Anavex Life Sciences Corp (AVXL)

[MayoMobile]

Simple Notes from Conference Call:

- Fragile X trial to take place in USA; talks with FDA recently conducted.

- Dr. Missling is keen to get data off to the FDA and EMA (European regulators mentioned a few times). I discuss this with Dr. Grimmer.

- Strong language indicating cross-CNS platform. I discuss this with Dr. Grimmer.

- Rett Syndrome Burden of Illness presentation mentioned for the first time in a long time - indicates the company will tie patient improvement to parent/caregiver greatest concerns.

- Dr. Missling mentions brain atrophy - as we know, Lecanemab patients saw SIGNIFICANT brain atrophy, especially in the hippocampus. Looking forward to this data and hopefully some comparative charts.

- Reaffirms S1R as important to patient efficacy. I discuss S1R as a biomarker with Dr. Grimmer.

- Very much so looking forward to PDD OLE. I discuss PDD briefly with Dr. Grimmer.