Anavex Life Sciences Corp (AVXL)

[ExtremelyBullishZig]

Stop taking drugs they are bad for you.

[ExtremelyBullishZig]

Lol...you don't ha very a clue about success. Anavex has not delivered any success...so therefore the manipulation you speak of is called real market activity responding to zero success...

Okay. I think I have finally caught up on the past 2 years of BS but the crook pumpers here...

[ExtremelyBullishZig]

LOL

[ExtremelyBullishZig]

No one here is paid. Bashers aren't paid to bash and pumpers aren't paid...well because...the company doesn't perform...ever...lol.

Paid posters is a false conspiracy.

[ExtremelyBullishZig]

LOL...thanks for finding what everyone can find without much effort...this still doesn't make you relevant...

[ExtremelyBullishZig]

So...thensame as the predictions the past 5+ years. Something is going to happen the share process is going to go up to X...what will the next scenario be to validate another $100 SP if this one doesn't pan out?

[kund]

Blast from the past...Anavex 2009 pipeline, nothing changed in 16year, same old crap.

[ExtremelyBullishZig]

Anavex is shredding documents as we speak...

[bb8675309]

That's terrible. Sounds like you defiantly have some recourse their but I know that doesn't help your health issues. We need to get 2-73 approved ASAP so you can help restore your mitochondria. Their has to be a way to access the drug through compassionate use.

Anyone know of a way to access A2-73 through compassionate use?

[XenaLives]

Tell me about it...

I have been poisoned twice by flouroquinolones, the second time was in 2018. After being prescribed Cipro for a routine UTI I informed the Doc that I had already had an adverse reaction that took years to recover from....

... the asshat told me I would get "antibiotic resistance" if I didn't continue to take Cipro .

I recently found out that there were HUGE FDA WARNINGS in 2016.

So he is still treating (???? poisoning ????) patients while every day I deal with damaged mitochondria that steal my health and ability to function.

[bb8675309]

Spot on, Xena. They support companies with black box warnings on their drugs that actually hurt or even kill the patient. Right now the retail investor has lost their protection against the corrupt market. Hope they can get it turned around. imo

[XenaLives]

You don't have a clue about market corruption...

It goes way beyond the influence of any CEO.......

Hedge funds and Market makers have been throwing their weight around for decades....

BUT NOW...

AI has amplified the ability of the "connected" persons and entities to manipulate.

The real value of a stock or it's IP has become totally irrelevant to stock price.

ALGOS RULE!!!!!!

.... and anyone who believes in an "efficient market" is a damn fool.

[kund]

New milestone "Analysis of RNA sequencing (RNA-seq) of the placebo-controlled Phase 2b/3 blarcamesine trial in early Alzheimer’s disease is underway. Interim data expected by mid 2024.

Another useless analysis, kick the can.....

[BIOChecker4]

CEO is a DUDster. I love it!

[poguemahone]

Yes, I remember it well. It was used in conjunction with the “tip of the iceberg” and firetruck and firehouse analogies.

The one thing our CEO has revealed to date is that he is an idiot.

[kund]

Another delusional long, list is growing. Every delusional long want approval without filing NDA, I guess they all live in parallel universe

[kund]

Oh boy! invoking Jesus name...back in 2015 Agora Finance told us "Messiah will stand up and world will take note of it". Clown presented tiny trial data with "Super Responder" at CTAD, igniting an uncontrollable frenzy of euphoria on this forum, rest is history. 10year and stock is still at the same place, but outstanding shares have ballooned 4x.

[poguemahone]

And all these wonderful catalysts and upcoming newsworthy events are worth……$3.81 per share.

I love Missling’s response to Tom Bishop-“we’re not happy about the SP.”. Well you idiot, then do something about it!! Ghosting shareholders and stakeholders for months is not an effective leadership strategy.

[kund]

Any one remember "Data Rich Quarter"? Only crook can come up with this kind of slogan and WGT still fall for it.

I believe he mean he getting rich from zilch, zero, none data

[poguemahone]

This ALZ data is taking WAY too long to be released—we’re approaching 18 months. Every deadline our CEO mentions gets delayed or never materializes. He mentioned in the CC how much work is involved in completing the submission package to the EMA. Get ready for that to be the reason why that submission gets pushed out indefinitely. This guy loves pushing everything to the next quarter, second half, or end of the year. When those deadlines come and go, he’ll blame anything and everything but himself.

I’m the FUDster?!! I think our CEO is a DUDster.

[kund]

Do same for 2021, 2022 and 2023 and see if there is any progress....LOL, it will be same for 2025.....2030

[powerwalker]

If poguemahone were not a FUDster, s/he sure acts like one.

Chose who you want to believe: the guy who knows the Anavex data or the one who denigrates him ... and DOES NOT KNOW THE DATA!!!

[sage4]

AVXL Calendar-  for the rest of year, gathered from  Earnings Call Transcript

- 6/18 to 6/19:  An educational presentation will be provided at the 2024 IRSF Rett Syndrome Scientific Meeting, taking place this year June 18, 2024 to June 19, 2024

- Mid-2024:   as well analysis of RNA sequencing of the trial is underway and interim data is expected by mid-2024.

2H:
- 7/25 to 7/28: the potentially pivotal ANAVEX2-73 Phase 2/3 clinical trial will be presented at the 19th National Fragile X Foundation Conference taking place in July 25, 2024 to July 28, 2024.

- the ATTENTION-AD open-label extension trial is ongoing and we expect to be able to share interim data in the second half of 2024

- PD initiation of an ANAVEX2-73 Phase 2b/3 six-month trial is expected in the second half of 2024.

- EMA Filing: Dr. M "we said we want to submit this year and we are well on track to do that. So we will provide updated timing when we get closer to the filing time. But we have very good on time with that. So stay tuned."  ".....There’s also interactions taking place with the EMA to be aligned on the technicalities,...."

[poguemahone]

We better hope that Missling can get off his arse and actually accomplish something—other than increasing his personal wealth.

As I have stated previously, his behavior and shadiness has all the makings of an episode of American Greed.

[sage4]

Q2 2024 Earnings Call Transcript
For those who can not read on Seeking Alpha website.

https://www.insidermonkey.com/blog/anavex-life-sciences-corp-nasdaqavxl-q2-2024-earnings-call-transcript-1300719/#q-and-a-session

[tredenwater2]

“ path to approval has likely also been helped by the mixed reception of the three recent mAb treatments at the FDA and EMA, and by lackluster uptake of Leqembi specifically in the marketplace.L

William yes indeed! They have had their day in the sun, albeit very short, and now we will get ours!

[tredenwater2]

“ SMH at the back and forth of you and some of the others, who express bi-polar feelings and thoughts about TGD and Anavex.”

Yes, many out there need Blarcasamine, including those that persecute, lie, and outright denigrate Dr. Misslings name.

Jesus showed us the greatest example of what to do and that is to unconditionally love even those that hate you. He loved those that spit on Him, beat Him, ridiculed and ultimately crucified Him.

Patience for the patients as management unwinds the extraordinary results never before seen in multiple trials and prepare for approval in multiple governing agencies.

Tred

[Investor2014]

Complete BS!

Anavex has certainly been delayed relative to the rapid approval of Big Pharma's marginally effective antibody drugs with very scary safety profiles!

Anavex have yet to file an NDA, an MAA or any other marketing application for A2-73. That has nothing, zero, zilch to do with FDA or anyone other than Anavex themselves holding back Anavex.

[dia76ca]

I have invested in many small biotechs over many years as have many others on this board. I see two common issues.
One. Many of these small companies have problems with the FDA while Big Pharma sail through rapidly with very ineffective products with huge safety concerns!
Two. Many of them have problems raising finances.
In regard to the first issue, Anavex has certainly been delayed relative to the rapid approval of Big Pharma's marginally effective antibody drugs with very scary safety profiles!
In regard to the second issue, finances, Anavex has done very well.
We still need to see the peer reviewed article! (Which will be savagely attacked by the usual players!)
We still need to see some positive response from EMA or FDA!
It looks like a classic HOLD situation with potentially large gains, OR significant losses.
Time will tell!

[kund]

I think your biased mind preventing you from recognizing real corruption, it is buzzword king Misleading, who is corrupt to the core. He comes up with useless timeline on the go, no strategy, no plan, simply because none is required; his sole aim is to fleece retailer and keep making easy million while on vacation.

Last December, he claimed that RETT data was delayed due to safety concerns. Within just ten days, he announced that the trial had failed. The entire drama was for his bonus payout.

[bb8675309]

It's hard to believe that you don't see the corrupt manipulation on the company and to the stock price.

[frrol]

Yes. While there was some medical and payor backlash, which can put regulators back on their heels, it also creates some impetus for cheaper and easier alternatives. This may have been a factor in the eased FDA guidelines.

After our initial AD readout, I posted about how there were two main factors that would determine our ultimate odds in getting AD approval based on the 2b/3 trial. 1) What else came out of trial readouts, and 2) How aggressive would regulators continue to be in getting other therapies approved. Re #1, the positive follow up disclosures (AB ratio, brain MRI data) were good to see. Re #2, the FDA's revised assessment guidelines and the EMA's receptiveness to our MAA were good to see.

[plexrec]

power--" forth of you and some of the others,"--after closely following Dr.Missling for 9 years--looking at our horsekrap share price---lots and lots of "I hope you all are excited as we are BULLSHIT---only one conclusion is logical !!!!! Dr.what have you done for me (us) lately ?????? In this game the Share Price is the scorecard---what else can one go by ???? Unfulfilled promises and --"it's coming just around the corner" Also 2nd half of '23 !!!!! I think I said enough !!!!!!!

[JoeBear906]

George, Thanks again for being Johnny on the spot with another very useful package of information first.

[WilliamMunny]

frrol, I might add that the path to approval has likely also been helped by the mixed reception of the three recent mAb treatments at the FDA and EMA, and by lackluster uptake of Leqembi specifically in the marketplace.

[powerwalker]

plex, did you ever hear of Enron?

You and your ilk (pogue, mrp, the 43 FUDsters et al) are "way off base" about TGD.

SMH at the back and forth of you and some of the others, who express bi-polar feelings and thoughts about TGD and Anavex.

[Thehubby]

I disagree..I do not think he is a crook ..I think it's more ineptitude..my feelings will change if it comes out that AZ endpoints were not met as advertised...that said, if I thought that were true, I wouldn't be here

[poguemahone]

Spot on post—if Missling is not a crook, he sure behaves like one.

[ExtremelyBullishZig]

Because that is most likely not what actually happened. It was most likely an exaggeration of what really was said by the EMA.

[plexrec]

mrp--got you beat on years of being an investor--bought AT&T as my 1st investment in 1965--so that makes my years of investing 59---" I've never seen such malfeasance and lack of transparency "--and with this quote I do have to agree--this investment of mine (in 2015) has turned out to be a total fiasco---Missling has been "kicking the can down the road" seems like forever----lots and lots of promises--never a positive reward (ending)--Con man ????? Sure fits the definition--Transparency and shareholder value thrown under the bus !!!!!!!!

[nidan7500]

Another possible implication is that Blarcamesine helps the brain with autophagy — regulating itself and recycling cell parts. Dr. Missling has noted in the past that the drug is designed to help with autophagy.

Through autophagy, then, the brain may be clearing the plaques on its own, as spurred on by Blarcamesine.

Dr, Peter Senge...

Systems thinking is an approach to problem solving which takes into account the overall system as well as its individual parts. According to Peter Senge, it's “a framework for seeing interrelationships rather than things, for seeing patterns rather than static snapshots.

That is why we call it CNS=Central Nervous System. It is what it is

[powerwalker]

mrp, I did not listen to the cc.

Thank you for your remarks and explanation.

Obviously, Roy and you are on the same page. I'm sure you believe $15 is too high if no EMA filing occurs in the next 12 months.

I think it does get filed by the end of September with peer review published as well. Delay with the peer review might be adding details on brain volume data.

If these occur as I cite, SP will be, at least, $50 and probably more if EMA likes what it sees.

Peace, mrp, and enjoy your weekend,
powerwalker

[frrol]

Your "literal" interpretation was silly, of course. If the company executes well, we will be able to submit the MAA late summer / early fall. It was nice to see that Missling is aware of the need to consult with the EMA during the 7+ month preparation phase to avoid delayed submission acceptance. I'm confident the company has third party assistance in the MAA, as we have ample cash to pay for it. As for manufacturing, the MAA includes information on the manufacturing process and planned site(s), but does not require contracts, and drug companies rarely announce them. So the wisest course in your case is to just wait for MAA submission.

Our Rett program had a setback, but AD has a plausible (albeit uncertain) path to approval, thanks to a drop/rationalization in regulatory standards, both in the US and Europe.

[nidan7500]

GOOD NEWS starting to flow from new sources...nice to see...C'MON... show (. FDA SPEAK. "Proven by provision of objective evidence", ) showing us the way to get started REALLY making news..."Before vs After images are killer proof, even W/S & FDA can't screw THAT UP".

The European Union is currently working with Anavex to examine Blarcamesine’s clinical trial results and other factors for possible approval for use in combating Alzheimer’s Disease.

The U.S. FDA currently is not evaluating Blarcamesine for approval in the United States.

Today, Anavex Life Sciences CEO Christopher Missling discussed data from the Phase 2b/3 drug trial of Blarcamesine showing that the drug lowered the level of beta amyloid plaques in the brains of Alzheimer’s patients. This result was actually somewhat surprising, as, according to Dr. Missling Blarcamesine is designed to alter brain chemistry upstream from the production of beta-amyloid.

Unlike Biogen’s Lecanemab, Blarcamesine is not designed to clear beta-amyloid plaques from the brain.

The implication seems to be that Blarcamesine, working upstream, prevents the production of these plaques rather than clearing them out.

Another possible implication is that Blarcamesine helps the brain with autophagy — regulating itself and recycling cell parts. Dr. Missling has noted in the past that the drug is designed to help with autophagy.

Through autophagy, then, the brain may be clearing the plaques on its own, as spurred on by Blarcamesine.

In the conference call, Dr. Missling also noted that the drug trial demonstrated that Blarcamesine prevents brain shrinkage among Alzheimer’s patients. In fact, in my reading of the results, this was perhaps the most statistically significant finding of the entire drug trial.

When I say “brain shrinkage” I mean the loss of brain mass: losing millions of brain cells. I have seen this loss in my mother’s brain scans; my mother suffers from Alzheimer’s Disease.

Could the preservation of brain mass be an effect of the autophagy that

BREAKING: Anavex’s Blarcamesine reduces plaque in Alzheimer’s brains without dangerous side effects

From ST

https://medium.com/@irwinbooks/breaking-anavexs-blarcamesine-reduces-plaque-in-alzheimer-s-brains-without-dangerous-side-effects-df893e362a37

[mrplmer]

Agreed Jerry. I heard the same thing. Some goof named Darby said I was wrong. Latest CC he said this year for EMA. Then stated FDA lowered their biomarker standards and could possibly file simultaneously. But I bet he waits for RETT retrial.

[gerry57]

I haven’t posted since January because I sold my position after the Rett TLR. I took my loss and considered what had transpired and really the reality was a compounded because of opportunity cost ( I had been in NvdA and sold it for Avxl) so I acted on the coulda woulda shoulda and and can now buy back 4 times as many shares as I sold in January. I won’t buy a single share back until there is a definitive agreement for the manufacturing and distribution of medication. I don’t think they can file with EMA or FDA without it . For me that will be the tell they are moving forward not backward. Just for ha ha Missling started this year misleading per usual. He stated they would file as early as possible in 2024 taken literally that would have been the morning of January 2nd,he didn’t.

[frrol]

That aphorism is a warning against leverage and speculation. Ironically, the very thing foolish people do when gambling on a pet stock. Folks can see their same foolish behavior on other stock boards: people decrying the "manipulation", how undervalued their precious is, "they're trying to steal our wonder drug, the only one that works". See boards of Cassava, Annovis, etc.

It's why the few investors here warn others not to be fools, to be investors, and to risk what you can afford. You can stay liquid forever, and make a great return. The market is not a casino unless you treat it like one.

Anavex is a promising risky biotech. Ignore fools.

[sage4]

Honestly, I never thought about it. hmmmm................so true.

[ignatiusrielly35]

Yep. Way too much emotion involved. “Oh, woe is me! Why didn’t I do that? Next time I won’t make that mistake.” Only to be repeated.

[Steady_T]

"The market can stay irrational longer than you can stay solvent."