii
Studies suggest that 90% of the population is deficient in one, the other, or both.
Fight Brittle Bones the Easy Way…
When your body is short of calcium, it takes it from your bones. This leads to osteoporosis.
The process works like this. You have a gland called the parathyroid gland. It has a calcium sensor. When your body needs calcium, this gland produces a hormone called PTH. PTH signals the kidneys to make more vitamin D, so that you get the calcium you need from the food you eat by absorbing it through your intestines.
When there is not enough calcium available from your food, vitamin D and the parathyroid hormone (PTH) work together to draw calcium from the bones. The result is osteoporosis.
Ideally, you want to have low levels of PTH, so your body never gets the signal to draw calcium from the bones. Vitamin D helps absorb calcium from food, which in turn keeps PTH levels low and prevents calcium loss from your bones.
To keep your PTH levels low, you need enough calcium in your system. To keep enough calcium in your system, you need enough vitamin D.
Your Body Cries Out for Vitamin D
Does it seem strange that vitamin D has such a wide range of therapeutic and health-related benefits? The reason is that almost all the cells and tissues in your body have a receptor for vitamin D.
Activated vitamin D is one of the most potent regulators of cell growth in both normal and cancerous cells. It helps to determine what each
cell becomes. As a result, vitamin D can dramatically decrease your risk of cancer.
You see, vitamin D inhibits abnormal cell growth. It also causes cells to mature and die when they are supposed to. When these processes go haywire cancer can get a foothold in your body.
Scientists have also found that your body has Vitamin D receptor sites throughout all the organs. These receptor sites are genetically designed to bind with activated vitamin D. Think of these receptor sites as puzzle pieces.
Without the matching piece of the puzzle—activated vitamin D—they don’t fulfill their function of turning genes on and off as the body needs. These genes that normally resist cancer, can actually promote cancer without activated vitamin D.
The more activated vitamin D your body can create, the better.
Amount of Calcidiol
Course in the body
Result
Severely deficient due to lack of sunshine and subsequent lack of calcidiol.
The body has little calcidiol for the kidney to make cacitriol for the blood.
Calcium levels in blood are compromised and virtually no calcidiol gets to the tissues.
More is available, but still deficient.
Virtually all of the calcidiol is still sent to the kidneys to make cacitriol in the blood.
The body has enough to maintain calcium levels in the blood; almost none gets to the tissues.
Adequate calcidiol due to sunshine and/or vitamin D supplementation.
After the kidneys have enough, the rest floods directly to cells where calcitriol is made for the tissues.
Maintenance of calcium levels AND flooding of receptor sites throughout your body with activated vitamin D.
You should do everything you can to make sure your body has enough activated vitamin D to go around!
If you have sufficient vitamin D to get to your tissues, your cells will convert it to activated vitamin D. The activated vitamin D works inside your cells triggering certain genes to switch on and off. This is important because these genes are either fighting or promoting cancer. In fact, billions of cells use vitamin D to respond to a wide variety of diseases and help the body heal.
In the monthly newsletter produced by the Vitamin D Council, Dr. John Cannell describes five of the many ways activated vitamin D helps you prevent or heal disease through controlling your genes.
Your Body Has a Genius Problem Solver:
Activated Vitamin D
The Problem
Vitamin D’s Solution
Protects you from cardiovascular disease and arthritis
Your body is producing too much of the inflammatory C-reactive protein (CRP)
Turns off the gene that makes CRP
Controls your blood sugar
Your pancreas needs to produce more insulin to control blood sugar
Turns on the gene to make more insulin
Regulates your blood pressure
Your kidney produces too much of a certain protein that raises your blood pressure
Turns off the gene that makes that protein
Helps prevent cloudy
Your brain is not
Increases production
Your Whole Body Depends on Vitamin D
In tissues throughout your body, activated vitamin D signals your genes to make hundreds of different enzymes, proteins, hormones and neurontransmitters that are crucial to maintaining health and fighting disease. Tissues in the prostate, breasts, colon, small intestine, bones, immune cells, brain, heart, skin, testicles, and most other organs in the body can activate vitamin D and use it for their specific needs.
thinking and depression
making enough neurotransmitters
of the enzyme you need to make these neurotransmitters
Helps you prevent cancer
Your breast or prostate begins to develop cancer cells
Forces those cells to remain normal and then die when they are supposed to
The more we learn, the more we understand that activated vitamin D plays a role in virtually every aspect of your health. More than thirty different tissues in the body have receptor sites to collect and use it, including the heart, stomach, pancreas, brain, skin, testicles and white blood cells of the immune system (lymphocytes). iv
Calcitriol is so potent that it is active in minute quantities. Dr. John Cannell tells us in his article “The Secrets of Vitamin D Production” that vitamin D becomes active in picogram quantities or 1/1,000,000,000,000 of a gram.v It is one of the most potent, powerful nutrients you can give to your body.
You can Take a Simple Test for Vitamin D
So how much vitamin D do you need to ensure that your kidneys and your tissues receive it? What's the best way to get it? Good questions.
But first, let’s look at the best way to determine if you're deficient in vitamin D. Most people are, but it's important to know your individual levels, before you can decide what actions you need to take for better health.
If you are not getting out in the sun almost daily and not eating appropriate vitamin D-rich foods or taking supplements, you are at high risk for a deficiency and the myriad diseases that can result.
The best way to know if you are deficient is to have a yearly measurement of 25-hydroxyvitamin D as part of your annual physical examination.
Many people have their cholesterol checked ever year, although the evidence that cholesterol levels increase heart attack risk is controversial. Optimal levels of vitamin D are more important to
overall health than low cholesterol, but hardly anyone routinely checks their levels of the sunshine vitamin.
Take Action: Get Your Levels Tested
Your next step toward better health is to get your vitamin D levels tested. If you haven't been to your doctor in the last year make an appointment today. If you have an appointment scheduled, write a note to yourself reminding you to request a vitamin D test.
The test you should ask for is a 25-hydroxyvitamin D test. This test measures levels of calcidiol in your blood and is the only test you should use to determine vitamin D deficiency. There is a second test that measures calcitriol but the 25(OH)D test measuring calcidiol is the better marker for overall health.
Optimal 25-hydroxyvitamin D values are:
45-50 ng/ml or 115-128 nmol/l
Normal 25-hydroxyvitamin D lab values are:
20-56 ng/ml 50-140 nmol/l
If you're concerned your doctor won't support you in your decision to test your vitamin D levels, you can arrange to have the test done without a doctor's appointment. Just visit www.DirectLabs.com to learn more.
One advantage to a home test is that you can analyze your results. Doctors rarely use optimum levels as their guide. Instead they look at anything within the normal range as fine, even though levels in the low range of normal can increase your risks of disease and cause problems.
Also remember, when looking at your results that you may see some seasonal variations. In other words, your levels will likely be a little lower in the winter than in the summer. It's best to measure your levels twice a year, once at the end of winter when your levels are lowest, and once at the end of fall when your levels are highest. At the very least, you should get an annual measurement.
The Best Ways to Get More Vitamin D
When you can't get enough vitamin D from the sun, dietary supplements are your next best bet. Most people should supplement in the late fall, winter, and early spring.
You should also consider supplementing year round if you have darkly pigmented skin, are over 65, if you're overweight, or if you just can't bring yourself to go into the sun without sunscreen.
You can start by adding a good quality multivitamin to your daily routine. But most multivitamins are only a start. The average multi contains 400 international units of vitamin D, only 40% of what you need.
Beyond a multi-vitamin, you can take a dedicated vitamin D supplement. Just make sure that it contains only the natural form of vitamin D3. This may be listed as cholecalciferol on the label.
Also, work with your doctor. You want to measure your vitamin D levels periodically to make sure that you're succeeding in bringing your levels into a healthy range… and to make sure you're not overdoing it. Of course, if you don't take more than 3000 units in a day, you should be just fine.
Easy-to-Find Food Sources of Vitamin D
You can also get vitamin D from food sources.
Cod liver oil is the most concentrated natural food source of vitamin D. One tablespoon contains about 1200 to 1400 IU.
Cod liver oil also offers several other health benefits. It's a rich source of vitamin A.vi It contains the powerful anti-oxidant coenzyme Q10. It’s one of the very best sources of beneficial omega-3 essential fatty acids. These cancer and inflammation fighting nutrients are hard to get in sufficient amounts in the modern diet.
Taking fish oils isn't the same as taking cod liver oil. Although fish oil has omega-3 essential fatty acids it doesn’t contain vitamins A and D. What’s more, cod liver oil has far more omega-3 fatty acids than your average fish oil. One tablespoon of regular cod liver oil or one-half
tablespoon of high-vitamin cod liver oil provides the equivalent of omega-3 fatty acids found in twelve 1,000 mg fish oil capsules!
Your body needs cholecalciferol, or vitamin D3. This is the compound your skin makes naturally when exposed to sunlight. The vitamin D in fortified foods such as milk usually isn't the same as the naturally occurring vitamin D, cholecalciferol.
There are few foods that contain cholecalciferol, and even those that do, contain small amounts. Below is a table of foods that contain natural vitamin D.
Natural Sources of Vitamin Dvii
Food Source
Amount
Vitamin D
Cod Liver Oil
1 tablespoon
1360 IU
Salmon (cooked)
3.5 ounces
360 IU
Sardines (canned)
3.5 ounces
270 IU
Tuna (canned)
3 ounces
200 IU
Egg (yolk)
1 egg
25 IU
Beef Liver (cooked)
3.5 ounces
15 IU
Swiss Cheese
1 ounces
12 IU
If you’re deficient in vitamin D, the first thing you should do is to start consuming more of these foods. Two of the best sources are Alaskan wild salmon and sardines. These fish not only supply a decent amount of vitamin D, they’re also free of mercury.
Avoid Foods “Fortified” with Vitamin D
What about fortified foods? I'm sure you've heard that fortified milk is a good source of vitamin D. Unfortunately, that's not usually the case. Often fortified foods contain a different form of vitamin D called ergocalciferol or vitamin D2.
Now, if you're deficient, any form of vitamin D is preferable to the higher risk of cancer, heart disease and other chronic health problems. Still, the natural form is far superior to the manufactured form.
1) The manufactured version isn’t as potent and doesn’t last as long in your body. The vitamin D found in milk, most fortified foods and even most vitamins is the synthetic version of vitamin D known as ergocalciferol. This man-made version is not nearly as potent, and it
doesn’t last as long in the body. Research shows the natural form of vitamin D is nearly twice as effective at raising circulating vitamin D levels than the synthetic version.viii
2) Synthetic vitamin D is linked to health problems. Synthetic vitamin D is now added to almost all milk, even baby foods, cereal, pasta, and flour. Already a number of prominent researchers have raised questions about the safety of long term use of synthetic vitamin D.ix In Dr. Zane Kime’s book Sunlight, published in 1980, he references a number of studies that link synthetic vitamin D to irritation of the lining of blood vessels.
3) It’s much easier to overdose synthetic vitamin D. Research shows synthetic vitamin D becomes toxic in the body at far lower levels than natural vitamin D. Some studies also suggest that milk can amplify the effect of synthetic vitamin D. In an experiment involving school children, the effects produced by 90 units of synthetic vitamin D were greater than the effects of ten times that, 900 units of natural vitamin D in the form of cod liver oil.x
4) You can never be sure your body’s getting enough. When Dr. Michael Holick and his colleagues at the Boston University School of Medicine tested samples of milk, they found 8 out of 10 samples contained either 20% less or 20% more vitamin D than the amount the label advertised. And some of the milk tested contained no vitamin D at all!xi
Vitamin D fortified foods are a gamble. As you can see, you don’t want to rely on them solely to ensure healthy levels of vitamin D. If you insist on staying out of the sun and refuse to get regular, moderate exposure, it’s essential to supplement. However, before supplementing with vitamin D, it’s wise to have your levels tested.
The Most Neglected Health Epidemic in History
If vitamin D deficiency is so widespread and so clearly implicated in a variety of different life threatening health problems, why don’t most doctors know about it?
While some of the best scientists are doctors, very few doctors are scientists. Doctors don’t spend their time in a lab, they spend their time treating patients. Few of them have extra time to keep up with the latest scientific discoveries in all fields of medical study. In fact,
new research is so prolific, that trying to follow it all could easily become a full time job in itself.
So doctors skim research to learn what's new. It's unfortunate that researchers with the most money to fund studies and reach out to doctors are the ones backed by drug companies. The sad fact is that unless a drug company has a profit-making reason to promote a new research discovery, they just don’t.
When it comes to vitamin D, no matter how beneficial and effective it is, sunlight is free. There's not way to profit from it. Vitamin D itself simply cannot be patented. Most market research will continue to ignore the deficiency unless they develop a patentable analog to natural vitamin D to make it profitable.
Getting the Right Dose of Vitamin D
Firs of all, remember that sunlight is your very best source of vitamin D. It is the safest source. It is completely natural. And it will not produce toxicity.
However, for most Americans, even the sun is not an adequate source in the winter. You should still get some sun every day possible in the winter, but you can't count on it to adequately boost your vitamin D.
You need dietary sources and possibly a supplement during the late fall, early spring, and winter months. Consider supplementing year round if you are overweight, over the age of 65, have dark skin, or always use sunscreen.
As we've seen, studies show that you can supplement with 3000 to 5000 IU of vitamin D a day, and your body will use all of it.
If you take a multi-vitamin, you probably get 400 IU a day. Your body would still use 2600 to 4600 more every day if you if it can get it.
One way to get this is to take a daily supplement of just vitamin D. If you do this, here are some guidelines.
1.
Aim to take 2000 IU a day… this leaves room for you to safely get additional vitamin D from other sources like the weak winter sun or from your diet.
2.
Take a supplement that contains cholecalciferol (vitamin D3) rather than ergocalciferol (vitamin D2).
3.
One of the best natural sources is cod liver oil. Take one to two tablespoons of cod liver oil a day with food. There is 1200 to 1400 IU of vitamin D in a tablespoon of cod liver oil.
To boost your dietary intake of vitamin D, add Alaskan salmon, sardines, and eggs to your diet. Eggs are a great way to start your day. Despite the cholesterol-phobia that surrounded eggs once upon a time, you can eat one or two eggs each morning without worrying about a negative health impact.
Aim to eat salmon and sardines one or twice a week. Alaskan salmon is the cleanest kind of salmon available… it contains little-to-no mercury. It's also versatile, and makes for a tasty dinner. Sardines are readily available in cans. Try topping your salad at lunch with sardines a couple of times each week. Add a spicy thousand island dressing, and you've got a tasty meal.
By taking these steps in the wintertime, you can boost your vitamin D to a healthy level year round and dramatically reduce your risks of many chronic diseases.
Remember if you fall into a high-risk category and need to supplement year round, work with your doctor to do this. Your doctor can help you monitor your levels so that you reach your target without overshooting it.
i Ross T. Study: Vitamin D Cuts Cancer Risk. The Seattle Times. Jun 11, 2007
ii Peterlik M, Cross HS. (2005). Vitamin D and calcium deficits predispose for multiple chronic diseases. Eur J Clin Invest. 35(5):290-304.
iii Peterlik M, Cross HS. (2005). Vitamin D and calcium deficits predispose for multiple chronic diseases. Eur J Clin Invest. 35(5):290-304.
iv Zittermann A. (2003). Vitamin D in preventive medicine: are we ignoring the evidence? Br J Nutr. 89(5):552-72.
v Cannell, J. (2006). The secret of Vitamin D production. The Vitamin D Council. http://www.mercola.com/2005/feb/2/vitamin_d_production.htm
vi Cannell, J. (2006). Up to 70 percent of Americans may be deficient in vitamin D- Find out why you don’t want to be one of them. The Vitamin D Council. http://www.mercola.com/2003/dec/24/vitamin_d_deficiency.htm
vii National Institutes of Health Office of Dietary Supplements. (2004). Dietary supplement fact sheet: vitamin D. http://ods.od.nih.gov/factsheets/vitamind.asp#h1
viii Trang HM, Cole DE, Rubin LA, Pierratos A, Siu S, Vieth, R. (1998). Evidence that vitamin D3 increases serum 25-hydroxyvitamin D more efficiently than does vitamin D2. Am J Clin Nutr. 68(4):854-8.
ix Vieth R, Chan PC, MacFarlane, GD. (2001). Efficacy and safety of vitamin D3 intake exceeding the lowest observed adverse effect level. Am J Clin Nutr. 73(2):288-94.
x Kime, ZR. (1980). Sunlight. Penryn, CA: World Health Publications. p. 148-151
xi Holick, MF, Jenkins, M. (2003). The UV Advantage. New York, NY: ibooks, Inc. p.149.
Has Man Finally Found The Secret of Immortality?
There is a recent discovery about the lengthening of telomeres through the use of a substance from a plant. Scientists all over the world are excited, and their hopes of unlocking the mystery of immortality are very high.
This phytochemical, known as astragaloside IV, is an extract from a Chinese herb called astralagus. Another company calls it TA-65 or Telomerase Activator 65. Theses extracts activate the telomerase in the body. It was proven in some experiments that these extracts can reverse the reduction of the length of telomeres during cell division. Scientists believe that this substance can extend the length of telomeres.
Telomeres are the end caps of chromosomes in DNA helix strands that prevent the chromosomes from fusing or joining together that may result to chromosomal abnormalities. It also prevents the cell from replicating continuously that may lead to carcinogenesis.
Telomeres are non-coding DNA that are normally composed of 8000 bases of DNA sequence repeats TTAGGG during birth. This number is reduced to 3000 bases at age 35 and becomes 1500 bases at age 65 and above. From age 35 up to 65, the length of telomeres are reduced at a rate of 50 bases per year.
The length of telomere is gradually shortened every time the cell divides. When the Hayflick limit of about 60 to 80 cell divisions is reached, the telomere unfolds from its closed structure, and the cell detects this uncapping as DNA damage which signals it to enters cellular senescence, growth arrest or apoptosis. This gradual reduction of the length of telomeres is the natural biological process we call aging.
The length of telomeres are extended by telomerase, a reverse transcriptase enzyme known as TERT or Telomerase Reverse Transcriptase. This enzyme is a ribonucleoprotein complex composed of protein component and RNA primer sequence. It is this template RNA known as TERC or Telomerase RNA Component in telomerase that contains the DNA sequence repeats TTAGGG. Telomerase extends the length of telomeres by adding these TTAGGG to the 3' end strand of the telomere regions. This action ‘immortalized’ the cells to preserve youthfulness.
But unfortunately, telomerase extension of telomeres is switched off in humans. This may be due to various detrimental factors that have greatly degraded the quality of life through the years. Not only is it switched off, but it sometimes causes the abnormal mutations of cells that lead to the start of cancer or carcinogenesis.
The effective destruction of this abnormal telomerase activity during cell mutation can be a solution to the total eradication of all forms of cancer. Scientists are focusing their studies on how to totally eradicate all forms of cancer and to completely stop the process of aging through telomerase.
Let us hope that TA-65 or astragaloside IV will indeed effectively activate the telomerase to lengthen the telomeres without creating any abnormality in the cells or in the body as a whole. It is precarious, and the boundary between immortality and carcinogenesis is dangerously thin to be tampered with.
Has man finally found the secret of immortality? The answer is still a resounding No! Telomerase may be able to extend man’s life to 100, 500 or even 1,000 years, but he is still eventually bound to die. Man was created perfect, but he was not created immortal. Even angels are not immortal. There is only one that is immortal, and that is God.
Turning on immortality: the debate over telomerase activation.
The role of telomerase in allowing the immortal growth of reproductive cells is well established in the scientific literature.
In the laboratory dish, the introduction of telomerase into cultured human cells transforms otherwise aging mortal cells into immortal cells without transforming them into cancer cells. On the heels of this discovery, small molecule activators of telomerase are being developed for use in treating cellular aging and at least one nutritional supplement is being marketed for the treatment of aging.
Do these compounds really work and are they safe? That is the question that was posed to two leaders in the field.
Arguing in favor of the marketing of telomerase activators for nutritional use is William H. Andrews, PhD, president & CEO, Sierra Sciences, who previously was director of molecular biology at Geron Corporation where the telomerase genes were first isolated.
Taking the opposing position is Michael D. West, PhD, who was the founder of Geron Corporation, and is currently the CEO of BioTime, Inc, which focuses on the stem cell biology and the resetting of cell life span by cellular reprogramming.
Until more human data are compiled, the Life Extension Foundation[R] does not have a position, one way or another, on the use of this particular telomere-extending therapy. The information for this article is written by two highly respected scientists. Some members may find this material technically challenging to comprehend.
DR. ANDREWS WRITES IN FAVOR OF ...
There is now compelling evidence that the length of a person's life span is dictated by the limited number of times a human cell can divide. Though the immortal reproductive cell can divide a limitless number of times, once the human reproductive cell, in the developing embryo, turns into a developmental cell the clock starts ticking and the cell's fate is doomed to a limited 75-100 number of cell divisions (the Hayflick Limit). Once that limit has been reached, the cell and all of its progeny completely lose the ability to divide and then enter a phase called senescence.
The ticking clock in this case is found at the tips of the cell's chromosomes in a region called the telomere. It is believed that telomeres may have evolved to prevent the unlimited growth of cells by limiting their life span. Telomeres are made up of subunits (or bases) of DNA called A, C, G, and T. In the telomere, these bases are arranged in six base repeat units of TTAGGG. When a human is first conceived, the length of the telomeres averages about 15,000 bases (up to 2,500 TTAGGG repeat units) as measured by a process called terminal restriction fragment length analysis. The length then begins to decrease at a rate of about 100 bases per cell division. By the time a person is born, the average telomere length has already dwindled to about 10,000 bases and then throughout the rest of a person's lifetime the average length of the telomeres gradually decreases to about 5,000 bases at which time the person's cells lose the ability to divide. These cells are then senescent, and the person suffers and dies of old age.
Very recently, remedies have been developed that could possibly alleviate, abolish, or reverse this "up to now" inevitable fate by activating an enzyme called telomerase, which may help maintain telomere length. One such remedy, a nutraceutical called TA-65, is already commercially available and several people have already signed up to benefit from its potential to extend health span and life span. Unfortunately, this remedy also carries with it a potential for promoting cancer. And so, we are brought back to the age-old question, "Do you give a risky cure to a dying person, or do you simply let the person die because the cure is too risky?" Every one of us is suffering from this disease, but most of us are in only the very early stages and have the luxury not to make this choice so hurriedly. However, many of the people in the later stages of aging feel that they don't have this luxury and choosing to take TA-65 may be what they feel to be their only recourse to "saving" their lives. Should these people be deprived? Should they be allowed to intentionally increase their risk of cancer to potentially enhance and prolong their health span and life span? We should let people who are concerned about their age-related deterioration, whether or not in the later stages of aging, decide for themselves.
[ILLUSTRATION OMITTED]
TA-65 is presently the only potential cure for telomere shortening and there won't be another one for a long time coming. Though the data are not overwhelming enough yet to convince scientists that TA-65 is, in fact, extending health span and life span, they do show a lot of promise and are supported on many theoretical grounds. Likewise, as stated above, there are also a lot of theoretical grounds for TA-65 increasing the chances that the person will be afflicted with cancer.
About 85-95% of all cancers express telomerase activity. Many research labs are working very hard to develop inhibitors of telomerase activity to cure cancer. So, one might think that we must be out of our minds to now want to intentionally turn telomerase activity on. But, the data show that telomerase is, in fact, not the cause of cancer. Instead, cancers turn on telomerase expression only to extend their life span; just like we want to turn on telomerase expression in our non-cancer cells to extend their life span. So, we've learned a lesson from cancer cells on how to extend cellular life span. But, true cancer cells already have telomerase activity. Giving someone a telomerase inducer isn't going to make an immortal cancer more immortal. So, it's not actually the true cancers we are concerned about. The cancers that are really at issue here are the pre-immortal cancers; that is, the cells that have lost growth control but that don't express telomerase activity or some other immortal pathway (such as the ALT [alternative lengthening of telomeres] pathway).
Fortunately, TA-65 is a transient inducer of telomerase activity. Cessation of taking TA-65 will shut down the expression of telomerase activity in cells, including the pre-immortal cancer cells, thus providing opportunities to still treat the pre-immortal cancer cells. Though, on one hand, the risk of cancer has still been elevated because of the extended telomere lengths, there are also strong reasons to believe that the longer telomeres have also significantly reduced the cancer risks; especially in the people suffering from later stages of aging. That is, short telomeres may actually be one of the major causes of cancer. When telomeres are short, they have a higher propensity to induce chromosome rearrangements. This can lead to aberrant expression of oncogenes and aberrant repression of tumor suppressor genes. In addition, our immune cells show decreased abilities to target and destroy cancer cells when telomeres are short. Keeping telomeres long should therefore decrease the incidence of cancer and help our immune systems to fight cancer. It's hard to know if the "pros" outweigh the "cons" when considering the cancer issues. The lack of a good animal model that ages by telomere shortening makes these issues almost untestable. So, at this time we can only speculate.
[ILLUSTRATION OMITTED]
In the meantime, people are aging, and people are dying of old age. Many cancer survivors will tell you that cancer is a fate worse than death. Many elderly people will tell you that suffering old age is a fate worse than death. There is little doubt that the potential for increased risk of cancer due to TA-65 is real. But the potential for increased risk of suffering from old age due to not taking TA-65 is more real.
DR. WEST WRITES AGAINST...
Recent advances in molecular and cell biology have allowed spectacular progress in our understanding of the molecular machinery of human aging. With this new information come insights into how that clockwork can be modified to slow or even reverse various facets of human aging. The discovery of the telomerase gene as a central regulator of replicative immortality and the "key" that winds and sets the length of telomeres (and hence cell replicative life span) in human cells has led to great optimism about the prospects of turning on the gene in the body to extend telomeres and potentially human life span.
Many scientists believe that the reason telomerase, and hence cellular immortality, is repressed in the majority of cells in the body while being left on in the reproductive cells is that this allows the human species to continue indefinitely, while repressing the unlimited growth of cells in the process of cancer formation. This conclusion is based in part on the observation that approximately 90% of human malignant tumors show the abnormal expression of telomerase compared with normal tissues.
The role of telomerase in cancer is best summarized by the car analogy. A cancer cell is like a runaway car on the freeway. Imagine a car with an accelerator stuck to the floorboard. That would be similar to the activation of oncogenes that drive cancer cells to divide rapidly even when inappropriate. Now imagine a car that in addition to the aforementioned mechanical difficulty also has a broken brake. This is analogous to the loss of tumor suppression also seen in many human cancers. The driver of such a runaway car could at least hope that he could avoid a collision long enough to run out of gas and safely steer the car to the shoulder of the road.
[ILLUSTRATION OMITTED]
However, now imagine that the car somehow acquired the capacity for an unlimited fuel supply (telomerase activation). Collision and death would then be the nearly certain outcome. In the same way, it has been demonstrated that a normal human cell can be transformed into a cancer cell by introducing oncogenes (broken accelerator), interrupting tumor suppression genes (broken brake), and then introducing human telomerase (infinite fuel supply).
The downside of nature's anticancer program, of course, is that our skin, bone, and blood cells, as well as many others, have a deadly clock ticking away that puts an absolute limit on their capacity for renewal and repair. To overuse the car analogy, in aging we see a highway littered with cars that have run out of gas, so to speak. So the question is can we find a way to fill up the gas tank of the aging cells in our body, to reawaken telomerase just enough to rewind the clock of cellular aging without causing an undue risk of runaway cells and cancer.
The nutritional supplement TA-65 is a single naturally occurring small molecule derived from the root of the plant Astragalus. Geron discovered that this molecule was capable of reawakening telomerase expression in mortal human cells in the laboratory dish, and there is now some published evidence of its utility in human beings. However, it should be pointed out that there is still no published evidence that this molecule results in a profound extension of telomere length or cell life span. The plant and extracts of the root of the plant have apparently been consumed safely by people for many years. However, the highly purified form of the compound, the administration at doses and for the length of time of 6-12 months in what is called the Patton Protocol (www.tasciences.com/pattonprotocol.html), has no precedent in normal nutrition.
If indeed TA-65 can induce telomerase expression sufficient to extend telomere length in human cells, then the long-term expression of telomerase in the entire human body may, in my opinion, expose a person to an unsafe risk of cancer. The data suggest that the adult human body has many "runaway" cells that have activated oncogenes and inactivated tumor suppressor genes but have stalled due to being mortal (pre-malignant growths). Examples of pre-malignant tumors would be colon polyps, growing prostates, or that large, but not yet malignant mole on your back. A protocol to reset cellular aging to benefit human health in aging needs to be carefully designed to increase the probability of human longevity without exposing people to unnecessary risk of cancer by allowing all of these pre-malignant cells just long enough to take off in unbridled growth.
In mice, which live only a couple of years, the genetic up-regulation of telomerase (which turns on telomerase throughout the body) clearly leads to an elevated risk of tumors such as breast cancer. So the bottom line, the mouse model suggests that long-term global elevation of telomerase in the mouse increases, not decreases, the risk of cancer. The one-year Patton Protocol is intended to activate telomerase throughout the human body for up to a year (approximately half of a mouse life span). One could therefore reasonably conclude that given the fact that the mass of a human is over 2,400 times that of a mouse, a year of continuous telomerase activation could reasonably allow occult pre-malignant lesions in the human body to expand into larger tumors that then could mutate into overt and immortal malignancies on their own even after the drug was removed.
Since pre-malignant tumor cells have activated oncogenes and inactivated tumor suppressor genes, they are thought to be dividing faster than their normal counterparts, and therefore even a modest extension of telomeres in the whole body could be expected to give a preferential extension of cell life span to these pre-malignant cells. Therefore, in my opinion, our best available mouse data argue that there is an unreasonable risk to treat a healthy individual with telomerase-activating compounds. Some would counter that current telomerase activators are weak enough that they would not be expected to extend telomeres to the point where they would increase cancer risk. However, one would then ask why they would be useful for the treatment of aging.
The concerns I am voicing regarding the reactivation of telomerase are restricted to: 1) the long-term continuous administration of these agents, 2) the administration to the whole body, and 3) the treatment of patients who are otherwise young and healthy. It seems reasonable that for patients who are very old and/or are at high risk of death from age-related disease within five years, the Patton Protocol may be a reasonable trade-off of risk and reward. Similarly, if telomerase activators could be given for shorter periods of time, or administered to localized tissues that are a specific near-term problem for the patient, such as the use of telomerase gene therapy to reset cell life span in a non-healing geriatric skin ulcer, the trade-off might again make sense.
The good news is that modern advances in medical research are leading to unprecedented discoveries into the actual mechanisms of human aging that lead to rational strategies for intervention. Even 15 years ago, few researchers would have predicted that such technologies were even possible. Those who have an interest in using these new and unregulated therapies either in a personal program of life extension or for a loved one should carefully consider the trade-off of risks versus benefits.
Hanging in the balance is not only the life of the individual patient, but the well-being of the emerging field of interventional gerontology.
COMMENTS FROM THE MANUFACTURER OF TA-65
The "against" article is not entirely negative. Dr. West says, "It seems reasonable that for patients who are very old and/or are at high risk of death from age-related disease, the Patton Protocol may be a reasonable trade-off." The issue boils down to the risk/reward ratio for those of us who are aging, but are not yet seriously compromised by the ravages of old age.
A study published in the September 2008 online edition of the prestigious journal Lancet Oncology shows that a healthy lifestyle increases telomerase and is beneficial in controlling the aging process. The study was conducted by Dr. Elizabeth Blackburn, the famed UCSF biochemist who discovered telomerase, and Dr. Dean Ornish, well-known author and head of the Preventive Medicine Research Institute in Sausalito, CA. This study included 30 men with low-risk prostate cancer who improved their diet, exercised moderately, and reduced stress. At the end of the study, the men had 29% higher levels of telomerase than when they began. The researchers also reported that gene expression in cells taken from the men had been modified and that the activity of diseasepreventing genes increased and some disease-promoting genes including those involved in prostate and breast cancer had shut down.
We don't hear anyone condemning Blackburn and Ornish's findings or even suggesting that raising telomerase by an improvement in lifestyle might result in an undue cancer risk. Since TA-65's mechanism of action is also to raise telomerase levels, why should raising telomerase by taking TA-65 be any different?
[ILLUSTRATION OMITTED]
HOW TO ACCESS TA-65
The TA Sciences Center is located in Manhattan, NY. The Patton Protocol with TA-65 costs approximately $2,500 for initial tests (including extensive blood work, telomere length measurements, and seven biomarkers of aging). The first six months of the protocol is approximately $6,725. Members of the Life Extension Foundation receive a 10% discount off of these prices. TA Sciences can be contacted at:
Toll Free: 888-360-8886 | Office: 212-588-8805 | Fax: 212-588-0058 | Web Site: www.tasciences.com
FINAL COMMENTS FROM LIFE EXTENSION[R]
We live on the very frontiers of achieving a radically extended life span. The molecular data presented in this article should impress anyone who understands the remarkable strides scientists are making in understanding the fundamental mechanisms of aging. While Dr. Michael West is a board member of the Life Extension Foundation[R], we as an organization don't as of yet have a formal position or recommendation as it relates to the use of TA-65.
COPYRIGHT 2009 LE Publications, Inc.
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2009 Gale, Cengage Learning. All rights reserved.
Enzyme telomerase activating compound discovered....
In continuation of telomerase and its importance...
Sierra Sciences, in collaboration with TA Sciences, Geron Corporation, PhysioAge, and the Spanish National Cancer Research Center (CNIO), has announced the first compound ever discovered that activates the enzyme telomerase in the human body - a critical prerequisite for technology that could arrest or reverse the aging process in humans. This compound is a natural product derived nutraceutical known as TA-65.
TA-65 , exclusively licensed to TA Sciences from Geron Corporation, is a >95% pure single chemical entity isolated from a proprietary extract of the dried root of Astragalus membranaceus and formulated into 5- to 10-mg capsules with inert excipients. Starting doses of 5–10 mg/day were considered safe on the basis of historical usage of extracts. Some subjects increased their dosage after several months on the product to 25–50 mg/day. Cumulative dose consumed during the year was recorded for each subject and used for preliminary dose–response analysis.
Researchers discovered that TA-65 was associated with a statistically significant "age-reversal" effect in the immune system, in that it led to declines in the percentage of senescent cytotoxic T cells and natural killer cells after six to twelve months of use. In addition, further analysis with automated high-throughput confocal microscopy (HT-qFISH) revealed a decline in the percentage of white blood cells with critically short telomeres after twelve to eighteen months of use.
Telomere shortening is thought to be the "clock of aging" contained within the human body. It has been repeatedly demonstrated that a human cell that does not undergo telomere shortening will divide indefinitely and is, by all available measurements, immortal.
Researchers reports that TA-65 can cause telomerase, an enzyme that lengthens telomeres, to become active in human cells. Telomerase activation by TA-65 was shown to lengthen the shortest telomeres in humans, potentially extending human lifespan and healthspan. Telomerase activation is thought to be a keystone of future regenerative medicine and a necessary condition for clinical immortality. Although TA-65 is probably too weak to completely arrest the aging process, it is the first telomerase activator recognized as safe for human use.
"We are on the cusp of curing aging," said William Andrews, Ph.D., co-author of this study and President and CEO of Sierra Sciences, LLC. "TA-65 is going to go down in history as the first supplement you can take that doesn't merely extend your life a few years by improving your health, but actually affects the underlying mechanisms of aging. Better telomerase inducers will be developed in the coming years, but TA-65 is the first of a whole new family of telomerase-activating therapies that could eventually keep us young and healthy forever."
Telomerase activation has potential medical applications beyond extending human lifespan. Epidemiological studies have shown that short telomeres in humans are a risk factor for diseases including, among others, atherosclerosis, diabetes, Alzheimer's, and cancer. The present study also reports encouraging news on the effect of TA-65 on the body's immune system. Infectious diseases lead to telomere shortening in the immune system, as immune cells divide to fight infections. Telomerase activation should prevent this telomere shortening and allow the body's immune system to fight a chronic infection indefinitely.
The present study on TA-65 lends support to this hypothesis. In individuals infected with CMV, a virus which prematurely ages the immune system and significantly reduces life expectancy, TA-65 caused an apparent "age reversal" of approximately 5 to 20 years based on one biomarker of immune aging. For the same reason, telomerase activation is a potential treatment for AIDS.
"We tend to see HIV turning into AIDS when the cells of the immune system develop critically short telomeres," said Andrews...
HIV can essentially cause the immune system to die of old age while the majority of the body is still young and therefore the researchers are hopeful that a telomerase activator could theoretically prevent an HIV-positive individual from ever developing AIDS....
Ref : http://www.liebertonline.com/doi/abs/10.1089/rej.2010.1085
Interesting news feature on evening news here warning to test for lead in the soil before growing veggies/fruits.
When testing soils in urban/suburban areas they found very lead levels in the soil where a garden should not be established.
Omega-3 bioavailability: Scientists lift the lid on which forms work best
Omega-3 fatty acids in the re-esterified triglyceride form may be the most bioavailable, compared, according to a new study omega-3 pioneer Jorn Dyerberg.
Dr Dyerberg and his Danish co-workers report that the bioavailability of omega-3s in the re-esterified triglyceride was 50 percent higher that omega-3 in the form of free fatty acids or ethyl esters, according to new findings published in Prostaglandins, Leukotrienes and Essential Fatty Acids.
“Our results demonstrate that bioavailability may differ between the commonly used types of concentrated fish oil preparations. Re-esterified triglycerides have superior bioavailability, whereas ethyl esters may have a lower bioavailability. Free fatty acids have medium bioavailability, which is not different from that of natural fish oil triglycerides,” wrote researchers from the University of Copenhagen and Aalborg Hospital.
Heart health and beyond
The heart health benefits of consuming oily fish, and the omega-3 fatty acids they contain, are well-documented, being first reported in the early 1970s by Dr Dyerberg and his co-workers in The Lancet and The American Journal of Clinical Nutrition. To date, the polyunsaturated fatty acids (PUFAs) have been linked to improvements in blood lipid levels, a reduced tendency of thrombosis, blood pressure and heart rate improvements, and improved vascular function.
Beyond heart health, omega-3 fatty acids, most notably EPA (eicosapentaenoic acid) and DHA (docosahexaenoic acid), have been linked to a wide-range of health benefits, including reduced risk of certain cancers, good development of a baby during pregnancy, joint health, and improved behaviour and mood.
Despite such benefits there are still problems with ensuring adequate omega-3 intakes from fatty fish. This has led to a fleet of omega-3-rich concentrates becoming available. Projections by Frost & Sullivan set annual growth for the omega-3 market at an impressive 24 per cent, and the market is estimated to be worth $1.6bn by 2014.
Various forms of concentrated omega-3 fatty acids are available on the market, and these include free fatty acids (FFA), ethyl esters (EE) or as re-esterified triglycerides (rTG). The latter term refers to products made from fish body oil, “in which the approximate 30 percent TG content is transferred to ethyl esters and then molecularly distilled to remove the short chain and the saturated fatty acids increasing the EPA and DHA contents to around 60 percent”, explain the researchers.
According to Dr Dyerberg and his co-workers, questions still remain as to the actual bioavailability of EPA and DHA from the various omega-3 formulations, and so they set out to test the availability of five commercially available fish oil supplements - natural TG in fish body oil, cod liver oil, EE, FFA and rTG. The blinded, placebo-controlled study involved 72 people aged between 21 and 56.
Participants received a daily supplement of one form of omega-3 (daily doses of EPA plus DHA between 3.1 and 3.6g) for two weeks.
Comparing the formulations
At the end of the intervention the researchers report that “the mean relative bioavailability of EPA plus DHA from EE was 73 percent, from FFA 91 percent and from rTG 124 percent. Adjusted for dosage, the results were 76, 86 and 134 percent, respectively”.
“Interestingly, we found an even higher index of bioavailability (124 percent) of rTG than of natural TG (fish body oil and cod liver oil), although it should be stressed that this difference was only significant when compared with cod liver oil. A tentative explanation for this finding could be that besides TG, rTG also contains both diglycerides and monoglycerides,” explained the researchers.
“It should, however, be stressed that these conclusions are based on a relatively short-term (two-week) study at a fixed daily omega-3 fatty acid dose of approximately 3.5g; it cannot be ignored, even if it seems unlikely that a different period of supplementation or a different dose may have led to different results,” concluded Dr Dyerberg and his co-workers.
The rTG, EE, FFA, and FBO supplements were all sourced from EPAX.
Source: Prostaglandins, Leukotrienes and Essential Fatty Acids
September 2010, Volume 83, Issue 3, Pages 137-141
“Bioavailability of marine n-3 fatty acid formulations Original Research Article”
Authors: J. Dyerberg, P. Madsen, J.M. Møller, I. Aardestrup, E.B. Schmidt
Dr. Oz featured Longo Tea today as a weight loss assist.
He also featured http://www.brancrispbread.com for excellent fiber souce that supposedly tastes good and helps satisfy hunger pangs to lose weight.
I ordered some to try it out.
Breaking News on Supplements & Nutrition - North America
Unilever breakthrough may open up tea compound’s brain potential
By Nathan Gray, 27-Sep-2010
Scientists from Unilever R&D have modelled the absorption and breakdown of L-theanine in humans, with results that may cast more light on the potential brain benefits of the tea compound.
The new research is said to be the first study to measure the pharmacokinetic parameters of L-theanine – assessing how the compound is absorbed and removed from blood plasma after dietary ingestion.
The results of the study, published in the Journal of Functional Foods, are believed to provide new model data, which could support further research into the potential health benefits of L-theanine.
“The obtained set of pharmacokinetic parameters from this study allows accurate prediction of L-theanine concentrations in plasma over a relevant dose range.
“The ability to predict L-theanine concentration may facilitate research about putative health effects of L-theanine in the brain,” stated the Unilever scientists.
“The impact of the composition of other food matrices like sugar, milk and … ingested meals … on the pharmacokinetic behaviour of L-theanine is unknown and could be studied in future research,” they added.
Health effects
Tea leaves contain numerous compounds, including caffeine and flavonoids – that dissolve when the leaves are mixed with hot water.
The amino acid L-theanine (c-glutamylethylamide) is almost exclusively found in tea plants. The compound only exists in the free form, and is the principal free amino acid in tea - accounting for approximately 50 percent of the total free amino acids.
Various health effects have been associated with L-theanine, including relaxation, neuroprotective effects, and improved attention.
During rest, L-theanine increases alpha activity in EEG models - suggesting greater relaxation. Whilst the amino acid is known to induce changes in alpha activity that indicates increased attentional processing during tasks that require attention.
The authors note that the source of L-theanine, and the matrix in which it is administered, might have an impact on its pharmacokinetics and absorption rate, respectively.
The new Unilever research investigated the pharmacokinetics of L-theanine in humans, using pure L-theanine from an aqueous solution, L-theanine from black tea, and L-theanine from enriched black tea.
Quick absorption
In all cases, the researchers reported that L-theanine was absorbed quickly, and resulted in maximum plasma concentrations of up to approximately 5 mg/L.
The results revealed that in aqueous solutions, such as water or tea, almost immediate release of L-theanine can be expected.
The researchers noted that dose-independent pharmacokinetic parameters were fairly consistent across the various doses, L-theanine source and matrices, whilst dose dose-dependent parameters were consistent - after correction to allow for body weight.
Future research
The authors concluded that L-Theanine - be it pure, biosynthetic, or tea-derived - is quickly absorbed and eliminated from the systemic circulation in humans.
Researchers stated that the pharmacokinetic model “will facilitate the design of studies related to L-theanine effects.”
Source: Journal of Functional Foods
Published online ahead of print, doi: 10.1016/j.jff.2010.08.001
“Human disposition of L-theanine in tea or aqueous solution”
Authors: P.C. van der Pijl, L. Chen, T.P.J. Mulder
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A little aspirin may prevent bowel cancer
A LITTLE aspirin might just go as far as a lot when it comes to preventing bowel cancer - with fewer side effects.
So says a five-year retrospective study led by Malcolm Dunlop of the University of Edinburgh, UK, that compared the aspirin habits of 2800 people with cancer and 3000 without. The team found that the risk of getting cancer was 25 per cent lower in those who had been taking 75 milligrams of the drug daily compared with those who had not (Gut, DOI: 10.1136/gut.2009.203000).
If everyone in the UK was taking a low dose of aspirin in 2007, the latest year for which data on bowel cancer incidence data is available, it would have prevented 16 cases per 100,000.
This small reduction in risk is comparable to that from earlier studies in which the doses were much higher. Andrew Chan of Harvard Medical School in Boston is not convinced: "I still believe that lower doses are not as effective as higher ones." His 20-year follow-ups on 80,000 women and 50,000 men showed that daily doses of 325 milligrams worked best for preventing bowel cancer.
Yes, he has about 200 patients that no longer need any further treatments after about 18 months. There are 3 or 4 of us who need on going treatment. However word of mouth brings more in every day.
Another new development in OTC pain relief was the introduction of Cobroxin last year. A derivative of Asian Cobra Venonom is used to block the nicotinic receptor in the brain stem utilizing a Homeopathic oral spray. There are no side affects, no addiction, no stomach issues, no cardiovascular impact and will even stop migraine headaches in most people. Cost is under $20 for a months supply if used every day. In addition, the receptor becomes more receptive over time so you use less product over time unlike addictive opids. http://www.cobroxin.com http://www.nutrapharma.com trading at 18 cents a share.
World wide release coming soon under the name Nyloxin with a more powerful version for extreme pain and under strict doctors care. http://www.nyloxin.com
By the way, their subsidiary, Receptofarm is in clinical trials with cobra venom to treat MS. Phase one early indications stopped and even reversed symptoms in some patients. Further trials will probably start in 2012. http://www.receptopharm.com
Your doctor is obviously a life saver..please continue to add more info on this subject..to have an amino acid protein play such an important role in your health is so very worthy of sharing with us..I bet that many folk out there are suffering of allergic responses and their doctors are running out of solutions..very scary~
I refined the link to the model that is a super buy and is very powerful. This guy from Hawaii discounts to under $2 grand and these things seem to last forever. My Chiro has made a lot of money with this piece of equipment.
I have gotten into extensive studies and research since I wouldn't be alive without an amino acid protein developed in Europe to control my auto immune disease. My Naturopathic Dr. fly's in shots from Europe for about 200 patients who can't get help from conventional medicine. The treatment "amino acid modulation " downregulates my immune system. It lasts exactly 3 weeks and then I get another shot. If I don't get the shot, I immediately start to deteriorate because my immune system attacks all my organs. We had a 5 day delay once and I was in severe trouble so we had to track down a dose in the US quickly. There aren't many doctors in the US who do this treatment, my Dr. was a top Internal Medicine practioner and resigned his position to start this practice.
This treatment has kept me alive for 3 1/2 years....I have also seen the Dr. provide total remission of allergic response that was untreatable by conventional methods. His practice is packed with patients and he accepts no medical insurance of any type.
Incredible..I hope people will be exposed to this sort of information more and more~
Breakthroughs in Nutrition and Health seem to occur daily. Methods of training and building muscle have seen much change. Food and healthy recipes are cool also~
Feel free to post the latest and newest~
No spamming please~
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