>The exact dosing protocol in the trial is being kept a secret (at Roche’s behest)< Not a secret anymore. Interesting protocol: <a href="http://clinicaltrials.gov/ct2/show/NCT00801255?term=Roche+hcv&rank=9" target="_blank">http://clinicaltrials.gov/ct2/show/NCT00801255?term=Roche+hcv&rank=9</a> The higher dose will only be tested if supported by safety data from the first 2 low dose cohorts and ITMN-191 dosed q8h.