I agree, the reason I went with the 10's and 12.5's is leverage. I was able to buy more out of the money options versus a couple at the money options. In my opinion, the 10's and 12.5's will be at the money by the time ASCO gets here, and I believe that after the ASCO they will be in the money. I only purchased what I could afford to lose, as options are a risky investment. If it works out as planned, the reward will be great, for what I perceive to be little risk.