Anavex Life Sciences Corp (AVXL)

[attilathehunt]

I believe the raise is twofold...


1). We are going RETT alone (most likely approval early 2024), so there will be funds needed to get the ball rolling. In fact, the ball has started to roll (i.e. recent new hires). TGD likes to maintain a hefty cash balance. As expenses increase, so will his appetite to increase the hoard. Remember we are going it alone on rare diseases so once RETT is approved, others will shorty follow, which will require money.

2). I'm slowly leaning toward a P4 (vs. outright approval) for AD and thus the case to raise cash. Most likely will be announced after RETT data in July. Remember a P4 will cost big dollars to monitor everyone prescribed!!!!

There will be another run (as high as 30+) very very soon, so IMO, TGD will raise then. Also keep in mind most here, when calculating share price, anticipate shares increasing. This recent LPC is just one of them.

Now that RETT is over, expect anecdotal news to start appearing more frequently.

All is good!!! We shall see 13 by end of week...Just watch!

[williamssc]

Who's to say they will be needing capital any time soon, a shelf placement is more of a contingency. Missling has control of when and if shares will be sold. Since they have 140mm in the bank now I suspect he wouldn't until share price exceeds 50 dollars.

[ExtremelyBullishZig]

They also said they didn't need dilution...so how does the comment about not yet meeting with the FDA have any truth to it.

They also have seen the data which triggered the silent money grab...guess they don't want to PR about the money...lol

[Pipilongstocking]

Yep seems like a good move to me.

[williamssc]

First off they need feedback from the FDA on whether another P3 is even needed and that meeting hasn't yet happened according to the last call. Missling just yesterday again released that their trial met both its co-primary and key secondary endpoints, showing statistically significant and clinically meaningful improvement in cognition and function as measured by ADAS-Cog, ADCS-ADL, and CDR-SB, respectively.

[mike_dotcom]

We're not the only small bio doing this - Annovis Bio Announces Approval For European Union Clinical Trial Sites For Phase 3 Study Of Buntanetap For Treatment Of Parkinson's Disease

[plexrec]

Good post on Stocktwits by Trainguy1--and I agree fully !! It’s well known that the people who least need to borrow money are the people offered the best interest rates. Similarly in businesses, a company that demonstrates its readiness to operate independently gets the best partnering offers. Even though we know Anavex wants to partner, they need to demonstrate complete readiness to operate independently. It’s a serious game of chicken. By signing the Lincoln Park agreement, Anavex is saying they’re ready to play. Game on!

[Gator328]

There are 2 ways to read your question:

1. Will AVXL be selling Blarcamesine within 6 months, as in will the drug be available on the open market?

2. Will AVXL be selling Blarcamesine within 6 months, as in will the company license or sell the rights?

I think you were referencing #2, but the answer to both is most likely "no." I expect at this point Dr. Missling is confident enough to submit to the FDA without a partner, and if approved maximize the leverage he has entering negotiation. At worst, he'll be told to run another confirmatory P3 trial -- and he has the cash to do so with minimal dilution. More likely, he'll be asked to run a P4 trial -- and with the LPC deal he'll have the cash to continue advancing the rest of the pipeline.

[ExtremelyBullishZig]

Sold plenty awhile ago...it has to fill that gap in the 8's sometime.

[ExtremelyBullishZig]

LOL...listen to the call...it is about BS...he has been feeding you lines for years...what does no more dilution mean to you?

[ExtremelyBullishZig]

Missling recently said...there is absolutely no reason for further dilution...in Missling we trust...yeah...we trust that there will be more lies. He must now be finished going through the data...his lack of enthusiasm, lack of timeline commitment to data, and lack of keeping to his word about dilution means one thing...data isn't good enough for a partner with up front payments. Need lots if money for a large P3.

[ExtremelyBullishZig]

They have 4 years cash with their currently plans...came from the horses mouth.

[ExtremelyBullishZig]

Sure do have a basis. A partner brings a fat upfront payment...but they have to scrape together a lousy 150 million...the amount of the voucher...must not be expecting good rett news if they cannot get the pediatric voucher withing the 4 years for which they already have enough funding.

Maybe you should stop being so laughable and but 2 and 2 together. A nice rett voucher or a partner would not require a bunch of money if you are planning on your current funds to get you through 4 years

I even spelled it out for you 2 different ways.

[Kb1123]

What’s 6 months? They have enough cash for 3 years

[WolfofMia]

Again listen to the conference call.

It is not about the start, it is about a good start, in order to finish strong.

Missling the forest for the trees is very common around here.

We have data from the two largest indications (markets $$$$$) to be broken down and explained (AD P2/P3, PDD OE).

But you want trial announcements? really?

Beats the schhhiiiiet out of me.

[Amatuer17]

He has been promising to start many of these new trials for some years - so he repeats it this year - we have to see which actually he starts

[WolfofMia]

I mean is better than playing with toilets.

But not quite as good as a real brain when it comes to bullshit detection.

[WolfofMia]

I guess you dont own any insurance on anything you do?

[WolfofMia]

Hey investor, did you sell any trading shares or core yesterday after the conference call?

Asking for a friend.

[WolfofMia]

Or perhaps the analysts you speak about were cleaning toilets as well.

Imagine being a share holder and not being able to listen to the call because of toilet cleaning duties.

Perhaps the analysts are losing interest and had better things to do this morning.

I’ve been cleaning my toilet.

[sab63090]

Powerwalker:

Thank you very much for that post.......what a great article and Steve Forbes is a clear thinker who gets it!

[Steady_T]

EBZ. I think that is premature emasculation.

LOL...no dilution...hahahaha...they can't get a partner and now have to go at it alone.

[Steady_T]

To maintain that $140 Million on hand. Does anybody think they will be selling 2-73 within 6 months?

[crescentmotor]

I just got 5% on 11 month FDIC CD @5%.

I hope that CD has a "step-up rate" provision. I recommend not going out past three months in this current environment with the Fed hinting at interest rate increases for a future indeterminate period perhaps even extending past 2023. My other half just found a one-month CD offered by a bank in Kentucky paying just over 4%.

[crescentmotor]

Very interesting that during the CC that foreign countries drug regulators could be focusing on Anavex and possible approval of Anavex drugs and, Anavec very aware of this ... and the possibility that our FDA would need to play catch-up

Given the questionable interactions/connections between BP and the U.S. regulatory health agencies, Missling made a very smart move (over and above minimizing trial expenses) to conduct many of the Anavex trials overseas.

[crescentmotor]

They obviously cannot get a partner for an unproven new science...

You keep repeating this absurd conclusion. Know anything about venture capitalists?

[crescentmotor]

they can't get a partner and now have to go at it alone.

You have no basis in fact for that conclusion. Your posts have become laughable absurdities over time.

[ExtremelyBullishZig]

P3 coming.

[ExtremelyBullishZig]

They obviously cannot get a partner for an unproven new science...

[crescentmotor]

I have often wondered just HOW the top FDA (NIH-all the rest) of the established BioPharm (BP) will react when the GREAT AWAKENING starts???.

Given the history of BP, and recently some very questionable actions by the regulators, I can only assume that there will be resistance. Hopefully, that resistance won't rise to the level of the shameful, if not illegal, activity observed during the Covid crisis when effective drugs were taken off the market and other very harmful drugs, such as Remdesivir, were used with reckless abandon by the medical-industrial complex. Given what has happened in the past, I am very suspicious of the regulatory/BP alliance.

[ExtremelyBullishZig]

LOL...no dilution...hahahaha...they can't get a partner and now have to go at it alone.

[crescentmotor]

Anavex doesn't need the money. But it's sending a clear signal that Dr. Missling getting his ducks in a row in case he doesn't receive any legitimate partnership offers.

Exactly--it's always a good idea to have defensive fortifications around your home base. The stock sales will only be made on an as needed basis. This flexible arrangement makes for very poor FUD fodder for the naysayers on the board.

[crescentmotor]

Perhaps the analysts are losing interest and had better things to do this morning.

Perhaps the analysts, like many posters on this board, were smart enough to realize that there was only a very slim possibility of material business updates given the small window of time since the recent 2b/III data release.

[Gator328]

Anavex doesn't need the money. But it's sending a clear signal that Dr. Missling getting his ducks in a row in case he doesn't receive any legitimate partnership offers. I don't think he wants to go at it alone but having access to cash is never a bad thing, because the cost of manufacturing and marketing will easily eat up all of the runway needed to get the other trials complete and further advance A371.

[Gator328]

The market rose as Powell began speaking of an end in sight with the rampant inflation, and the markets faded just as quickly when it became clear the process was going to take a very long time. Overlay the AVXL chart with the DJIA chart and you can see exactly when the spike and drop occurred across the entire market.

The price action had very little to do with Dr. Missling or the company as whole. If anything, one analyst allegedly lowered his price target from $80 to $58.

[georgejjl]

Key Near Term Pipeline Updates:

Alzheimer’s disease: Full data ANAVEX®2-73-AD-004: Potentially pivotal Phase 2b/3 clinical trial

Parkinson’s disease dementia: Data of 48-week OLE Phase 2 study

Parkinson’s disease: Initiation of ANAVEX®2-73 imaging-focused clinical trial

Fragile X: Initiation of potentially pivotal ANAVEX®2-73 Phase 2/3 clinical trial

Schizophrenia: Initiation of ANAVEX®3-71 Phase 2 clinical trial

New Rare disease: Initiation of potentially pivotal ANAVEX®2-73 Phase 2/3 clinical trial

Publications:
Several clinical publications involving
ANAVEX®2-73,
ANAVEX®3-71
and Rett syndrome Burden of Illness study

Good luck and GOD bless,

[sumbuysumsell]

Dude has been playing with ChatGPT AI.... here is a sample Q&A.....

Question - How should publicly traded companies communicate with shareholders?
Answer - Publicly traded companies should communicate with shareholders in a transparent, timely, and accurate manner. This can be achieved through various channels such as earnings releases, annual reports, investor presentations, conference calls, and other regulatory filings such as SEC filings. Additionally, companies can also use social media, websites, and email to reach shareholders. The goal of these communications should be to provide shareholders with a clear understanding of the company's financial performance, strategy, and prospects, and to respond to questions and concerns in a prompt and helpful manner.

[georgejjl]

NONSENSE

[catdaddy]

More verbal diarrhea!

[ignatiusrielly35]

Wow, an ATM agreement. (Yawn)

[peeved]

Good question..

If partnership was in works i don’t think they would need agreement w vulture firm…they could just file for more shares

If no p3 needed for ad, then, 4 years of cash should have been enough..so its curious timing

So that leaves one option imo..

[Steady_T]

Wow. I think the AGM should start with everyone singing Kumbaya.

The communication you describe would be nice. It is not close to essential.

What is essential is the company delivering on developing and marketing a drug.

[kund]

You don't know how LPC vulture works, Misleading used them earlier, diluted from 25mil to 70mil shares in 5year, collecting pennies. LPC is his comfort zone, he might be expecting share to drop big time and needed continues ATM.

[BIOChecker4]

It takes a lot of money to do trials and commercialize drugs for every human disease known to man.

[Twice Worthy]

In over 38 years Big Pharmas or, biotech companies that focused exclusively on the plaque/tau none have been successful in their treatment of the disease of AD. Even our FDA in desperation to find a meaningful approach to this catastrophic disease approved 2 Biogen drugs that do little to alleviate the significant issues of the disease ... plus their drugs are very expensive, must be given I.V. and must be done by medical personnel ... adding more expense for the treatment .... and the treatment can cause the patient's brain to bleed, which could result in the patient's death. Summed up, just more failures with this dangerous approach.

Am awaiting the approval of Anavex's blarcamesine drug/2 - 73, a safe drug, a pill taken by mouth, that has demonstrated significant results with neuro-degenerative and neuro-developmental diseases affecting the CNS.

[BIOChecker4]

Missling is back in bed with vulture investor LPC but not because he couldn’t get any real WS banks to take it on. It’s because he doesn’t want to have to answer hard questions from sophisticated institutional investors or be accountable to those investors who might buy in.

[ALP7]

This dogma was challenged by two Australian physicians........ When not ignored, their discoveries were derided. Only after many years ........did the medical world accept their truths.

This is something that has been true in scientific and medical fields for a long time. The doctor (Ignaz Semmelweis) that realized that washing hands and sterilizing equipment would save many lives was ridiculed, fired and eventually driven insane. Over 20 years later another doctor (Joseph Lister) was actually able to advance this novel concept so that it became commonplace.

Here are their stories:
https://www.npr.org/sections/health-shots/2015/01/12/375663920/the-doctor-who-championed-hand-washing-and-saved-women-s-lives

https://www.smithsonianmag.com/smart-news/idea-sterilizing-surgical-instruments-only-150-years-old-180962498/

[ignatiusrielly35]

Another fudster masquerading as a shareholder. How refreshing.

[Anshu2]

Haha. My takes from CM’s CC.

1. AD full data. In 2023? Not sure — could be 2024, 2025. But, I assure you asap.

2. Excellence trial endpoint. RIGHT NOW, our plan is delta-RSBQ, but you know us — can’t promise what it will be in 2 months, or when we see the data.

3. PDD OLD. Oops, are you guys still waiting for it?! Give us 6-12 more months. We need a few more months to compute an average of 400 values.

4. AD discussion with FDA. After we get our “hands” on full data (see #1 above), then we’ll talk **aggressively** with the agencies. Just 1-2 more years wait.

5. Other trials: All our previous trials have failed — so we are being extra cautious that these new ones succeed. So, that’s the reason for delay.

6. PDD trial full data: Forget about it!

[oldandintheway]

The obsession with this dead-end approach has been fanatical, almost cultlike.


There's a lot of that going around these days....